rpoB Family assigned · medium auto-curated

H37Rv Rv0667 · MTBC0 mtbc0_000705 · 1172 aa · 763893–767411 MTBC0 (+) · RefSeq NP_215181.1

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This gene (outlined) in its genomic context; arrows are neighbouring genes coloured by verdict. Click any gene to navigate. Pan and zoom in the full browser.

Annotation: from legacy to revised

Legacy (H37Rv / Mycobrowser)DNA-directed RNA polymerase subunit beta
MTBC0 PGAP re-annotationDNA-directed RNA polymerase subunit beta
Revised (this work)DNA-directed RNA polymerase subunit beta. Pfam: RNA_pol_Rpb2_1 (PF04563.21), RNA_pol_Rpb2_2 (PF04561.20), RNA_pol_Rpb2_3 (PF04565.22), RNA_pol_Rpb2_45 (PF10385.15), RNA_pol_Rpb2_6 (PF00562.34), RNA_pol_Rpb2_7 (PF04560.26).
Functional category (TubercuList)information pathways

Curation note: P16.23 (phase135, 2026-08-17): couche tss ajoutee (leaderless=False). P49.1 (phase233, 2026-09-15): couche tss re-clee (leaderless=False).

Auto-curated: this verdict and function were generated by rules from PGAP + Pfam + Foldseek and have not been hand-reviewed.

In the literature (TB corpus sweep) 2140 publications

2140 TB publications mention this gene. 2140 publications discuss this gene. Queried separately, 1701 records carry a M. tuberculosis context and 303 a non-TB mycobacterial context (species named in the 40-record verified sample: M. abscessus (18), M. leprae (11), M. marinum (10), M. smegmatis (3)). The three counts come from three distinct PubMed queries (each with its own context filter), so they neither partition the total nor need to add up to it.

5 of 2140: the most recently indexed records of the curated sweep at its date, not necessarily the most recent papers on this gene — the exhaustive list below is later and broader and may hold newer ones.
PublicationDate
A diagnostic performance study of multiplex polymerase chain reaction-based targeted next-generation sequencing for the accurate identification of Mycobacterium tuberculosis in bronchoalveolar lavage fluid. doi:10.3389/fcimb.2026.1807848 2026
Halorubrum marinum sp. nov., Halorubrum rarum sp. nov., Halorubrum wangae sp. nov., Halorubrum shenae sp. nov., and Halorubrum zhoui sp. nov., halophilic archaea from coastal tidal flats, a saline lake, and a marine solar saltern. doi:10.1016/j.syapm.2026.126750 2026
Machine learning-based analysis of drug resistance mutations in Mycobacterium tuberculosis. doi:10.1371/journal.pone.0352863 2026
Genetic surveillance of first- and second-line drug-resistant isolates of Mycobacterium tuberculosis in Peru. doi:10.1371/journal.pone.0352881 2026
The potential of molecular testing and mutation analysis for detecting isoniazid and rifampicin-resistant Mycobacterium tuberculosis in Thailand. doi:10.1590/S1678-9946202668040 2026
2180 records returned by the alias sweep (a separate sweep from the 2140 above; both are shown, neither is exhaustive)

Searched as: Rv0667, rpoB, Mb0686, ML1891c, MMAR_0995, MSMEG_1367, MAB_3869c — each in conjunction with a mycobacterial context term. Swept 2026-09-07.

