MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 1 314 954–1 714 954 bp (400 000 bp)
+ strand − strand fadH (Rv1175c) — requalified: NADPH-dependent 2%2C4-dienoyl-CoA reductase Rv1176c (Rv1176c) — family_assigned: PadR family transcriptional regulator fdxC (Rv1177) — family_assigned: ferredoxin family protein dapC (Rv1178) — requalified: succinyldiaminopimelate transaminase Rv1179c (Rv1179c) — family_assigned: DEAD/DEAH box helicase family protein papA3 (Rv1182) — requalified: acyltransferase PapA3 mmpL10 (Rv1183) — requalified: RND transporter MmpL10 chp2 (Rv1184c) — requalified: diacyltrehalose acyltransferase Chp2 fadD21 (Rv1185c) — requalified: fatty-acid--AMP ligase FAAL21/FadD21 Rv1186c (Rv1186c) — family_assigned: PucR family transcriptional regulator rocA (Rv1187) — requalified: L-glutamate gamma-semialdehyde dehydrogenase Rv1188 (Rv1188) — requalified: proline dehydrogenase sigI (Rv1189) — requalified: RNA polymerase sigma factor SigI Rv1190 (Rv1190) — requalified: alpha/beta fold hydrolase Rv1191 (Rv1191) — family_assigned: alpha/beta hydrolase Rv1192 (Rv1192) — family_assigned: alpha/beta hydrolase fadD36 (Rv1193) — requalified: acyl-CoA synthetase Rv1194c (Rv1194c) — family_assigned: PucR family transcriptional regulator esxK (Rv1197) — requalified: type VII secretion system ESX-5 protein EsxJ esxL (Rv1198) — requalified: type VII secretion system ESX-5 protein EsxL Rv1200 (Rv1200) — family_assigned: MHS family MFS transporter dapD (Rv1201c) — requalified: 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succi Rv1205 (Rv1205) — family_assigned: TIGR00730 family Rossman fold protein fadD6 (Rv1206) — requalified: long-chain-acyl-CoA synthetase FadD6 folP2 (Rv1207) — requalified: dihydropteroate synthase gpgS (Rv1208) — requalified: glucosyl-3-phosphoglycerate synthase Rv1209 (Rv1209) — family_assigned: DivIVA domain-containing protein tagA (Rv1210) — requalified: DNA-3-methyladenine glycosylase I glgA (Rv1212c) — requalified: glycogen synthase Rv1215c (Rv1215c) — family_assigned: CocE/NonD family hydrolase Rv1216c (Rv1216c) — family_assigned: isoprenylcysteine carboxylmethyltransferase family protein Rv1217c (Rv1217c) — family_assigned: multidrug efflux ABC transporter permease Rv1218c (Rv1218c) — family_assigned: multidrug efflux ABC transporter ATP-binding protein raaS (Rv1219c) — family_assigned: transcriptional regulator RaaS sigE (Rv1221) — requalified: RNA polymerase sigma factor SigE rseA (Rv1222) — requalified: anti-sigma E factor RseA tatB (Rv1224) — requalified: Sec-independent protein translocase protein TatB Rv1225c (Rv1225c) — family_assigned: HAD-IIA family hydrolase Rv1226c (Rv1226c) — family_assigned: PH domain-containing protein Rv1227c (Rv1227c) — family_assigned: PH domain-containing protein lpqX (Rv1228) — dark: hypothetical protein mrp (Rv1229c) — family_assigned: Mrp/NBP35 family ATP-binding protein Rv1230c (Rv1230c) — family_assigned: lytic transglycosylase domain-containing protein Rv1231c (Rv1231c) — family_assigned: DUF1003 domain-containing protein Rv1232c (Rv1232c) — requalified: magnesium transporter Rv1233c (Rv1233c) — family_assigned: DUF4190 domain-containing protein Rv1234 (Rv1234) — requalified: general stress protein lpqY (Rv1235) — family_assigned: trehalose ABC transporter substrate-binding protein LpqY sugA (Rv1236) — family_assigned: trehalose ABC transporter permease SugA sugB (Rv1237) — family_assigned: trehalose ABC transporter permease SugB sugC (Rv1238) — family_assigned: trehalose ABC transporter ATP-binding protein SugC corA (Rv1239c) — requalified: magnesium/cobalt transporter CorA mdh (Rv1240) — requalified: malate dehydrogenase vapB33 (Rv1241) — requalified: