Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| dnaA Rv0001 |
mtbc0_000001 |
chromosomal replication initiator protein DnaA | Chromosomal replication initiator protein DnaA. Pfam: Bac_DnaA (PF00308.25), IstB_IS21 (PF01695.24), AAA (PF00004.36), Bac_DnaA_C (PF08299.18). | Bac_DnaA IstB_IS21 AAA Bac_DnaA_C |
Resolved |
| dnaN Rv0002 |
mtbc0_000002 |
DNA polymerase III subunit beta | DNA polymerase III subunit beta. Pfam: DNA_pol3_beta (PF00712.25), DNA_pol3_beta_2 (PF02767.22), DNA_pol3_beta_3 (PF02768.21). | DNA_pol3_beta DNA_pol3_beta_2 DNA_pol3_beta_3 |
Family assigned |
| recF Rv0003 |
mtbc0_000003 |
DNA replication/repair protein RecF | DNA replication/repair protein RecF. Pfam: SMC_N (PF02463.26), AAA_23 (PF13476.13). | SMC_N AAA_23 |
Resolved |
| Rv0004 Rv0004 |
mtbc0_000004 |
hypothetical protein | DciA, DNA replication protein. Directly binds DNA and the replicative helicase DnaB and regulates the DnaB-DnaA interaction; functional analogue of the DnaC/DnaI helicase loaders that mycobacteria lack. Essential for viability; its depletion blocks cell-cycle progression. | DciA |
Resolved |
| gyrB Rv0005 |
mtbc0_000005 |
DNA gyrase subunit B | DNA topoisomerase (ATP-hydrolyzing) subunit B. Pfam: HATPase_c (PF02518.32), DNA_gyraseB (PF00204.32), Toprim (PF01751.29), DNA_gyraseB_C (PF00986.27). | HATPase_c DNA_gyraseB Toprim DNA_gyraseB_C |
Family assigned |
| gyrA Rv0006 |
mtbc0_000006 |
DNA gyrase subunit A | DNA topoisomerase (ATP-hydrolyzing) subunit A. Pfam: DNA_topoisoIV (PF00521.27), DNA_gyraseA_C (PF03989.19). | DNA_topoisoIV DNA_gyraseA_C |
Family assigned |
| Rv0007 Rv0007 |
mtbc0_000007 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF3566. Function unknown. | DUF3566 |
Still unknown |
| Rv0008c Rv0008c |
- |
cell wall synthesis protein CwsA | Cell wall synthesis protein CwsA. Pfam: CwsA (PF10814.15). | CwsA |
Resolved |
| ppiA Rv0009 |
- |
iron-regulated peptidyl-prolyl cis-trans isomerase PpiA | Iron-regulated peptidyl-prolyl cis-trans isomerase PpiA. Pfam: Pro_isomerase (PF00160.27). | Pro_isomerase |
Resolved |
| Rv0010c Rv0010c |
mtbc0_000014 |
membrane protein | PH domain-containing protein. Pfam: bPH_6 (PF10756.16). | bPH_6 |
Family assigned |
| crgA Rv0011c |
mtbc0_000015 |
cell division protein CrgA | Cell division protein CrgA. Pfam: CrgA (PF06781.18). | CrgA |
Resolved |
| Rv0012 Rv0012 |
- |
membrane protein | Membrane protein. | DUF881 |
Family assigned |
| trpG Rv0013 |
- |
anthranilate synthase component II | Anthranilate synthase component II. Pfam: GATase (PF00117.35), Peptidase_C26 (PF07722.20). | GATase Peptidase_C26 |
Resolved |
| pknB Rv0014c |
mtbc0_000018 |
serine/threonine-protein kinase PknB | Stk1 family PASTA domain-containing Ser/Thr kinase. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), ABC1 (PF03109.23), Pkinase_fungal (PF17667.8), PASTA (PF03793.25). | Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal PASTA |
Family assigned |
| pknA Rv0015c |
mtbc0_000019 |
serine/threonine-protein kinase PknA | Serine/threonine protein kinase PknA. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), Kdo (PF06293.21), ABC1 (PF03109.23). | Pkinase PK_Tyr_Ser-Thr Kdo ABC1 |
Resolved |
| pbpA Rv0016c |
mtbc0_000020 |
penicillin-binding protein PbpA | D%2CD-transpeptidase PbpA. Pfam: PBP_dimer_2 (PF21922.2), Transpeptidase (PF00905.28). | PBP_dimer_2 Transpeptidase |
Resolved |
| rodA Rv0017c |
mtbc0_000021 |
cell division protein RodA | Cell shape-determining peptidoglycan glycosyltransferase RodA. Pfam: FTSW_RODA_SPOVE (PF01098.25). | FTSW_RODA_SPOVE |
Resolved |
| pstP Rv0018c |
- |