PublicationJournalYear
Multiplex crRNAs powered CRISPRCas13a detection for rifampicin-resistant mycobacterium tuberculosis. doi:10.1016/j.jiph.2026.103348 J Infect Public Health 2026
Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis. doi:10.1038/s41564-026-02437-w Nat Microbiol 2026
Implications of edge cases for antimicrobial susceptibility predictions for rifampin, delamanid, and pretomanid with the WHO Mycobacterium tuberculosis mutation catalog. doi:10.1128/spectrum.01821-26 Microbiol Spectr 2026
Genomic epidemiology of the Mycobacterium tuberculosis complex in Fiji reveals community transmission and human Mycobacterium bovis infection. doi:10.3389/fmicb.2026.1933597 Front Microbiol 2026
Genetic diversity of clinical Mycobacterium bovis BCG isolates from an immunocompromised patient with BCG infection. doi:10.1016/j.meegid.2026.106014 Infect Genet Evol 2026
Genomic characterization of drug-resistant Mycobacterium tuberculosis complex in western Kenya reveals predominance of isoniazid resistance and discordance with routine susceptibility testing. doi:10.3389/ftubr.2026.1855780 Front Tuberc 2026
Comparative whole genome analysis of Mycobacterium tuberculosis isolated from BPaLM and individualized regimen treated patients at Dr. Soetomo Hospital, Indonesia. doi:10.1007/s11033-026-12652-7 Mol Biol Rep 2026
Utility of RGM medium for recovery of Mycobacterium abscessus from presumptive pulmonary tuberculosis patients and its molecular phylogenetic characterization. doi:10.18502/ijm.v18i4.22198 Iran J Microbiol 2026
Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilot. doi:10.3389/fepid.2026.1813571 Front Epidemiol 2026
[Drug resistance of clinical Mycobacterium tuberculosis isolates and molecular characteristics of rifampicin-resistant isolates from elderly pulmonary tuberculosis patients in Beijing, 2024]. doi:10.3760/cma.j.cn112338-20251111-00816 Zhonghua Liu Xing Bing Xue Za Zhi 2026
Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria. doi:10.3390/ijms27156893 Int J Mol Sci 2026
Whole-genome sequencing reveals lineage-associated drug resistance and enables machine learning-based prediction in Mycobacterium tuberculosis clinical isolates. doi:10.3389/fmicb.2026.1828991 Front Microbiol 2026
Disinfection and damage of nontuberculous mycobacteria by different UV wavelengths. doi:10.1128/aem.01078-26 Appl Environ Microbiol 2026
Mycobacterium shimoidei causing granulomatous inflammation in a captive bird species, the white-cheeked turaco. doi:10.1177/10406387261471130 J Vet Diagn Invest 2026
Genomic diversity and transmission routes of Mycobacterium tuberculosis isolates in Morocco. doi:10.1016/j.meegid.2026.105997 Infect Genet Evol 2026
Rapid Extensively Drug-Resistant (XDR) TB Diagnosis: An In-House DNA Biochip for Drug Resistance Detection and Mutation Profiling of Mycobacterium tuberculosis. doi:10.1155/cjid/5518992 Can J Infect Dis Med Microbiol 2026
Rifabutin Cross-resistance and Associated rpoB Mutations in Rifampicin-resistant Mycobacterium tuberculosis Complex Isolates. doi:10.4274/ThoracResPract.2026.2026-1-16 names it Thorac Res Pract 2026
Genomic insights into low-level rifampicin resistance mediated by borderline rpoB mutations in Mycobacterium tuberculosis: prevalence and phylogeny in Northeast China. doi:10.1128/spectrum.00327-26 names it Microbiol Spectr 2026
Thin-Film-Based Three-Chamber Microfluidic Chip Powered by Pyrococcus furiosus Argonaute for Sample-to-Answer Multiplex Genotyping of Tuberculosis Drug-Resistance Mutations. doi:10.1021/acssensors.6c01347 ACS Sens 2026
A diagnostic performance study of multiplex polymerase chain reaction-based targeted next-generation sequencing for the accurate identification of Mycobacterium tuberculosis in bronchoalveolar lavage fluid. doi:10.3389/fcimb.2026.1807848 Front Cell Infect Microbiol 2026
Machine learning-based analysis of drug resistance mutations in Mycobacterium tuberculosis. doi:10.1371/journal.pone.0352863 PLoS One 2026
Genetic surveillance of first- and second-line drug-resistant isolates of Mycobacterium tuberculosis in Peru. doi:10.1371/journal.pone.0352881 PLoS One 2026
The potential of molecular testing and mutation analysis for detecting isoniazid and rifampicin-resistant Mycobacterium tuberculosis in Thailand. doi:10.1590/S1678-9946202668040 Rev Inst Med Trop Sao Paulo 2026
Pulmonary infection by non-tuberculous mycobacteria in an endemic region for tuberculosis in Northeast Brazil. doi:10.1590/1414-431X2026e15340 Braz J Med Biol Res 2026
Phenotypic discordance in rifampicin resistance detection among Mycobacterium tuberculosis isolates from China: insights from whole-genome sequencing and a structured literature review. doi:10.1128/spectrum.03261-25 Microbiol Spectr 2026
Molecular Evaluation of Rifampicin and Isoniazid Resistance in Pulmonary Tuberculosis Using Cartridge-Based Nucleic Acid Amplification Test and Line Probe Assay. doi:10.7759/cureus.110237 Cureus 2026
ZILA-SRM: a probabilistic framework with zero-inflated latent models for robust strain reconstruction from metagenomes. doi:10.1128/spectrum.04101-25 Microbiol Spectr 2026
Genotypic Characterization of Drug Resistance-associated Mutations in Mycobacterium tuberculosis Using Line Probe Assays in Central India. doi:10.4103/ijmy.ijmy_85_26 Int J Mycobacteriol 2026
Analysis of Drug Resistance Characteristics and Risk Factors of Cavitary Tuberculosis Based on Whole Genome Sequencing and Machine Learning. doi:10.1093/ofid/ofag328 Open Forum Infect Dis 2026
Leveraging rpoB amplicon signals from Xpert MTB/RIF ultra as a diagnostic opportunity for identifying Non-tuberculous mycobacteria in TB-negative specimens. doi:10.1038/s41598-026-57683-z names it Sci Rep 2026
Targeted next-generation sequencing implementation in Eswatini identifies rifampicin and bedaquiline resistance undetected by routine diagnostic testing. doi:10.1038/s41467-026-73551-w Nat Commun 2026
Influence of Diabetes Mellitus on the Development of Multidrug-Resistant Tuberculosis (MDR-TB) in Relation With Genetic Mutations of M. tuberculosis Isolates in Ethiopia. doi:10.1155/cjid/7830270 Can J Infect Dis Med Microbiol 2026
Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis. doi:10.1038/s41467-026-73952-x Nat Commun 2026
Simultaneous molecular detection of Mycobacterium tuberculosis and multidrug resistance using CRISPR-AaCas12b-based nucleic acid assay. doi:10.3389/fcimb.2026.1844184 Front Cell Infect Microbiol 2026
Diagnostic Challenges in Disseminated Mycobacterium szulgai Infection: A Case Report in the Setting of Advanced HIV Infection. doi:10.7759/cureus.108067 Cureus 2026
A cross-sectional study on discordances between Anyplex™ II MTB/MDR and BACTEC MGIT 960 system for assessing susceptibility for Mycobacterium tuberculosis: analysis of clinical specimens from patients with isoniazid-monoresistant, rifampicin-monoresistant, and multidrug-resistant tuberculosis. doi:10.1186/s12941-026-00864-5 Ann Clin Microbiol Antimicrob 2026
An Uncommon Case of Recurring Pulmonary, Lymphatic, and Skeletal Tuberculosis Accompanied by Myositis: Is It Associated with Particular Resistance? doi:10.2147/IMCRJ.S584317 Int Med Case Rep J 2026
Genetic Characterization of First-Line Drug-Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis. doi:10.3390/pathogens15050455 Pathogens 2026
Uncovering resistance pathways to first- and last-line antibiotics in Mycobacterium tuberculosis populations. doi:10.1099/mgen.0.001723 Microb Genom 2026
Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes. doi:10.1038/s41598-026-53296-8 names it Sci Rep 2026
In vitro antimicrobial resistance properties of rifapentine and rifampicin are indistinguishable. doi:10.1128/spectrum.00627-26 Microbiol Spectr 2026
Evolutionary dynamics of drug resistance in MDR-TB: Heterogeneous minor variants and extensive compensatory mutations. doi:10.1016/j.ijmm.2026.151714 Int J Med Microbiol 2026
Predictive Analysis of Drug-Resistant Tuberculosis: Integrating Molecular Markers, Clinical Governance, and Community-Engaged Education in Rural South Africa. doi:10.3390/diseases14040132 Diseases 2026
Assessment of Antimicrobial Resistance in M. leprae Strains From Kiribati. doi:10.1111/tmi.70146 Trop Med Int Health 2026
Identification of Mycobacterium leprae and Mycobacterium lepromatosis Cases with Broad-Range Molecular Assays at a Single Large Reference Laboratory. doi:10.4269/ajtmh.25-0379 Am J Trop Med Hyg 2026
Description and complete genome sequence of Mycobacterium venezuelense sp. nov., a rapidly growing species recovered from a soft tissue infection. doi:10.3389/fmicb.2026.1780266 Front Microbiol 2026
Iron supplementation potentiates oxidative stress, modulates gene expression and enhances killing of Mycobacterium tuberculosis treated with rifampicin and vitamin C. doi:10.1016/j.tube.2026.102765 Tuberculosis (Edinb) 2026
Diagnosis of Mycobacteriosis in Cultured Hybrid Tilapia (Oreochromis spp.) in Trinidad and Tobago. doi:10.1111/jfd.70156 J Fish Dis 2026
Mycobacterium cajalii sp. nov., a novel scotochromogenic rapid-growing nontuberculous mycobacterial species closely related to Mycobacterium servetii. doi:10.1007/s10482-026-02301-1 Antonie Van Leeuwenhoek 2026
Clinical characteristics, susceptibility profiles and treatment outcomes of pulmonary disease caused by Mycobacterium paraense. doi:10.1016/j.diagmicrobio.2026.117406 Diagn Microbiol Infect Dis 2026
Prevalence of nontuberculous mycobacteria isolates and pulmonary disease from respiratory tract samples in persons investigated for presumed tuberculosis from three West African countries, an analysis of three prospective cohort studies. doi:10.1186/s12879-026-13211-y BMC Infect Dis 2026
First-line drug-resistant tuberculosis among children under 15 years in Ethiopia: insights from phenotypic and whole-genome sequencing approaches. doi:10.1186/s12879-026-13206-9 BMC Infect Dis 2026
A cartridge-based assay for improved detection of multidrug-resistant Mycobacterium tuberculosis directly from sputum. doi:10.1128/jcm.01100-25 J Clin Microbiol 2026
Analysis of rpoB mutations associated with rifampicin resistance in Mycobacterium tuberculosis isolates in Malawi. doi:10.1186/s12879-026-13126-8 names it BMC Infect Dis 2026
Decoding antibiotic resistance in tuberculosis: Role of RRDR and non-RRDR mutations in diagnostic perspectives. doi:10.1016/j.bbrc.2026.153563 Biochem Biophys Res Commun 2026
Drug-Resistant Pulmonary Tuberculosis among Adolescents and Young Adults in China. doi:10.3967/bes2025.159 Biomed Environ Sci 2026
Simultaneous detection of Mycobacterium tuberculosis complex and rifampin/isoniazid resistance with sanity 2.0 MTBC-MDR: a moderate-complexity automated NAAT. doi:10.1007/s11274-026-04858-5 World J Microbiol Biotechnol 2026
Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study. doi:10.1128/spectrum.02597-25 Microbiol Spectr 2026
Nanopore-targeted sequencing improves the diagnosis and treatment of patients with infectious ascites. doi:10.1186/s12967-026-07965-x J Transl Med 2026
Evaluation of Xpert MTB/RIF assay accuracy for diagnosing TB and detecting rifampin resistance in patients with very low bacterial loads results: a retrospective study in Hunan, China. doi:10.1186/s12879-026-12933-3 BMC Infect Dis 2026
Genetic diversity and drug resistance profiles of Mycobacterium tuberculosis among Ethiopian children as determined by whole-genome sequencing. doi:10.1128/spectrum.02736-25 Microbiol Spectr 2026
Investigation of Gene Regions Responsible for Drug Resistance in Clinical Isolates of Mycobacterium tuberculosis Complex Resistant to at Least Two First-Line Anti-Tuberculosis Drugs. doi:10.3390/pathogens15020222 Pathogens 2026
Single Isothermal Assay for Multi-Site Mutation Detection of Rifampicin Resistance in Mycobacterium tuberculosis. doi:10.3390/pathogens15020187 Pathogens 2026
Pattern and prevalence of rifampicin and isoniazid-resistant tuberculosis using genotype MTBDRplus assay in Ethiopia. doi:10.1128/spectrum.01454-25 Microbiol Spectr 2026
In Silico Design of gRNA for CRISPR System for Detection of Multidrug Resistant Tuberculosis Using Indian Mycobacterium tuberculosis Genomes: A Computational Study. doi:10.7759/cureus.101851 Cureus 2026
First insight of characteristics and prediction of Mycobacterium tuberculosis drug resistance by whole genome sequencing in Fujian Province, China. doi:10.1038/s41598-026-40398-6 Sci Rep 2026
Comment on "Epidemiology and molecular characterization of multidrug-resistant Mycobacterium tuberculosis among patients with pulmonary symptoms in Kaduna State, Nigeria". doi:10.1016/j.actatropica.2026.108027 Acta Trop 2026
Phenotypic drug resistance and genome sequencing based identified mutations linked to resistance in Mycobacterium tuberculosis isolated from extrapulmonary clinical specimens. doi:10.1038/s41598-026-40253-8 Sci Rep 2026
Precision detection of rifampicin-resistant rpoB_L378R mutation in Mycobacterium tuberculosis with CRISPR-Cas12a. doi:10.1039/d5ay01718a names it Anal Methods 2026
A multiplex assay based on capillary electrophoresis to detect Mycobacterium tuberculosis complex: development and clinical validation. doi:10.1007/s00253-025-13701-0 Appl Microbiol Biotechnol 2026
Comparison of the diagnostic value of targeted next-generation sequencing, metagenomic next-generation sequencing, and Xpert MTB/RIF in adult pulmonary tuberculosis. doi:10.1186/s12879-026-12673-4 BMC Infect Dis 2026
Characterization of pulmonary tuberculosis in high-altitude region using nanopore targeted sequencing. doi:10.1186/s12866-026-04761-x BMC Microbiol 2026
Improved detection of Mycobacterium tuberculosis in lymph node aspirates through GeneXpert MTB/RIF assay in Bangladesh. doi:10.1186/s12879-026-12619-w BMC Infect Dis 2026
Mutations related to rifampicin and isoniazid resistance in Mycobacterium tuberculosis strains in Ankara, Turkey. doi:10.1556/030.2026.02818 Acta Microbiol Immunol Hung 2026
A profile on the Truenat assays for the detection of pulmonary tuberculosis and rifampicin resistance. doi:10.1080/14737159.2026.2616751 Expert Rev Mol Diagn 2026
Resistance to anti-leprosy drugs in multi-bacillary leprosy patients: The need for transformative action. doi:10.25259/IJDVL_1842_2024 Indian J Dermatol Venereol Leprol 2026
Mycobacterium wolinskyi as an emerging cause of pacemaker pocket infection and lead endocarditis: a case report and genomic characterization. doi:10.1128/asmcr.00146-25 ASM Case Rep 2026
Molecular epidemiology of drug resistance and transmission of Mycobacterium tuberculosis in Meigu County, Sichuan Province, China. doi:10.1128/spectrum.02685-25 Microbiol Spectr 2026
Geographical trends of drug-resistant strains of Mycobacterium leprae in TLM hospitals: insights from a four-year study across eleven hospitals in eight Indian States. doi:10.1007/s10096-025-05351-x Eur J Clin Microbiol Infect Dis 2026
Clinically present mycobacterium tuberculosis RNA polymerase subunit RpoB K446 mutation confers broad-spectrum antibiotics resistance via pupylation. doi:10.1016/j.bioorg.2025.109388 names it Bioorg Chem 2026
Undetected rifampicin-resistant tuberculosis associated with rpoB I491F and V170F mutations in Botswana: Diagnostic implications. doi:10.1016/j.jgar.2025.12.005 names it J Glob Antimicrob Resist 2026
Distribution, prevalence of non-tuberculous mycobacteria on Hainan Island and antibiotic resistance of Mycobacterium abscessus. doi:10.1128/spectrum.01134-25 Microbiol Spectr 2026
Nationwide longitudinal evaluation of a machine learning approach for enhanced interpretation of Xpert MTB/RIF ultra rifampicin-resistance results in low bacterial load tuberculosis specimens. doi:10.1016/j.jiph.2025.103064 J Infect Public Health 2026
A Case of Granulomatous Nodule Caused by a Previously Undescribed Species of Nontuberculous Mycobacterium. doi:10.1111/cup.70012 J Cutan Pathol 2026
Quantification and detection of Mycobacterium tuberculosis, HIV-1 co-localization, and reciprocal expansion in spinal tuberculosis tissues. doi:10.1016/j.ijid.2025.108204 Int J Infect Dis 2026
Understanding recurrence in Mycobacterium avium complex pulmonary disease: genotypic strategies to support clinical decision-making. doi:10.1128/jcm.01086-25 J Clin Microbiol 2026
A POC label-free biosensor to detect point mutations in the rpoB gene of Mycobacterium tuberculosis from RR-TB raw sputum samples. doi:10.1016/j.bioelechem.2025.109138 names it Bioelectrochemistry 2026
Machine learning approaches to predict drug resistance in tuberculosis. doi:10.1016/j.compbiolchem.2025.108705 Comput Biol Chem 2026
Retrospective Cohort Analysis for Identification of Discordant Rifampicin-resistant Xpert MTB/RIF Assay Results in South Kivu, Eastern Democratic Republic of the Congo, a High Burden Tuberculosis Setting. doi:10.1093/cid/ciaf451 Clin Infect Dis 2026
Epidemiologic and Bacterial Factors Facilitating Long-term Transmission of Multidrug-Resistant Tuberculosis in Shanghai, China. doi:10.1093/cid/ciaf313 Clin Infect Dis 2026
Artificial intelligence for screening drug resistance in tuberculosis. doi:10.25259/IJMR_1546_2025 Indian J Med Res 2025
Beyond Hotspot Mutations: Diagnostic Relevance of High Frequency, Low Frequency, and Disputed rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis. doi:10.3390/pathogens15010016 names it Pathogens 2025
NGS-based approach for diagnostically unidentified Mycobacterium saskatchewanense, a rare non-tuberculous mycobacterium. doi:10.3389/fcimb.2025.1685898 Front Cell Infect Microbiol 2025
Unraveling Drug Resistance in Mycobacterium leprae: Exploring Genetic Mutations to Enhance Treatment Strategies for Human Leprosy-A Narrative Review. doi:10.1155/ijm/7204337 Int J Microbiol 2025
Deciphering the population dynamics and drug-resistance characteristics of extrapulmonary tuberculosis: genomic and clinical insights from a Chinese hospital. doi:10.3389/fcimb.2025.1692783 Front Cell Infect Microbiol 2025
Drug resistance profile of Mycobacterium tuberculosis in China: update until 2024. doi:10.3389/fmicb.2025.1697490 Front Microbiol 2025
A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis. doi:10.1186/s12866-025-04601-4 BMC Microbiol 2025
Association of D516V, H526Y, and S531L rpoB gene polymorphisms and risk factors with rifampicin resistance in Mycobacterium tuberculosis isolates from pulmonary TB patients in Northwest Amhara, Ethiopia: cross-sectional study. doi:10.1186/s12879-025-12351-x names it BMC Infect Dis 2025
Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil. doi:10.1007/s00430-025-00864-w Med Microbiol Immunol 2025
Characterization of Drug Resistance Patterns, Mutation Profiles and Prevalence of Mycobacterium tuberculosis in Shaoxing. doi:10.2147/IDR.S570295 Infect Drug Resist 2025
The performance of A rpob gene mutation linked to A resistant to rifampicin mycobacterium tuberculosis isolate from an Indonesian referral hospital. doi:10.1016/j.ijtb.2024.06.013 names it Indian J Tuberc 2025
Molecular characterization of rifampicin-resistant Mycobacterium tuberculosis isolates by line probe assay method. A cross-sectional study from a nodal DR-TB centre of Bihar. doi:10.1016/j.ijtb.2025.06.005 Indian J Tuberc 2025
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda. doi:10.1371/journal.pone.0328957 PLoS One 2025
Molecular Epidemiology of Mycobacterium tuberculosis in Mexico. doi:10.3390/microorganisms13112453 Microorganisms 2025
Therapeutic failure of multidrug therapy for leprosy: A retrospective case series in a hyperendemic Brazilian City. doi:10.1371/journal.pntd.0013616 PLoS Negl Trop Dis 2025
Detection of rifampin-resistant Mycobacterium tuberculosis using CRISPR/Cas14a-enabled molecular techniques. doi:10.1186/s12879-025-12190-w BMC Infect Dis 2025
Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015). doi:10.1186/s12879-025-11913-3 BMC Infect Dis 2025
A Comparative Analysis of Resistance Patterns in Rifampin-Resistant Tuberculosis: Mutations Within and Outside the Rifampicin Resistance-Determining Region. doi:10.7759/cureus.93975 Cureus 2025
Diagnosing tuberculous meningitis from cell-free DNA by multi-targeted real-time PCR: An experience from 170 cases. doi:10.1016/j.tube.2025.102705 Tuberculosis (Edinb) 2025
First isolation of Mycobacterium brisbanense from humans in the Americas. doi:10.1590/0074-02760250063 Mem Inst Oswaldo Cruz 2025
Molecular epidemiology of drug-resistant tuberculosis in Jiangxi Province, China, 2022-2023. doi:10.35772/ghm.2025.01065 Glob Health Med 2025
Antimicrobial susceptibility patterns and genotypic characteristics of Mycobacterium marinum and Mycobacterium abscessus isolated from cutaneous infections: A retrospective study. doi:10.1016/j.jgar.2025.10.001 J Glob Antimicrob Resist 2025
Epidemiological Profile and rpoB Gene Mutations in Pulmonary Tuberculosis Patients From Sulaymaniyah, Iraq: Evidence of Novel Genetic Variations and Beijing Lineage Emergence. doi:10.1155/ijm/6691977 names it Int J Microbiol 2025
Molecular insights of drug-resistant tuberculosis: genetic mutations and their profile. doi:10.3389/fmicb.2025.1669327 Front Microbiol 2025
Prevalence and drug resistance profiles of nontuberculous mycobacteria isolated from Iranian fish pond waters. doi:10.1038/s41598-025-20286-1 Sci Rep 2025
DNAzyme-activated rolling circle amplification cascade nanomachine for sub-femtomolar detection of tuberculosis single-nucleotide mutation. doi:10.1016/j.aca.2025.344666 Anal Chim Acta 2025
Population structure and antibiotic resistance profiles of Mycobacterium tuberculosis isolates from Ibadan, Nigeria (2019-2020): a pilot study to improve affordable molecular diagnostic tools. doi:10.3389/fpubh.2025.1657825 Front Public Health 2025
Molecular Epidemiology of Non-Tuberculous Mycobacteria Among Tuberculosis-Suspected Patients in Iran: Species Distribution and Drug Resistance. doi:10.1177/10766294251375421 Microb Drug Resist 2025
Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China. doi:10.1186/s12866-025-04390-w BMC Microbiol 2025
Correlation Between Xpert MTB/RIF Results and rpoB Mutations within Probe-Targeted Regions in Mycobacterium tuberculosis Isolates from Sichuan Basin. doi:10.2147/IDR.S541544 names it Infect Drug Resist 2025
Genetic diversity, drug resistance, and transmission patterns of tuberculosis based on whole-genome sequencing in Almaty, Kazakhstan. doi:10.3389/fmicb.2025.1649137 Front Microbiol 2025
Characterization of Drug Resistance Mutations in Mycobacterium tuberculosis Isolates from Moroccan Patients Using Deeplex Targeted Next-Generation Sequencing. doi:10.3390/microorganisms13092163 Microorganisms 2025
Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting. doi:10.1590/0037-8682-0184-2025 Rev Soc Bras Med Trop 2025
Species distribution of nontuberculous mycobacteria isolated from respiratory specimens at a tertiary care hospital in South Korea, 2017-2022. doi:10.1128/spectrum.00554-25 Microbiol Spectr 2025
Prospective Comparative Evaluation of the Xpert MTB/RIF and Xpert MTB/RIF Ultra Assays for Detecting Mycobacterium tuberculosis and Rifampin Resistance in High-resource, Intermediate-burden Settings. doi:10.3343/alm.2025.0101 Ann Lab Med 2025
Development of SNP-LAMP Combined with Lateral Flow Dipstick to Detect the S531L rpoB Gene Mutation in Rifampicin-Resistant Mycobacterium tuberculosis. doi:10.3390/diagnostics15172183 names it Diagnostics (Basel) 2025
A Case Report of Refractory Mycobacterium wolinskyi Knee Infection in a Metabolic Syndrome Patient: mNGS Diagnosis and Pharmacist-Guided Therapy. doi:10.2147/IDR.S542439 Infect Drug Resist 2025
Recurrent breast abscess caused by Lawsonella clevelandensis: A case report and literature review. doi:10.1097/MD.0000000000044218 Medicine (Baltimore) 2025
Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis. doi:10.1186/s12941-025-00816-5 names it Ann Clin Microbiol Antimicrob 2025
Mycobacterium hainanense sp. nov. represents an emerging nontuberculous Mycobacterium associated with chronic pulmonary disease. doi:10.1038/s41598-025-16906-5 Sci Rep 2025
Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis. doi:10.3389/fcimb.2025.1641385 Front Cell Infect Microbiol 2025
Mycobacterium avium Subspecies Hominissuis-Induced Fatal Vasculitis in Zebra Finches (Taeniopygia guttata), USA. doi:10.3390/ijms26157555 Int J Mol Sci 2025
Comparative evaluation of MALDI-ToF mass spectrometry and Sanger sequencing of the 16S, hsp65, and rpoB genes for non tuberculous mycobacteria species identification. doi:10.3389/fcimb.2025.1612459 names it Front Cell Infect Microbiol 2025
Anti-Mycobacterium tuberculosis activity of 17-hydroxy-jolkinolide B by interacting with RNA polymerase. doi:10.1016/j.bioorg.2025.108851 Bioorg Chem 2025
Factors associated with unfavourable treatment outcomes among patients with Multidrug-resistant Tuberculosis receiving outpatients care. doi:10.1038/s41598-025-13227-5 Sci Rep 2025
Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China. doi:10.1186/s12879-025-11312-8 BMC Infect Dis 2025
RpoB mutation patterns in Rifampicin-resistant tuberculosis: a Jiangxi Province study, 2021-2023. doi:10.1038/s41598-025-11949-0 names it Sci Rep 2025
Dissecting rifampicin heteroresistance in Mycobacterium tuberculosis: integrating whole-genome sequencing with phenotypic and clonal validation. doi:10.1099/jmm.0.002048 J Med Microbiol 2025
Rifaximin resistance in Clostridioides difficile is associated with specific rpoB alleles and multilocus sequence typing (MLST) clades. doi:10.1186/s12866-025-04164-4 names it BMC Microbiol 2025
