MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 432 565–832 565 bp (400 000 bp)
+ strand − strand Rv0356c (Rv0356c) — family_assigned: PaaI family thioesterase purA (Rv0357c) — requalified: adenylosuccinate synthase Rv0358 (Rv0358) — requalified: peptidase M50 Rv0359 (Rv0359) — family_assigned: site-2 protease family protein Rv0361 (Rv0361) — family_assigned: hypothetical protein mgtE (Rv0362) — requalified: magnesium transporter fba (Rv0363c) — requalified: class II fructose-bisphosphate aldolase Rv0364 (Rv0364) — family_assigned: VTT domain-containing protein Rv0365c (Rv0365c) — family_assigned: glycoside hydrolase family 76 protein Rv0366c (Rv0366c) — family_assigned: zeta toxin family protein Rv0367c (Rv0367c) — family_assigned: hypothetical protein Rv0368c (Rv0368c) — family_assigned: VWA domain-containing protein Rv0370c (Rv0370c) — family_assigned: MoxR family ATPase Rv0371c (Rv0371c) — family_assigned: NTP transferase domain-containing protein Rv0372c (Rv0372c) — family_assigned: XdhC family protein Rv0373c (Rv0373c) — family_assigned: aerobic carbon-monoxide dehydrogenase large subunit Rv0374c (Rv0374c) — family_assigned: (2Fe-2S)-binding protein Rv0377 (Rv0377) — family_assigned: LysR family transcriptional regulator Rv0378 (Rv0378) — dark: hypothetical protein Rv0381c (Rv0381c) — dark: hypothetical protein ttfA (Rv0383c) — requalified: trehalose monomycolate transport factor TtfA Rv0385 (Rv0385) — requalified: FAD-binding oxidoreductase Rv0386 (Rv0386) — family_assigned: LuxR family transcriptional regulator purT (Rv0389) — requalified: phosphoribosylglycinamide formyltransferase 2 Rv0390 (Rv0390) — family_assigned: rhodanese-like domain-containing protein metZ (Rv0391) — requalified: O-succinylhomoserine sulfhydrylase ndhA (Rv0392c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0394c (Rv0394c) — requalified: hyaluronidase/chondrosulfatase Rv0395 (Rv0395) — dark: hypothetical protein Rv0396 (Rv0396) — dark: hypothetical protein Rv0398c (Rv0398c) — family_assigned: hypothetical protein lpqK (Rv0399c) — family_assigned: serine hydrolase domain-containing protein fadE7 (Rv0400c) — requalified: acyl-CoA dehydrogenase Rv0401 (Rv0401) — dark: DUF3054 domain-containing protein mmpL1 (Rv0402c) — requalified: RND transporter MmpL1 mmpS1 (Rv0403c) — family_assigned: MmpS family protein fgd1 (Rv0407) — requalified: glucose-6-phosphate dehydrogenase (coenzyme-F420) pta (Rv0408) — requalified: phosphate acetyltransferase ackA (Rv0409) — requalified: acetate kinase pknG (Rv0410c) — requalified: serine/threonine protein kinase PknG glnH (Rv0411c) — family_assigned: glutamate ABC transporter substrate-binding protein glnX (Rv0412c) — requalified: protein kinase G-activating protein GlnX thiE (Rv0414c) — requalified: thiamine phosphate synthase thiO (Rv0415) — requalified: glycine oxidase ThiO thiS (Rv0416) — requalified: sulfur carrier protein ThiS thiG (Rv0417) — requalified: thiazole synthase lpqL (Rv0418) — family_assigned: M28 family metallopeptidase lpqM (Rv0419) — requalified: neutral zinc metallopeptidase Rv0421c (Rv0421c) — family_assigned: alpha/beta family hydrolase thiC (Rv0423c) — requalified: phosphomethylpyrimidine synthase ThiC Rv0424c (Rv0424c) — dark: hypothetical protein ctpH (Rv0425c) — requalified: cation-translocating P-type ATPase Rv0426c (Rv0426c) — dark: hypothetical protein Rv0428c (Rv0428c) — family_assigned: GNAT family N-acetyltransferase def (Rv0429c) — requalified: peptide deformylase napA (Rv0430) — requalified: DUF3263 domain-containing protein sodC (Rv0432) — family_assigned: superoxide dismutase family protein Rv0433 (Rv0433) — requalified: glutamate--cysteine ligase Rv0434 (Rv0434) — family_assigned: LON peptidase substrate-binding domain-containing protein Rv0435c (Rv0435c) — family_assigned: AAA family ATPase