phosphoserine/threonine phosphatase PstP | Phosphoserine/threonine phosphatase PstP. Pfam: PP2C (PF00481.27), PP2C_2 (PF13672.12). | PP2C PP2C_2 |
Resolved |
| fhaB Rv0019c |
mtbc0_000023 |
FHA domain-containing protein FhaB | FHA domain-containing protein. Pfam: Yop-YscD_cpl (PF16697.11), FHA (PF00498.32). | Yop-YscD_cpl FHA |
Family assigned |
| fhaA Rv0020c |
mtbc0_000024 |
FHA domain-containing protein FhaA | Cell division-associated protein FhaA. Pfam: FhaA_N (PF12401.14), Yop-YscD_cpl (PF16697.11), FHA (PF00498.32). | FhaA_N Yop-YscD_cpl FHA |
Resolved |
| Rv0021c Rv0021c |
mtbc0_000026 |
hypothetical protein | Nitronate monooxygenase (NMO) family protein; FMN-dependent oxidoreductase of the NMO / 2-nitropropane dioxygenase class. Pfam confirms a tandem NMO (PF03060) + FMN_dh (PF01070) architecture. The precise physiological substrate in M. tuberculosis is not experimentally established. | NMO FMN_dh |
Family assigned |
| whiB5 Rv0022c |
mtbc0_000027 |
transcriptional regulator WhiB5 | Transcriptional regulator WhiB5. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| Rv0023 Rv0023 |
mtbc0_000028 |
transcriptional regulator | Helix-turn-helix transcriptional regulator. Pfam: HTH_31 (PF13560.13), HTH_3 (PF01381.29). | HTH_31 HTH_3 |
Family assigned |
| Rv0024 Rv0024 |
mtbc0_000029 |
NLP/P60 family protein | C40 family peptidase. Pfam: NLPC_P60 (PF00877.26). | NLPC_P60 |
Family assigned |
| Rv0025 Rv0025 |
mtbc0_000030 |
hypothetical protein | Conserved hypothetical protein; DUF4226 domain-containing. Function unknown. | DUF4226 |
Still unknown |
| Rv0026 Rv0026 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4226. Function unknown. | DUF4226 |
Still unknown |
| Rv0027 Rv0027 |
mtbc0_000032 |
hypothetical protein | Type VII secretion system (ESX) EspC-family protein. Pfam assigns the T7SS_ESX_EspC domain (PF10824, E=2.2e-31), a more specific call than the PGAP 'ESX-1 secretion-associated protein' label; consistent with a secreted ESX/Esp-associated substrate. No Rv0027-specific experimental characterization was found. | T7SS_ESX_EspC |
Family assigned |
| Rv0028 Rv0028 |
mtbc0_000033 |
hypothetical protein | ESX-1 secretion-associated protein (EspH-like). RefSeq leaves it 'hypothetical protein'. | DUF2694 |
Family assigned |
| Rv0029 Rv0029 |
mtbc0_000035 |
hypothetical protein | Conserved hypothetical protein; tandem DUF5631 + DUF5632 domains. Foldseek finds a significant structural match to Rv3899c (PDB 5IMU), another conserved hypothetical M. tuberculosis protein of unknown function (a proposed vaccine candidate): the fold is thus structurally characterised but the biological function remains unassigned. | DUF5632 DUF5631 |
Still unknown |
| Rv0030 Rv0030 |
mtbc0_000036 |
hypothetical protein | Conserved hypothetical protein; DUF2710 domain-containing. Function unknown. Foldseek yields only weak, near-threshold matches to uncharacterised proteins (e.g. H. pylori HP0035), with no functional assignment. | DUF2710 |
Still unknown |
| bioF2 Rv0032 |
mtbc0_000037 |
8-amino-7-oxononanoate synthase | Pyridoxal phosphate-dependent aminotransferase family protein. Pfam: Acetyltransf_6 (PF13480.14), Aminotran_1_2 (PF00155.28), Beta_elim_lyase (PF01212.28), DegT_DnrJ_EryC1 (PF01041.24). | Acetyltransf_6 Aminotran_1_2 Beta_elim_lyase DegT_DnrJ_EryC1 |
Family assigned |
| acpA Rv0033 |
mtbc0_000038 |
acyl carrier protein AcpA | Acyl carrier protein. Pfam: PP-binding (PF00550.32). | PP-binding |
Resolved |
| Rv0034 Rv0034 |
mtbc0_000039 |
hypothetical protein | NTF2-like / SnoaL-like superfamily protein (Pfam SnoaL_2, PF12680). This alpha+beta cone fold occurs in polyketide cyclases, ketosteroid isomerases and NTF2 domains, often binding a hydrophobic ligand in a deep cavity. The precise physiological role in M. tuberculosis is not established. | SnoaL_2 |