type II toxin-antitoxin system antitoxin VapB33 vapC33 (Rv1242) — family_assigned: type II toxin-antitoxin system VapC family toxin lpqZ (Rv1244) — family_assigned: glycine betaine ABC transporter substrate-binding protein Rv1245c (Rv1245c) — family_assigned: SDR family NAD(P)-dependent oxidoreductase relE (Rv1246c) — requalified: type II toxin-antitoxin system mRNA interferase RelE relB (Rv1247c) — family_assigned: type II toxin-antitoxin system Phd/YefM family antitoxin Rv1248c (Rv1248c) — family_assigned: multifunctional oxoglutarate decarboxylase/oxoglutarate dehy Rv1249c (Rv1249c) — family_assigned: hypothetical protein Rv1250 (Rv1250) — requalified: MFS transporter Rv1251c (Rv1251c) — family_assigned: TM0106 family RecB-like putative nuclease lprE (Rv1252c) — family_assigned: LppP/LprE family lipoprotein deaD (Rv1253) — requalified: DEAD/DEAH box helicase Rv1254 (Rv1254) — requalified: acyltransferase Rv1255c (Rv1255c) — family_assigned: helix-turn-helix domain-containing protein cyp130 (Rv1256c) — requalified: cytochrome P450 Cyp130 Rv1257c (Rv1257c) — family_assigned: FAD-linked oxidase C-terminal domain-containing protein Rv1258c (Rv1258c) — requalified: MFS transporter Rv1260 (Rv1260) — family_assigned: FAD-binding protein Rv1261c (Rv1261c) — requalified: F420H(2)-dependent quinone reductase Rv1262c (Rv1262c) — family_assigned: HIT family protein amiB2 (Rv1263) — requalified: amidase Rv1264 (Rv1264) — requalified: adenylate cyclase pknH (Rv1266c) — requalified: serine/threonine protein kinase PknH embR (Rv1267c) — requalified: response regulator transcription factor EmbR Rv1268c (Rv1268c) — family_assigned: C39 family peptidase Rv1269c (Rv1269c) — family_assigned: DUF4189 domain-containing protein lprA (Rv1270c) — requalified: TLR2 agonist LprA Rv1271c (Rv1271c) — family_assigned: DUF732 domain-containing protein Rv1272c (Rv1272c) — family_assigned: fatty acid ABC transporter ATP-binding protein/permease Rv1273c (Rv1273c) — family_assigned: ABC transporter ATP-binding protein lprB (Rv1274) — family_assigned: DUF3558 domain-containing protein lprC (Rv1275) — family_assigned: DUF3558 domain-containing protein Rv1278 (Rv1278) — family_assigned: AAA family ATPase Rv1279 (Rv1279) — family_assigned: GMC family oxidoreductase N-terminal domain-containing prote oppA (Rv1280c) — family_assigned: oligopeptide ABC transporter substrate-binding protein OppA oppD (Rv1281c) — family_assigned: ABC transporter ATP-binding protein oppC (Rv1282c) — family_assigned: ABC transporter permease oppB (Rv1283c) — family_assigned: ABC transporter permease canA (Rv1284) — requalified: beta-carbonic anhydrase CanA cysD (Rv1285) — family_assigned: sulfate adenylyltransferase subunit CysD cysC (Rv1286) — requalified: adenylyl-sulfate kinase Rv1287 (Rv1287) — family_assigned: RrF2 family transcriptional regulator Rv1288 (Rv1288) — requalified: esterase Rv1289 (Rv1289) — family_assigned: hypothetical protein Rv1290c (Rv1290c) — family_assigned: DUF2254 domain-containing protein Rv1291c (Rv1291c) — family_assigned: DUF732 domain-containing protein argS (Rv1292) — requalified: arginine--tRNA ligase lysA (Rv1293) — requalified: diaminopimelate decarboxylase thrA (Rv1294) — requalified: homoserine dehydrogenase thrC (Rv1295) — requalified: threonine synthase thrB (Rv1296) — requalified: homoserine kinase rho (Rv1297) — requalified: transcription termination factor Rho rpmE (Rv1298) — requalified: 50S ribosomal protein L31 prfA (Rv1299) — requalified: peptide chain release factor 1 hemK (Rv1300) — requalified: peptide chain release factor N(5)-glutamine methyltransferas Rv1301 (Rv1301) — requalified: L-threonylcarbamoyladenylate synthase