pssA (Rv0436c) — requalified: CDP-diacylglycerol--serine O-phosphatidyltransferase psd (Rv0437c) — requalified: phosphatidylserine decarboxylase Rv0439c (Rv0439c) — family_assigned: SDR family NAD(P)-dependent oxidoreductase groEL2 (Rv0440) — requalified: chaperonin GroEL Rv0441c (Rv0441c) — family_assigned: pyridoxamine 5'-phosphate oxidase family protein Rv0443 (Rv0443) — requalified: mycothiol transferase rskA (Rv0444c) — requalified: anti-sigma-K factor RskA sigK (Rv0445c) — family_assigned: sigma-70 family RNA polymerase sigma factor SigK Rv0446c (Rv0446c) — family_assigned: DUF1295 domain-containing protein ufaA1 (Rv0447c) — requalified: class I SAM-dependent methyltransferase Rv0449c (Rv0449c) — requalified: NAD(P)/FAD-dependent oxidoreductase mmpS4 (Rv0451c) — requalified: siderophore RND transporter accessory protein MmpS4 Rv0452 (Rv0452) — family_assigned: TetR family transcriptional regulator Rv0455c (Rv0455c) — family_assigned: DUF5078 domain-containing protein echA2 (Rv0456c) — family_assigned: crotonase/enoyl-CoA hydratase family protein Rv0457c (Rv0457c) — family_assigned: prolyl oligopeptidase family protein Rv0458 (Rv0458) — family_assigned: aldehyde dehydrogenase family protein Rv0459 (Rv0459) — family_assigned: DUF779 domain-containing protein lpdC (Rv0462) — requalified: dihydrolipoyl dehydrogenase Rv0463 (Rv0463) — dark: hypothetical protein Rv0464c (Rv0464c) — family_assigned: carboxymuconolactone decarboxylase family protein ramB (Rv0465c) — family_assigned: acetate metabolism transcriptional regulator RamB Rv0466 (Rv0466) — requalified: acyl-[acyl-carrier-protein] thioesterase fadB2 (Rv0468) — requalified: 3-hydroxybutyryl-CoA dehydrogenase FadB2 Rv0471c (Rv0471c) — requalified: 1%2C4-dihydroxy-2-naphthoate prenyltransferase Rv0472c (Rv0472c) — family_assigned: TetR/AcrR family transcriptional regulator Rv0473 (Rv0473) — dark: DUF445 domain-containing protein Rv0474 (Rv0474) — family_assigned: helix-turn-helix transcriptional regulator hbhA (Rv0475) — requalified: heparin-binding hemagglutinin HbhA Rv0477 (Rv0477) — dark: DUF2599 domain-containing protein deoC (Rv0478) — requalified: deoxyribose-phosphate aldolase Rv0479c (Rv0479c) — family_assigned: DUF2993 domain-containing protein Rv0480c (Rv0480c) — family_assigned: carbon-nitrogen hydrolase family protein Rv0481c (Rv0481c) — family_assigned: DUF2505 domain-containing protein murB (Rv0482) — requalified: UDP-N-acetylmuramate dehydrogenase lprQ (Rv0483) — requalified: L%2CD-transpeptidase LdtMt5 Rv0484c (Rv0484c) — family_assigned: SDR family oxidoreductase Rv0485 (Rv0485) — family_assigned: transcriptional regulator mshA (Rv0486) — requalified: D-inositol-3-phosphate glycosyltransferase Rv0487 (Rv0487) — family_assigned: YbjN domain-containing protein senX3 (Rv0490) — requalified: two-component system sensor histidine kinase SenX3 Rv0492c (Rv0492c) — family_assigned: GMC family oxidoreductase Rv0497 (Rv0497) — family_assigned: hypothetical protein Rv0498 (Rv0498) — requalified: sugar phosphate isomerase/epimerase Rv0499 (Rv0499) — family_assigned: thioesterase family protein galE2 (Rv0501) — family_assigned: SDR family oxidoreductase Rv0502 (Rv0502) — family_assigned: lysophospholipid acyltransferase family protein cmaA2 (Rv0503c) — requalified: cyclopropane mycolic acid synthase CmaA2 Rv0504c (Rv0504c) — family_assigned: MaoC family dehydratase N-terminal domain-containing protein mmpS2 (Rv0506) — family_assigned: MmpS family protein mmpL2 (Rv0507) — requalified: RND transporter MmpL2 Rv0508 (Rv0508) — family_assigned: glutaredoxin family protein hemA (Rv0509) — requalified: glutamyl-tRNA reductase hemC (Rv0510) — requalified: hydroxymethylbilane synthase hemB (Rv0512) — requalified: porphobilinogen synthase Rv0513 (Rv0513) — family_assigned: DUF3093 domain-containing protein