Re-annotating the Mycobacterium tuberculosis complex
Taking over from Mycobrowser: every MTBC gene is re-examined from the MTBC0 ancestral genome (Harrison et al. 2024), its legacy annotation verified, and its hypothetical proteins resolved through PGAP, Pfam domains, ESM Atlas signal and the literature — every claim sourced.
610
already re-annotated by PGAP on MTBC0
3906fully enriched fiches
Curated verdicts
- Still unknown 332
- Family assigned 1786
- Resolved 1788
Enriched genes
| Gene | MTBC0 | Legacy | Revised | Pfam | Verdict |
|---|---|---|---|---|---|
| dnaA Rv0001 |
mtbc0_000001 |
chromosomal replication initiator protein DnaA | Chromosomal replication initiator protein DnaA. Pfam: Bac_DnaA (PF00308.25), Ist | Bac_DnaA IstB_IS21 AAA Bac_DnaA_C |
Resolved |
| dnaN Rv0002 |
mtbc0_000002 |
DNA polymerase III subunit beta | DNA polymerase III subunit beta. Pfam: DNA_pol3_beta (PF00712.25), DNA_pol3_beta | DNA_pol3_beta DNA_pol3_beta_2 DNA_pol3_beta_3 |
Family assigned |
| recF Rv0003 |
mtbc0_000003 |
DNA replication/repair protein RecF | DNA replication/repair protein RecF. Pfam: SMC_N (PF02463.26), AAA_23 (PF13476.1 | SMC_N AAA_23 |
Resolved |
| Rv0004 Rv0004 |
mtbc0_000004 |
hypothetical protein | DciA, DNA replication protein. Directly binds DNA and the replicative helicase D | DciA |
Resolved |
| gyrB Rv0005 |
mtbc0_000005 |
DNA gyrase subunit B | DNA topoisomerase (ATP-hydrolyzing) subunit B. Pfam: HATPase_c (PF02518.32), DNA | HATPase_c DNA_gyraseB Toprim DNA_gyraseB_C |
Family assigned |
| gyrA Rv0006 |
mtbc0_000006 |
DNA gyrase subunit A | DNA topoisomerase (ATP-hydrolyzing) subunit A. Pfam: DNA_topoisoIV (PF00521.27), | DNA_topoisoIV DNA_gyraseA_C |
Family assigned |
| Rv0007 Rv0007 |
mtbc0_000007 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF3566. Function unknown. | DUF3566 |
Still unknown |
| Rv0008c Rv0008c |
- |
cell wall synthesis protein CwsA | Cell wall synthesis protein CwsA. Pfam: CwsA (PF10814.15). | CwsA |
Resolved |
| ppiA Rv0009 |
- |
iron-regulated peptidyl-prolyl cis-trans isomerase PpiA | Iron-regulated peptidyl-prolyl cis-trans isomerase PpiA. Pfam: Pro_isomerase (PF | Pro_isomerase |
Resolved |
| Rv0010c Rv0010c |
mtbc0_000014 |
membrane protein | PH domain-containing protein. Pfam: bPH_6 (PF10756.16). | bPH_6 |
Family assigned |
| crgA Rv0011c |
mtbc0_000015 |
cell division protein CrgA | Cell division protein CrgA. Pfam: CrgA (PF06781.18). | CrgA |
Resolved |
| Rv0012 Rv0012 |
- |
membrane protein | Membrane protein. | DUF881 |
Family assigned |