Sentinel-Site-Based Surveillance of Mycobacterium tuberculosis Drug Resistance and Epidemiology in Sichuan, China. doi:10.3390/antibiotics14070625 Antibiotics (Basel) 2025
Whole-genome sequencing for analyzing the transmission characteristics of drug-resistant Mycobacterium tuberculosis in Ganzhou, China. doi:10.1186/s12879-025-11356-w BMC Infect Dis 2025
Genomic-enabled classification of three Mycobacteroides abscessus subspecies and an effective subspecies-specific identification method. doi:10.1128/jcm.00697-25 J Clin Microbiol 2025
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Whole genome sequencing to complement tuberculosis drug resistance surveys in Uganda. doi:10.1016/j.meegid.2016.02.019 Infect Genet Evol 2016
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Systematic screening for drug-resistant tuberculosis with Xpert(®) MTB/RIF in a referral hospital in Cambodia. doi:10.5588/ijtld.14.0956 Int J Tuberc Lung Dis 2015
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Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium shinjukuense: The First Reported Case in Korea. doi:10.4046/trd.2015.78.4.416 Tuberc Respir Dis (Seoul) 2015
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Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations. doi:10.1016/j.diagmicrobio.2015.01.009 Diagn Microbiol Infect Dis 2015
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Computational Simulation Techniques to Understand Rifampicin Resistance Mutation (S425L) of rpoB in M. leprae. doi:10.1002/jcb.25083 names it J Cell Biochem 2015
Early detection of multi-drug resistance and common mutations in Mycobacterium tuberculosis isolates from Delhi using GenoType MTBDRplus assay. doi:10.4103/0255-0857.150879 Indian J Med Microbiol 2015
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Nontuberculous mycobacterial ocular infections--comparing the clinical and microbiological characteristics between Mycobacterium abscessus and Mycobacterium massiliense. doi:10.1371/journal.pone.0116236 PLoS One 2015
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Detailed investigation of the microbial community in foaming activated sludge reveals novel foam formers. doi:10.1038/srep07637 Sci Rep 2015
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Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin. doi:10.1128/AAC.04374-14 names it Antimicrob Agents Chemother 2015
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Characterization of phenotypic and genotypic drug resistance patterns of Mycobacterium tuberculosis isolates from a city in Mexico. doi:10.1016/j.eimc.2014.04.005 Enferm Infecc Microbiol Clin 2015
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Assessment of the genotype MTBDRplus assay for rifampin and isoniazid resistance detection on sputum samples in Cote d'Ivoire. doi:10.1556/EUJMI-D-14-00014 Eur J Microbiol Immunol (Bp) 2014
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[DNA mutations associated to rifampicin or isoniazid resistance in M. tuberculosis clinical isolates from Sonora, Mexico]. doi:10.1590/s0036-36342012000200013 Salud Publica Mex 2012
First isolation of Mycobacterium kyorinense from clinical specimens in Brazil. doi:10.1128/JCM.00023-12 J Clin Microbiol 2012
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The GenoType® MTBDRplus assay for detection of drug resistance in Mycobacterium tuberculosis in Sweden. doi:10.1111/j.1600-0463.2011.02845.x APMIS 2012
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Drug and multidrug resistance among Mycobacterium leprae isolates from Brazilian relapsed leprosy patients. doi:10.1128/JCM.06561-11 J Clin Microbiol 2012
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. doi:10.1371/journal.pone.0034538 PLoS One 2012
Estimating fitness by competition assays between drug susceptible and resistant Mycobacterium tuberculosis of predominant lineages in Mumbai, India. doi:10.1371/journal.pone.0033507 PLoS One 2012
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Sequencing-based detection of drug-resistant Mycobacterium tuberculosis in patients with spinal tuberculosis. doi:10.1007/s00402-012-1506-7 Arch Orthop Trauma Surg 2012
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated in Nepal. doi:10.1128/AAC.06418-11 Antimicrob Agents Chemother 2012
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Fully integrated thermoplastic genosensor for the highly sensitive detection and identification of multi-drug-resistant tuberculosis. doi:10.1002/anie.201200732 Angew Chem Int Ed Engl 2012
The use of rpoB sequence analysis in the differentiation of Mycobacterium abscessus and Mycobacterium chelonae: a critical judgement in cystic fibrosis? doi:10.1111/j.1469-0691.2012.03785.x names it Clin Microbiol Infect 2012
The evaluation of an identification algorithm for Mycobacterium species using the 16S rRNA coding gene and rpoB. doi:10.1016/j.ijmyco.2012.01.004 names it Int J Mycobacteriol 2012
Drug resistance of Mycobacterium tuberculosis strains in southern Brazil. doi:10.1590/s0037-86822012000100018 Rev Soc Bras Med Trop 2012
Comparison of the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide tube method with the conventional method and real-time polymerase chain reaction for the detection of rifampicin resistance in Mycobacterium tuberculosis. doi:10.4103/0255-0857.93047 Indian J Med Microbiol 2012
Detection of genomic mutations in katG, inhA and rpoB genes of Mycobacterium tuberculosis isolates using polymerase chain reaction and multiplex allele-specific polymerase chain reaction. doi:10.1016/s1413-8670(12)70275-1 names it Braz J Infect Dis 2012
Assessing the utility of three TaqMan probes for the diagnosis of tuberculosis and resistance to rifampin and isoniazid in Veracruz, México. doi:10.1139/w11-127 Can J Microbiol 2012
Use of a molecular diagnostic test in AFB smear positive tuberculosis suspects greatly reduces time to detection of multidrug resistant tuberculosis. doi:10.1371/journal.pone.0031563 PLoS One 2012
New insight into the molecular characterization of isoniazid and rifampicin resistant Mycobacterium tuberculosis strains from Saudi Arabia. doi:10.1016/j.meegid.2012.01.024 Infect Genet Evol 2012
Analysis of gene mutations associated with isoniazid, rifampicin and ethambutol resistance among Mycobacterium tuberculosis isolates from Ethiopia. doi:10.1186/1471-2334-12-37 BMC Infect Dis 2012
Evaluation of the GenoType® MTBDRplus assay and identification of a rare mutation for improving MDR-TB detection. doi:10.5588/ijtld.11.0269 Int J Tuberc Lung Dis 2012
First evaluation of an improved assay for molecular genetic detection of tuberculosis as well as rifampin and isoniazid resistances. doi:10.1128/JCM.05903-11 J Clin Microbiol 2012
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Drug resistance mutations and heteroresistance detected using the GenoType MTBDRplus assay and their implication for treatment outcomes in patients from Mumbai, India. doi:10.1186/1471-2334-12-9 BMC Infect Dis 2012
Chronic pulmonary disease due to Mycobacterium monacense infection: the first case from Iran. doi:10.3343/alm.2012.32.1.87 Ann Lab Med 2012
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Genotype MTBDRplus for direct detection of Mycobacterium tuberculosis and drug resistance in strains from gold miners in South Africa. doi:10.1128/JCM.05723-11 J Clin Microbiol 2012
Using likelihood ratios to estimate diagnostic accuracy of a novel multiplex nested PCR in extra-pulmonary tuberculosis. doi:10.5588/ijtld.11.0322 Int J Tuberc Lung Dis 2012
False-positive rifampicin resistance on Xpert® MTB/RIF: case report and clinical implications. doi:10.5588/ijtld.11.0395 Int J Tuberc Lung Dis 2012
The TDR Tuberculosis Strain Bank: a resource for basic science, tool development and diagnostic services. doi:10.5588/ijtld.11.0223 Int J Tuberc Lung Dis 2012
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The use of a two-gene sequencing approach to accurately distinguish between the species within the Mycobacterium abscessus complex and Mycobacterium chelonae. doi:10.1007/s10096-011-1510-9 Eur J Clin Microbiol Infect Dis 2012
Standardization and evaluation of a tetraplex polymerase chain reaction to detect and differentiate Mycobacterium tuberculosis complex and nontuberculous Mycobacteria--a retrospective study on pulmonary TB patients. doi:10.1016/j.diagmicrobio.2011.11.006 Diagn Microbiol Infect Dis 2012
Mycobacterium leprae: pathogenic agent in leprosy. Discovery of new species Mycobacterium lepromatosis. Perspectives in research and diagnosis of leprosy. Int Marit Health 2012
Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types. doi:10.1128/JCM.05183-11 J Clin Microbiol 2012
Molecular characteristics of rifampin- and isoniazid-resistant mycobacterium tuberculosis strains isolated in Vietnam. doi:10.1128/JCM.05171-11 J Clin Microbiol 2012
Clinical failures associated with rpoB mutations in phenotypically occult multidrug-resistant Mycobacterium tuberculosis. doi:10.5588/ijtld.11.0178 names it Int J Tuberc Lung Dis 2012
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Potentially pathogenic nontuberculous mycobacteria found in aquatic systems. Analysis from a reclaimed water and water distribution system in Mexico City. doi:10.1007/s10096-011-1359-y Eur J Clin Microbiol Infect Dis 2012
Mycobacterium koreense sp. nov., a slowly growing non-chromogenic species closely related to Mycobacterium triviale. doi:10.1099/ijs.0.033274-0 Int J Syst Evol Microbiol 2012
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Molecular identification and typing of Mycobacterium massiliense isolated from postsurgical infections in Brazil. doi:10.1016/s1413-8670(11)70224-0 Braz J Infect Dis 2011
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Identification of Mycobacterium spp. of veterinary importance using rpoB gene sequencing. doi:10.1186/1746-6148-7-77 names it BMC Vet Res 2011
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Evaluation of a rapid assay for identification of Mycobacterium tuberculosis grown in solid and liquid media. doi:10.5588/ijtld.10.0709 Int J Tuberc Lung Dis 2011
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Silent mutation in rpoB detected from clinical samples with rifampin-susceptible Mycobacterium tuberculosis. doi:10.1128/JCM.05314-11 names it J Clin Microbiol 2011
Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes. doi:10.1186/1471-2334-11-255 BMC Infect Dis 2011
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Surface plasmon resonance detection of oligonucleotide sequences of the rpoB genes of Mycobacterium tuberculosis. doi:10.1016/j.talanta.2011.07.032 names it Talanta 2011
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Study of Genetic Evolution in Mycobacterium tuberculosis Isolates from Patients with Active Pulmonary Tuberculosis in the Iran and Belarus. doi:10.2174/1874285801105010032 Open Microbiol J 2011
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Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro. doi:10.1016/j.tube.2011.05.002 Tuberculosis (Edinb) 2011
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Detection of mutations in folp1, rpoB and gyrA genes of M. leprae by PCR- direct sequencing--a rapid tool for screening drug resistance in leprosy. names it Lepr Rev 2011
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First report on isolation and molecular characterization of clinical Mycobacterium setense isolates in Asia. Jpn J Infect Dis 2011
The K+ uptake regulator TrkA controls membrane potential, pH homeostasis and multidrug susceptibility in Mycobacterium smegmatis. doi:10.1093/jac/dkr165 J Antimicrob Chemother 2011
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Improved rapid molecular diagnosis of multidrug-resistant tuberculosis using a new reverse hybridization assay, REBA MTB-MDR. doi:10.1099/jmm.0.032292-0 J Med Microbiol 2011
Genotyping of Mycobacterium leprae from Brazilian leprosy patients suggests the occurrence of reinfection or of bacterial population shift during disease relapse. doi:10.1099/jmm.0.029389-0 J Med Microbiol 2011
Detection of mutations associated with multidrug-resistant Mycobacterium tuberculosis clinical isolates. doi:10.1111/j.1574-695X.2011.00814.x FEMS Immunol Med Microbiol 2011
Isolation of Mycobacterium tuberculosis strains with a silent mutation in rpoB leading to potential misassignment of resistance category. doi:10.1128/JCM.00659-11 names it J Clin Microbiol 2011
Multiplex fluorescence melting curve analysis for mutation detection with dual-labeled, self-quenched probes. doi:10.1371/journal.pone.0019206 PLoS One 2011
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Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. doi:10.1164/rccm.201101-0056OC Am J Respir Crit Care Med 2011
First report of molecular detection of fluoroquinolone resistance-associated gyrA mutations in multidrug-resistant clinical Mycobacterium tuberculosis isolates in Kuwait. doi:10.1186/1756-0500-4-123 BMC Res Notes 2011
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Polymerase chain reaction-restriction fragment length polymorphism of the rpoB gene for identification of Mycobacterium avium subsp. paratuberculosis and differentiation of Mycobacterium avium subspecies. doi:10.1016/j.diagmicrobio.2011.01.014 names it Diagn Microbiol Infect Dis 2011
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Rapid detection of multidrug-resistant Mycobacterium tuberculosis by multiplex allele-specific polymerase chain reaction. doi:10.5588/ijtld.10.0397 Int J Tuberc Lung Dis 2011
Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis. doi:10.1093/jac/dkq519 J Antimicrob Chemother 2011
Immunohistochemical and Taqman real-time PCR detection of mycobacterial infections in fish. doi:10.1111/j.1365-2761.2010.01231.x J Fish Dis 2011
Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis. doi:10.1128/AAC.01550-10 Antimicrob Agents Chemother 2011
Analysis of drug-resistant strains of Mycobacterium leprae in an endemic area of Vietnam. doi:10.1093/cid/ciq217 Clin Infect Dis 2011
Mutation detection and accurate diagnosis of extensively drug-resistant tuberculosis: report from a tertiary care center in India. doi:10.1128/JCM.00113-11 J Clin Microbiol 2011
Performance comparison of four methods for detecting multidrug-resistant Mycobacterium tuberculosis strains. Int J Tuberc Lung Dis 2011
Deep resequencing of serial sputum isolates of Mycobacterium tuberculosis during therapeutic failure due to poor compliance reveals stepwise mutation of key resistance genes on an otherwise stable genetic background. doi:10.1016/j.jinf.2011.01.003 J Infect 2011
Rapid molecular detection of tuberculosis. doi:10.1056/NEJMc1011919 N Engl J Med 2011
Rapid detection of Mycobacterium tuberculosis complex and rifampin resistance in smear-negative clinical samples by use of an integrated real-time PCR method. doi:10.1128/JCM.01831-10 J Clin Microbiol 2011
Multiple cases of cutaneous Mycobacterium massiliense infection in a "hot spa" in Japan. doi:10.1128/JCM.00817-10 J Clin Microbiol 2011
Pulmonary tuberculosis in the West Bank, Palestinian Authority: molecular diagnostic approach. doi:10.1111/j.1365-3156.2010.02697.x Trop Med Int Health 2011
Multilocus sequence analysis and rpoB sequencing of Mycobacterium abscessus (sensu lato) strains. doi:10.1128/JCM.01274-10 names it J Clin Microbiol 2011
Diversity of pulsed-field gel electrophoresis patterns of Mycobacterium abscessus type 2 clinical isolates. doi:10.1128/JCM.01665-10 J Clin Microbiol 2011
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. doi:10.1093/nar/gkq1149 Nucleic Acids Res 2011
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Mycobacterium sherrisii sp. nov., a slow-growing non-chromogenic species. doi:10.1099/ijs.0.024752-0 Int J Syst Evol Microbiol 2011
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First insights into the genetic diversity of Mycobacterium tuberculosis isolates from HIV-infected Mexican patients and mutations causing multidrug resistance. doi:10.1186/1471-2180-10-82 BMC Microbiol 2010
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Extensive transmission of isoniazid resistant M. tuberculosis and its association with increased multidrug-resistant TB in two rural counties of eastern China: a molecular epidemiological study. doi:10.1186/1471-2334-10-43 BMC Infect Dis 2010
Evaluation of cost-effective total nucleic acids extraction protocols for cultured Mycobacterium tuberculosis; a comparison by PCR amplification of genes associated with drug resistance. doi:10.1186/1756-0500-3-48 BMC Res Notes 2010
Rapid detection of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis by high-resolution melting analysis. doi:10.1128/JCM.02036-09 J Clin Microbiol 2010
Novel insertion and deletion mutants of RpoB that render Mycobacterium smegmatis RNA polymerase resistant to rifampicin-mediated inhibition of transcription. doi:10.1099/mic.0.036970-0 names it Microbiology (Reading) 2010
Isolation of novel mycobacteria contaminating an aquarium fish tank in a Japanese university hospital. doi:10.1111/j.1365-2672.2010.04680.x J Appl Microbiol 2010
Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis. doi:10.1128/JB.01135-09 J Bacteriol 2010
Combined real-time PCR and rpoB gene pyrosequencing for rapid identification of Mycobacterium tuberculosis and determination of rifampin resistance directly in clinical specimens. doi:10.1128/JCM.02149-09 names it J Clin Microbiol 2010
A mutation in Mycobacterium tuberculosis rpoB gene confers rifampin resistance in three HIV-TB cases. doi:10.1016/j.tube.2010.01.001 names it Tuberculosis (Edinb) 2010
Multidrug-resistant tuberculosis: treatment outcome in Denmark, 1992-2007. doi:10.3109/00365540903456282 Scand J Infect Dis 2010
Genetic characterisation of drug-resistant Mycobacterium tuberculosis in rural China: a population-based study. Int J Tuberc Lung Dis 2010
Mycobacterium paraterrae sp. nov. recovered from a clinical specimen: novel chromogenic slow growing mycobacteria related to Mycobacterium terrae complex. doi:10.1111/j.1348-0421.2009.00184.x Microbiol Immunol 2010
[THE SENSITIVITY AND SPECIFICITY OF THE MOLECULAR GENOTYPE MTBDRPL US ASSAY (HAIN LIFESCIENCE GMBH, GERMANY) FOR RAPID DIAGNOSIS OF DRUG SUSCEPTIBILITY IN MYCOBACTERIUM TUBERCULOSIS ON SPUTUM SPECIMENS]. Tuberk Biolezni Legkih 2010
[CIRCULATION OF MULTIDRUG-RESISTANT TUBERCULOSIS PATHOGEN STRAINS IN THE REPUBLIC OF KARELIA]. Tuberk Biolezni Legkih 2010
Re-emergence of the progenitors of a multidrug-resistant outbreak strain of Mycobacterium tuberculosis among the post-outbreak case patients. doi:10.1086/649900 J Infect Dis 2010
Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China. doi:10.1128/AAC.00964-09 Antimicrob Agents Chemother 2010
An interesting case of rifampicin-dependent/-enhanced multidrug-resistant tuberculosis. Int J Tuberc Lung Dis 2010
Mycobacterium tuberculosis spoligotypes in Monterrey, Mexico. doi:10.1128/JCM.01894-09 J Clin Microbiol 2010
Revival and emended description of 'Mycobacterium paraffinicum' Davis, Chase and Raymond 1956 as Mycobacterium paraffinicum sp. nov., nom. rev. doi:10.1099/ijs.0.016972-0 Int J Syst Evol Microbiol 2010
A distinct physiological role of MutY in mutation prevention in mycobacteria. doi:10.1099/mic.0.033621-0 Microbiology (Reading) 2010
Clinical efficacy of direct DNA sequencing analysis on sputum specimens for early detection of drug-resistant Mycobacterium tuberculosis in a clinical setting. doi:10.1378/chest.09-0150 Chest 2010
A pyrosequencing method for molecular monitoring of regions in the inhA, ahpC and rpoB genes of Mycobacterium tuberculosis. doi:10.1111/j.1469-0691.2009.02932.x names it Clin Microbiol Infect 2010
Mycobacterium paraseoulense sp. nov., a slowly growing, scotochromogenic species related genetically to Mycobacterium seoulense. doi:10.1099/ijs.0.012054-0 Int J Syst Evol Microbiol 2010
[Population-based molecular epidemiologic study of rifampicin-resistant tuberculosis in rural area of eastern China]. Zhonghua Liu Xing Bing Xue Za Zhi 2009
[Species-specific detection of Mycobacterium tuberculosis complex]. Tuberk Biolezni Legkih 2009
Characterization of Molecular Evolution in Multi-Drug Resistant of Mycobacterium tuberculosis by rpoB Gene in Patient with Active Pulmonary Tuberculosis from Iranian Isolates. names it Int J Biomed Sci 2009
Detection of isoniazid and rifampicin resistance by sequencing of katG, inhA, and rpoB genes in Korea. doi:10.3343/kjlm.2009.29.5.455 names it Korean J Lab Med 2009
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. doi:10.1371/journal.pone.0007778 PLoS One 2009
[Molecular genetic and bacteriological methods for the diagnosis of multidrug resistant M. tuberculosis]. Tuberk Biolezni Legkih 2009
Molecular characterisation of rifampicin-resistant Mycobacterium tuberculosis strains from Morocco. Int J Tuberc Lung Dis 2009
[Cross-resistance between rifampicin and rifabutin among multi-drug resistant Mycobacterium tuberculosis strains]. Kekkaku 2009
Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones. doi:10.1128/JCM.01229-09 J Clin Microbiol 2009
[Sequence analysis on drug-resistant gene of rpoB in Mycobacterium tuberculosis L-forms among pneumoconiosis patients complicated with tuberculosis]. names it Zhonghua Liu Xing Bing Xue Za Zhi 2009
Molecular identification of rapidly growing mycobacteria isolates from pulmonary specimens of patients in the State of Pará, Amazon region, Brazil. doi:10.1016/j.diagmicrobio.2009.08.003 Diagn Microbiol Infect Dis 2009
Separate production of single-stranded DNA is not necessary: circuit denaturation of double-stranded DNA followed by hybridization of single strands on oligonucleotide microchips. doi:10.1080/07391102.2009.10507321 J Biomol Struct Dyn 2009
Mycobacterium tuberculosis strains with highly discordant rifampin susceptibility test results. doi:10.1128/JCM.01209-09 J Clin Microbiol 2009
PCR-restriction fragment length polymorphism analysis as a tool for Mycobacterium species identification in lepromas for lepromin production. Lepr Rev 2009
Clinical relevance of Mycobacterium chelonae-abscessus group isolation in 95 patients. doi:10.1016/j.jinf.2009.08.016 J Infect 2009
Rapid detection of rpoB gene mutations in rif-resistant M. tuberculosis isolates by oligonucleotide microarray. doi:10.1016/s0895-3988(09)60053-2 names it Biomed Environ Sci 2009
High-level rifampin resistance correlates with multiple mutations in the rpoB gene of pulmonary tuberculosis isolates from the Afghanistan border of Iran. doi:10.1128/JCM.r00548-09 names it J Clin Microbiol 2009
Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso. doi:10.1186/1471-2334-9-142 BMC Infect Dis 2009
Isoniazid and rifampicin resistance-associated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing. doi:10.1093/jac/dkp292 J Antimicrob Chemother 2009
Recent patents on DNA sequences and diagnostic methods for the identification and strain differentiation of Mycobacterium tuberculosis. doi:10.2174/187221509789318333 Recent Pat DNA Gene Seq 2009
Comparative growth pattern of multi drug resistance versus susceptible isolates of Mycobacterium tuberculosis in mice lungs. Indian J Med Res 2009
Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine. doi:10.4142/jvs.2009.10.3.177 J Vet Sci 2009
Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates in Guangdong, China. Jpn J Infect Dis 2009
Mycobacterium marseillense sp. nov., Mycobacterium timonense sp. nov. and Mycobacterium bouchedurhonense sp. nov., members of the Mycobacterium avium complex. doi:10.1099/ijs.0.010637-0 Int J Syst Evol Microbiol 2009
Mycobacterium mantenii sp. nov., a pathogenic, slowly growing, scotochromogenic species. doi:10.1099/ijs.0.010405-0 Int J Syst Evol Microbiol 2009
[Evaluation of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in clinical Mycobacterium tuberculosis complex clinical isolates]. Mikrobiyol Bul 2009
Proposal to elevate Mycobacterium avium complex ITS sequevar MAC-Q to Mycobacterium vulneris sp. nov. doi:10.1099/ijs.0.008854-0 Int J Syst Evol Microbiol 2009
Polyphasic taxonomic analysis establishes Mycobacterium indicus pranii as a distinct species. doi:10.1371/journal.pone.0006263 PLoS One 2009
Characterization of RPO B gene for detection of rifampicin drug resistance by SSCP and sequence analysis. doi:10.4103/0255-0857.45364 Indian J Med Microbiol 2009
Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis isolates from Eastern Poland. names it New Microbiol 2009
Characterization of mycobacteria from a major Brazilian outbreak suggests that revision of the taxonomic status of members of the Mycobacterium chelonae-M. abscessus group is needed. doi:10.1128/JCM.00808-09 J Clin Microbiol 2009
[Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains]. Probl Tuberk Bolezn Legk 2009
Mycobacterial infections in coal workers' pneumoconiosis patients in South Korea. doi:10.1080/00365540903089468 Scand J Infect Dis 2009
Rapid, accurate determination of multidrug resistance in M. tuberculosis isolates and sputum using a biochip system. Int J Tuberc Lung Dis 2009
Mutations in rpoB and katG genes in Mycobacterium isolates from the Southeast of Mexico. doi:10.1590/s0074-02762009000300012 names it Mem Inst Oswaldo Cruz 2009
Diagnosis and species identification of mycobacterial infections by polymerase chain reaction-restriction fragment length polymorphism analysis of sterile body fluids. doi:10.3904/kjim.2009.24.2.135 Korean J Intern Med 2009