Rv0514 (Rv0514) — dark: hypothetical protein oprA (Rv0516c) — requalified: osmosensory protein OprA Rv0518 (Rv0518) — family_assigned: SGNH/GDSL hydrolase family protein Rv0523c (Rv0523c) — family_assigned: nitroreductase family deazaflavin-dependent oxidoreductase hemL (Rv0524) — requalified: glutamate-1-semialdehyde 2%2C1-aminomutase Rv0525 (Rv0525) — family_assigned: histidine phosphatase family protein Rv0528 (Rv0528) — requalified: cytochrome c biogenesis protein ResB ccsA (Rv0529) — requalified: c-type cytochrome biogenesis protein CcsB Rv0530 (Rv0530) — family_assigned: MinD/ParA family protein Rv0531 (Rv0531) — family_assigned: DUF4229 domain-containing protein fabH (Rv0533c) — requalified: beta-ketoacyl-ACP synthase III menA (Rv0534c) — requalified: 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase Rv0537c (Rv0537c) — dark: hypothetical protein ptrp (Rv0538) — family_assigned: hypothetical protein Rv0540 (Rv0540) — family_assigned: DUF2064 domain-containing protein Rv0541c (Rv0541c) — family_assigned: integral membrane protein menE (Rv0542c) — requalified: o-succinylbenzoate--CoA ligase Rv0543c (Rv0543c) — family_assigned: DUF3349 domain-containing protein Rv0544c (Rv0544c) — family_assigned: hypothetical protein pitA (Rv0545c) — requalified: anion permease Rv0546c (Rv0546c) — family_assigned: VOC family protein Rv0547c (Rv0547c) — family_assigned: SDR family oxidoreductase vapC3 (Rv0549c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB3 (Rv0550c) — family_assigned: type II toxin-antitoxin system CcdA family antitoxin fadD8 (Rv0551c) — requalified: fatty-acid--CoA ligase FadD8 Rv0552 (Rv0552) — requalified: amidohydrolase menC (Rv0553) — requalified: o-succinylbenzoate synthase bpoC (Rv0554) — family_assigned: alpha/beta hydrolase menD (Rv0555) — requalified: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxyli Rv0556 (Rv0556) — family_assigned: DUF3592 domain-containing protein Rv0559c (Rv0559c) — family_assigned: DUF732 domain-containing protein menJ (Rv0561c) — requalified: menaquinone reductase grcC1 (Rv0562) — requalified: polyprenyl-diphosphate synthase GrcC htpX (Rv0563) — requalified: zinc metalloprotease HtpX gpdA1 (Rv0564c) — requalified: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Rv0565c (Rv0565c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0566c (Rv0566c) — family_assigned: YajQ family cyclic di-GMP-binding protein Rv0567 (Rv0567) — requalified: methyltransferase cyp135B1 (Rv0568) — requalified: cytochrome P450 Rv0569 (Rv0569) — family_assigned: DUF1918 domain-containing protein nrdZ (Rv0570) — requalified: adenosylcobalamin-dependent ribonucleoside-diphosphate reduc Rv0571c (Rv0571c) — family_assigned: phosphoribosyltransferase family protein Rv0572c (Rv0572c) — family_assigned: hypothetical protein pncB2 (Rv0573c) — requalified: nicotinate phosphoribosyltransferase Rv0574c (Rv0574c) — family_assigned: CapA family protein Rv0575c (Rv0575c) — requalified: FAD-binding domain Rv0576 (Rv0576) — family_assigned: TIGR03086 family metal-binding protein TB27.3 (Rv0577) — family_assigned: VOC family protein Rv0579 (Rv0579) — family_assigned: Mut7-C RNAse domain-containing protein Rv0580c (Rv0580c) — requalified: mycobacterial cell wall protein Rv0580c vapB26 (Rv0581) — requalified: type II toxin-antitoxin system antitoxin VapB26 vapC26 (Rv0582) — requalified: type II toxin-antitoxin system toxin ribonuclease C26 lpqN (Rv0583c) — family_assigned: LpqN/LpqT family lipoprotein Rv0584 (Rv0584) — family_assigned: GH92 family glycosyl hydrolase Rv0585c (Rv0585c) — family_assigned: lysylphosphatidylglycerol synthase transmembrane domain-cont mce2R (Rv0586) — family_assigned: FadR family transcriptional regulator Mce2R yrbE2A (Rv0587) — family_assigned: ABC transporter permease Rv0588 (Rv0588) — family_assigned: ABC transporter permease mce2C (Rv0591) — family_assigned: virulence factor Mce family protein mce2D (Rv0592) — family_assigned: virulence factor Mce family protein mce2F (Rv0594) — family_assigned: MlaD family protein vapC4 (Rv0595c) — requalified: type II toxin-antitoxin system toxin ribonuclease C4 vapB4 (Rv0596c) — requalified: type II toxin-antitoxin system antitoxin VapB4 Rv0597c (Rv0597c) — family_assigned: ATP-binding protein vapC27 (Rv0598c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB27 (Rv0599c) — requalified: type II toxin-antitoxin system antitoxin VapB27 Rv0603 (Rv0603) — family_assigned: hypothetical protein lpqO (Rv0604) — family_assigned: DUF1259 domain-containing protein Rv0605 (Rv0605) — family_assigned: IS607-like element IS1536 family transposase vapB28 (Rv0608) — family_assigned: type II toxin-antitoxin system VapB family antitoxin vapC28 (Rv0609) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv0610c (Rv0610c) — family_assigned: hypothetical protein Rv0611c (Rv0611c) — family_assigned: DUF4926 domain-containing protein Rv0612 (Rv0612) — family_assigned: hypothetical protein Rv0613c (Rv0613c) — family_assigned: SEC-C domain-containing protein Rv0614 (Rv0614) — dark: hypothetical protein Rv0615 (Rv0615) — family_assigned: hypothetical protein vapC29 (Rv0617) — requalified: type II toxin-antitoxin system ribonuclease VapC29 galK (Rv0620) — requalified: galactokinase Rv0622 (Rv0622) — dark: DUF732 domain-containing protein vapB30 (Rv0623) — requalified: type II toxin-antitoxin system antitoxin VapB30 vapC30 (Rv0624) — requalified: type II toxin-antitoxin system toxin ribonuclease C30 Rv0625c (Rv0625c) — family_assigned: TVP38/TMEM64 family protein vapB5 (Rv0626) — family_assigned: type II toxin-antitoxin system Phd/YefM family antitoxin vapC5 (Rv0627) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv0628c (Rv0628c) — family_assigned: FIST N-terminal domain-containing protein recD (Rv0629c) — family_assigned: exodeoxyribonuclease V subunit alpha recB (Rv0630c) — family_assigned: exodeoxyribonuclease V subunit beta recC (Rv0631c) — family_assigned: exodeoxyribonuclease V subunit gamma echA3 (Rv0632c) — family_assigned: crotonase/enoyl-CoA hydratase family protein Rv0633c (Rv0633c) — family_assigned: hypothetical protein Rv0634c (Rv0634c) — requalified: MBL fold metallo-hydrolase hadA (Rv0635) — family_assigned: (3R)-hydroxyacyl-ACP dehydratase subunit HadA hadB (Rv0636) — family_assigned: (3R)-hydroxyacyl-ACP dehydratase subunit HadB hadC (Rv0637) — family_assigned: (3R)-hydroxyacyl-ACP dehydratase subunit HadC nusG (Rv0639) — requalified: transcription termination/antitermination protein NusG rplK (Rv0640) — requalified: 50S ribosomal protein L11 rplA (Rv0641) — requalified: 50S ribosomal protein L1 mmaA4 (Rv0642c) — requalified: hydroxymycolate synthase MmaA4 mmaA3 (Rv0643c) — requalified: methoxy mycolic acid synthase MmaA3 mmaA2 (Rv0644c) — requalified: cyclopropane mycolic acid synthase MmaA2 mmaA1 (Rv0645c) — requalified: mycolic acid methyltransferase MmaA1 lipG (Rv0646c) — requalified: lipase/esterase LipG Rv0650 (Rv0650) — family_assigned: ROK family protein rplJ (Rv0651) — requalified: 50S ribosomal protein L10 rplL (Rv0652) — requalified: 50S ribosomal protein L7/L12 Rv0653c (Rv0653c) — family_assigned: TetR/AcrR family transcriptional regulator Rv0654 (Rv0654) — requalified: carotenoid cleavage oxygenase vapC6 (Rv0656c) — requalified: ribonuclease VapC6 vapB6 (Rv0657c) — family_assigned: type II toxin-antitoxin system VapB family antitoxin Rv0658c (Rv0658c) — family_assigned: CPBP family intramembrane glutamic endopeptidase mazF2 (Rv0659c) — family_assigned: type II toxin-antitoxin system PemK/MazF family toxin mazE2 (Rv0660c) — family_assigned: ribbon-helix-helix protein%2C CopG family vapC7 (Rv0661c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB7 (Rv0662c) — requalified: antitoxin atsD (Rv0663) — requalified: arylsulfatase AtsD vapC8 (Rv0665) — family_assigned: PIN domain-containing protein Rv0666 (Rv0666) — dark: hypothetical protein rpoB (Rv0667) — family_assigned: DNA-directed RNA polymerase subunit beta Rv0669c (Rv0669c) — requalified: neutral ceramidase end (Rv0670) — requalified: deoxyribonuclease IV lpqP (Rv0671) — family_assigned: PHB depolymerase family esterase fadE8 (Rv0672) — family_assigned: acyl-CoA dehydrogenase family protein echA4 (Rv0673) — family_assigned: crotonase/enoyl-CoA hydratase family protein Rv0674 (Rv0674) — family_assigned: PaaX family transcriptional regulator C-terminal domain-cont mmpL5 (Rv0676c) — requalified: siderophore RND transporter MmpL5 mmpS5 (Rv0677c) — requalified: siderophore transporter accessory protein MmpS5 mmpR5 (Rv0678) — family_assigned: siderophore transport transcriptional regulator MmpR5 Rv0679c (Rv0679c) — family_assigned: DUF3060 domain-containing protein Rv0680c (Rv0680c) — dark: DUF3060 domain-containing protein Rv0681 (Rv0681) — family_assigned: TetR/AcrR family transcriptional regulator rpsL (Rv0682) — requalified: 30S ribosomal protein S12 Rv0686 (Rv0686) — family_assigned: SHOCT domain-containing protein Rv0687 (Rv0687) — family_assigned: Rv0687 family mycofactocin-dependent SDR oxidoreductase Rv0688 (Rv0688) — requalified: FAD/NAD(P)-binding oxidoreductase Rv0690c (Rv0690c) — family_assigned: DUF2332 domain-containing protein mftR (Rv0691c) — family_assigned: mycofactocin system transcriptional regulator mftB (Rv0692) — requalified: mycofactocin biosynthesis chaperone MftB mftC (Rv0693) — requalified: mycofactocin radical SAM maturase mftD (Rv0694) — requalified: pre-mycofactocin synthase MftD mftE (Rv0695) — requalified: mycofactocin biosynthesis peptidyl-dipeptidase MftE mftF (Rv0696) — requalified: mycofactocin biosynthesis glycosyltransferase MftF mftG (Rv0697) — family_assigned: mycofactocin system GMC family oxidoreductase MftG Rv0699 (Rv0699) — dark: hypothetical protein rplC (Rv0701) — requalified: 50S ribosomal protein L3 rplD (Rv0702) — requalified: 50S ribosomal protein L4 rplW (Rv0703) — requalified: 50S ribosomal protein L23 rplB (Rv0704) — requalified: 50S ribosomal protein L2 rpsS (Rv0705) — requalified: 30S ribosomal protein S19 rplV (Rv0706) — requalified: 50S ribosomal protein L22 rpsC (Rv0707) — requalified: 30S ribosomal protein S3 rplP (Rv0708) — requalified: 50S ribosomal protein L16 rpmC (Rv0709) — requalified: 50S ribosomal protein L29 rpsQ (Rv0710) — requalified: 30S ribosomal protein S17 atsA (Rv0711) — requalified: arylsulfatase AtsA Rv0712 (Rv0712) — family_assigned: formylglycine-generating enzyme family protein Rv0713 (Rv0713) — dark: DUF4436 domain-containing protein rplX (Rv0715) — requalified: 50S ribosomal protein L24 rplE (Rv0716) — requalified: 50S ribosomal protein L5 rplR (Rv0720) — requalified: 50S ribosomal protein L18 rpsE (Rv0721) — requalified: 30S ribosomal protein S5 rpmD (Rv0722) — requalified: 50S ribosomal protein L30 rplO (Rv0723) — requalified: 50S ribosomal protein L15 Rv0726c (Rv0726c) — requalified: class I SAM-dependent methyltransferase fucA (Rv0727c) — requalified: L-fuculose-phosphate aldolase serA2 (Rv0728c) — requalified: D-3-phosphoglycerate dehydrogenase SerA xylB (Rv0729) — requalified: FGGY-family carbohydrate kinase Rv0731c (Rv0731c) — requalified: class I SAM-dependent methyltransferase secY (Rv0732) — family_assigned: preprotein translocase subunit SecY adk (Rv0733) — requalified: adenylate kinase sigL (Rv0735) — family_assigned: sigma-70 family RNA polymerase sigma factor SigL rslA (Rv0736) — requalified: anti-sigma-L factor RslA 466 kb 532 kb 598 kb 665 kb 732 kb 798 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.