rfe (Rv1302) — requalified: UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucos Rv1303 (Rv1303) — family_assigned: ATP synthase subunit I atpB (Rv1304) — family_assigned: F0F1 ATP synthase subunit A atpE (Rv1305) — family_assigned: F0F1 ATP synthase subunit C atpF (Rv1306) — family_assigned: F0F1 ATP synthase subunit B atpH (Rv1307) — family_assigned: F0F1 ATP synthase subunit B/delta atpA (Rv1308) — family_assigned: F0F1 ATP synthase subunit alpha atpG (Rv1309) — family_assigned: F0F1 ATP synthase subunit gamma atpD (Rv1310) — family_assigned: F0F1 ATP synthase subunit beta atpC (Rv1311) — family_assigned: F0F1 ATP synthase subunit epsilon Rv1312 (Rv1312) — family_assigned: DUF2550 domain-containing protein Rv1314c (Rv1314c) — requalified: cob(I)yrinic acid a%2Cc-diamide adenosyltransferase murA (Rv1315) — requalified: UDP-N-acetylglucosamine 1-carboxyvinyltransferase ogt (Rv1316c) — requalified: methylated-DNA--protein-cysteine methyltransferase alkA (Rv1317c) — family_assigned: bifunctional regulatory protein/DNA repair enzyme AlkA Rv1318c (Rv1318c) — family_assigned: adenylate/guanylate cyclase domain-containing protein Rv1320c (Rv1320c) — family_assigned: adenylate/guanylate cyclase domain-containing protein Rv1322 (Rv1322) — family_assigned: hypothetical protein Rv1324 (Rv1324) — requalified: co-chaperone YbbN glgB (Rv1326c) — requalified: 1%2C4-alpha-glucan branching protein GlgB glgP (Rv1328) — family_assigned: glycosyltransferase family 1 protein dinG (Rv1329c) — requalified: ATP-dependent helicase DinG pncB1 (Rv1330c) — requalified: nicotinate phosphoribosyltransferase clpS (Rv1331) — requalified: ATP-dependent Clp protease adapter ClpS Rv1333 (Rv1333) — family_assigned: P1 family peptidase mec (Rv1334) — requalified: CysO-cysteine peptidase cysO (Rv1335) — requalified: sulfur carrier protein CysO cysM (Rv1336) — requalified: O-phosphoserine sulfhydrylase Rv1337 (Rv1337) — family_assigned: rhomboid family intramembrane serine protease murI (Rv1338) — requalified: glutamate racemase rphA (Rv1340) — requalified: ribonuclease PH rdgB (Rv1341) — family_assigned: RdgB/HAM1 family non-canonical purine NTP pyrophosphatase lprD (Rv1343c) — family_assigned: hypothetical protein mbtM (Rv1345) — requalified: long-chain-fatty acid--ACP ligase MbtM mbtN (Rv1346) — requalified: acyl-ACP dehydrogenase MbtN mbtK (Rv1347c) — requalified: lysine N-acyltransferase MbtK irtA (Rv1348) — family_assigned: iron ABC transporter ATP-binding protein/permease IrtA irtB (Rv1349) — family_assigned: iron ABC transporter ATP-binding protein/permease IrtB fabG2 (Rv1350) — requalified: 3-oxoacyl-ACP reductase FabG Rv1352 (Rv1352) — family_assigned: hypothetical protein Rv1353c (Rv1353c) — family_assigned: TetR/AcrR family transcriptional regulator C-terminal domain Rv1354c (Rv1354c) — requalified: bifunctional diguanylate cyclase/phosphodiesterase moeY (Rv1355c) — family_assigned: Rv1355c family protein Rv1357c (Rv1357c) — requalified: cyclic diguanylate phosphodiesterase Rv1358 (Rv1358) — family_assigned: LuxR C-terminal-related transcriptional regulator Rv1360 (Rv1360) — requalified: LLM class F420-dependent oxidoreductase Rv1362c (Rv1362c) — family_assigned: hypothetical protein Rv1363c (Rv1363c) — dark: hypothetical protein rsfA (Rv1365c) — requalified: anti-sigma-F factor antagonist RsfA Rv1366 (Rv1366) — family_assigned: GTP pyrophosphokinase family protein lprF (Rv1368) — requalified: lipoprotein LprF Rv1371 (Rv1371) — family_assigned: cytochrome b5 domain-containing protein Rv1373 (Rv1373) — requalified: glycolipid sulfotransferase Rv1374c (Rv1374c) — dark: hypothetical protein Rv1375 (Rv1375) — family_assigned: YcaO-like