Delineating bacteriostatic and bactericidal targets in mycobacteria using IPTG inducible antisense expression. doi:10.1371/journal.pone.0005923 PLoS One 2009
Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada. doi:10.1093/jac/dkp183 J Antimicrob Chemother 2009
Comparison of two commercial assays for the characterization of rpoB mutations in Mycobacterium tuberculosis and description of new mutations conferring weak resistance to rifampicin. doi:10.1093/jac/dkp204 names it J Antimicrob Chemother 2009
Inaccuracy of single-target sequencing for discriminating species of the Mycobacterium abscessus group. doi:10.1128/JCM.00037-09 J Clin Microbiol 2009
Mycobacterium insubricum sp. nov. doi:10.1099/ijs.0.003459-0 Int J Syst Evol Microbiol 2009
Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens. doi:10.1099/ijs.0.000760-0 Int J Syst Evol Microbiol 2009
Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis. doi:10.1128/JCM.02499-08 J Clin Microbiol 2009
rpoB nested PCR and sequencing for the early diagnosis of tuberculous meningitis and rifampicin resistance. names it Int J Tuberc Lung Dis 2009
RETRACTED: High level Rifampin Resistance Correlates with Multiple Mutations in the rpoB Gene of Pulmonary Tuberculosis Isolates from the Afghanistan Border of Iran. doi:10.1128/JCM.00548-09 names it J Clin Microbiol 2009
Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii. doi:10.1128/JCM.01688-08 J Clin Microbiol 2009
Mycobacterium riyadhense sp. nov., a non-tuberculous species identified as Mycobacterium tuberculosis complex by a commercial line-probe assay. doi:10.1099/ijs.0.005629-0 Int J Syst Evol Microbiol 2009
Epidemic of postsurgical infections caused by Mycobacterium massiliense. doi:10.1128/JCM.00027-09 J Clin Microbiol 2009
Rapid identification of multidrug-resistant Mycobacterium tuberculosis isolates by rpoB gene scanning using high-resolution melting curve PCR analysis. doi:10.1093/jac/dkp124 names it J Antimicrob Chemother 2009
Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH. doi:10.1093/jac/dkp125 names it J Antimicrob Chemother 2009
Novel diagnostic algorithm using tuf gene amplification and restriction fragment length polymorphism is promising tool for identification of nontuberculous mycobacteria. doi:10.4014/jmb.0804.267 J Microbiol Biotechnol 2009
Combining polymerase chain reaction restriction enzyme analysis with phenotypic characters for mycobacteria identification in Taiwan. Int J Tuberc Lung Dis 2009
[Practical value of the TB-biochip MDR test system in the rapid identification of multidrug-resistant M. tuberculosis strains]. Klin Lab Diagn 2009
Mycobacterium noviomagense sp. nov.; clinical relevance evaluated in 17 patients. doi:10.1099/ijs.0.001511-0 Int J Syst Evol Microbiol 2009
Genotypic rpoB and gyrA profiles for detection of rifampicin and fluoroquinolone susceptibilities of Mycobacterium tuberculosis isolates directly from clinical sputum specimens. doi:10.1016/j.ijantimicag.2009.02.010 names it Int J Antimicrob Agents 2009
Performance of the Genotype MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian Federation. doi:10.1186/1472-6890-9-2 BMC Clin Pathol 2009
First insight into genetic diversity of the Mycobacterium tuberculosis complex in Albania obtained by multilocus variable-number tandem-repeat analysis and spoligotyping reveals the presence of beijing multidrug-resistant isolates. doi:10.1128/JCM.02284-08 J Clin Microbiol 2009
Molecular analysis of Mycobacterium isolates from extrapulmonary specimens obtained from patients in Mexico. doi:10.1186/1472-6890-9-1 BMC Clin Pathol 2009
In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type. doi:10.1371/journal.pone.0004540 PLoS One 2009
Mycobacterium phocaicum in therapy pool water. doi:10.1016/j.ijheh.2008.10.002 Int J Hyg Environ Health 2009
Polycyclic aromatic hydrocarbon-degrading species isolated from Hawaiian soils: Mycobacterium crocinum sp. nov., Mycobacterium pallens sp. nov., Mycobacterium rutilum sp. nov., Mycobacterium rufum sp. nov. and Mycobacterium aromaticivorans sp. nov. doi:10.1099/ijs.0.65827-0 Int J Syst Evol Microbiol 2009
Genotypic detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis strains by DNA sequencing: a randomized trial. doi:10.1186/1476-0711-8-4 Ann Clin Microbiol Antimicrob 2009
Performance of MTBDR plus for detecting high/low levels of Mycobacterium tuberculosis resistance to isoniazid. Int J Tuberc Lung Dis 2009
Validation of the line-probe assay for rapid detection of rifampicin-resistant Mycobacterium tuberculosis in Vietnam. Int J Tuberc Lung Dis 2009
Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin. doi:10.1186/1471-2180-9-10 names it BMC Microbiol 2009
Molecular identification of mutations associated with anti-tuberculosis drug resistance among strains of Mycobacterium tuberculosis. doi:10.1016/j.ijid.2008.10.006 Int J Infect Dis 2009
Molecular detection of drug-resistant Mycobacterium tuberculosis with a scanning-frame oligonucleotide microarray. doi:10.1007/978-1-59745-207-6_26 Methods Mol Biol 2009
Application of denaturing HPLC to rapidly identify rifampicin-resistant Mycobacterium tuberculosis in low- and high-prevalence areas. doi:10.1093/jac/dkn506 J Antimicrob Chemother 2009
M. tuberculosis Central Asian Strain 1 MDR isolates have more mutations in rpoB and katG genes compared with other genotypes. doi:10.1080/00365540802570519 names it Scand J Infect Dis 2009
Direct electrochemical genosensing for multiple point mutation detection of Mycobacterium tuberculosis during the development of rifampin resistance. doi:10.1016/j.bios.2008.08.033 Biosens Bioelectron 2009
At Baltic crossroads: a molecular snapshot of Mycobacterium tuberculosis population diversity in Kaliningrad, Russia. doi:10.1111/j.1574-695X.2008.00470.x FEMS Immunol Med Microbiol 2009
Prospective evaluation of pyrosequencing for the rapid detection of isoniazid and rifampin resistance in clinical Mycobacterium tuberculosis isolates. doi:10.1007/s10096-008-0584-5 Eur J Clin Microbiol Infect Dis 2009
Identification of rifampin-resistant genotypes in Mycobacterium tuberculosis by PCR-reverse dot blot hybridization. doi:10.1007/s12033-008-9085-0 Mol Biotechnol 2009
Localised pyogranulomatous dermatitis due to Mycobacterium abscessus in a cat: a case report. doi:10.1016/j.tvjl.2007.08.026 Vet J 2009
[Drug sensitivity in Mycobacterium tuberculosis versus its viability, cytotoxicity, genotype, and the course of the process in patients with pulmonary tuberculosis]. Probl Tuberk Bolezn Legk 2008
[Distribution of mutations in the rpoB, katG, inhA, ahpC gene of rifampicin and isoniazid resistant M. tuberculosis strains isolated in Kyrgyz Republic]. names it Mol Gen Mikrobiol Virusol 2008
[Characterization of the drug resistance spectrum of rifampicin-resistant M. tuberculosis to other first-line antituberculous drugs]. Probl Tuberk Bolezn Legk 2008
Targeting the rpoB gene using nested PCR-restriction fragment length polymorphism for identification of nontuberculous mycobacteria in hospital tap water. doi:10.1007/s12275-008-0102-6 names it J Microbiol 2008
[Microbiological properties of M. porcinum isolated from a patient with impairments in IL-12/IFN-gamma pathway]. Kekkaku 2008
The first surgical treatment case of pulmonary Mycobacterium malmoense infection in Japan. doi:10.2169/internalmedicine.47.1520 Intern Med 2008
Mycobacterium stomatepiae sp. nov., a slowly growing, non-chromogenic species isolated from fish. doi:10.1099/ijs.0.2008/001164-0 Int J Syst Evol Microbiol 2008
rpoB sequence-based identification of Mycobacterium avium complex species. doi:10.1099/mic.0.2008/020164-0 names it Microbiology (Reading) 2008
A new Mycobacterium species causing diffuse lepromatous leprosy. doi:10.1309/AJCPP72FJZZRRVMM Am J Clin Pathol 2008
Evaluation of new GenoType MTBDRplus for detection of resistance in cultures and direct specimens of Mycobacterium tuberculosis. Int J Tuberc Lung Dis 2008
Emergence of nosocomial Mycobacterium massiliense infection in Goiás, Brazil. doi:10.1016/j.micinf.2008.09.008 Microbes Infect 2008
Direct application of the PCR restriction analysis method for identifying NTM species in AFB smear-positive respiratory specimens. Int J Tuberc Lung Dis 2008
Comparison of MAS-PCR and GenoType MTBDR assay for the detection of rifampicin-resistant Mycobacterium tuberculosis. Int J Tuberc Lung Dis 2008
Mycobacterium arosiense sp. nov., a slowly growing, scotochromogenic species causing osteomyelitis in an immunocompromised child. doi:10.1099/ijs.0.65503-0 Int J Syst Evol Microbiol 2008
Predominance of Mycobacterium fortuitum-chelonae complex in Ghatampur field area, endemic for leprosy. Indian J Lepr 2008
A novel method for simple detection of mutations conferring drug resistance in Mycobacterium leprae, based on a DNA microarray, and its applicability in developing countries. doi:10.1099/jmm.0.2008/002600-0 J Med Microbiol 2008
[Evaluation of the discrepant Mycobacterium tuberculosis strains between any ordinary susceptibility testing and rpoB gene analysis by the line probe assay]. names it Kekkaku 2008
[Drug resistance of multibacillary leprosy patients in Japan--results of molecular genetic analyses]. doi:10.5025/hansen.77.187 Nihon Hansenbyo Gakkai Zasshi 2008
Rapid molecular detection of rifampicin resistance facilitates early diagnosis and treatment of multi-drug resistant tuberculosis: case control study. doi:10.1371/journal.pone.0003173 PLoS One 2008
Proportions of Mycobacterium massiliense and Mycobacterium bolletii strains among Korean Mycobacterium chelonae-Mycobacterium abscessus group isolates. doi:10.1128/JCM.00319-08 J Clin Microbiol 2008
On-chip ligation of multiplexing probe-pairs for identifying point mutations out of dense SNP loci. doi:10.1016/j.bios.2008.07.009 Biosens Bioelectron 2008
[Mycobacterium gordonae as potential cause of granulomatous lesions of the toe tips in the South African clawed frog (Xenopus laevis)]. Berl Munch Tierarztl Wochenschr 2008
Phenotypic and genotypic characterization of drug-resistant Mycobacterium tuberculosis strains. doi:10.1016/j.diagmicrobio.2008.06.013 Diagn Microbiol Infect Dis 2008
[Utility of gene analysis for evaluation of the current status of tuberculosis developing long after primary infection]. Nihon Koshu Eisei Zasshi 2008
Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria. doi:10.1016/j.meegid.2008.06.006 Infect Genet Evol 2008
Molecular characterization of drug-resistant mycobacterium tuberculosis isolates from Sichuan Province in china. Jpn J Infect Dis 2008
Genotypic analysis of isoniazid and rifampin resistance in drug-resistant clinical Mycobacterium tuberculosis complex isolates in southern Turkey. Jpn J Infect Dis 2008
[Evaluation of pyrosequencing for the detection of rpoB gene mutation in Mycobacterium tuberculosis]. names it Zhonghua Yu Fang Yi Xue Za Zhi 2008
Cost-effectiveness analysis of introduction of rapid, alternative methods to identify multidrug-resistant tuberculosis in middle-income countries. doi:10.1086/590010 Clin Infect Dis 2008
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis. doi:10.1093/jac/dkn269 J Antimicrob Chemother 2008
The effect of oxidative stress on the mutation rate of Mycobacterium tuberculosis with impaired catalase/peroxidase function. doi:10.1093/jac/dkn259 J Antimicrob Chemother 2008
Multidrug-resistant tuberculosis in Lisbon, Portugal: a molecular epidemiological perspective. doi:10.1089/mdr.2008.0798 Microb Drug Resist 2008
[Fast identification of rifampicin-and isoniazid resistance of M. Tuberculosis strains by the "TB-biochip" test system]. Georgian Med News 2008
[Intraspecies divergence of 16S rDNA, ITS, rpoB gene and hsp65 gene sequence for Mycobacterium lentiflavum]. names it Kekkaku 2008
Multidrug-resistant tuberculosis: rapid detection of resistance to rifampin and high or low levels of isoniazid in clinical specimens and isolates. doi:10.1007/s10096-008-0548-9 Eur J Clin Microbiol Infect Dis 2008
A seven-gene, multilocus, genus-wide approach to the phylogeny of mycobacteria using supertrees. doi:10.1099/ijs.0.65658-0 Int J Syst Evol Microbiol 2008
The evolution of drug resistance in Mycobacterium tuberculosis: from a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population. doi:10.1086/588822 J Infect Dis 2008
Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn's disease. doi:10.3748/wjg.14.2723 names it World J Gastroenterol 2008
[Detection of rifampin resistant mycobacterium tuberculosis complex using denaturing HPLC]. doi:10.3343/kjlm.2008.28.2.95 Korean J Lab Med 2008
Novel DNA glycosylases from Mycobacterium tuberculosis. doi:10.1134/s0006297908040093 Biochemistry (Mosc) 2008
Detection of Mycobacterium immunogenum by real-time quantitative Taqman PCR. doi:10.1016/j.mimet.2008.03.006 J Microbiol Methods 2008
Characterization of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis from eastern China. doi:10.1111/j.1365-2672.2008.03815.x names it J Appl Microbiol 2008
[Study of rifampin and dapsone resistance in three patients with recurring leprosy]. doi:10.1590/s1020-49892008000200001 Rev Panam Salud Publica 2008
Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR. doi:10.1089/mdr.2008.0772 Microb Drug Resist 2008
Mycobacterium senuense sp. nov., a slowly growing, non-chromogenic species closely related to the Mycobacterium terrae complex. doi:10.1099/ijs.0.65374-0 Int J Syst Evol Microbiol 2008
Multiphasic approach reveals genetic diversity of environmental and patient isolates of Mycobacterium mucogenicum and Mycobacterium phocaicum associated with an outbreak of bacteremias at a Texas hospital. doi:10.1128/AEM.02476-07 Appl Environ Microbiol 2008
[Evaluation of the performances of AdvanSure TB/NTM real time PCR kit for detection of mycobacteria in respiratory specimens]. doi:10.3343/kjlm.2008.28.1.34 Korean J Lab Med 2008
Fluorometric assay for testing rifampin susceptibility of Mycobacterium tuberculosis complex. doi:10.1128/JCM.02343-07 J Clin Microbiol 2008
Distribution of rpoB mutations among multidrug-resistant Mycobacterium tuberculosis (MDRTB) strains from Thailand and development of a rapid method for mutation detection. doi:10.1111/j.1469-0691.2008.01951.x names it Clin Microbiol Infect 2008
Molecular genetics of drug-resistant Mycobacterium tuberculosis isolates in Finland, 1995-2004. Int J Tuberc Lung Dis 2008
[Mycobacterial tests]. Kekkaku 2008
Mycobacterium setense sp. nov., a Mycobacterium fortuitum-group organism isolated from a patient with soft tissue infection and osteitis. doi:10.1099/ijs.0.65222-0 Int J Syst Evol Microbiol 2008
Development and evaluation of a novel multiple-primer PCR amplification refractory mutation system for the rapid detection of mutations conferring rifampicin resistance in codon 425 of the rpoB gene of Mycobacterium leprae. doi:10.1099/jmm.0.47534-0 names it J Med Microbiol 2008
Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures. doi:10.1128/JCM.02052-07 J Clin Microbiol 2008
Homology modeling of wild-type, D516V, and H526L Mycobacterium tuberculosis RNA polymerase and their molecular docking study with inhibitors. doi:10.1080/07391102.2008.10507185 J Biomol Struct Dyn 2008
Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis. doi:10.1128/JCM.01821-07 J Clin Microbiol 2008
Prevalence of and molecular basis for tuberculosis drug resistance in the Republic of Georgia: validation of a QIAplex system for detection of drug resistance-related mutations. doi:10.1128/AAC.01124-07 Antimicrob Agents Chemother 2008
Molecular characterization of a novel fastidious mycobacterium causing lepromatous lesions of the skin, subcutis, cornea, and conjunctiva of cats living in Victoria, Australia. doi:10.1128/JCM.01186-07 J Clin Microbiol 2008
Development of a real-time PCR-based method for rapid differential identification of Mycobacterium species. doi:10.1111/j.1472-765X.2007.02278.x Lett Appl Microbiol 2008
The frequency of drug resistance mutations in Mycobacterium leprae isolates in untreated and relapsed leprosy patients from Myanmar, Indonesia and the Philippines. Lepr Rev 2007
Identification of mutations in the rpoB encoding the RNA polymerase beta subunit in rifampicine-resistant Mycobacterium tuberculosis strains from Iran. names it Tuberk Toraks 2007
Protein chip for detection of DNA mutations. doi:10.1007/978-1-59745-304-2_11 Methods Mol Biol 2007
Molecular systematics support the revival of Mycobacterium salmoniphilum (ex Ross 1960) sp. nov., nom. rev., a species closely related to Mycobacterium chelonae. doi:10.1099/ijs.0.64841-0 Int J Syst Evol Microbiol 2007
A newly identified 191A/C mutation in the Rv2629 gene that was significantly associated with rifampin resistance in Mycobacterium tuberculosis. doi:10.1021/pr070242z J Proteome Res 2007
Transmission of Mycobacterium tuberculosis in a family proved by genotyping. doi:10.1016/S0929-6646(08)60045-5 J Formos Med Assoc 2007
WITHDRAWN: High frequency of mutations in the rpoB gene in rifampicin-resistant clinical isolates of Mycobacterium tuberculosis from Iran. doi:10.1016/j.ijantimicag.2007.08.010 names it Int J Antimicrob Agents 2007
A novel genotypic test for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates by a multiplex probe array. doi:10.1111/j.1365-2672.2007.03350.x J Appl Microbiol 2007
[Evaluation of biochips for the rifampin resistance detection of M. tuberculosis in strains isolated at the Novosibirsk and Tomsk regions]. Mol Gen Mikrobiol Virusol 2007
Specific mutations in the Mycobacterium tuberculosis rpoB gene are associated with increased dnaE2 expression. doi:10.1111/j.1574-6968.2007.00905.x names it FEMS Microbiol Lett 2007
[Statistically mapping modeling of the spread of rifampicin-resistant M. tuberculosis strains in different regions of the Kyrghyz Republic]. Probl Tuberk Bolezn Legk 2007
Molecular investigation of recurrent tuberculosis in patients from Rwanda. Int J Tuberc Lung Dis 2007
[Analysis of mutations of multidrug-resistant M. tuberculosis strains in patients with tuberculosis in the Kyrghyz Republic]. Probl Tuberk Bolezn Legk 2007
Characterization of Tunisian Mycobacterium tuberculosis rifampin-resistant clinical isolates. doi:10.1128/JCM.00643-07 J Clin Microbiol 2007
Identification of Mycobacterium using the EF-Tu encoding (tuf) gene and the tmRNA encoding (ssrA) gene. doi:10.1099/jmm.0.47105-0 J Med Microbiol 2007
Characterization of rpoB mutations by line probe assay in rifampicin-resistant mycobacterium tuberculosis clinical isolates from the aegean region in Turkey. names it Jpn J Infect Dis 2007
Mycobacterium species identification--a new approach via dnaJ gene sequencing. doi:10.1016/j.syapm.2007.06.003 Syst Appl Microbiol 2007
Outbreak of Mycobacterium massiliense infection associated with intramuscular injections. doi:10.1128/JCM.00608-07 J Clin Microbiol 2007
Mass-spectrometry based minisequencing method for the rapid detection of drug resistance in Mycobacterium tuberculosis. doi:10.1016/j.mimet.2007.05.015 J Microbiol Methods 2007
M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern Tanzania. doi:10.1186/1471-2180-7-51 BMC Microbiol 2007
Evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimens. doi:10.1128/JCM.00521-07 J Clin Microbiol 2007
Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing, China. Chin Med J (Engl) 2007
Comparative assays of the rpoB gene for identification of Mycobacterium tuberculosis isolated from patients in Sudan. names it Int J Tuberc Lung Dis 2007
Development and evaluation of a multiplex PCR for rapid detection and differentiation of Mycobacterium tuberculosis complex members from non-tuberculous mycobacteria. Jpn J Infect Dis 2007
Evaluation of direct detection of Mycobacterium tuberculosis rifampin resistance by a nitrate reductase assay applied to sputum samples in Cotonou, Benin. doi:10.1128/JCM.00691-07 J Clin Microbiol 2007
[Mechanism of drug resistance in M. tuberculosis and non-tuberculous acid-fast bacilli]. Nihon Rinsho 2007
[Diagnostic methods for mycobacterial diseases]. Nihon Rinsho 2007
Diversity of environmental Mycobacterium isolates from hemodialysis water as shown by a multigene sequencing approach. doi:10.1128/AEM.02934-06 Appl Environ Microbiol 2007
Molecular characteristics of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis isolates from the Russian Federation. doi:10.1093/jac/dkm086 J Antimicrob Chemother 2007
Identification of an emerging pathogen, Mycobacterium massiliense, by rpoB sequencing of clinical isolates collected in the United States. doi:10.1128/JCM.00563-07 names it J Clin Microbiol 2007
Association of specific mutations in katG, rpoB, rpsL and rrs genes with spoligotypes of multidrug-resistant Mycobacterium tuberculosis isolates in Russia. doi:10.1111/j.1469-0691.2007.01711.x names it Clin Microbiol Infect 2007
Detection of rifampin resistant tuberculosis meningitis by polymerase chain reaction linked single strand conformation polymorphism analysis of cerebrospinal fluid. Neurosciences (Riyadh) 2007
Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong. doi:10.1093/jac/dkm054 J Antimicrob Chemother 2007
Rapid detection of rifampin-resistant Mycobacterium tuberculosis directly from stained sputum smears using single-tube nested polymerase chain reaction deoxyribonucleic acid sequencing. doi:10.1016/j.diagmicrobio.2007.01.007 Diagn Microbiol Infect Dis 2007
Mycobacterium seoulense sp. nov., a slowly growing scotochromogenic species. doi:10.1099/ijs.0.64744-0 Int J Syst Evol Microbiol 2007
Molecular epidemiology and prevalence of mutations conferring rifampicin and isoniazid resistance in Mycobacterium tuberculosis strains from the southern Ukraine. doi:10.1111/j.1469-0691.2006.01583.x Clin Microbiol Infect 2007
Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from central China. doi:10.1007/s10528-006-9074-6 Biochem Genet 2007
Molecular analysis of Mycobacterium tuberculosis causing multidrug-resistant tuberculosis meningitis. Int J Tuberc Lung Dis 2007
Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda. doi:10.1186/1476-0711-6-1 Ann Clin Microbiol Antimicrob 2007
Evaluation of different primer sets for the rapid diagnosis of tuberculosis. doi:10.3923/pjbs.2007.107.111 Pak J Biol Sci 2007
Prevalence of non-tuberculous mycobacteria in a hospital environment. doi:10.1016/j.jhin.2006.10.004 J Hosp Infect 2007
Detection of multidrug resistance in Mycobacterium tuberculosis. doi:10.1128/JCM.00750-06 J Clin Microbiol 2007
Newly developed primers for comprehensive amplification of the rpoB gene and detection of rifampin resistance in Mycobacterium tuberculosis. doi:10.1128/JCM.01489-06 names it J Clin Microbiol 2007
A Case of Acquired Rifampin Resistance in Mycobacterium Bovis Bacillus Calmette-Guérin-induced Cystitis: Necessity for Treatment Guidelines. doi:10.1155/2006/263932 Can J Infect Dis Med Microbiol 2006
A drug-resistant leprosy case detected by DNA sequence analysis from a relapsed Mexican leprosy patient. Rev Latinoam Microbiol 2006
[Identification of Nontuberculous Mycobacteria by Sequence Analysis of the 16S Ribosomal RNA, the Heat-shock Protein 65 and the RNA Polymerase beta-Subunit Genes.]. doi:10.3343/kjlm.2006.26.3.153 Korean J Lab Med 2006
[Determination of genetic mutations in rpoB of the isolates of Mycobacterium tuberculosis complex those susceptibilities to rifampicin were interpreted as indeterminate by BrothMIC MTB]. names it Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2006
Mutation in the rpoB gene of the rifampicin resistant M. avium complex strains from Thailand. names it Southeast Asian J Trop Med Public Health 2006
[Study on the characteristics of mutation on Mycobacterium tuberculosis rifampicin-resistance gene]. Zhonghua Liu Xing Bing Xue Za Zhi 2006
[Study of rifampicin resistance in L-forms of Mycobacterium tuberculosis, by analyzing rpoB gene mutations]. names it Probl Tuberk Bolezn Legk 2006
Molecular characterization of rpoB gene mutations in rifampicine-resistant Mycobacterium tuberculosis isolates from tuberculosis patients in Belarus. doi:10.1002/biot.200600153 names it Biotechnol J 2006
Mycobacterium kumamotonense Sp. Nov. recovered from clinical specimen and the first isolation report of Mycobacterium arupense in Japan: Novel slowly growing, nonchromogenic clinical isolates related to Mycobacterium terrae complex. doi:10.1111/j.1348-0421.2006.tb03865.x Microbiol Immunol 2006
[Microbiologically identified isolates of Mycobacterium heckeshornense in two patients]. Kekkaku 2006
[Modern diagnosis of tuberculosis]. doi:10.1016/S0755-4982(06)74892-8 Presse Med 2006
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic. doi:10.3201/eid1209.060361 Emerg Infect Dis 2006
Detection of rifampin resistance patterns in Mycobacterium tuberculosis strains isolated in Iran by polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods. doi:10.1590/s0074-02762006000600004 Mem Inst Oswaldo Cruz 2006
Evaluation of the rpoB macroarray assay to detect rifampin resistance in Mycobacterium tuberculosis in Beijing, China. doi:10.1007/s10096-006-0215-y names it Eur J Clin Microbiol Infect Dis 2006
[Identification of mycobacteria by sequencing of rpoB gene and 16S rRNA]. names it Kekkaku 2006
[Mechanisms of action of and resistance to rifampicin and isoniazid in Mycobacterium tuberculosis: new information on old friends]. Rev Argent Microbiol 2006