Family assigned |
| fadD34 Rv0035 |
- |
fatty-acid--CoA ligase FadD34 | Fatty-acid--CoA ligase FadD34. Pfam: AMP-binding (PF00501.35). | AMP-binding |
Resolved |
| Rv0036c Rv0036c |
mtbc0_000041 |
hypothetical protein | Putative DinB/YfiT-like metal-dependent enzyme (Pfam DinB_2 PF12867, with MDMPI_N PF11716). The DinB superfamily is a versatile metal-binding four-helix bundle; PGAP annotates a TIGR03084-family metal-binding protein. Distinct from the Y-family DNA polymerases DinB1/DinB2 (Rv1537/Rv3056); the specific catalytic activity of Rv0036c is not established. | MDMPI_N DinB_2 Wyosine_form |
Family assigned |
| Rv0037c Rv0037c |
mtbc0_000042 |
MFS-type transporter | MFS transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| Rv0038 Rv0038 |
mtbc0_000043 |
hypothetical protein | UPF0301 / YqgE/AlgH family protein (Pfam DUF179, PF02622). A widely conserved bacterial family of unknown precise molecular function; the AlgH homolog has been linked to alginate regulation in Pseudomonas, but the activity is uncharacterised. Role in M. tuberculosis unknown. | DUF179 |
Family assigned |
| Rv0039c Rv0039c |
mtbc0_000044 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| mtc28 Rv0040c |
mtbc0_000045 |
hypothetical protein | Cell-envelope lipoprotein of the LpqN/LpqT family (Pfam Lpp-LpqN, PF10738). Members are anchored to the mycobacterial envelope; the specific physiological role of this locus is not established here. | Lpp-LpqN |
Family assigned |
| leuS Rv0041 |
mtbc0_000046 |
leucine--tRNA ligase | Leucine--tRNA ligase. Pfam: tRNA-synt_1 (PF00133.29), tRNA-synt_1g (PF09334.18), tRNA-synt_1_2 (PF13603.13), Anticodon_1 (PF08264.20). | tRNA-synt_1 tRNA-synt_1g tRNA-synt_1_2 Anticodon_1 |
Resolved |
| Rv0042c Rv0042c |
- |
transcriptional regulator | Transcriptional regulator. Pfam: MarR_2 (PF12802.14), Staph_reg_Sar_Rot (PF22381.3), MarR (PF01047.29), HTH_27 (PF13463.13). | MarR_2 Staph_reg_Sar_Rot MarR HTH_27 |
Family assigned |
| Rv0043c Rv0043c |
mtbc0_000048 |
HTH-type transcriptional regulator | GntR family transcriptional regulator. Pfam: GntR (PF00392.28). | GntR |
Family assigned |
| Rv0044c Rv0044c |
mtbc0_000049 |
oxidoreductase | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv0045c Rv0045c |
mtbc0_000050 |
hydrolase | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| ino1 Rv0046c |
mtbc0_000051 |
inositol-3-phosphate synthase | Inositol-3-phosphate synthase. Pfam: Inos-1-P_synth (PF01658.23). | Inos-1-P_synth |
Resolved |
| Rv0047c Rv0047c |
mtbc0_000052 |
hypothetical protein | PadR-family transcriptional regulator (Pfam PadR, PF03551). PadR repressors typically control detoxification and multidrug/stress-response genes; the regulon governed by this locus in M. tuberculosis is not established. | PadR |
Family assigned |
| Rv0048c Rv0048c |
mtbc0_000053 |
membrane protein | Lipoprotein of the EnvF-like family (cell-envelope). RefSeq leaves it 'membrane protein'. | DUF1707 |
Family assigned |
| Rv0049 Rv0049 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5318. Function unknown. Foldseek best (non-significant) hit: 6ewl-assembly1_A Danio rerio CEP120 first C2 domain (C2A) (prob 0.20, TM 0.40). | DUF5318 |
Still unknown |
| ponA1 Rv0050 |
- |
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase | Bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase. Pfam: Transgly (PF00912.29), Transpeptidase (PF00905.28). | Transgly Transpeptidase |
Resolved |
| Rv0051 Rv0051 |
mtbc0_000056 |
transmembrane protein | Glycosyltransferase family 87 protein. Pfam: GT87 (PF09594.17). | GT87 |
Family assigned |