family protein Rv1376 (Rv1376) — family_assigned: TfuA-like protein Rv1377c (Rv1377c) — requalified: class I SAM-dependent methyltransferase pyrR (Rv1379) — family_assigned: bifunctional pyr operon transcriptional regulator/uracil pho pyrB (Rv1380) — family_assigned: aspartate carbamoyltransferase catalytic subunit pyrC (Rv1381) — requalified: dihydroorotase Rv1382 (Rv1382) — requalified: transporter carA (Rv1383) — family_assigned: glutamine-hydrolyzing carbamoyl-phosphate synthase small sub pyrF (Rv1385) — requalified: orotidine-5'-phosphate decarboxylase gmk (Rv1389) — requalified: guanylate kinase rpoZ (Rv1390) — family_assigned: DNA-directed RNA polymerase subunit omega dfp (Rv1391) — requalified: bifunctional phosphopantothenoylcysteine decarboxylase/phosp Rv1393c (Rv1393c) — requalified: NAD(P)/FAD-dependent oxidoreductase vapC10 (Rv1397c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB10 (Rv1398c) — family_assigned: CopG family transcriptional regulator nlhH (Rv1399c) — family_assigned: alpha/beta hydrolase lipI (Rv1400c) — family_assigned: alpha/beta hydrolase Rv1403c (Rv1403c) — requalified: class I SAM-dependent methyltransferase Rv1404 (Rv1404) — family_assigned: MarR family transcriptional regulator Rv1405c (Rv1405c) — requalified: virulence-associated methyltransferase fmt (Rv1406) — requalified: methionyl-tRNA formyltransferase fmu (Rv1407) — requalified: 16S rRNA m5C967 methyltransferase rpe (Rv1408) — requalified: ribulose-phosphate 3-epimerase ribG (Rv1409) — requalified: bifunctional diaminohydroxyphosphoribosylaminopyrimidine dea Rv1410c (Rv1410c) — requalified: aminoglycoside/tetracycline transporter lprG (Rv1411c) — requalified: lipoarabinomannan carrier protein LprG ribC (Rv1412) — requalified: riboflavin synthase ribA2 (Rv1415) — requalified: bifunctional 3%2C4-dihydroxy-2-butanone-4-phosphate synthase ribH (Rv1416) — requalified: 6%2C7-dimethyl-8-ribityllumazine synthase Rv1417 (Rv1417) — family_assigned: PH domain-containing protein lprH (Rv1418) — family_assigned: hypothetical protein Rv1419 (Rv1419) — requalified: lectin uvrC (Rv1420) — family_assigned: excinuclease ABC subunit UvrC rapZ (Rv1421) — requalified: RNase adapter RapZ cuvA (Rv1422) — requalified: carbon utilization/virulence protein CuvA whiA (Rv1423) — family_assigned: DNA-binding protein WhiA Rv1424c (Rv1424c) — dark: hypothetical protein Rv1425 (Rv1425) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase lipO (Rv1426c) — family_assigned: alpha/beta hydrolase fadD12 (Rv1427c) — requalified: acyl-CoA ligase FadD12 Rv1428c (Rv1428c) — family_assigned: lysophospholipid acyltransferase family protein Rv1429 (Rv1429) — family_assigned: PucR family transcriptional regulator Rv1431 (Rv1431) — family_assigned: DUF3556 domain-containing protein Rv1432 (Rv1432) — requalified: NAD(P)/FAD-dependent oxidoreductase ldtMt3 (Rv1433) — requalified: L%2CD-transpeptidase LdtMt3 Rv1434 (Rv1434) — dark: hypothetical protein hsr1 (Rv1435c) — requalified: hypothetical protein gap (Rv1436) — requalified: type I glyceraldehyde-3-phosphate dehydrogenase pgk (Rv1437) — requalified: phosphoglycerate kinase tpi (Rv1438) — requalified: triose-phosphate isomerase Rv1439c (Rv1439c) — family_assigned: nuclear transport factor 2 family protein secG (Rv1440) — family_assigned: preprotein translocase subunit SecG bisC (Rv1442) — requalified: molybdopterin guanine dinucleotide-containing S/N-oxide redu devB (Rv1445c) — requalified: 6-phosphogluconolactonase opcA (Rv1446c) — requalified: glucose-6-phosphate dehydrogenase assembly protein OpcA zwf2 (Rv1447c) — requalified: glucose-6-phosphate dehydrogenase tal (Rv1448c) — requalified: transaldolase tkt (Rv1449c) — requalified: transketolase ctaB (Rv1451) — requalified: heme o synthase Rv1453 (Rv1453) — family_assigned: PucR family transcriptional regulator qor (Rv1454c) — requalified: quinone oxidoreductase Rv1455 (Rv1455) — family_assigned: hypothetical protein Rv1456c (Rv1456c) — requalified: heme A synthase Rv1457c (Rv1457c) — family_assigned: ABC transporter permease Rv1458c (Rv1458c) — family_assigned: ABC transporter ATP-binding protein mptB (Rv1459c) — requalified: polyprenol phosphomannose-dependent alpha 1%2C6 mannosyltran sufR (Rv1460) — family_assigned: suf operon transcriptional regulator SufR sufB (Rv1461) — requalified: intein-containing Fe-S cluster assembly protein SufB sufD (Rv1462) — requalified: Fe-S cluster assembly protein SufD sufC (Rv1463) — requalified: Fe-S cluster assembly ATPase SufC csd (Rv1464) — requalified: cysteine desulfurase Rv1465 (Rv1465) — family_assigned: SUF system NifU family Fe-S cluster assembly protein Rv1466 (Rv1466) — requalified: metal-sulfur cluster assembly factor fadE15 (Rv1467c) — requalified: acyl-CoA dehydrogenase ctpD (Rv1469) — requalified: cobalt-translocating P-type ATPase CtpD trxA (Rv1470) — family_assigned: thioredoxin family protein echA12 (Rv1472) — requalified: enoyl-CoA hydratase Rv1473 (Rv1473) — family_assigned: macrolide ABC transporter ATP-binding protein Rv1474c (Rv1474c) — family_assigned: helix-turn-helix domain-containing protein acn (Rv1475c) — requalified: iron-regulated aconitate hydratase Acn Rv1476 (Rv1476) — family_assigned: DUF6676 family protein ripA (Rv1477) — family_assigned: NlpC/P60 family peptidoglycan endopeptidase RipA ripB (Rv1478) — family_assigned: NlpC/P60 family peptidoglycan endopeptidase RipB Rv1480 (Rv1480) — family_assigned: DUF58 domain-containing protein Rv1481 (Rv1481) — family_assigned: VWA domain-containing protein Rv1482c (Rv1482c) — family_assigned: hypothetical protein fabG1 (Rv1483) — requalified: 3-oxoacyl-ACP reductase FabG1 inhA (Rv1484) — requalified: NADH-dependent enoyl-ACP reductase InhA hemZ (Rv1485) — requalified: ferrochelatase Rv1486c (Rv1486c) — family_assigned: hypothetical protein Rv1487 (Rv1487) — family_assigned: NfeD family protein Rv1488 (Rv1488) — family_assigned: SPFH domain-containing protein Rv1490 (Rv1490) — family_assigned: hypothetical protein Rv1491c (Rv1491c) — family_assigned: TVP38/TMEM64 family protein mutA (Rv1492) — family_assigned: methylmalonyl-CoA mutase small subunit mutB (Rv1493) — requalified: methylmalonyl-CoA mutase mazE4 (Rv1494) — requalified: type II toxin-antitoxin system antitoxin MazE4 mazF4 (Rv1495) — requalified: type II toxin-antitoxin system toxin endoribonuclease MazF4 meaB (Rv1496) — requalified: methylmalonyl Co-A mutase-associated GTPase MeaB lipL (Rv1497) — family_assigned: serine hydrolase domain-containing protein Rv1499 (Rv1499) — requalified: glycosyltransferase (part1) Rv1500 (Rv1500) — family_assigned: glycosyltransferase family 2 protein Rv1501 (Rv1501) — family_assigned: phytanoyl-CoA dioxygenase family protein Rv1502 (Rv1502) — family_assigned: hypothetical protein Rv1505c (Rv1505c) — requalified: acetyltransferase Rv1507c (Rv1507c) — family_assigned: WbqC family protein Rv1508c (Rv1508c) — family_assigned: glycosyltransferase 87 family protein Rv1509 (Rv1509) — family_assigned: methyltransferase domain-containing protein Rv1510 (Rv1510) — family_assigned: hypothetical protein gmdA (Rv1511) — requalified: GDP-mannose 4%2C6-dehydratase epiA (Rv1512) — requalified: GDP-L-fucose synthase Rv1513 (Rv1513) — family_assigned: FkbM family methyltransferase 1 330 kb 1 396 kb 1 463 kb 1 530 kb 1 596 kb 1 662 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.