Use of smear-positive samples to assess the PCR-based genotype MTBDR assay for rapid, direct detection of the Mycobacterium tuberculosis complex as well as its resistance to isoniazid and rifampin. doi:10.1128/JCM.01506-06 J Clin Microbiol 2006
Direct detection of Mycobacterium tuberculosis complex DNA and rifampin resistance in clinical specimens from tuberculosis patients by line probe assay. doi:10.1128/JCM.01332-06 J Clin Microbiol 2006
Molecular characterisation of Mycobacterium tuberculosis isolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela. doi:10.1186/1471-2180-6-90 BMC Microbiol 2006
Performance of the genotype MTBDR line probe assay for detection of resistance to rifampin and isoniazid in strains of Mycobacterium tuberculosis with low- and high-level resistance. doi:10.1128/JCM.01054-06 J Clin Microbiol 2006
Mycobacterium barrassiae sp. nov., a Mycobacterium moriokaense group species associated with chronic pneumonia. doi:10.1128/JCM.00724-06 J Clin Microbiol 2006
Reverse line probe assay for the rapid detection of rifampicin resistance in Mycobacterium leprae. Nepal Med Coll J 2006
[Efficiency of chemotherapy of destructive pulmonary tuberculosis, based on the results of rapid detection of drug sensitivity to isoniazid and rifampicin with the "TB-Biochip" test system]. Probl Tuberk Bolezn Legk 2006
[Validation of the PCR-based universal heteroduplex generator assay for identification of rifampicin-resistant and multiresistant Mycobacterium tuberculosis in Lima, Peru]. doi:10.1157/13092465 Enferm Infecc Microbiol Clin 2006
rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China. doi:10.1128/JCM.00515-06 names it J Clin Microbiol 2006
An outbreak of keratitis caused by Mycobacterium immunogenum. doi:10.1128/JCM.00656-06 J Clin Microbiol 2006
[Detection of rpoB gene mutations in Mycobacterium tuberculosis]. names it Fen Zi Xi Bao Sheng Wu Xue Bao 2006
An outbreak of Mycobacterium jacuzzii infection following insertion of breast implants. doi:10.1086/507535 Clin Infect Dis 2006
[Detection of rpoB mutations in rifampicin-resistant Mycobacterium kansasii]. names it Kekkaku 2006
[Determination of multidrug resistance of M. tuberculosis by different methods]. Probl Tuberk Bolezn Legk 2006
Resistance levels and rpoB gene mutations among in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants. doi:10.1128/AAC.00303-06 names it Antimicrob Agents Chemother 2006
Identification of single-point mutations in mycobacterial 16S rRNA sequences by confocal single-molecule fluorescence spectroscopy. doi:10.1093/nar/gkl495 Nucleic Acids Res 2006
Isolation and identification of mycobacteria from soils at an illegal dumping site and landfills in Japan. doi:10.1111/j.1348-0421.2006.tb03821.x Microbiol Immunol 2006
Rapid genotypic detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis directly in clinical specimens. doi:10.1128/JCM.00752-06 J Clin Microbiol 2006
Use of genotype MTBDR assay for molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical strains isolated in Italy. doi:10.1128/JCM.00083-06 J Clin Microbiol 2006
Evaluation of the TB-Biochip oligonucleotide microarray system for rapid detection of rifampin resistance in Mycobacterium tuberculosis. doi:10.1128/JCM.00439-06 J Clin Microbiol 2006
Evaluation of the Genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis isolates. doi:10.1128/JCM.00425-06 J Clin Microbiol 2006
Mutations prevalent among rifampin- and isoniazid-resistant Mycobacterium tuberculosis isolates from a hospital in Vietnam. doi:10.1128/JCM.00330-06 J Clin Microbiol 2006
In house reverse line hybridization assay for rapid detection of susceptibility to rifampicin in isolates of Mycobacterium tuberculosis. doi:10.1016/j.mimet.2006.04.008 J Microbiol Methods 2006
The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. doi:10.1126/science.1124410 Science 2006
Tuberculosis-like peritonitis due to an atypical Mycobacterium infection in a Japanese woman. Jpn J Infect Dis 2006
Denaturing HPLC for high-throughput screening of rifampicin-resistant Mycobacterium tuberculosis isolates. Int J Tuberc Lung Dis 2006
Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains from Thailand and its evolutionary implication. names it Southeast Asian J Trop Med Public Health 2006
Rapid detection of rifampin resistance in Mycobacterium tuberculosis by Pyrosequencing technology. doi:10.1128/JCM.02210-05 J Clin Microbiol 2006
[Characteristics of Mycobacterium tuberculosis clinical strains genotype A1]. Mol Gen Mikrobiol Virusol 2006
[Evaluation of reasons of the MDR M. tuberculosis strains dissemination by analysis of the rifampicin and/or isoniazid resistant isolates]. Mol Gen Mikrobiol Virusol 2006
Rapid detection of rifampicin-resistant Mycobacterium tuberculosis by in-house, reverse line blot assay. doi:10.1016/j.diagmicrobio.2006.03.015 Diagn Microbiol Infect Dis 2006
Comparison of a conventional antimicrobial susceptibility assay to an oligonucleotide chip system for detection of drug resistance in Mycobacterium tuberculosis isolates. doi:10.1128/JCM.44.5.1619-1624.2006 J Clin Microbiol 2006
rpoB gene sequencing and spoligotyping of multidrug-resistant Mycobacterium tuberculosis isolates from India. doi:10.1016/j.meegid.2006.03.001 names it Infect Genet Evol 2006
Description of Mycobacterium conceptionense sp. nov., a Mycobacterium fortuitum group organism isolated from a posttraumatic osteitis inflammation. doi:10.1128/JCM.44.4.1268-1273.2006 J Clin Microbiol 2006
Rapid detection of specific gene mutations associated with isoniazid or rifampicin resistance in Mycobacterium tuberculosis clinical isolates using non-fluorescent low-density DNA microarrays. doi:10.1093/jac/dkl058 J Antimicrob Chemother 2006
Report of two fatal cases of Mycobacterium mucogenicum central nervous system infection in immunocompetent patients. doi:10.1128/JCM.44.3.837-840.2006 J Clin Microbiol 2006
Emergence of rifampicin resistance in methicillin-resistant Staphylococcus aureus in tuberculosis wards. doi:10.1007/s10156-005-0417-8 J Infect Chemother 2006
Use of PCR-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by Mycobacterium abscessus and Mycobacterium chelonae. doi:10.1016/j.vetmic.2005.12.006 Vet Microbiol 2006
rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov. doi:10.1099/ijs.0.63969-0 names it Int J Syst Evol Microbiol 2006
Association of rpoB mutations with rifampicin resistance in Mycobacterium avium. doi:10.1016/j.ijantimicag.2005.09.015 names it Int J Antimicrob Agents 2006
Isolation of Mycobacterium septicum from the sputum of a patient suffering from hemoptoic pneumonia. doi:10.1016/j.resmic.2005.10.006 Res Microbiol 2006
Temperature-mediated heteroduplex analysis for the detection of drug-resistant gene mutations in clinical isolates of Mycobacterium tuberculosis by denaturing HPLC, SURVEYOR nuclease. doi:10.1016/j.micinf.2005.06.008 Microbes Infect 2006
The use of macroarrays for the identification of MDR Mycobacterium tuberculosis. doi:10.1016/j.mimet.2005.08.002 J Microbiol Methods 2006
Characterization of a 411-bp fragment of the rpoB gene in clinical isolates of Mycobacterium tuberculosis in a university hospital in northern Taiwan. names it J Formos Med Assoc 2005
Rapid determination of rifampin resistance in clinical isolates of Mycobacterium tuberculosis by real-time PCR. doi:10.1128/JCM.43.12.6015-6019.2005 J Clin Microbiol 2005
Polyphasic characterization reveals that the human pathogen Mycobacterium peregrinum type II belongs to the bovine pathogen species Mycobacterium senegalense. doi:10.1128/JCM.43.12.5925-5935.2005 J Clin Microbiol 2005
Catheter-associated bacteremia by Mycobacterium senegalense in Korea. doi:10.1186/1471-2334-5-107 BMC Infect Dis 2005
Molecular analysis of isoniazid, rifampin and streptomycin resistance in Mycobacterium tuberculosis isolates from patients with tuberculosis in Düzce, Turkey. Jpn J Infect Dis 2005
Multidrug-resistant tuberculosis detection, Latvia. doi:10.3201/eid1109.041236 Emerg Infect Dis 2005
Rifampicin and isoniazid resistance mutations in Mycobacterium tuberculosis strains isolated from patients in Kazakhstan. Int J Tuberc Lung Dis 2005
[Use of biological microchips in the determination of drug-resistance of Mycobacterium tuberculosis to rifampicin]. Probl Tuberk Bolezn Legk 2005
[The characteristics of the sensitivity of Mycobacterium tuberculosis to rifampicin and isoniazid through determination of mutations in the genes rpoB, katG, inhA, oxyR, and kasA by different molecular biological assays]. names it Probl Tuberk Bolezn Legk 2005
[A new multiplex allele-specific polymerase chain reaction assay for detection of rifampin-resistant Mycobacterium tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi 2005
Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis clinical isolates from Lithuania. names it Int J Tuberc Lung Dis 2005
The occurrence of rare rpoB mutations in rifampicin-resistant clinical Mycobacterium tuberculosis isolates from Kuwait. doi:10.1016/j.ijantimicag.2005.06.009 names it Int J Antimicrob Agents 2005
Use of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis complex isolates. doi:10.1128/JCM.43.8.3699-3703.2005 J Clin Microbiol 2005
[Anti-drug pattern of drug-resistant Mycobacterium tuberculosis and analysis of mutation in drug-target genes]. doi:10.11150/kansenshogakuzasshi1970.79.388 Kansenshogaku Zasshi 2005
Construction and characterization of different MutS fusion proteins as recognition elements of DNA chip for detection of DNA mutations. doi:10.1016/j.bios.2004.08.045 Biosens Bioelectron 2005
Rifampicin resistance in tuberculosis outbreak, London, England. doi:10.3201/eid1106.041262 Emerg Infect Dis 2005
Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency. doi:10.1186/1476-0711-4-9 Ann Clin Microbiol Antimicrob 2005
Microarray and allele specific PCR detection of point mutations in Mycobacterium tuberculosis genes associated with drug resistance. doi:10.1016/j.mimet.2005.04.026 J Microbiol Methods 2005
[Clinical application of testing methods on acid-fast bacteria]. Kekkaku 2005
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. doi:10.1128/AAC.49.6.2200-2209.2005 names it Antimicrob Agents Chemother 2005
Restriction endonuclease analysis as a solution for determining rifampin resistance mutations by automated DNA sequencing in heteroresistant Mycobacterium tuberculosis strains. doi:10.1089/mdr.2005.11.137 Microb Drug Resist 2005
Molecular analysis of isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates recovered from Barcelona. doi:10.1089/mdr.2005.11.107 Microb Drug Resist 2005
Molecular characterization of isoniazid and rifampin resistance of Mycobacterium tuberculosis clinical isolates from Malatya, Turkey. doi:10.1089/mdr.2005.11.94 Microb Drug Resist 2005
Comparison of drug resistance genotypes between Beijing and non-Beijing family strains of Mycobacterium tuberculosis in Korea. doi:10.1016/j.mimet.2005.03.002 J Microbiol Methods 2005
Direct detection in clinical samples of multiple gene mutations causing resistance of Mycobacterium tuberculosis to isoniazid and rifampicin using fluorogenic probes. doi:10.1093/jac/dki132 J Antimicrob Chemother 2005
High frequency of mutations in the rpoB gene in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Singapore. doi:10.1128/JCM.43.4.2026-2027.2005 names it J Clin Microbiol 2005
Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? doi:10.1093/jac/dki069 names it J Antimicrob Chemother 2005
Development of a pyrosequencing approach for rapid screening of rifampin, isoniazid and ethambutol-resistant Mycobacterium tuberculosis. Int J Tuberc Lung Dis 2005
[Mutations linked with antimicrobial resistance in Mycobacterium tuberculosis isolated from tuberculosis patients in the Samara region]. Zh Mikrobiol Epidemiol Immunobiol 2005
rpoB gene mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis in northern Lima, Peru. doi:10.1089/mdr.2005.11.26 names it Microb Drug Resist 2005
Comparative evaluation of polymerase chain reaction and restriction enzyme analysis: two amplified targets, hsp65 and rpoB, for identification of cultured mycobacteria. doi:10.1016/j.diagmicrobio.2004.09.006 names it Diagn Microbiol Infect Dis 2005
Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan. doi:10.1128/JCM.43.3.1390-1394.2005 names it J Clin Microbiol 2005
Systematic molecular characterization of multidrug-resistant Mycobacterium tuberculosis complex isolates from Spain. doi:10.1128/JCM.43.3.1220-1227.2005 J Clin Microbiol 2005
Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany. doi:10.1128/AAC.49.3.1229-1231.2005 Antimicrob Agents Chemother 2005
Single-nucleotide polymorphism-based differentiation and drug resistance detection in Mycobacterium tuberculosis from isolates or directly from sputum. doi:10.1111/j.1469-0691.2004.01034.x Clin Microbiol Infect 2005
Prevalence of katG Ser315 substitution and rpoB mutations in isoniazid-resistant Mycobacterium tuberculosis isolates from Brazil. names it Int J Tuberc Lung Dis 2005
A multigene approach to phylogenetic analysis using the genus Mycobacterium as a model. doi:10.1099/ijs.0.63222-0 Int J Syst Evol Microbiol 2005
Detection and identification of Mycobacterium tuberculosis in joint biopsy specimens by rpoB PCR cloning and sequencing. doi:10.1128/JCM.43.1.174-178.2005 names it J Clin Microbiol 2005
Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea. doi:10.1016/j.jinf.2004.03.012 J Infect 2005
A mutation at codon 516 in the rpoB gene of Mycobacterium leprae confers resistance to rifampin. doi:10.1489/1544-581X(2004)72<468:AMACIT>2.0.CO;2 names it Int J Lepr Other Mycobact Dis 2004
Sequence analysis of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Turkey. doi:10.1089/mdr.2004.10.325 names it Microb Drug Resist 2004
Molecular epidemiology of drug-resistant Mycobacterium tuberculosis strains isolated from patients with pulmonary tuberculosis in Poland: a 1-year study. Int J Tuberc Lung Dis 2004
[Molecular mutations of rpoB gene of multidrug resistant Mycobacterium tuberculosis isolates from China]. names it Yi Chuan Xue Bao 2004
Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates from India and Mexico by a molecular beacon assay. doi:10.1128/JCM.42.12.5512-5516.2004 J Clin Microbiol 2004
Amoebal coculture of "Mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumonia. doi:10.1128/JCM.42.12.5493-5501.2004 J Clin Microbiol 2004
Genetic bases of the rifampin resistance phenotype in Brucella spp. doi:10.1128/JCM.42.12.5439-5443.2004 J Clin Microbiol 2004
RpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis strains isolated in the Aegean region of Turkey. doi:10.1179/joc.2004.16.5.442 names it J Chemother 2004
Mycobacterium cosmeticum sp. nov., a novel rapidly growing species isolated from a cosmetic infection and from a nail salon. doi:10.1099/ijs.0.63238-0 Int J Syst Evol Microbiol 2004
Dissection of phylogenetic relationships among 19 rapidly growing Mycobacterium species by 16S rRNA, hsp65, sodA, recA and rpoB gene sequencing. doi:10.1099/ijs.0.63094-0 names it Int J Syst Evol Microbiol 2004
Dual-probe assay for rapid detection of drug-resistant Mycobacterium tuberculosis by real-time PCR. doi:10.1128/JCM.42.11.5277-5285.2004 J Clin Microbiol 2004
Characterization of drug-resistant isolates of Mycobacterium tuberculosis derived from Russian inmates. Int J Tuberc Lung Dis 2004
[Multi-drug resistant Mycobacterium leprae from patients with leprosy]. doi:10.5025/hansen.73.227 Nihon Hansenbyo Gakkai Zasshi 2004
[Drug resistance of Mycobacterium tuberculosis of the genotype Beijing in imprisonment places in the Arkhangelsk Region]. Probl Tuberk Bolezn Legk 2004
Multiplex detection of mutations in clinical isolates of rifampin-resistant Mycobacterium tuberculosis by short oligonucleotide ligation assay on DNA chips. doi:10.1128/JCM.42.10.4850-4852.2004 J Clin Microbiol 2004
Detection of mutations associated with isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates from Samara Region, Russian Federation. doi:10.1128/JCM.42.10.4498-4502.2004 J Clin Microbiol 2004
Direct detection of rifampin-resistant mycobacterium tuberculosis in respiratory specimens by PCR-DNA sequencing. doi:10.1128/JCM.42.10.4438-4443.2004 J Clin Microbiol 2004
Direct rapid diagnosis of rifampicin-resistant M. tuberculosis infection in clinical samples by line probe assay (INNO LiPA Rif-TB). New Microbiol 2004
Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis. doi:10.1186/1471-2105-5-137 names it BMC Bioinformatics 2004
Peptide nucleic acid-mediated competitive PCR clamping for detection of rifampin-resistant Mycobacterium tuberculosis. doi:10.1128/AAC.48.10.4023-4026.2004 Antimicrob Agents Chemother 2004
[Mycobacterium shinshuense isolated from cutaneous ulcer lesion of right lower extremity in a 37-year-old woman]. Kekkaku 2004
Correlation of mutations detected by INNO-LiPA with levels of rifampicin resistance in Mycobacterium tuberculosis. Indian J Med Res 2004
Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection. doi:10.3201/eid1007.030598 names it Emerg Infect Dis 2004
Identification of Mycobacterium tuberculosis by PCR-linked reverse hybridization using specific rpoB oligonucleotide probes. doi:10.1016/j.mimet.2004.06.004 names it J Microbiol Methods 2004
[New technologies in the determination of drug susceptibility in Mycobacterium tuberculosis]. Probl Tuberk Bolezn Legk 2004
[Molecular identification of mycobacteria and detection of antibiotic resistance]. Ann Biol Clin (Paris) 2004
Evaluation of usefulness of single-strand conformation polymorphism method for rapid detection of rifampicin-resistant Mycobacterium tuberculosis. doi:10.2298/vsp0402169t Vojnosanit Pregl 2004
Active surveillance of leprosy contacts in country with low prevalence rate. doi:10.1489/1544-581X(2004)072<0050:ASOLCI>2.0.CO;2 Int J Lepr Other Mycobact Dis 2004
In-vitro activity of rifabutin against rifampicin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. doi:10.1111/j.1469-0691.2004.00917.x names it Clin Microbiol Infect 2004
[Rapid detection of rpoB mutations in Mycobacterium tuberculosis by gene array]. names it Zhonghua Jie He He Hu Xi Za Zhi 2004
Genetic polymorphism in Mycobacterium tuberculosis isolates from patients with chronic multidrug-resistant tuberculosis. doi:10.1086/421501 J Infect Dis 2004
Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland. doi:10.1128/JCM.42.6.2425-2431.2004 J Clin Microbiol 2004
Simultaneous identification of rifampin-resistant Mycobacterium tuberculosis and nontuberculous mycobacteria by polymerase chain reaction-single strand conformation polymorphism and sequence analysis of the RNA polymerase gene (rpoB). doi:10.1016/j.mimet.2004.03.009 names it J Microbiol Methods 2004
Multicenter evaluation of reverse line blot assay for detection of drug resistance in Mycobacterium tuberculosis clinical isolates. doi:10.1016/j.mimet.2004.02.006 J Microbiol Methods 2004
Resistant Mycobacterium bovis Bacillus Calmette-Guérin disease: implications for management of Bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected children. doi:10.1097/01.inf.0000126593.21006.ac Pediatr Infect Dis J 2004
Newer diagnostic modalities for tuberculosis. doi:10.1007/BF02724274 Indian J Pediatr 2004
Direct detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis in auramine-rhodamine-positive sputum specimens by real-time PCR. doi:10.1128/JCM.42.4.1585-1589.2004 J Clin Microbiol 2004
Use of a high-density DNA probe array for detecting mutations involved in rifampicin resistance in Mycobacterium tuberculosis. doi:10.1111/j.1198-743X.2004.00889.x Clin Microbiol Infect 2004
Antimicrobial susceptibility determined by the E test, Löwenstein-Jensen proportion, and DNA sequencing methods among Mycobacterium tuberculosis isolates discrepancies, preliminary results. doi:10.1590/s0074-02762004000100019 Mem Inst Oswaldo Cruz 2004
Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. doi:10.1128/AAC.48.4.1289-1294.2004 names it Antimicrob Agents Chemother 2004
Oligonucleotide ligation assay-based DNA chip for multiplex detection of single nucleotide polymorphism. doi:10.1016/j.bios.2003.11.022 Biosens Bioelectron 2004
Differential identification of Mycobacterium tuberculosis complex and nontuberculous mycobacteria by duplex PCR assay using the RNA polymerase gene (rpoB). doi:10.1128/JCM.42.3.1308-1312.2004 names it J Clin Microbiol 2004
Study of resistance to anti-tuberculosis drugs in five districts of Equatorial Guinea: rates, risk factors, genotyping of gene mutations and molecular epidemiology. Int J Tuberc Lung Dis 2004
Detection of rifampin-resistant Mycobacterium tuberculosis strains by using a specialized oligonucleotide microarray. doi:10.1016/j.diagmicrobio.2003.08.005 Diagn Microbiol Infect Dis 2004
Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates from Monterrey, Mexico. doi:10.1099/jmm.0.05343-0 J Med Microbiol 2004
Molecular fingerprinting of multidrug-resistant Mycobacterium tuberculosis strains in Beirut reveals genetic diversity and father to daughter transmission. J Med Liban 2003
[Molecular genetic characteristics of rifampicin-resistant Mycobacterium tuberculosis isolates in Novosibirsk]. Probl Tuberk Bolezn Legk 2003
Evaluation of two recovery methods for detection of Mycobacterium avium subsp. paratuberculosis by PCR: direct-dilution--centrifugation and C(18)-carboxypropylbetaine processing. doi:10.1016/S0378-1097(03)00790-0 FEMS Microbiol Lett 2003
Typing of Mycobacterium tuberculosis strains resistant to rifampicin and isoniazid by molecular biological methods. doi:10.1023/b:bebm.0000008981.63290.ef Bull Exp Biol Med 2003
Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru. doi:10.1128/JCM.41.12.5774-5777.2003 J Clin Microbiol 2003
rpoB-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria. doi:10.1128/JCM.41.12.5699-5708.2003 names it J Clin Microbiol 2003
A MutS-based protein chip for detection of DNA mutations. doi:10.1021/ac020719k Anal Chem 2003
Characterization of clinical isolates of Mycobacterium tuberculosis resistant to drugs and detection of RpoB mutation in multidrug-resistant tuberculosis in the Philippines. names it Int J Tuberc Lung Dis 2003
Prevalence of Beijing genotype in Latvian multidrug-resistant Mycobacterium tuberculosis isolates. Int J Tuberc Lung Dis 2003
Detection of isoniazid and rifampin resistance in Mycobacterium tuberculosis strains by single-strand conformation polymorphism analysis and restriction fragment length polymorphism. New Microbiol 2003
[Investigation of drug-resistance to rifampin and rpoB gene sequence analysis of Mycobacterium abscessus]. names it Zhonghua Jie He He Hu Xi Za Zhi 2003
A rifampin-hypersensitive mutant reveals differences between strains of Mycobacterium smegmatis and presence of a novel transposon, IS1623. doi:10.1128/AAC.47.10.3208-3213.2003 Antimicrob Agents Chemother 2003
Direct detection of multidrug-resistant Mycobacterium tuberculosis in clinical specimens in low- and high-incidence countries by line probe assay. doi:10.1128/JCM.41.9.4454-4456.2003 J Clin Microbiol 2003
Rapid detection of mutations in rpoB gene of rifampicin resistant Mycobacterium tuberculosis strains by line probe assay. names it Indian J Med Res 2003
Chronic cases of tuberculosis in Casablanca, Morocco. Int J Tuberc Lung Dis 2003
Low-stringency single-specific-primer PCR as a tool for detection of mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis. doi:10.1128/JCM.41.7.3384-3386.2003 names it J Clin Microbiol 2003
Use of molecular methods to identify the Mycobacterium tuberculosis complex (MTBC) and other mycobacterial species and to detect rifampin resistance in MTBC isolates following growth detection with the BACTEC MGIT 960 system. doi:10.1128/JCM.41.7.2822-2826.2003 J Clin Microbiol 2003
[Determination of rifampin resistance in Mycobacterium tuberculosis isolates by the RNA/RNA mismatch method]. Mikrobiyol Bul 2003
Allele-specific rpoB PCR assays for detection of rifampin-resistant Mycobacterium tuberculosis in sputum smears. doi:10.1128/AAC.47.7.2231-2235.2003 names it Antimicrob Agents Chemother 2003
Novel polymorphic region of the rpoB gene containing Mycobacterium species-specific sequences and its use in identification of mycobacteria. doi:10.1128/JCM.41.5.2213-2218.2003 names it J Clin Microbiol 2003
Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from China. doi:10.1128/JCM.41.5.2209-2212.2003 names it J Clin Microbiol 2003
Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR. doi:10.1016/S0928-8244(03)00038-5 FEMS Immunol Med Microbiol 2003
Molecular analysis of rifampicin-resistant Mycobacterium tuberculosis isolated in Spain (1996-2001). Description of new mutations in the rpoB gene and review of the literature. doi:10.1016/s0924-8579(03)00036-0 names it Int J Antimicrob Agents 2003
Frequency of mutations in rpoB and codons 315 and 463 of katG in rifampin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates from northeast Mexico. doi:10.1089/107662903764736328 names it Microb Drug Resist 2003
Rapid detection of resistance against rifampicin in isolates of Mycobacterium tuberculosis from Brazilian patients using a reverse-phase hybridization assay. doi:10.1016/s0167-7012(02)00253-1 J Microbiol Methods 2003
Heterogeneity of RNA polymerase gene (rpoB) sequences of Mycobacterium gordonae clinical isolates identified with a DNA probe kit and by conventional methods. doi:10.1128/JCM.41.4.1656-1663.2003 names it J Clin Microbiol 2003
Improved real-time PCR for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates. doi:10.1016/s0732-8893(02)00521-7 Diagn Microbiol Infect Dis 2003
Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. doi:10.1128/AAC.47.4.1228-1232.2003 Antimicrob Agents Chemother 2003
Use of DNA extracts from Ziehl-Neelsen-stained slides for molecular detection of rifampin resistance and spoligotyping of Mycobacterium tuberculosis. doi:10.1128/JCM.41.3.1101-1108.2003 J Clin Microbiol 2003
Rapid detection of rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates in shanghai by using the amplification refractory mutation system. doi:10.1128/JCM.41.3.993-997.2003 names it J Clin Microbiol 2003
Characterization of rifampicin-resistant Mycobacterium tuberculosis in Taiwan. doi:10.1099/jmm.0.05045-0 J Med Microbiol 2003
Deciphering an outbreak of drug-resistant Mycobacterium tuberculosis. doi:10.1128/JCM.41.1.67-72.2003 J Clin Microbiol 2003
[Study on drug-resistance of Mycobacterium tuberculosis isolated from coal workers with silico-tuberculosis]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2002
[Diagnosed tuberculosis using specific DNA probe hybridization methods]. Rinsho Byori 2002
[Bacteriological investigations about paratuberculosis in dairy herds in Switzerland]. Dtsch Tierarztl Wochenschr 2002
Improving bacteriological diagnosis of tuberculosis. Indian J Pediatr 2002
Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Kuwait and Dubai. doi:10.1016/s0732-8893(02)00457-1 names it Diagn Microbiol Infect Dis 2002
[Detecting rpoB gene mutation in rifampin-resistant Mycobacterium tuberculosis by using the reverse dot-blot hybridization method]. names it Zhonghua Jie He He Hu Xi Za Zhi 2002
[Clinical application and evaluation of the detection of five drugs resistance genes in Mycobacterium tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi 2002
A low cost, home-made, reverse-line blot hybridisation assay for rapid detection of rifampicin resistance in Mycobacterium tuberculosis. Int J Tuberc Lung Dis 2002
Characterization of rpoB mutations in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Turkey by DNA sequencing and line probe assay. doi:10.1128/JCM.40.12.4435-4438.2002 names it J Clin Microbiol 2002
Molecular analysis of sarcoidosis tissues for mycobacterium species DNA. doi:10.3201/eid0811.020318 Emerg Infect Dis 2002
Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: dominance of the beijing strain family. doi:10.3201/eid0811.020507 Emerg Infect Dis 2002
Characterization of rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolated in China. doi:10.1054/tube.2002.0326 names it Tuberculosis (Edinb) 2002
Mutations in the rpoB and katG genes leading to drug resistance in Mycobacterium tuberculosis in Latvia. doi:10.1128/JCM.40.10.3789-3792.2002 names it J Clin Microbiol 2002
[Clinical value of microchip technology in determination of drug resistance of Mycobacterium tuberculosis]. Probl Tuberk 2002
The spectrum of spontaneous rifampin resistance mutations in the rpoB gene of Bacillus subtilis 168 spores differs from that of vegetative cells and resembles that of Mycobacterium tuberculosis. doi:10.1128/JB.184.17.4936-4940.2002 names it J Bacteriol 2002
Localisation of mycobacterial DNA and mRNA in human tuberculous granulomas. doi:10.1016/s0167-7012(02)00076-3 J Microbiol Methods 2002
Molecular analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with persistent disease in the Khartoum region of Sudan. doi:10.1053/jinf.2001.0992 J Infect 2002
Rapid indication of multidrug-resistant tuberculosis from liquid cultures using FASTPlaqueTB-RIF, a manual phage-based test. doi:10.5588/09640569513048 Int J Tuberc Lung Dis 2002
Molecular characterization of multiple-drug-resistant Mycobacterium tuberculosis isolates from northwestern Russia and analysis of rifampin resistance using RNA/RNA mismatch analysis as compared to the line probe assay and sequencing of the rpoB gene. doi:10.1016/s0923-2508(02)01311-6 names it Res Microbiol 2002
Temperature-mediated heteroduplex analysis performed by using denaturing high-performance liquid chromatography to identify sequence polymorphisms in Mycobacterium tuberculosis complex organisms. doi:10.1128/JCM.40.5.1610-1616.2002 J Clin Microbiol 2002
Nested PCR for diagnosis of tuberculous lymphadenitis and PCR-SSCP for identification of rifampicin resistance in fine-needle aspirates. doi:10.1002/dc.10092 Diagn Cytopathol 2002
Cross-resistance between rifampicin and KRM-1648 is associated with specific rpoB alleles in Mycobacterium tuberculosis. names it Int J Tuberc Lung Dis 2002
Rifampin and isoniazid resistance associated mutations in Mycobacterium tuberculosis clinical isolates in Seville, Spain. Int J Tuberc Lung Dis 2002
Peptide nucleic acid probe detection of mutations in Mycobacterium tuberculosis genes associated with drug resistance. doi:10.2144/02323st01 Biotechniques 2002
rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries. doi:10.1128/JCM.40.3.1091-1094.2002 names it J Clin Microbiol 2002
New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis. doi:10.1128/JCM.40.3.988-995.2002 J Clin Microbiol 2002
Detection of rpoB mutations in Mycobacterium tuberculosis with LightCycler technology. doi:10.1128/JCM.40.2.735.2002 names it J Clin Microbiol 2002
Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India. doi:10.1128/AAC.46.2.443-450.2002 Antimicrob Agents Chemother 2002
Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy. doi:10.1086/324623 Clin Infect Dis 2002
Characterization of rpoB gene mutations in rifampicin resistant Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients at 5 Mexican public hospitals. names it Rev Invest Clin 2001
A method for rapid detection of rifampicin-resistant isolates of Mycobacterium leprae. doi:10.5935/0305-7518.20010052 Lepr Rev 2001
[Characterization of rpoB mutation in rifampin - resistant clinical Mycobacterium tuberculosis isolates from China]. names it Zhonghua Jie He He Hu Xi Za Zhi 2001
[Rapid detection of Mycobacterium tuberculosis resistance to rifampin using DNA chip]. Zhonghua Jie He He Hu Xi Za Zhi 2001
rpoB Gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism. doi:10.3201/eid0706.010615 names it Emerg Infect Dis 2001
Multidrug resistant Mycobacterium leprae from patients with leprosy. doi:10.1128/AAC.45.12.3635-3639.2001 Antimicrob Agents Chemother 2001
Detection of rifampin resistance in Mycobacterium tuberculosis in a single tube with molecular beacons. doi:10.1128/JCM.39.11.4131-4137.2001 J Clin Microbiol 2001
Rifampin resistance in Mycobacterium kansasii is associated with rpoB mutations. doi:10.1128/AAC.45.11.3056-3058.2001 names it Antimicrob Agents Chemother 2001
Molecular characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Hungary by DNA sequencing and the line probe assay. doi:10.1128/JCM.39.10.3736-3739.2001 J Clin Microbiol 2001
Detection of rpoB mutations in Mycobacterium tuberculosis by biprobe analysis. doi:10.1128/JCM.39.9.3350-3352.2001 names it J Clin Microbiol 2001
Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India. doi:10.1128/JCM.39.8.2987-2990.2001 names it J Clin Microbiol 2001
Detection of rifampin-resistant Mycobacterium tuberculosis in sputa by nested PCR-linked single-strand conformation polymorphism and DNA sequencing. doi:10.1128/JCM.39.7.2610-2617.2001 J Clin Microbiol 2001
Identification of rifampin-resistant Mycobacterium tuberculosis strains by hybridization, PCR, and ligase detection reaction on oligonucleotide microchips. doi:10.1128/JCM.39.7.2531-2540.2001 J Clin Microbiol 2001
rpoB sequence analysis of cultured Tropheryma whippelii. doi:10.1128/JCM.39.7.2425-2430.2001 names it J Clin Microbiol 2001
Capillary electrophoresis-based heteroduplex analysis with a universal heteroduplex generator for detection of point mutations associated with rifampin resistance in tuberculosis. Clin Chem 2001
Characterization of IS6110 restriction fragment length polymorphism patterns and mechanisms of antimicrobial resistance for multidrug-resistant isolates of Mycobacterium tuberculosis from a major reference hospital in Assiut, Egypt. doi:10.1128/JCM.39.6.2330-2334.2001 J Clin Microbiol 2001
Differentiation of mycobacterial species by PCR-restriction analysis of DNA (342 base pairs) of the RNA polymerase gene (rpoB). doi:10.1128/JCM.39.6.2102-2109.2001 names it J Clin Microbiol 2001
Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy. doi:10.1128/AAC.45.6.1645-1648.2001 Antimicrob Agents Chemother 2001
Detection of rifampicin-resistant Mycobacterium tuberculosis strains by hybridization and polymerase chain reaction on a specialized TB-microchip. doi:10.1023/a:1017555318388 Bull Exp Biol Med 2001
Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis isolates in Spain and their rapid detection by PCR-enzyme-linked immunosorbent assay. doi:10.1128/JCM.39.5.1813-1818.2001 names it J Clin Microbiol 2001
Integration of multiple PCR amplifications and DNA mutation analyses by using oligonucleotide microchip. doi:10.1006/abio.2001.5082 Anal Biochem 2001
Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains isolated in Brazil and France. doi:10.1590/s0074-02762001000200019 names it Mem Inst Oswaldo Cruz 2001
Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates. doi:10.1128/JCM.39.1.107-110.2001 names it J Clin Microbiol 2001
Rapid detection of smear-negative Mycobacterium tuberculosis by PCR and sequencing for rifampin resistance with DNA extracted directly from slides. doi:10.1128/JCM.39.1.51-52.2001 J Clin Microbiol 2001
[The studies on the molecular mechanism of rifampin-resistant Mycobacterium tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi 2000
Multiple mutations in the rpoB gene of Mycobacterium leprae strains from leprosy patients in Thailand. names it Southeast Asian J Trop Med Public Health 2000
Characterization by single strand conformation polymorphism of mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis in strains from Vancouver, Mexico City and New Delhi. names it J Assoc Physicians India 2000
Rifampicin resistance in tuberculosis--are we back to the future? J Assoc Physicians India 2000
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Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India. doi:10.1016/s1201-9712(00)90075-4 Int J Infect Dis 2000
Characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from the Middle East. doi:10.1016/s0732-8893(00)00200-5 names it Diagn Microbiol Infect Dis 2000
[Detection of rifampin-resistant Mycobacterium tuberculosis by line probe assay (LiPA)]. Kekkaku 2000
Characterization of spontaneous, In vitro-selected, rifampin-resistant mutants of Mycobacterium tuberculosis strain H37Rv. doi:10.1128/AAC.44.12.3298-3301.2000 Antimicrob Agents Chemother 2000
PCR amplification on a microarray of gel-immobilized oligonucleotides: detection of bacterial toxin- and drug-resistant genes and their mutations. doi:10.2144/00294rr01 Biotechniques 2000
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis. doi:10.1073/pnas.210391497 Proc Natl Acad Sci U S A 2000
[Molecular mechanisms of multidrug resistance in Mycobacterium tuberculosis]. doi:10.7888/juoeh.22.269 J UOEH 2000
Genotypic determination of Mycobacterium tuberculosis antibiotic resistance using a novel mutation detection method, the branch migration inhibition M. tuberculosis antibiotic resistance test. doi:10.1128/JCM.38.10.3656-3662.2000 J Clin Microbiol 2000
Sequencing of the rpoB gene in Legionella pneumophila and characterization of mutations associated with rifampin resistance in the Legionellaceae. doi:10.1128/AAC.44.10.2679-2683.2000 names it Antimicrob Agents Chemother 2000
Use of real-time PCR and fluorimetry for rapid detection of rifampin and isoniazid resistance-associated mutations in Mycobacterium tuberculosis. doi:10.1128/JCM.38.9.3194-3199.2000 J Clin Microbiol 2000
Chemical cleavage of mismatches in heteroduplexes of the rpoB gene for detection of mutations associated with resistance of Mycobacterium tuberculosis to rifampin. doi:10.1080/003655400750044962 names it Scand J Infect Dis 2000
rpoB mutations as an epidemiologic marker in rifampin-resistant Mycobacterium tuberculosis. names it Int J Tuberc Lung Dis 2000
Mycobacterium tuberculosis H37Rv comparative gene-expression analysis in synthetic medium and human macrophage. doi:10.1016/s0378-1119(00)00249-3 Gene 2000
Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil. doi:10.1128/JCM.38.8.3119-3122.2000 names it J Clin Microbiol 2000
Species identification of mycobacteria by PCR-restriction fragment length polymorphism of the rpoB gene. doi:10.1128/JCM.38.8.2966-2971.2000 names it J Clin Microbiol 2000
Simultaneous identification and typing of multi-drug-resistant Mycobacterium tuberculosis isolates by analysis of pncA and rpoB. doi:10.1099/0022-1317-49-7-651 names it J Med Microbiol 2000
Identification of drug-resistantMycobacterium tuberculosis by single strand conformation polymorphism and cleavase fragment length polymorphism. doi:10.1007/BF02883734 Indian J Clin Biochem 2000
Genetic antagonism and hypermutability in Mycobacterium smegmatis. doi:10.1128/JB.182.12.3331-3335.2000 J Bacteriol 2000
[Drug resistance in Mycobacterium tuberculosis: diagnostic methods]. Ann Biol Clin (Paris) 2000
Sporotrichoid dermatosis caused by Mycobacterium abscessus from a public bath. doi:10.1111/j.1346-8138.2000.tb02162.x J Dermatol 2000
Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis. doi:10.1128/AAC.44.5.1296-1301.2000 Antimicrob Agents Chemother 2000
[Molecular mechanisms of mycobacterium tuberculosis strains resistance to rifampicin and isoniazid]. Probl Tuberk 2000
Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis. doi:10.1128/AAC.44.4.1075-1077.2000 names it Antimicrob Agents Chemother 2000
[Molecular characteristics of multiresistant clinical strains of Mycobacterium tuberculosis isolated in Russia]. Mol Gen Mikrobiol Virusol 2000
Rapid screening of Mycobacterium tuberculosis for susceptibility to rifampicin and streptomycin. Int J Tuberc Lung Dis 2000
[Direct, rapid detection for rifampin susceptibility to M. tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi 1999
Molecular mechanisms of drug resistance in Mycobacterium tuberculosis clinical isolates. Chin Med J (Engl) 1999
Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy. doi:10.1054/tuld.1999.0222 Tuber Lung Dis 1999
Molecular analysis of rifampin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in Seville, Spain. doi:10.1054/tuld.1998.0195 Tuber Lung Dis 1999
Bacteriological and molecular analysis of rifampin-resistant Mycobacterium tuberculosis strains isolated in Australia. doi:10.1128/JCM.37.12.3844-3850.1999 J Clin Microbiol 1999
Detection of rifampin resistance in Mycobacterium tuberculosis by double gradient-denaturing gradient gel electrophoresis. doi:10.1128/AAC.43.10.2550 Antimicrob Agents Chemother 1999
Mutations in rpoB gene and rifabutin susceptibility of multidrug-resistant Mycobacterium tuberculosis strains isolated in Australia. doi:10.1080/003130299105089 names it Pathology 1999
Line probe assay for rapid detection of mutations in the rpoB gene of Mycobacterium tuberculosis. names it J Formos Med Assoc 1999
Line probe assay in the rapid detection of rifampin-resistant Mycobacterium tuberculosis directly from clinical specimens. doi:10.1080/00365549950163563 Scand J Infect Dis 1999
Mycobacterium tuberculosis rpoB gene DNA sequencing: implications for detection of rifamycin resistance. doi:10.1093/jac/44.2.294 names it J Antimicrob Chemother 1999
Discrimination of multidrug-resistant Mycobacterium tuberculosis IS6110 fingerprint subclusters by rpoB gene mutation analysis. doi:10.1128/JCM.37.9.3022-3024.1999 names it J Clin Microbiol 1999
Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis. doi:10.1128/AAC.43.8.1866 Antimicrob Agents Chemother 1999
Universal pattern of RpoB gene mutations among multidrug-resistant isolates of Mycobacterium tuberculosis complex from Africa. names it Int J Tuberc Lung Dis 1999
[Detection and characteristics of rpoB gene mutations in rifampicin-resistant clinical strains of M. tuberculosis]. names it Probl Tuberk 1999
Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis strains isolated mostly in Asian countries and their rapid detection by line probe assay. doi:10.1128/JCM.37.8.2663-2666.1999 names it J Clin Microbiol 1999
Rifampin and rifabutin resistance mechanism in Helicobacter pylori. doi:10.1128/AAC.43.6.1497 Antimicrob Agents Chemother 1999
Phenotypic and genotypic characterization of Mycobacterium africanum isolates from West Africa. doi:10.1128/JCM.37.6.1921-1926.1999 J Clin Microbiol 1999
Identification of mycobacterial species by comparative sequence analysis of the RNA polymerase gene (rpoB). doi:10.1128/JCM.37.6.1714-1720.1999 names it J Clin Microbiol 1999
Solid-phase sequence scanning for drug resistance detection in tuberculosis. doi:10.1006/mcpr.1998.0212 Mol Cell Probes 1999
Drug-resistant strains of Mycobacterium tuberculosis isolated in Russia. Int J Tuberc Lung Dis 1999
rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy. doi:10.1128/JCM.37.4.1197-1199.1999 names it J Clin Microbiol 1999
Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997). doi:10.1128/JCM.37.4.998-1003.1999 J Clin Microbiol 1999
Application of molecular methods for detection and transmission analysis of mycobacterium tuberculosis drug resistance in patients attending a reference hospital in Italy. doi:10.1086/314677 J Infect Dis 1999
Mycobacterium species identification and rifampin resistance testing with high-density DNA probe arrays. doi:10.1128/JCM.37.1.49-55.1999 J Clin Microbiol 1999
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Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru. doi:10.1054/tuld.1998.0013 Tuber Lung Dis 1998
Comparative Evaluation of Cleavase Fragment Length Polymorphism With PCR-SSCP and PCR-RFLP to Detect Antimicrobial Agent Resistance in Mycobacterium tuberculosis. doi:10.154/MODI00300081 Mol Diagn 1998
Comparison of Two Nonradioactive, Single-Strand Conformation Polymorphism Electrophoretic Methods for Identification of rpoB Mutations in Rifampin- Resistant Isolates of Mycobacterium tuberculosis. doi:10.154/MODI00300073 names it Mol Diagn 1998
Comparison of PCR-heteroduplex characterization by automated DNA sequencing and line probe assay for the detection of rifampicin resistance in Mycobacterium tuberculosis isolates from KwaZulu-Natal, South Africa. doi:10.1089/mdr.1998.4.263 Microb Drug Resist 1998
Antibiotic resistance in mycobacteria. Novartis Found Symp 1998
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Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis. doi:10.1093/jac/42.5.621 names it J Antimicrob Chemother 1998
A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia. doi:10.1128/AAC.42.9.2443 Antimicrob Agents Chemother 1998
Rapid detection of rifampin-resistant Mycobacterium tuberculosis by sequencing and line probe assay. doi:10.1080/003655498750003492 Scand J Infect Dis 1998
Molecular analysis of rifampin-resistant Mycobacterium tuberculosis isolated from Korea by polymerase chain reaction-single strand conformation polymorphism sequence analysis. Int J Tuberc Lung Dis 1998
Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. doi:10.1128/AAC.42.7.1853 names it Antimicrob Agents Chemother 1998
Comparison of three molecular assays for rapid detection of rifampin resistance in Mycobacterium tuberculosis. doi:10.1128/JCM.36.7.1969-1973.1998 J Clin Microbiol 1998
Dideoxy fingerprinting for rapid screening of rpoB gene mutations in clinical isolates of Mycobacterium tuberculosis. names it J Formos Med Assoc 1998
Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays. doi:10.1101/gr.8.5.435 Genome Res 1998
Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis. doi:10.1038/nbt0498-359 Nat Biotechnol 1998
Detecting drug-resistant tuberculosis: beacons in the dark. doi:10.1038/nbt0498-331 Nat Biotechnol 1998
Molecular evolution of rifampicin resistance in Streptococcus pneumoniae. doi:10.1089/mdr.1998.4.65 Microb Drug Resist 1998
Plasmid-mediated rifampicin resistance in Pseudomonas fluorescens. doi:10.1099/00222615-47-3-197 J Med Microbiol 1998
The rapid diagnosis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis--a molecular story. doi:10.1099/00222615-47-3-189 J Med Microbiol 1998
Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Greece. doi:10.1128/JCM.36.1.20-23.1998 names it J Clin Microbiol 1998
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Development of a suicide gene as a novel approach to killing Mycobacterium tuberculosis. doi:10.1164/ajrccm.156.6.9611079 Am J Respir Crit Care Med 1997
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Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis. doi:10.1099/00222615-46-10-847 J Med Microbiol 1997
Detection of rifampin resistance by single-strand conformation polymorphism analysis of cerebrospinal fluid of patients with tuberculosis of the central nervous system. doi:10.1128/jcm.35.11.2802-2806.1997 J Clin Microbiol 1997
Evaluation of the INNO-LiPA Rif. TB assay, a reverse hybridization assay for the simultaneous detection of Mycobacterium tuberculosis complex and its resistance to rifampin. doi:10.1128/AAC.41.10.2093 Antimicrob Agents Chemother 1997
Characterization of the rpoC gene of Streptomyces coelicolor A3(2) and its use to develop a simple and rapid method for the purification of RNA polymerase. doi:10.1016/s0378-1119(97)00179-0 Gene 1997
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Disequilibria in the distribution of rpoB alleles in rifampicin-resistant M. tuberculosis isolates from Germany and Sierra Leone. doi:10.1089/mdr.1997.3.195 names it Microb Drug Resist 1997
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Evaluation of a line probe assay kit for characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from New York City. doi:10.1128/jcm.35.5.1281-1283.1997 names it J Clin Microbiol 1997
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Molecular cloning and characterization of Borrelia burgdorferi rpoB. doi:10.1016/s0378-1119(96)00714-7 names it Gene 1997
Mutations in the rpoB gene of Mycobacterium tuberculosis that interfere with PCR-single-strand conformation polymorphism analysis for rifampin susceptibility testing. doi:10.1128/jcm.35.2.492-494.1997 names it J Clin Microbiol 1997
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Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. doi:10.1128/AAC.40.11.2655 names it Antimicrob Agents Chemother 1996
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Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan. doi:10.1128/AAC.40.4.1053 names it Antimicrob Agents Chemother 1996
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Sequence and analysis of the rpoB gene of Mycobacterium smegmatis. doi:10.1128/AAC.39.9.2164 names it Antimicrob Agents Chemother 1995
Evolution of rifampin resistance in human immunodeficiency virus-associated tuberculosis. doi:10.1164/ajrccm.152.3.7663785 Am J Respir Crit Care Med 1995
Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting. doi:10.1128/jcm.33.6.1617-1623.1995 J Clin Microbiol 1995
Mutations in rpoB gene of rifampicin resistant clinical isolates of Mycobacterium tuberculosis in Japan. doi:10.11150/kansenshogakuzasshi1970.69.413 names it Kansenshogaku Zasshi 1995
Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. doi:10.1093/infdis/171.4.954 J Infect Dis 1995
Direct genotypic detection of Mycobacterium tuberculosis rifampin resistance in clinical specimens by using single-tube heminested PCR. doi:10.1128/jcm.33.3.556-561.1995 J Clin Microbiol 1995
Detection of rifampin resistance among isolates of Mycobacterium tuberculosis from Mozambique. doi:10.1089/mdr.1995.1.321 Microb Drug Resist 1995
Isolation of the gene for the beta subunit of RNA polymerase from rifampicin-resistant Mycobacterium tuberculosis and identification of new mutations. doi:10.1165/ajrcmb.11.6.7946393 Am J Respir Cell Mol Biol 1994
[Evaluation for rapid detection of rifampicin-resistant mycobacterium tuberculosis by polymerase chain reaction-single strand conformation polymorphism]. Kekkaku 1994
Characterization of rifampin-resistance in pathogenic mycobacteria. doi:10.1128/AAC.38.10.2380 Antimicrob Agents Chemother 1994
Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study. doi:10.1016/s0140-6736(94)91338-2 Lancet 1994
The rpoB gene of Mycobacterium tuberculosis. doi:10.1128/AAC.38.4.805 names it Antimicrob Agents Chemother 1994
Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas. doi:10.1128/jcm.32.4.1095-1098.1994 names it J Clin Microbiol 1994
Detection of a genetic locus encoding resistance to rifampin in mycobacterial cultures and in clinical specimens. doi:10.1016/0732-8893(94)90024-8 Diagn Microbiol Infect Dis 1994
Evaluation of the rpoB gene in rifampicin-susceptible and -resistant Mycobacterium avium and Mycobacterium intracellulare. doi:10.1093/jac/33.3.661-a names it J Antimicrob Chemother 1994
A simple and rapid technique for the detection of rifampin resistance in Mycobacterium leprae. Int J Lepr Other Mycobact Dis 1993
Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism analysis. doi:10.1128/AAC.37.10.2054 Antimicrob Agents Chemother 1993
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. doi:10.1016/0140-6736(93)90417-f Lancet 1993
Molecular basis of rifampin resistance in Mycobacterium leprae. doi:10.1128/AAC.37.3.414 Antimicrob Agents Chemother 1993

Title+abstract index only: a paper that names this gene solely in its body text, a figure legend or a supplement is invisible here. That is why this list sits beside the curated layer rather than replacing it - Rv0007's characterisation, found by a full-text sweep, returns zero in this one. Absence from this list is not absence from the literature. Source: PubMed E-utilities sweep (esearch + esummary), every alias of the gene searched in conjunction with a mycobacterial context term; ambiguous common-word aliases excluded. phase198, 2026-09-06.

This layer CITES the literature and adds context; it does not change the verdict or the function stated elsewhere in this fiche. This distinguishes a gene that is dark because nobody has looked from one that is dark despite having been studied. Source: PubMed (whole): H37Rv locus tag + GENE NAME + ortholog identifiers (Mb…, MMAR_…, MSMEG_…, ML…, MAB_…), under a mycobacterial context filter; hits verified against the abstract text. Species-context counts distinguish M. tuberculosis literature from literature on other mycobacteria. phase76/phase77, 2026-07-13.

Conditional expression context (iModulons)

Member of 1 independently-modulated gene set(s): WhiB1 (whiB1).

iModulon membership (independently-modulated gene sets from a 647-sample RNA-seq compendium): the conditional co-expression context. Co-expression is a regulatory context, NOT a molecular function. Source: iModulonDB / modulome_mtb (Yoo 2022).

Transcriptional start site (informative, coordinates unchanged)

Primary TSS at position 759592 (+ strand), 197 bp 5'UTR. TSS-derived candidate start codon: 759789 (902 bp from the annotated start) -- candidate only, not applied to this record's coordinates.

Genome-wide 5'-triphosphate-enriched RNA-seq TSS mapping (Cortes et al. 2013): informative context on transcript architecture only. reannotated_start_candidate is the authors' TSS-derived candidate start codon -- reported for information, NEVER applied to this atlas's start_mtbc0/end_mtbc0 coordinates (P19 MTBC0<->H37Rv anchoring). Row re-keyed to this locus by matching its genomic boundary against the H37Rv GFF3 (P49.1 (phase233, 2026-09-15), P49): the original ingestion (P16.23/phase135, 2026-08-17) trusted the source table's own gene-identity column, which was desynchronised from its own numeric columns on 547/651 checkable rows -- see P49 for the full diagnostic. A missing primary_tss here means this gene falls outside the 680-gene re-annotation-candidate subset the source table covers, not an absence of transcription. Source: Cortes et al. 2013 (Cell Reports), Table S3 (TSS mapping and re-annotation of start codons), 680-gene re-annotation-candidate subset of >4,000 genome-wide TSS -- row re-keyed to this locus by coordinate match (P49).

CRISPRi vulnerability

Vulnerability index -9.57 (95% CI -10.06 to -9.07). A more negative index = more vulnerable to knockdown (better drug-target quality); indicative threshold VI ≤ -6 = highly vulnerable.

Quantitative CRISPRi knockdown, graded (finer than binary Tn-seq essentiality). Source: CRISPRi vulnerability index (Bosch 2021, supplementary Table S2 'mmc3.xlsx', bulk import via Europe PMC -- supersedes the per-gene pebble.rockefeller.edu scrape of phase46_crispri_vulnerability.py).

Legacy record & comparison (Mycobrowser)

Mycobrowser functionCatalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates [catalytic activity: N nucleoside triphosphate = N diphosphate + {RNA}(N)].
Mycobrowser EC 2.7.7.6 · agrees with the atlas

The legacy Mycobrowser record is shown for verification. Mycobrowser is no longer maintained; its EC numbers predate recent nomenclature revisions, so a class change usually reflects re-numbering, not a conflict.

Orthologues (reciprocal best hits across mycobacteria)

M. bovis Mb0686 · 99.9% identity
M. leprae ML1891c · 95.0% identity
M. marinum MMAR_0995 · 94.9% identity
M. smegmatis MSMEG_1367 · 91.9% identity
M. orygis RJtmp_000703 · 99.7% identity
M. abscessus MAB_3869c · 89.1% identity

Reciprocal-best-hit orthologues (DIAMOND) against the Mycobrowser reference proteomes. A missing species is informative: e.g. a gene absent from M. leprae was likely lost in its reductive genome evolution. Locus tags link to Mycobrowser.

Curated reference (UniProt)

UniProt P9WGY9 SwissProt · reviewed · Evidence at protein level
UniProt nameDNA-directed RNA polymerase subunit beta
EC (curated) EC 2.7.7.6
Curated functionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Functional vocabulary (eggNOG-mapper, orthology transfer)

COG category K Transcription
Preferred namerpoB
eggNOG descriptionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Orthologous groupCOG0085
EC number EC 2.7.7.6
KEGG orthology K03043
KEGG pathways map00230, map00240, map01100, map03020
KEGG modules M00183
Gene Ontology (21) GO:0000428, GO:0005575, GO:0005618, GO:0005622, GO:0005623, GO:0005737, GO:0005829, GO:0005886, GO:0008150, GO:0016020, GO:0030312, GO:0030880 +9 more

Orthology-based transfer (eggNOG 5.0.2, diamond). EC/KO/GO/CAZy are computed annotations, not manual curation; cross-check against the primary literature before treating a specific reaction as established.

Conservation & selection (intra-MTBC, 142 601 strains, snapshot of 2026-09-29)

pN/pS 1.079 · relaxed/neutral
Polymorphic sites (≥ 0.1% of strains) 9 synonymous, 30 missense, 0 nonsense, 0 frameshift

pN/pS from segregating SNPs (singletons removed) normalised by possible sites. Low pN/pS = purifying selection (a strong signal that a "hypothetical" is a real, constrained gene). A high pN/pS is ambiguous: relaxed constraint or positive selection (drug resistance, antigenic variation) inflate it; e.g. rpoB/katG/pncA score high here for resistance, not loss of function. A clonal disruption (one allele over a clade) suggests lineage pseudogenisation; a convergent one (many independent alleles) is typical of resistance loss-of-function.

Outgroup conservation (beyond the MTBC) Bacteria

M. canettii dN/dS (deep-divergence selection) 0.0 (low power) · 1 consensus substitution(s)
low power (1 canettii-consensus substitution(s)); present in M. canettii but dN/dS not reliable
Limitation: dN/dS mixes fixed canettii-H37Rv divergence with intra-canettii polymorphism, and is not polarised (the per-gene repolarisation is not viable: 79 % of the consensus SPDI lie outside the polarised table).
Genus-wide presence (~53 non-MTBC Mycobacterium) present in 53/53 (100%) · mean identity 94.0% · 4/4 closest MTBAP relatives
conserved across the genus (present in 53/53 non-MTBC Mycobacterium genomes, incl. distant relatives) — an ancient core gene predating the genus radiation
Phylostratum (deepest detected homolog) MTBC-specific → Mycobacterium → Mycobacteriaceae → Corynebacteriales → Actinomycetia → Bacteria
detected in 13/13 non-Mycobacterium reference genomes (down to Bacteria) · mean identity 76.7%
detected down to outside the phylum (Proteobacteria/Firmicutes controls) — a universally conserved, ancient bacterial gene

Two orthogonal outgroup signals. M. canettii (the immediate outgroup) gives a deep-divergence dN/dS (a low value confirms a constrained, real gene; shown as confident only at ≥8 substitutions, else flagged low-power). Genus-wide presence/absence (tblastn vs assembled non-MTBC genomes) places the gene on the ancient-core ↔ MTBC-specific axis: a gene absent even from the closest MTBAP relatives is a candidate MTBC-specific innovation (possible host-adaptation factor, to confirm by synteny). The phylostratum extends that axis outside the genus (tblastn vs 13 reference genomes spanning Mycobacteriaceae → Corynebacteriales → Actinomycetia → outside the phylum): it is the deepest clade in which a homolog is still detected, i.e. a proxy for gene age. Read it with the null model in mind: a shallow (young) stratum can also reflect homology-detection failure for short or fast-evolving ORFs, so it is a descriptive axis, not a proof of novelty.

Essentiality (transposon mutagenesis) essential

DeJesus 2017 callES · essential
What the call meansessential: insertions absent across the whole ORF
TA sites (Himar1) 39 in the ORF — 38 in the essential state, 0 growth-defect, 1 non-essential, 0 growth-advantage. Saturation 0.051, mean read count 19.5. A region of the protein devoid of TA sites is invisible to this assay: nothing can be inferred about it, in either direction.
All 39 sites lie in this ORF alone (no overlapping CDS shares any), so the call is attributable to this gene.

Genome-wide Himar1 transposon essentiality in H37Rv (DeJesus 2017). An essential call (ES/ESD/GD) is strong, independent evidence that a "hypothetical" locus encodes a functional, selectively required gene — orthogonal to intra-species conservation.

Chemical-genetic target & druggability (PROSPECT) hypomorph tool strain validated drug target

This gene is part of the PROSPECT collection of TetON transcriptional-knockdown (hypomorph) strains of essential M. tuberculosis genes, built as a sensitised background for chemical-genetic mechanism-of-action deconvolution. Being in the panel means the gene is an essential / vulnerable target for which a validated knockdown tool strain exists.

Hypomorph strainrpoB-tetOn-10 (TetON promoter 10)
Baseline knockdown fitness4.139 median doublings (across 6 screen pool(s)) — fewer doublings = stronger growth defect on knockdown
Used in target deconvolutionyes (informs phenotypic-cluster / MOA assignment)
Drug-target cross-referenceannotated mechanism-of-action target RpoB: 8 reference compound(s) phenocopy its inhibition — chemically-validated druggable target

Panel membership reflects essentiality/vulnerability and the availability of a genetic tool, not a specific molecular function; it never changes the verdict here. Source: Bond AN et al., Nat Commun 2025;16:9673 (doi:10.1038/s41467-025-64662-x); PROSPECT chemical-genetic platform.

Drug resistance (WHO catalogue) rifampicin

rifampicin381 catalogued resistance-associated variant(s)

This gene carries mutations classed Associated with resistance (WHO grade 1–2) in the consolidated catalogue (WHO 2nd ed. 2023 + tb-profiler). Only the R-associated tier is shown; "uncertain" and empirical-only signals are excluded. Test a specific strain or variant with the resistance tester. Research context, not a clinical diagnostic.

Proteomics (mass spectrometry) detected

MS detectiondetected in 16 of 16 independent MS datasets
Integrated abundance1332.0 ppm · rank 163/3519 (95.4th percentile)

Detection by mass spectrometry is direct, experimental evidence that the protein product exists — orthogonal to sequence conservation and to Tn-seq essentiality, and especially decisive for a "hypothetical" locus. Read the dataset count as abundance, not as replication. Measured across this atlas (3,491 detected proteins), the number of datasets a protein appears in tracks its abundance almost monotonically: median 1.2 ppm at 1 dataset of 16, 27 ppm at 10, 392 ppm at 15, 1,325 ppm at 16 — three orders of magnitude. A high count therefore says the protein is abundant more than it says several independent experiments confirmed it. What the count does establish, at any value, is that the product exists.

Predicted localisation (DeepTMHMM + lipobox) no export signal, no TM helix

Predictionno signal peptide, no TM helix (DeepTMHMM class GLOB)
DeepTMHMM classGLOB

A verified absence of signals, which is not a compartment. No Sec/Tat signal peptide, no transmembrane helix and no lipobox were found on this sequence. The predictor reports topology and export signals; it does not measure where the protein ends up, so this page draws no cytoplasmic conclusion from it. In M. tuberculosis that reservation is not theoretical: the 12 Esx paralogues of this atlas — EsxA/ESAT-6 and EsxB/CFP-10 among them, the best-established secreted proteins of the species — carry this very call, because substrates of the type VII (ESX) secretion system leave no recognisable signal. « Secreted » and « no signal peptide » are true together here.

Transmembrane topology and signal peptide from DeepTMHMM (deep-learning reference predictor); lipoproteins from a (myco)bacterial lipobox motif. A sequence-based prediction of subcellular context.

Physico-chemical properties (computed, ProtParam)

Length1172 aa
Molecular weight129.2 kDa
Theoretical pI4.93
GRAVY-0.326 (hydrophilic)
Aliphatic index88.1
Aromaticity0.057
Instability index44.2 (unstable)

Computed from the ancestral MTBC0 sequence with the ExPASy ProtParam method (Biopython). Descriptive biophysical context: a positive GRAVY flags a hydrophobic (often membrane) protein, a high instability index (>40) predicts a short in-vitro half-life, an extreme pI hints at compartment or binding partner.

Domains (Pfam, hmmscan --cut_ga)

PfamAccessioni-EvalueResiduesDescription
RNA_pol_Rpb2_1PF04563.21 4.0e-16111–417 RNA polymerase beta subunit
RNA_pol_Rpb2_2PF04561.20 2.1e-27175–373 RNA polymerase Rpb2, domain 2
RNA_pol_Rpb2_3PF04565.22 6.0e-28432–500 RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_45PF10385.15 4.4e-28510–576 RNA polymerase beta subunit external 1 domain
RNA_pol_Rpb2_6PF00562.34 1.8e-125637–1056 RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7PF04560.26 1.7e-271058–1132 RNA polymerase Rpb2, domain 7

3D structure (interactive — Mol*/pdbe-molstar)

Experimental structure 9mrq (PDBe), the strongest available structural evidence for this gene. Drag to rotate, scroll to zoom; hetero-groups (ligands, ions, waters hidden by default) shown as sticks.

Experimental structures (Protein Data Bank) 92 solved

PDBMethodResolutionCoverage
9mrq Electron Microscopy 2.97 Å 100%
8ehq Electron Microscopy 3.0 Å 100%
8eos Electron Microscopy 3.1 Å 100%
9e85 Electron Microscopy 3.1 Å 100%
8ej3 Electron Microscopy 3.13 Å 100%
8eoe Electron Microscopy 3.2 Å 100%
8exy Electron Microscopy 3.2 Å 100%
9ji5 Electron Microscopy 3.2 Å 100%

Experimentally solved structures mapped from the UniProt accession via PDBe/SIFTS (92 total; up to 8 shown, ranked by sequence coverage then resolution). An experimental structure is direct proof of the folded product and the strongest structural evidence — superseding the predicted ESMFold/AlphaFold models below for any covered region.

Structural search (AlphaFold DB model, Foldseek vs PDB — genome-wide) pLDDT 91.1

PDB hitprobTM (aln)TM (query)TM (target)Seq. id.Cov. q / tE-valueDescription
6jcx-assembly1_C 1.00 0.99 0.96 0.99 100% 97% / 100% 0.0e+00 sig 6jcx-assembly1_C Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt RNA
6koo-assembly1_C 1.00 0.99 0.95 0.99 100% 97% / 100% 0.0e+00 sig 6koo-assembly1_C Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 7 nt
6tyg-assembly1_C 1.00 0.99 0.94 0.99 100% 95% / 100% 0.0e+00 sig 6tyg-assembly1_C Crystal structure of MTB sigma L transcription initiation complex with 9 nt long RNA primer
5zx3-assembly1_C 1.00 0.99 0.93 0.99 97% 97% / 100% 0.0e+00 sig 5zx3-assembly1_C Mycobacterium tuberculosis RNA polymerase holoenzyme with ECF sigma factor sigma H
6vw0-assembly1_C 1.00 0.99 0.94 0.99 100% 94% / 100% 0.0e+00 sig 6vw0-assembly1_C Mycobacterium tuberculosis RNAP S456L mutant open promoter complex

Foldseek search of the AlphaFold DB model (mean pLDDT 91.1, gated at 70) against the PDB — a genome-wide extension of the ESMFold dark-gene search that also covers proteins beyond the single-sequence length limit. Confident structural neighbours (E < 0.01) shown.

Genomic context (neighbours & predicted operon) operon of 2

Upstream (5' on genome)Rv0666 (+ strand, 497 bp gap)
Downstream (3' on genome)rpoC (+ strand, 44 bp gap)
Predicted operon rpoB · rpoC

Neighbours from the H37Rv annotation (+ strand). The operon is predicted by co-directional intergenic distance (same strand, gaps ≤50 bp) — a transcription-unit hypothesis, not a mapped TSS. For a "hypothetical", co-transcription with a characterised operon is a concrete functional lead (complements the STRING neighborhood channel below).

Published operon evidence (two independent sources)

Roback 2007 (logistic regression: distance + expression correlation, 474 microarrays) operon of 2: rpoB · rpoC — agrees with the distance heuristic above
REMap 2016 (RNA-seq coverage continuity, CDC1551, tag MT0695) exponential phase: operon of 9, Rv0667 · Rv0668 · Rv0670 · Rv0671 · Rv0672 · Rv0673 · Rv0674 · Rv0675 (coverage 16.62)
stationary phase: operon of 3, Rv0667 · Rv0668 (coverage 105.89) — agrees with the distance heuristic above

Two independent published operon maps, cited alongside the distance heuristic above: an association corroborating or contradicting the heuristic, never proof of shared function. REMap's RNA-seq coverage continuity is the most direct of the three signals; Roback's logistic regression and the intergenic-distance heuristic are statistical proxies.

Transcriptional regulation (signed TRN: ChIP-seq + TFOE)

Regulated by (1 TF) Rv3488 (represses)

Regulatory edges from the ISB signed transcriptional regulatory network (TF ChIP-seq binding, Minch 2015 + TF-overexpression response, Rustad 2014). An edge is regulatory evidence (binding and/or expression change), not necessarily direct. For a "hypothetical", membership in a known regulon (e.g. DosR dormancy, PhoP virulence) is a physiological-context lead, not a function.

Condition: Condition-blind by construction. These edges come from transcription-factor OVEREXPRESSION in a single laboratory condition, so a listed regulator is not a claim that it governs this gene in every circumstance. Measured counter-examples exist within this atlas (see Rv2516c, where the DosR regulon collapses under moxifloxacin while the gene itself rises). Read a regulator as 'capable of shifting this gene', and look for the condition before building a hypothesis on it.

Additional regulons (curated, outside the TFOE-derived TRN)

crp binding site only -- direction not determined (low confidence · CRP regulon (Kahramanoglou et al. 2014))
ChIP-seq : site de fixation CRP (1 des 191 sites de Kahramanoglou et al. 2014) ; aucun changement d'expression rapporte pour ce gene chez le mutant delta-crp
Caveat: Site de fixation CRP mesure par ChIP-seq (Kahramanoglou et al. 2014), SANS changement d'expression mesure pour ce gene chez le mutant delta-crp : le sens de la regulation n'est PAS determine. Ecrire « site de fixation CRP en amont », jamais « regule par CRP ». L'article ne distingue pas « non differentiellement exprime » de « sous le seuil », donc l'absence de ce gene de la table d'expression n'est pas une preuve de non-regulation.

Curated from primary literature not covered by the ISB signed TRN (Minch 2015 / Rustad 2014): Zur regulon (Maciag et al. 2007, PMID 17098899), SigG regulon (Gaudion et al. 2013, PMID 23871545), LexA/SOS regulon (Smollett et al. 2012, PMID 22528497) — added P16.25 (2026-08-18); CRP regulon (Kahramanoglou et al. 2014, PMID 24957601) — added P16.25b (2026-09-27). Confidence and caveats are per-edge and carried from the source paper — read them before citing a specific gene as "regulated by" its listed TF. An entry reading "binding site only — direction not determined" is not a regulation claim: it records a measured ChIP-seq binding site for which the source reports no expression change, and the absence of such a change is not evidence of absent regulation.

Functional interaction network (STRING v12, guilt-by-association)

Explore full network →

Node colour = verdict, dashed = still uncharacterised; edge colour = evidence (green experimental, orange genomic-context, grey co-expression), width ∝ score. Click a partner to open its page; "Explore full network" to walk the graph.

Closest characterised functional partner: rpoC (DNA-directed RNA polymerase subunit beta'), high confidence (score 1000, all STRING channels except text-mining; the partner is chosen on its genomic-context evidence). The pair's experimental or database support is transferred from orthologous pairs in other proteomes only: nothing was measured in M. tuberculosis, so it is an association inferred by orthology rather than measured in this organism.

Showing the 15 strongest of this gene's 387 partners at medium confidence (157 at high confidence). The table is an extract, not a neighbourhood: across the proteome the real median degree is 34 while the served median is 15, so no hub, degree distribution or centrality may be read on this table. Of the 387 partners, 4 rest on an interaction measured in M. tuberculosis itself.

PartnerProductScoreNo text-miningChannels (≥400)
Rv0668 rpoC exp (transferred) curated DNA-directed RNA polymerase subunit beta' 999 1000 ctx neighborhood:817 fusion:900 cooccurence:767 coexpression:962 experimental:999 database:844 textmining:959
Rv3457c rpoA exp (transferred) curated DNA-directed RNA polymerase subunit alpha 999 1000 ctx cooccurence:481 coexpression:970 experimental:999 database:844 textmining:973
Rv2703 sigA exp (transferred) RNA polymerase sigma factor SigA 999 1000 experimental:999 textmining:514
Rv1390 rpoZ exp (transferred) curated DNA-directed RNA polymerase subunit omega 999 1000 coexpression:655 experimental:999 database:844 textmining:850
Rv2710 sigB exp (transferred) RNA polymerase sigma factor SigB 999 1000 experimental:999
Rv0735 sigL exp (transferred) ECF RNA polymerase sigma factor SigL 999 999 experimental:999
Rv3583c carD measured in Mtb RNA polymerase-binding transcription factor CarD 999 999 experimental:999
Rv3223c sigH exp (transferred) ECF RNA polymerase sigma factor SigH 999 999 experimental:999
Rv0640 rplK exp (transferred) 50S ribosomal protein L11 998 997 ctx cooccurence:621 coexpression:918 experimental:908
Rv0719 rplF exp (transferred) 50S ribosomal protein L6 997 996 coexpression:958 experimental:902
Rv0700 rpsJ exp (transferred) 30S ribosomal protein S10 997 995 coexpression:955 experimental:820 textmining:586
Rv0721 rpsE exp (transferred) 30S ribosomal protein S5 996 995 coexpression:962 experimental:812 textmining:409
Rv0701 rplC exp (transferred) 50S ribosomal protein L3 998 994 coexpression:968 experimental:771 textmining:701
Rv0706 rplV exp (transferred) 50S ribosomal protein L22 994 993 coexpression:958 experimental:785
Rv0704 rplB exp (transferred) 50S ribosomal protein L2 997 992 coexpression:967 experimental:707 textmining:665

STRING combines evidence channels (neighborhood, fusion, cooccurrence, coexpression, experimental, database, text-mining) into a 0–1000 score. The ctx badge marks edges carried by the genomic-context channels (conserved neighborhood, fusion, phylogenetic co-occurrence), which are independent of orthology and structure and the strongest signal for an unknown gene. The no text-mining column recomputes the score from data alone, so a link that does not depend on the literature is visible. Association is a function hypothesis, not proof: corroborate with the operon context and the primary literature before assigning a function.

Where the experimental evidence comes from, and why it matters here. STRING's experimental channel fuses interactions measured in M. tuberculosis with interactions measured in another organism and transferred to this pair by orthology. The two are not equivalent for this atlas, whose standing rule is that better studied elsewhere is not a function established in M. tuberculosis. Measured on the served network: of the 38 229 partner pairs shown across the atlas, 13 483 partner rows carry a non-zero experimental channel, and only 106 pairs rest on an interaction measured in M. tuberculosis itself — 0.3 % of the network. Those 106 are long-established complexes (ESX-1/ESAT-6, RNA polymerase with CarD and RbpA, the Pup–Mpa proteasome, gyrase, Emb, GarA with PknB and PknG, the Rel modules); no still-uncharacterised gene is among them. The reason is not a gap in this atlas but in the literature: there is almost no experimental interactome of this bacterium, IntAct holding 134 curated protein pairs for a ~4 000-gene proteome. A exp (transferred) badge is therefore a lead, never a measurement, and an absence of badge is not evidence that the pair does not interact.

Evidence

  • Legacy H37Rv annotation: DNA-directed RNA polymerase subunit beta
  • MTBC0 PGAP product: DNA-directed RNA polymerase subunit beta
  • Pfam (hmmscan --cut_ga): RNA_pol_Rpb2_1 PF04563.21 (E=4e-16), RNA_pol_Rpb2_2 PF04561.20 (E=2e-27), RNA_pol_Rpb2_3 PF04565.22 (E=6e-28), RNA_pol_Rpb2_45 PF10385.15 (E=4e-28), RNA_pol_Rpb2_6 PF00562.34 (E=2e-125), RNA_pol_Rpb2_7 PF04560.26 (E=2e-27)
  • (auto-curated by rules from PGAP + Pfam + Foldseek; not hand-reviewed)

Sources

  • Ancestral sequence & coordinates: Harrison LB et al. (2024), An imputed ancestral reference genome for the MTBC, doi:10.1101/2023.09.07.556366
  • Product annotation: NCBI PGAP on MTBC0; legacy from H37Rv NC_000962.3 (RefSeq NP_215181.1)
  • Domains: Pfam-A via hmmscan --cut_ga — RNA_pol_Rpb2_1 (PF04563.21), RNA_pol_Rpb2_2 (PF04561.20), RNA_pol_Rpb2_3 (PF04565.22), RNA_pol_Rpb2_45 (PF10385.15), RNA_pol_Rpb2_6 (PF00562.34), RNA_pol_Rpb2_7 (PF04560.26)
  • Sequence-level signal: ESM Atlas (EvolutionaryScale × BioHub) — exploratory
  • Controlled vocabulary: eggNOG-mapper 2.1.12 (Cantalapiedra et al. 2021, doi:10.1093/molbev/msab293), eggNOG 5.0 DB (Huerta-Cepas et al. 2019) — OG COG0085
  • Curated reference: UniProt P9WGY9 (SwissProt, reviewed; Evidence at protein level)
  • Intra-MTBC selection: pN/pS and disruption from SPDI variants of 142 601 MTBC strains (this work, local collection vs H37Rv NC_000962.3)
  • Genome-wide structure: AlphaFold DB model (Jumper et al. 2021, doi:10.1038/s41586-021-03819-2; Varadi et al. 2024, doi:10.1093/nar/gkad1011) searched vs PDB with Foldseek (mean pLDDT 91.1)
  • Interaction network: STRING v12.0 (Szklarczyk et al. 2023, doi:10.1093/nar/gkac1000), taxon 83332, CC-BY 4.0 — 387 functional partner(s); context anchor rpoC
  • Essentiality: genome-wide transposon mutagenesis in H37Rv — DeJesus et al. 2017 (mBio, doi:10.1128/mBio.02133-16, CC BY)
  • Proteomics: integrated mass-spectrometry abundance from PaxDb 5.0 (Huang et al. 2023, doi:10.1016/j.mcpro.2023.100640), taxon 83332 — weighted average of 16 datasets, incl. Schubert et al. 2013 (doi:10.1016/j.chom.2013.04.008) and Albrethsen et al. 2013 (doi:10.1074/mcp.M112.018846)
  • Functional category: TubercuList scheme (Cole et al. 1998, doi:10.1038/31159), via Mycobrowser (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006)
  • Orthologues: reciprocal best hits (DIAMOND, Buchfink et al. 2021, doi:10.1038/s41592-021-01101-x) against Mycobrowser release 5 reference proteomes
  • Experimental structures: PDBe/SIFTS UniProt→PDB mapping (Dana et al. 2019, doi:10.1093/nar/gky1114)
  • Genomic context / operon: H37Rv annotation; operon predicted by co-directional intergenic distance (Salgado et al. 2000, doi:10.1073/pnas.030539397)
  • Transcriptional regulation: ISB signed TRN — TF ChIP-seq (Minch et al. 2015, doi:10.1038/ncomms6829) + TF overexpression (Rustad et al. 2014, doi:10.1186/gb-2014-15-11-502)
  • Drug resistance: consolidated catalogue, WHO 2nd ed. 2023 (9789240082410) + tb-profiler; only the resistance-associated tier (grade 1–2) is surfaced
  • Physico-chemical properties: ExPASy ProtParam method via Biopython (Gasteiger et al. 2005), computed from the MTBC0 sequence
  • Predicted localisation: DeepTMHMM (Hallgren et al. 2022, doi:10.1101/2022.04.08.487609) for transmembrane topology and signal peptide
  • Primary literature: none located yet; annotation rests on the domain/homology sources above.

Ancestral MTBC0 protein sequence

>mtbc0_000705|Rv0667|rpoB
MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA