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ACS Sens |
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Pathogens |
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| Routine Molecular Surveillance of Drug-Resistant Tuberculosis: Translating Mutation Proxies into Clinical Governance Intelligence in Rural Eastern Cape.
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Healthcare (Basel) |
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| Predictive Analysis of Drug-Resistant Tuberculosis: Integrating Molecular Markers, Clinical Governance, and Community-Engaged Education in Rural South Africa.
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| Association of katG, inhA, and AhpC Mutations with Isoniazid Resistance of Mycobacterium tuberculosis in Pulmonary Tuberculosis Patients from Nanjing, China.
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Microb Drug Resist |
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| In Vitro and In Silico Approaches for the Evaluation of Antimycobacterial and Biofilm Inhibition Activity of Asiatic Acid Against Dual Targets of Mycobacterium smegmatis.
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Curr Top Med Chem |
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Nat Commun |
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Integr Biol (Camb) |
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| A cartridge-based assay for improved detection of multidrug-resistant Mycobacterium tuberculosis directly from sputum.
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JACS Au |
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| Prevalence and resistance spectrum of ahpC mutations in isoniazid-resistant Mycobacterium tuberculosis isolates.
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Microbiol Spectr |
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| Predicting isoniazid resistance in Mycobacterium tuberculosis complex in New York State using whole-genome sequencing.
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J Clin Microbiol |
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| Design and synthesis of 2-benzyl-1H-benzimidazole derivatives as direct InhA inhibitors with potential anti-tubercular activity.
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Lancet Oncol |
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Bioorg Med Chem Lett |
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| Polynuclear Silver(I)-Quinoxaline Complex: Comprehensive Structural Characterization, Antimycobacterial Properties and DNA/BSA Binding Study.
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Pharmaceutics |
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| Investigation of Gene Regions Responsible for Drug Resistance in Clinical Isolates of Mycobacterium tuberculosis Complex Resistant to at Least Two First-Line Anti-Tuberculosis Drugs.
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Pathogens |
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| Synthesis, Characterization, and Computational Studies of Novel 5-(Substituted)-1,5-Dihydro-2H-Chromeno[2,3-d]Pyrimidine-2,4(3H)-Dione Scaffolds as Potent Biological Agents.
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Chem Biodivers |
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| Isoniazid-derived vanillin and Salicylaldehyde Hydrazones: Promising Antimycobacterials with KatG-dependent activation.
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Bioorg Chem |
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| iFIND INH/FQ: a LC-aNAAT assay for rapid simultaneous detection of isoniazid and fluoroquinolone resistance in Mycobacterium tuberculosis.
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Microbiol Spectr |
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| Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti-Mycobacterium tuberculosis agents.
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RSC Med Chem |
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| Targeting Mycobacterium tuberculosis: The Role of Alkyl Substitution in Pyrazinamide Derivatives.
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ACS Omega |
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| Integrated approach to design 5-indolyl-pyrazoles as anti-TB agent.
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| Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach.
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J Med Chem |
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Folia Microbiol (Praha) |
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| Targeting InhA for Tuberculosis Therapy: A Review of Recent Advances in Enzyme Inhibition and Drug Development.
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Curr Drug Targets |
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| 4-[(Aryloylhydrazineylidene)methyl]-N-phenylbenzamides as a new class of antimycobacterial agents: design, synthesis and biological evaluation.
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Bioorg Chem |
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| Mutations related to rifampicin and isoniazid resistance in Mycobacterium tuberculosis strains in Ankara, Turkey.
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Acta Microbiol Immunol Hung |
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| Pyridine embedded 1,3,4-oxadiazole derivatives: Design, synthesis, molecular docking and antitubercular activity evaluation.
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Tuberculosis (Edinb) |
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| Synthesis, antitubercular activity and computational studies of click-tethered phosphonium salts.
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Bioorg Chem |
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| Tuberculosis and increased risk of cardio-cerebrovascular disease: A nationwide cohort study.
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Int J Infect Dis |
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| Uncovering the structural impact of KatG Ser315 mutations in Mycobacterium tuberculosis via cryo-EM.
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Protein Sci |
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| Pharmacogenomics and mutation informatics: correlation of NAT2 mutations and isoniazid acetylation rate.
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Drug Discov Today |
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| Machine Learning-Driven discovery of mushroom-derived inhibitors targeting InhA of Mycobacterium tuberculosis: An integrated QSAR, molecular docking and molecular dynamic simulation approach.
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J Mol Graph Model |
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| Machine learning approaches to predict drug resistance in tuberculosis.
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Comput Biol Chem |
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J Mol Graph Model |
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Indian J Med Res |
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| The microevolutionary trajectory of endemic multidrug-resistant tuberculosis strains in Portugal toward increased drug resistance levels and its clinical significance.
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Front Microbiol |
2025 |
| Effects of mutations in multiple Ethionamide-resistance-associated genes among Mycobacterium tuberculosis clinical isolates from China.
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Front Cell Infect Microbiol |
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| Drug resistance profile of Mycobacterium tuberculosis in China: update until 2024.
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Front Microbiol |
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| A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
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BMC Microbiol |
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| Current drug susceptibility testing in the Löwenstein-Jensen medium leads to underestimating of prothionamide resistance in multi-drug resistant Mycobacterium tuberculosis.
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BMC Microbiol |
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| Decoding drug tolerance: insights into the Rv0274 gene's role in isoniazid tolerance.
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Front Microbiol |
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| Characterization of Drug Resistance Patterns, Mutation Profiles and Prevalence of Mycobacterium tuberculosis in Shaoxing.
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Infect Drug Resist |
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New Microbes New Infect |
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| Evaluation of multiplex allele-specific PCR for rapid detection of isoniazid and fluoroquinolone resistance in Mycobacterium tuberculosis: A cross-sectional study in high-TB-burden settings in India.
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Indian J Tuberc |
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| Molecular characterization of rifampicin-resistant Mycobacterium tuberculosis isolates by line probe assay method. A cross-sectional study from a nodal DR-TB centre of Bihar.
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Indian J Tuberc |
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| N-(Arylcarbamothioyl)benzamide Derivatives as Selective Antimycobacterial Agents and Their Supramolecular Structural Features.
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ACS Appl Bio Mater |
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| Molecular docking and pharmacokinetic studies of bioactive compounds from medicinal plants as promising inhibitory agents against Mycobacterium tuberculosis enoyl-acyl carrier protein (ACP)-reductase (InhA).
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In Silico Pharmacol |
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| Design, synthesis, bioactivity evaluation, and molecular modeling of pyridin-2-yl-pyrimidine: Potential Antimicrobial and anti-tuberculosis agents.
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Bioorg Chem |
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| Design, synthesis, deep learning-guided prediction, and biological evaluation of novel pyridine-thiophene-based imine-benzalacetophenone hybrids as promising antimicrobial agent.
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J Comput Aided Mol Des |
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| Synthesis, Spectroscopic Characterization, Structural Analysis, Antimycobacterial Study, Molecular Docking, DFT, and ADME Studies of Novel Hybrid Pyrrole-Pyrazole-Piperazine Chalcone.
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ACS Omega |
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| A Multiplexed, Target-Based Phenotypic Screening Platform Using CRISPR Interference in Mycobacterium abscessus.
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ACS Infect Dis |
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| Molecular insights of drug-resistant tuberculosis: genetic mutations and their profile.
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Front Microbiol |
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| Synthesis and biological evaluation of furan-1,3,4-oxadiazole as antitubercular, antibacterial, and antioxidant agents.
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Future Med Chem |
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| Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
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Lancet |
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| Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
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Lancet |
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| Population structure and antibiotic resistance profiles of Mycobacterium tuberculosis isolates from Ibadan, Nigeria (2019-2020): a pilot study to improve affordable molecular diagnostic tools.
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Front Public Health |
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| Discrepancies in isoniazid susceptibility profiles: Bactec MGIT 960-resistant but GenoType MTBDRplus-susceptible Mycobacterium tuberculosis strains in Hunan, China.
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Microbiol Spectr |
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| Innowave MTB/RIF/INH facilitates timely and accurate diagnosis of multiple-drug resistant tuberculosis as a near POCT technique: a multicenter prospective on-site performance evaluation study.
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Ann Clin Microbiol Antimicrob |
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| Characterization of Drug Resistance Mutations in Mycobacterium tuberculosis Isolates from Moroccan Patients Using Deeplex Targeted Next-Generation Sequencing.
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Microorganisms |
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| Isoniazid-Derived Hydrazones Featuring Piperazine/Piperidine Rings: Design, Synthesis, and Investigation of Antitubercular Activity.
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Biomolecules |
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| Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting.
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Rev Soc Bras Med Trop |
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| Genotypic study of isolated resistance to isoniazid in the Mycobacterium tuberculosis complex in a Moroccan hospital.
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| Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide-Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis.
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ChemMedChem |
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| Hydrazineyl-linked imidazole[1,2-a]pyrimidine-thiazole hybrids: design, synthesis, and in vitro biological evaluation studies.
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RSC Adv |
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| Rationally Designed InhA Inhibitors: A Comparative Anti-Tubercular Activity Study of Sulfonate Esters of Isoniazid Hydrazones and Their Structurally Flexible Benzyl Analogues.
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Chem Biol Drug Des |
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| Advancements in the design and development of pyrazoline-based antimycobacterial agents: an update and future perspectives.
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RSC Adv |
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| Isoniazid-rhodanine molecular hybrids: design, synthesis, antimycobacterial activity and computational validation.
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RSC Adv |
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| Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N'-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives.
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ChemMedChem |
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| Exploration of New Dihydroindazole Derivatives as Promising Anti-TB Agents: Design, Synthesis, In Silico, and Biological Evaluation.
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Arch Pharm (Weinheim) |
2025 |
| Mechanistic evaluation of Clerodendrum serratum anti-biofilm potency against Mycobacterium species.
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Microb Pathog |
2025 |
| Promising Antimycobacterial Agents: Salicylidenehydrazines.
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Arch Pharm (Weinheim) |
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| Designing Novel InhA Inhibitors for Antituberculosis Agents Using ab Initio Fragment Molecular Orbital Calculations.
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ACS Omega |
2025 |
| Epidemiology and molecular characterization of multidrug-resistant Mycobacterium tuberculosis among patients with pulmonary symptoms in Kaduna State, Nigeria.
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Acta Trop |
2025 |
| Lineage identification and mutation profile of Mycobacterium tuberculosis: A study from National Reference Laboratory, India.
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Indian J Med Microbiol |
2025 |
| Innovo GenMax MTB-RIF/INH: a moderate-complexity automated NAAT for rapid simultaneous detection of Mycobacterium tuberculosis complex and rifampin/isoniazid resistance.
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Front Cell Infect Microbiol |
2025 |
| Anti-Bacterial Activity of Furan Chalcone Derivatives Against Mycobacterium tuberculosis: Design, Synthesis, Anti-Bacterial Screening, Pharmacokinetic Properties, and Toxicity Parameters.
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Curr Microbiol |
2025 |
| CRISPRi knockdown of mycobacterial tkt gene potentiates the anti-mycobacterial activity of phyto-compounds from selected medicinal plants.
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BMC Complement Med Ther |
2025 |
| Exploration of pyrazole-based pyridine-4-carbohydrazide derivatives as drug-resistant Mtb agents: design, synthesis, biological evaluation, and in-silico studies.
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Future Med Chem |
2025 |
| Development and evaluation of novel InhA inhibitors inspired by thiadiazole and tetrahydropyran series of inhibitors.
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Acta Pharm |
2025 |
| Delayed culture conversion predicts poor outcomes for isoniazid mono-resistant TB in Uganda: a retrospective cross-sectional study from 2017- 2022.
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BMC Infect Dis |
2025 |
| Deciphering rifampicin resistance among tuberculosis patients who have trace results on Xpert MTB/RIF ultra assay.
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medRxiv |
2025 |
| Prevalence and molecular characterization of drug-resistant Mycobacterium tuberculosis in Heyuan City in China.
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Front Cell Infect Microbiol |
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| Molecular Characterization of Mycobacterium Tuberculosis in HIV Patients Receiving Antiretroviral Drugs in Cameroon.
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Int J Mycobacteriol |
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| Unearthing novel mutations and genetic variation in drug sensitive and resistant isolates of Mycobacterium tuberculosis through whole genome sequencing: A study from eastern Uttar Pradesh, India.
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Indian J Med Microbiol |
2025 |
| Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015-2021.
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Microbiol Spectr |
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| An exploratory study on the application of nanopore sequencing for detecting Mycobacterium tuberculosis drug resistance in respiratory specimens.
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BMC Pulm Med |
2025 |
| Hybrid virtual screening identifies dipyrazole carboxamide derivatives as novel direct InhA inhibitors with antitubercular activity.
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Biochim Biophys Acta Gen Subj |
2025 |
| Review of Recent Advances in Thiazolidin-4-One Derivatives as Promising Antitubercular Agents (2021-Present).
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Molecules |
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| High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment.
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JAC Antimicrob Resist |
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| Design, synthesis and in silico molecular modelling studies of 2-Hydrazineyl-2-oxoethyl-4-(1H-pyrrol-1-yb) benzoate derivatives: a potent dual DHFR and ENR-reductase inhibitors with antitubercular, antibacterial and cytotoxic potential.
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PLoS One |
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| Utility of Rapid Molecular Assays for Detecting Multidrug-Resistant Mycobacterium tuberculosis in Extrapulmonary Samples.
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Diagnostics (Basel) |
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| Coumarin hybrids: dual-target candidates for future antimicrobial and antitubercular therapies.
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Future Med Chem |
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| Evaluation of the therapeutic potential of a Schiff Base Compound: Pharmacokinetic profiling, molecular docking for Enoyl-Acyl carrier protein reductase (InhA), antimicrobial, and anticancer properties.
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Int J Biol Macromol |
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| Ferromagnetic Resonance Multiplexing of Orthogonal Magnetic Nanoparticle Agglutination for Simultaneous Analysis of Nucleic Acid Mutations and Nonspecific Interactions.
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| Identification of novel inhibitors targeting Mycobacterium abscessus InhA through virtual screening, docking, and molecular dynamic simulations.
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Sci Rep |
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| Prevalence and Genetic Analysis of Isoniazid-Resistant Tuberculosis in Eastern Uttar Pradesh, India.
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| Is Mycobacterial InhA a Suitable Target for Rational Drug Design?
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ChemMedChem |
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| A duplex one-step recombinase aided PCR assay for the rapid and sensitive detection of the isoniazid resistance genes katG and inhA in Mycobacterium tuberculosis.
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Front Microbiol |
2025 |
| Application value of nucleic acid MALDI-TOF MS in mycobacterial species identification and drug resistance detection in Mycobacterium tuberculosis.
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Microbiol Spectr |
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| In silico discovery of potential novel anti-tuberculosis drug candidates from phytoconstituents of Chlorophytum borivilianum and Asparagus racemosus.
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Heliyon |
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| Multi-drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam.
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Trop Med Int Health |
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| Exploring the Anti-Tubercular Potential of 2-(1H-Pyrazol-1-yl) Pyrimidine: Design, Synthesis, Biological Evaluation and Molecular Docking Studies.
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Chem Biodivers |
2025 |
| Isoniazid-Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation.
doi:10.1002/cmdc.202400949
|
ChemMedChem |
2025 |
| Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon.
doi:10.1186/s12866-025-03816-9
names it
|
BMC Microbiol |
2025 |
| Exploration of quinoxaline triazoles as antimycobacterial agents: design, synthesis and biological evaluation.
doi:10.1016/j.bmcl.2025.130177
|
Bioorg Med Chem Lett |
2025 |
| Experimental and theoretical studies on antituberculosis activity of different benzimidazole derivatives.
doi:10.1016/j.heliyon.2025.e42674
|
Heliyon |
2025 |
| Generative AI, molecular docking and molecular dynamics simulations assisted identification of novel transcriptional repressor EthR inhibitors to target Mycobacterium tuberculosis.
doi:10.1016/j.heliyon.2025.e42593
|
Heliyon |
2025 |
| Development of Novel Sulfonamide-Based Pyrazole-Clubbed Pyrazoline Derivatives: Synthesis, Biological Evaluation, and Molecular Docking Study.
doi:10.1021/acsomega.4c10198
|
ACS Omega |
2025 |
| Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment.
doi:10.3201/eid3103.241473
|
Emerg Infect Dis |
2025 |
| Synthesis, DFT study, in silico ADMET evaluation, molecular docking, and QSAR analysis of new anti-tuberculosis drugs derived from 2-hydroxybenzohydrazide derivatives.
doi:10.1007/s11030-025-11130-9
|
Mol Divers |
2025 |
| Repurposing of apoptotic inducer drugs against Mycobacterium tuberculosis.
doi:10.1038/s41598-025-91096-8
|
Sci Rep |
2025 |
| Chroman-Schiff base derivatives as potential Anti-Tubercular Agents: In silico studies, Synthesis, and Biological evaluation.
doi:10.1016/j.bioorg.2025.108249
|
Bioorg Chem |
2025 |
| Computational approaches: atom-based 3D-QSAR, molecular docking, ADME-Tox, MD simulation and DFT to find novel multi-targeted anti-tubercular agents.
doi:10.1186/s13065-024-01357-2
|
BMC Chem |
2025 |
| Xpert MTB/RIF Ultra-resistant and MTBDRplus-susceptible rifampicin results in people with tuberculosis: utility of FluoroType MTBDR and deep sequencing.
doi:10.1128/aac.01671-24
|
Antimicrob Agents Chemother |
2025 |
| Targeting InhA in drug-resistant Mycobacterium tuberculosis: potent antimycobacterial activity of diaryl ether dehydrozingerone derivatives.
doi:10.1007/s00203-025-04238-x
names it
|
Arch Microbiol |
2025 |
| Trifluoromethylcinnamanilides - Effective dual inhibitors of Mycobacterium smegmatis and Plasmodium falciparum.
doi:10.1016/j.bioorg.2024.107957
|
Bioorg Chem |
2025 |
| Design, Synthesis, and Anti-Mycobacterial Evaluation of Triclosan-Isoniazid Hybrids.
doi:10.1002/cbdv.202401967
|
Chem Biodivers |
2025 |
| Synthesis, Biological Evaluation, Molecular Docking Studies and ADMET Prediction of Oxindole-based Hybrids for the Treatment of Tuberculosis.
doi:10.2174/0115734099353857241022102426
|
Curr Comput Aided Drug Des |
2025 |
| Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review.
doi:10.2174/0113895575309785240902102421
names it
|
Mini Rev Med Chem |
2025 |
| Computational Exploration of Isatin Derivatives for InhA Inhibition in Tuberculosis: Molecular Docking, MD Simulations and ADMET Insights.
doi:10.2174/0115734099333313240909103833
names it
|
Curr Comput Aided Drug Des |
2025 |
| In silico development of potential InhA inhibitors through 3D-QSAR analysis, virtual screening and molecular dynamics.
doi:10.1080/07391102.2023.2291549
names it
|
J Biomol Struct Dyn |
2025 |
| Exploring natural products library to identify potential inhibitors targeting isoniazid-resistant tuberculosis.
doi:10.1080/07391102.2023.2283159
|
J Biomol Struct Dyn |
2025 |
| In silico study of bioactive compounds derived from Indonesian marine invertebrates as a novel antituberculosis agent.
doi:10.55730/1300-0144.5923
|
Turk J Med Sci |
2024 |
| Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical approaches.
doi:10.1038/s41598-024-77947-w
|
Sci Rep |
2024 |
| The CRISPR-dCas9 interference system suppresses inhA gene expression in Mycobacterium smegmatis.
doi:10.1038/s41598-024-77442-2
names it
|
Sci Rep |
2024 |
| Microwave-Assisted Synthesis and Characterization of Novel 1,3,4-Oxadiazole Derivatives and Evaluation of In Vitro Antimycobacterial Activity.
doi:10.7759/cureus.69679
|
Cureus |
2024 |
| Rational design and microwave-promoted synthesis of triclosan-based dimers: targeting InhA for anti-mycobacterial profiling.
doi:10.1098/rsos.240676
names it
|
R Soc Open Sci |
2024 |
| Contribution of direct InhA inhibitors to novel drug regimens in a mouse model of tuberculosis.
doi:10.1128/aac.00357-24
names it
|
Antimicrob Agents Chemother |
2024 |
| Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.
doi:10.1039/d4ra05616g
names it
|
RSC Adv |
2024 |
| The performance of Xpert MTB/RIF and MTBDRplus within a Programmatic setting at TB Laboratory in Rio de Janeiro, Brazil.
doi:10.1590/0037-8682-0167-2024
|
Rev Soc Bras Med Trop |
2024 |
| Halogenated chalcones against Mycobacterium tuberculosis targeting InhA: Rational design, in silico and in vitro evaluation.
doi:10.1016/j.micpath.2024.106945
names it
|
Microb Pathog |
2024 |
| Detection of katG, inhA and ahpC gene mutation in clinical isolates of isoniazid-resistant Mycobacterium tuberculosis in Makassar City, South Sulawesi, Indonesia.
doi:10.1016/j.ijtb.2023.03.019
names it
|
Indian J Tuberc |
2024 |
| Diagnostic Accuracy of FluoroCycler XT MTBDR Assay for Detection of Rifampicin and Isoniazid-resistant Mycobacteria tuberculosis in Clinical Isolates from Kenya.
doi:10.4103/ijmy.ijmy_202_23
|
Int J Mycobacteriol |
2024 |
| Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against Mycobacterium tuberculosis in vivo by targeting Enoyl-ACP reductase.
doi:10.1016/j.ejmech.2024.116806
|
Eur J Med Chem |
2024 |
| The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti-TB Drugs-A Perspective.
doi:10.1111/cbdd.14612
|
Chem Biol Drug Des |
2024 |
| Detection of multidrug-resistance in Mycobacterium tuberculosis by phenotype- and molecular-based assays.
doi:10.1186/s12941-024-00741-z
|
Ann Clin Microbiol Antimicrob |
2024 |
| Evaluation of GeneNAT Real-Time Polymerase Chain Reaction Analyzer and Pre-loaded Chip-Based Mycobacterium tuberculosis and Multidrug-Resistant Tuberculosis Detection in the Diagnosis of Pulmonary Tuberculosis.
doi:10.7759/cureus.65067
|
Cureus |
2024 |
| Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity.
doi:10.3389/fchem.2024.1424017
names it
|
Front Chem |
2024 |
| Occurrence of multidrug-resistant Mycobacterium tuberculosis in upper Southern Thailand.
doi:10.14202/vetworld.2024.1405-1412
|
Vet World |
2024 |
| Mutational analysis in drug resistant Mycobacterium tuberculosis in Western Uttar Pradesh.
doi:10.1016/j.ijtb.2024.01.009
|
Indian J Tuberc |
2024 |
| In Silico Approach: Anti-Tuberculosis Activity of Caespitate in the H37Rv Strain.
doi:10.3390/cimb46070387
|
Curr Issues Mol Biol |
2024 |
| Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy.
doi:10.1080/17568919.2024.2379240
|
Future Med Chem |
2024 |
| Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues.
doi:10.1039/d4ra04262j
|
RSC Adv |
2024 |
| Design and Synthesis of Isatin-Tagged Isoniazid Conjugates with Cogent Antituberculosis and Radical Quenching Competence: In-vitro and In-silico Evaluations.
doi:10.1002/cbdv.202400765
|
Chem Biodivers |
2024 |
| Imidazoquinoline Derivatives as Potential Inhibitors of InhA Enzyme and Mycobacterium tuberculosis.
doi:10.3390/molecules29133076
names it
|
Molecules |
2024 |
| Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA).
doi:10.1039/d4ra02746a
names it
|
RSC Adv |
2024 |
| Polymerase Chain Reaction (PCR) Profiling of Extensively Drug-Resistant (XDR) Pathogenic Bacteria in Pulmonary Tuberculosis Patients.
doi:10.7759/cureus.61424
|
Cureus |
2024 |
| The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.
doi:10.1513/AnnalsATS.202312-1076OC
|
Ann Am Thorac Soc |
2024 |
| Identification of potent indolizine derivatives against Mycobacterial tuberculosis: In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies.
doi:10.1016/j.ijbiomac.2024.133285
|
Int J Biol Macromol |
2024 |
| Cu-promoted synthesis of triclosan-Mannich and Glaser adducts: anti-mycobacterial evaluation with in silico validations.
doi:10.4155/fmc-2023-0298
|
Future Med Chem |
2024 |
| Design and Synthesis of the Linezolid Bioisosteres to Resolve the Serotonergic Toxicity Associated with Linezolid.
doi:10.1021/acsmedchemlett.4c00114
|
ACS Med Chem Lett |
2024 |
| Accurate and affordable detection of rifampicin and isoniazid resistance in Tuberculosis sputum specimens by multiplex PCR-multiple probes melting analysis.
doi:10.1007/s15010-024-02295-w
|
Infection |
2024 |
| New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling.
doi:10.1016/j.bioorg.2024.107511
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|
Bioorg Chem |
2024 |
| Advanced integrative molecular platform for high-throughput screening of drug-resistant tuberculosis.
doi:10.1016/j.diagmicrobio.2024.116373
|
Diagn Microbiol Infect Dis |
2024 |
| Evaluation of a real-time PCR assay performance to detect Mycobacterium tuberculosis, rifampicin, and isoniazid resistance in sputum specimens: a multicenter study in two major cities of Indonesia.
doi:10.3389/fmicb.2024.1372647
|
Front Microbiol |
2024 |
| Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.
doi:10.4269/ajtmh.24-0042
|
Am J Trop Med Hyg |
2024 |
| Rapid Detection of M. tuberculosis and Its Resistance to Rifampicin and Isoniazid with the mfloDx™ MDR-TB test.
doi:10.4103/ijmy.ijmy_21_24
|
Int J Mycobacteriol |
2024 |
| An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
doi:10.1073/pnas.2318003121
|
Proc Natl Acad Sci U S A |
2024 |
| Dual-centre evaluation of the FluoroType MTBDR version 2 assay for detection of Mycobacterium tuberculosis complex and resistance-conferring mutations in pulmonary and extrapulmonary samples from Denmark, Germany and Sierra Leone.
doi:10.1016/j.cmi.2024.04.006
|
Clin Microbiol Infect |
2024 |
| Activity against Mycobacterium tuberculosis of a new class of spirooxindolopyrrolidine embedded chromanone hybrid heterocycles.
doi:10.1039/d4ra01501k
|
RSC Adv |
2024 |
| Whole-genome sequencing of clinical isolates from tuberculosis patients in India: real-world data indicates a high proportion of pre-XDR cases.
doi:10.1128/spectrum.02770-23
|
Microbiol Spectr |
2024 |
| High-Dose Isoniazid Lacks EARLY Bactericidal Activity against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized Phase II Clinical Trial.
doi:10.1164/rccm.202311-2004OC
|
Am J Respir Crit Care Med |
2024 |
| Concordance of targeted and whole genome sequencing for Mycobacterium tuberculosis genotypic drug susceptibility testing.
doi:10.1016/j.diagmicrobio.2024.116249
|
Diagn Microbiol Infect Dis |
2024 |
| Molecular Detection of Multidrug Resistance and Characterizations of Mutations in Mycobacterium Tuberculosis Using Polycarbonate Track-Etched Membrane Based DNA Bio-Chip.
doi:10.1007/s12088-023-01116-2
|
Indian J Microbiol |
2024 |
| Unlocking InhA: Novel approaches to inhibit Mycobacterium tuberculosis.
doi:10.1016/j.bioorg.2024.107250
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Bioorg Chem |
2024 |
| Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis.
doi:10.1016/j.ijpharm.2024.123960
|
Int J Pharm |
2024 |
| Identification of Mycobacterium tuberculosis transcriptional repressor EthR inhibitors: Shape-based search and machine learning studies.
doi:10.1016/j.heliyon.2024.e26802
|
Heliyon |
2024 |
| Machine learning assisted methods for the identification of low toxicity inhibitors of Enoyl-Acyl Carrier Protein Reductase (InhA).
doi:10.1016/j.compbiolchem.2024.108034
names it
|
Comput Biol Chem |
2024 |
| Phenotypic and Genotypic Drug Resistance of Mycobacterium tuberculosis Strains Isolated from HIV-Infected Patients from a Third-Level Public Hospital in Mexico.
doi:10.3390/pathogens13020098
|
Pathogens |
2024 |
| The first-in-class pyrazole-based dual InhA-VEGFR inhibitors towards integrated antitubercular host-directed therapy.
doi:10.1016/j.bioorg.2024.107179
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|
Bioorg Chem |
2024 |
| Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis.
doi:10.1128/mbio.02968-23
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|
mBio |
2024 |
| Identification of new anti-mycobacterial agents based on quinoline-isatin hybrids targeting enoyl acyl carrier protein reductase (InhA).
doi:10.1016/j.bioorg.2024.107138
names it
|
Bioorg Chem |
2024 |
| Insights into the in-vitro Susceptibility and Drug-Drug Interaction Profiles Against Drug-Resistant and Susceptible Mycobacterium tuberculosis Clinical Isolates in Amhara, Ethiopia.
doi:10.2147/IDR.S440947
|
Infect Drug Resist |
2024 |
| Rapid detection of drug-resistant Mycobacterium tuberculosis by Modified MODS assay suitable for resource-poor settings.
doi:10.1371/journal.pntd.0011852
|
PLoS Negl Trop Dis |
2024 |
| Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors.
doi:10.1016/j.bioorg.2023.107032
names it
|
Bioorg Chem |
2024 |
| High frequency of isoniazid and fluroquinolone resistance among patients with rifampicin sensitive tuberculosis.
doi:10.1016/j.diagmicrobio.2023.116159
|
Diagn Microbiol Infect Dis |
2024 |
| Computational insights into potential marine natural products as selective inhibitors of Mycobacterium tuberculosis InhA: A structure-based virtual screening study.
doi:10.1016/j.compbiolchem.2023.107991
names it
|
Comput Biol Chem |
2024 |
| Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.
doi:10.1016/S2666-5247(23)00252-5
|
Lancet Microbe |
2024 |
| A descriptive study on isoniazid resistance-associated mutations, clustering and treatment outcomes of drug-resistant tuberculosis in a high burden country.
doi:10.1007/s10096-023-04693-8
|
Eur J Clin Microbiol Infect Dis |
2024 |
| Identification of potential inhibitors of Mtb InhA: a pharmacoinformatics approach.
doi:10.1080/07391102.2023.2242499
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|
J Biomol Struct Dyn |
2024 |
| Repurposing Azoles to Resolve Serotogenic Toxicity Associated with Linezolid to Combat Multidrug-Resistant Tuberculosis.
doi:10.1021/acsmedchemlett.3c00406
|
ACS Med Chem Lett |
2023 |
| Missed phenotypic drug resistance in pediatric tuberculosis: A cause of concern in a resource-limited setting.
doi:10.1016/j.ijtb.2023.04.004
|
Indian J Tuberc |
2023 |
| Real-world first-line afatinib for advanced EGFR mutation-positive non-small cell lung cancer in Korea: updated survival data.
doi:10.21037/tlcr-23-383
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Transl Lung Cancer Res |
2023 |
| Tailoring selective triclosan azo-adducts: Design, synthesis, and anti-mycobacterial evaluation.
doi:10.1016/j.heliyon.2023.e22182
|
Heliyon |
2023 |
| Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay.
doi:10.21037/jtd-23-138
|
J Thorac Dis |
2023 |
| Novel Quinoline-Based Thiosemicarbazide Derivatives: Synthesis, DFT Calculations, and Investigation of Antitubercular, Antibacterial, and Antifungal Activities.
doi:10.1021/acsomega.3c03018
|
ACS Omega |
2023 |
| Design, synthesis, in vitro and in silico evaluation of novel substituted 1,2,4-triazole analogues as dual human VEGFR-2 and TB-InhA inhibitors.
doi:10.1016/j.bioorg.2023.106883
names it
|
Bioorg Chem |
2023 |
| Synthesis of novel furan-based chalcone derivatives as anti-tuberculosis agents: in vitro, cytotoxicity assessment and in silico.
doi:10.4155/fmc-2023-0110
|
Future Med Chem |
2023 |
| Computational evaluation of marine demospongiae sponges metabolites activity as mycolic acid biosynthesis inhibitors in Mycobacterium tuberculosis.
doi:10.4103/ijmy.ijmy_149_23
|
Int J Mycobacteriol |
2023 |
| Discovery of novel and potent InhA direct inhibitors by ensemble docking-based virtual screening and biological assays.
doi:10.1007/s10822-023-00530-4
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|
J Comput Aided Mol Des |
2023 |
| Isoniazid and Rifampicin Resistance-Conferring Mutations in Mycobacterium tuberculosis Isolates from South Africa.
doi:10.3390/pathogens12081015
|
Pathogens |
2023 |
| Delphi Survey on the Current and Future Korean Guidelines for Isoniazid-Monoresistant Tuberculosis.
doi:10.2147/IDR.S420830
|
Infect Drug Resist |
2023 |
| Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance.
doi:10.1016/j.jctube.2023.100387
|
J Clin Tuberc Other Mycobact Dis |
2023 |
| Deciphering the emerging role of phytocompounds: Implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage.
doi:10.1016/j.jiph.2023.07.016
|
J Infect Public Health |
2023 |
| In silico study of phytochemicals contained in Brucea javanica in inhibiting the InhA enzyme as antituberculosis.
doi:10.4081/jphia.2023.2518
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J Public Health Afr |
2023 |
| In vitro modeling of isoniazid resistance mechanisms in Mycobacterium tuberculosis H37Rv.
doi:10.3389/fmicb.2023.1171861
|
Front Microbiol |
2023 |
| The Detection of Mutations and Genotyping of Drug-Resistant Mycobacterium tuberculosis Strains Isolated from Patients in the Rural Eastern Cape Province.
doi:10.3390/idr15040041
|
Infect Dis Rep |
2023 |
| Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
doi:10.1016/j.ejmech.2023.115646
names it
|
Eur J Med Chem |
2023 |
| Characterization of Genetic Mutations in Multi-Drug-Resistant Isolates of Mycobacterium tuberculosis Bacilli Conferring Resistance to a Second-Line Anti-tuberculosis Drug.
doi:10.7759/cureus.40442
|
Cureus |
2023 |
| Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis.
doi:10.1016/j.jctube.2023.100379
|
J Clin Tuberc Other Mycobact Dis |
2023 |
| Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha.
doi:10.1016/j.ijmmb.2023.100373
names it
|
Indian J Med Microbiol |
2023 |
| Design, synthesis and anti-Tb evaluation of chalcone derivatives as novel inhibitors of InhA.
doi:10.1080/07391102.2023.2227711
names it
|
J Biomol Struct Dyn |
2023 |
| Whole-genome sequencing reveals genotypic resistance in phenotypically susceptible Mycobacterium tuberculosis clinical isolates.
doi:10.4103/ijmy.ijmy_101_23
|
Int J Mycobacteriol |
2023 |
| Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids.
doi:10.1021/acsomega.2c07267
|
ACS Omega |
2023 |
| New therapeutic strategies for Mycobacterium abscessus pulmonary diseases - untapping the mycolic acid pathway.
doi:10.1080/14787210.2023.2224563
|
Expert Rev Anti Infect Ther |
2023 |
| Synthesis, biological screening and in silico studies of new N-phenyl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine derivatives as potential antifungal and antitubercular agents.
doi:10.1016/j.ejmech.2023.115548
|
Eur J Med Chem |
2023 |
| Evaluation of Antituberculosis Activity and in Silico Properties of Oxymethylene-cyclo-1,3-diones.
doi:10.1002/cbdv.202300779
|
Chem Biodivers |
2023 |
| Transmission and resistome of extremely drug-resistant tuberculosis in Beijing, China: A retrospective population-based epidemiological study.
doi:10.1016/j.jiph.2023.05.020
|
J Infect Public Health |
2023 |
| Evaluating the Impact of the Tyr158 pK(a) on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis.
doi:10.1021/acs.biochem.2c00606
names it
|
Biochemistry |
2023 |
| Genetic Characterization Conferred Co-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Isolates from Southern Xinjiang, China.
doi:10.2147/IDR.S407525
|
Infect Drug Resist |
2023 |
| Heteroresistance to rifampicin & isoniazid in clinical samples of patients with presumptive drug-resistant tuberculosis in Central India.
doi:10.4103/ijmr.ijmr_607_22
|
Indian J Med Res |
2023 |
| Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis.
doi:10.1016/j.bioorg.2023.106591
names it
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Bioorg Chem |
2023 |
| Quantification of Isoniazid-Heteroresistant Mycobacterium tuberculosis Using Droplet Digital PCR.
doi:10.1128/jcm.01884-22
|
J Clin Microbiol |
2023 |
| Molecular Characterization of katG and inhA Mutations by Genotype MTBDRplus Line Probe Assay To Guide Isoniazid and Ethionamide Use for Drug-Resistant Tuberculosis.
doi:10.7759/cureus.37136
names it
|
Cureus |
2023 |
| Facing Antitubercular Resistance: Identification of Potential Direct Inhibitors Targeting InhA Enzyme and Generation of 3D-pharmacophore Model by in silico Approach.
doi:10.2147/AABC.S394535
names it
|
Adv Appl Bioinform Chem |
2023 |
| Effectiveness of Xpert MTB/RIF and the Line Probe Assay tests for the rapid detection of drug-resistant tuberculosis in the Central African Republic.
doi:10.1371/journal.pgph.0001847
|
PLOS Glob Public Health |
2023 |
| Recent Advances in Anti-Tuberculosis Drug Discovery Based on Hydrazide-Hydrazone and Thiadiazole Derivatives Targeting InhA.
doi:10.3390/ph16040484
names it
|
Pharmaceuticals (Basel) |
2023 |
| Diagnostic performance of the GenoType MTBDRplus VER 2.0 line probe assay for the detection of isoniazid resistant Mycobacterium tuberculosis in Ethiopia.
doi:10.1371/journal.pone.0284737
|
PLoS One |
2023 |
| Development of DNA Bio-chip for Detection of Mutations of rpoB, embB and inhA Genes in Drug-Resistant Mycobacterium Tuberculosis.
doi:10.1007/s12291-022-01044-w
names it
|
Indian J Clin Biochem |
2023 |
| Spatial Distribution of Drug-Resistant Mycobacterium tuberculosis Infections in Rural Eastern Cape Province of South Africa.
doi:10.3390/pathogens12030475
|
Pathogens |
2023 |
| In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum.
doi:10.1128/aac.01607-22
|
Antimicrob Agents Chemother |
2023 |
| In silico analyses of isoniazid and streptomycin resistance-associated mutations in Mycobacterium tuberculosis.
doi:10.1016/j.csbj.2023.02.035
|
Comput Struct Biotechnol J |
2023 |
| Computational Analysis to Predict Drug Targets for the Therapeutic Management of Mycobacterium avium sub. Paratuberculosis.
doi:10.2174/1570163820666230310140613
|
Curr Drug Discov Technol |
2023 |
| Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
doi:10.1016/j.bmc.2023.117212
|
Bioorg Med Chem |
2023 |
| Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis.
doi:10.1101/2023.02.06.527416
names it
|
bioRxiv |
2023 |
| Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort.
doi:10.1128/jcm.01478-22
|
J Clin Microbiol |
2023 |
| Design, Synthesis, and Antimycobacterial Evaluation of Novel Tetrahydroisoquinoline Hydrazide Analogs.
doi:10.1002/cbdv.202200939
|
Chem Biodivers |
2023 |
| Design, Synthesis, Anti-Tubercular Evaluation and Teratogenicity Studies of Furanyl Pyrazolo[3,4-b] Quinoline-5-Ones.
doi:10.1134/S1068162023010053
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Russ J Bioorg Chem |
2023 |
| Structure-based drug design of novel M. tuberculosis InhA inhibitors based on fragment molecular orbital calculations.
doi:10.1016/j.compbiomed.2022.106434
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Comput Biol Med |
2023 |
| Strain diversity and gene mutations associated with presumptive multidrug-resistant Mycobacterium tuberculosis complex isolates in Northwest Ethiopia.
doi:10.1016/j.jgar.2022.11.012
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J Glob Antimicrob Resist |
2023 |
| Genetic mutations underlying isoniazid-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan.
doi:10.1016/j.tube.2022.102286
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Tuberculosis (Edinb) |
2023 |
| Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
doi:10.1016/j.ejmech.2022.114908
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Eur J Med Chem |
2023 |
| Molecular Characterization of Mutations in Isoniazid- and Rifampicin-Resistant Mycobacterium tuberculosis Isolated in Thailand.
doi:10.7883/yoken.JJID.2022.055
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Jpn J Infect Dis |
2023 |
| Discovery of newer pyrazole derivatives with potential anti-tubercular activity via 3D-QSAR based pharmacophore modelling, virtual screening, molecular docking and molecular dynamics simulation studies.
doi:10.1007/s11030-022-10511-8
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Mol Divers |
2023 |
| Isonicotinic acid N-oxide, from isoniazid biotransformation by Aspergillus niger, as an InhA inhibitor antituberculous agent against multiple and extensively resistant strains supported by in silico docking and ADME prediction.
doi:10.1080/14786419.2022.2103695
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Nat Prod Res |
2023 |
| Inhibition of Mycobacterium tuberculosis InhA (Enoyl-acyl carrier protein reductase) by synthetic Chalcones: a molecular modelling analysis and in-vitro evidence.
doi:10.1080/07391102.2022.2086922
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J Biomol Struct Dyn |
2023 |
| Isolated Tuberculous Myositis: A Systematic Review and Multicenter Cases.
doi:10.4078/jrd.22.0014
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J Rheum Dis |
2022 |
| An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs.
doi:10.1099/mic.0.001285
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Microbiology (Reading) |
2022 |
| Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases.
doi:10.3389/fmicb.2022.1069292
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Front Microbiol |
2022 |
| Structural homology between 11 beta-hydroxysteroid dehydrogenase and Mycobacterium tuberculosis Inh-A enzyme: Dehydroepiandrosterone as a potential co-adjuvant treatment in diabetes-tuberculosis comorbidity.
doi:10.3389/fendo.2022.1055430
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Front Endocrinol (Lausanne) |
2022 |
| QSAR Studies, Molecular Docking, Molecular Dynamics, Synthesis, and Biological Evaluation of Novel Quinolinone-Based Thiosemicarbazones against Mycobacterium tuberculosis.
doi:10.3390/antibiotics12010061
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Antibiotics (Basel) |
2022 |
| Drug Resistance and Molecular Characteristics of Mycobacterium tuberculosis: A Single Center Experience.
doi:10.3390/jpm12122088
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J Pers Med |
2022 |
| Genotypic Distribution and the Epidemiology of Multidrug Resistant Tuberculosis in Upper Northern Thailand.
doi:10.3390/antibiotics11121733
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Antibiotics (Basel) |
2022 |
| The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development.
doi:10.1186/s43556-022-00106-y
|
Mol Biomed |
2022 |
| Synthesis, Biological Evaluation and Computational Studies of New Hydrazide Derivatives Containing 1,3,4-Oxadiazole as Antitubercular Agents.
doi:10.3390/ijms232315295
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Int J Mol Sci |
2022 |
| Trifluoromethylcinnamanilide Michael Acceptors for Treatment of Resistant Bacterial Infections.
doi:10.3390/ijms232315090
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Int J Mol Sci |
2022 |
| Identification of novel anti-tuberculosis agent: An in silico investigation.
doi:10.1016/j.ijtb.2021.08.014
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Indian J Tuberc |
2022 |
| Multi-omics Investigation into the Mechanism of Action of an Anti-tubercular Fatty Acid Analogue.
doi:10.1021/jacs.2c08238
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J Am Chem Soc |
2022 |
| Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam.
doi:10.1183/23120541.00122-2022
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ERJ Open Res |
2022 |
| Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity.
doi:10.3390/ph15101301
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Pharmaceuticals (Basel) |
2022 |
| Comparison on Major Gene Mutations Related to Rifampicin and Isoniazid Resistance between Beijing and Non-Beijing Strains of Mycobacterium tuberculosis: A Systematic Review and Bayesian Meta-Analysis.
doi:10.3390/genes13101849
|
Genes (Basel) |
2022 |
| Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia.
doi:10.1128/spectrum.01586-22
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Microbiol Spectr |
2022 |
| Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance.
doi:10.3390/cimb44090283
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Curr Issues Mol Biol |
2022 |
| Novel diaryl ether derivatives as InhA inhibitors: Design, synthesis and antimycobacterial activity.
doi:10.1016/j.bioorg.2022.106125
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Bioorg Chem |
2022 |
| Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.
doi:10.1021/acsinfecdis.2c00314
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ACS Infect Dis |
2022 |
| Binding Thermodynamics and Dissociation Kinetics Analysis Uncover the Key Structural Motifs of Phenoxyphenol Derivatives as the Direct InhA Inhibitors and the Hotspot Residues of InhA.
doi:10.3390/ijms231710102
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Int J Mol Sci |
2022 |
| Effects of intravesical BCG maintenance therapy duration on recurrence rate in high-risk non-muscle invasive bladder cancer (NMIBC): Systematic review and network meta-analysis according to EAU COVID-19 recommendations.
doi:10.1371/journal.pone.0273733
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PLoS One |
2022 |
| Design and Synthesis of Quinazolinone-Triazole Hybrids as Potent Anti-Tubercular Agents.
doi:10.1021/acsabm.2c00562
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ACS Appl Bio Mater |
2022 |
| Identification of Novel Inhibitor of Enoyl-Acyl Carrier Protein Reductase (InhA) Enzyme in Mycobacterium tuberculosis from Plant-Derived Metabolites: An In Silico Study.
doi:10.3390/antibiotics11081038
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Antibiotics (Basel) |
2022 |
| Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.
doi:10.1371/journal.pone.0271508
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PLoS One |
2022 |
| Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity.
doi:10.7717/peerj.13645
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PeerJ |
2022 |
| Design, Synthesis and Molecular Docking of Novel Acetophenone-1,2,3-Triazoles Containing Compounds as Potent Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors.
doi:10.3390/ph15070799
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Pharmaceuticals (Basel) |
2022 |
| How a PCR Sequencing Strategy Can Bring New Data to Improve the Diagnosis of Ethionamide Resistance.
doi:10.3390/microorganisms10071436
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Microorganisms |
2022 |
| Epidemiology-based Analysis of Characteristics of Dual Infection of Tuberculosis /Acquired Immune Deficiency Syndrome (AIDS) and Drug Resistance Mechanism of Related Genes.
doi:10.14715/cmb/2022.68.2.16
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Cell Mol Biol (Noisy-le-grand) |
2022 |
| Detection of Isoniazid and Rifampin Resistance in Mycobacterium tuberculosis Clinical Isolates from Sputum Samples by High-Resolution Melting Analysis.
doi:10.1007/s00284-022-02960-z
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Curr Microbiol |
2022 |
| Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities.
doi:10.1002/ddr.21958
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Drug Dev Res |
2022 |
| Designing quinoline-isoniazid hybrids as potent anti-tubercular agents inhibiting mycolic acid biosynthesis.
doi:10.1016/j.ejmech.2022.114531
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Eur J Med Chem |
2022 |
| Frequency of rpoB, katG, and inhA Gene Polymorphisms Associated with Multidrug-Resistant Mycobacterium tuberculosis Complex Isolates among Ethiopian TB Patients: A Systematic Review.
doi:10.1155/2022/1967675
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Interdiscip Perspect Infect Dis |
2022 |
| Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp.
doi:10.3390/md20060400
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Mar Drugs |
2022 |
| Spoligotype-based population structure and isoniazid-resistance gene mutation of Mycobacterium tuberculosis isolates from Thailand.
doi:10.1016/j.jgar.2022.06.013
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J Glob Antimicrob Resist |
2022 |
| High-Throughput Variant Detection Using a Color-Mixing Strategy.
doi:10.1016/j.jmoldx.2022.04.015
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J Mol Diagn |
2022 |
| An effective nano drug delivery and combination therapy for the treatment of Tuberculosis.
doi:10.1038/s41598-022-13682-4
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Sci Rep |
2022 |
| 1,3,4-oxadiazole derivatives as potential antimicrobial agents.
doi:10.1111/cbdd.14100
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Chem Biol Drug Des |
2022 |
| [Exploratory study on detection of drug resistance of Mycobacterium tuberculosis in sputum specimens by next-generation sequencing].
doi:10.3760/cma.j.cn112147-20211104-00775
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Zhonghua Jie He He Hu Xi Za Zhi |
2022 |
| Development of New Antimycobacterial Sulfonyl Hydrazones and 4-Methyl-1,2,3-thiadiazole-Based Hydrazone Derivatives.
doi:10.3390/antibiotics11050562
|
Antibiotics (Basel) |
2022 |
| Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin.
doi:10.1002/14651858.CD014841.pub2
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Cochrane Database Syst Rev |
2022 |
| Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Molecular Docking.
doi:10.3390/ijms23094706
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Int J Mol Sci |
2022 |
| Application of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) in the detection of drug resistance of Mycobacterium tuberculosis in re-treated patients.
doi:10.1016/j.tube.2022.102209
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Tuberculosis (Edinb) |
2022 |
| Synthesis and in vitro studies for structure-based design of novel chalcones as antitubercular agents targeting InhA.
doi:10.4155/fmc-2022-0052
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Future Med Chem |
2022 |
| Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
doi:10.1186/s12879-022-07414-2
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BMC Infect Dis |
2022 |
| Trends in rifampicin and isoniazid resistance in patients with presumptive TB.
doi:10.5588/ijtld.21.0455
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Int J Tuberc Lung Dis |
2022 |
| Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives.
doi:10.1016/j.bioorg.2022.105807
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Bioorg Chem |
2022 |
| Discovery of novel and potent InhA inhibitors by an in silico screening and pharmacokinetic prediction.
doi:10.4155/fmc-2021-0348
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Future Med Chem |
2022 |
| Highly conserved protein Rv1211 in Mycobacterium tuberculosis is a natively unfolded protein that binds to a calmodulin antagonist, trifluoperazine.
doi:10.1016/j.bbrc.2022.04.045
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Biochem Biophys Res Commun |
2022 |
| Recent Discoveries of Nitrogen-Containing Heterocyclic Compounds as InhA Inhibitors against Mycobacterium tuberculosis: An Overview.
doi:10.2174/1871526522666220420092618
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Infect Disord Drug Targets |
2022 |
| Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis.
doi:10.1016/j.bioorg.2022.105809
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Bioorg Chem |
2022 |
| Characterization of Fluoroquinolone-Resistant and Multidrug-Resistant Mycobacterium tuberculosis Isolates Using Whole-Genome Sequencing in Tianjin, China.
doi:10.2147/IDR.S361635
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Infect Drug Resist |
2022 |
| Mutation in Eth A protein of Mycobacterium tuberculosis conferred drug tolerance against enthinoamide in Mycobacterium smegmatis mc(2)155.
doi:10.1016/j.compbiolchem.2022.107677
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Comput Biol Chem |
2022 |
| Detection and characterization of mutations in genes related to isoniazid resistance in Mycobacterium tuberculosis clinical isolates from Iran.
doi:10.1007/s11033-022-07404-2
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Mol Biol Rep |
2022 |
| The first report on effect of fecal microbiota transplantation as a complementary treatment in a patient with steroid-refractory Cronkhite-Canada syndrome: A case report.
doi:10.1097/MD.0000000000029135
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Medicine (Baltimore) |
2022 |
| Differential expression of the Mycobacterium tuberculosis heat shock protein genes in response to drug-induced stress.
doi:10.1016/j.tube.2022.102201
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Tuberculosis (Edinb) |
2022 |
| Establishment and evaluation of an overlap extension polymerase chain reaction technique for rapid and efficient detection of drug-resistance in Mycobacterium tuberculosis.
doi:10.1186/s40249-022-00953-5
|
Infect Dis Poverty |
2022 |
| Molecular Determinants of Ethionamide Resistance in Clinical Isolates of Mycobacterium tuberculosis.
doi:10.3390/antibiotics11020133
|
Antibiotics (Basel) |
2022 |
| Mandelic acid-based spirothiazolidinones targeting M. tuberculosis: Synthesis, in vitro and in silico investigations.
doi:10.1016/j.bioorg.2022.105688
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Bioorg Chem |
2022 |
| Potentiating the Anti-Tuberculosis Efficacy of Peptide Nucleic Acids through Combinations with Permeabilizing Drugs.
doi:10.1128/spectrum.01262-21
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Microbiol Spectr |
2022 |
| Whole genome sequencing of isoniazid monoresistant clinical isolates of Mycobacterium tuberculosis reveals novel genetic polymorphisms.
doi:10.1016/j.tube.2022.102173
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Tuberculosis (Edinb) |
2022 |
| The Regulation of ManLAM-Related Gene Expression in Mycobacterium tuberculosis with Different Drug Resistance Profiles Following Isoniazid Treatment.
doi:10.2147/IDR.S346869
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Infect Drug Resist |
2022 |
| Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
doi:10.1128/spectrum.01358-21
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Microbiol Spectr |
2022 |
| Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents.
doi:10.1016/j.bmcl.2022.128604
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Bioorg Med Chem Lett |
2022 |
| Characterization of Pyridomycin B Reveals the Formation of Functional Groups in Antimycobacterial Pyridomycin.
doi:10.1128/AEM.02035-21
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Appl Environ Microbiol |
2022 |
| Microwave-assisted organic synthesis, antimycobacterial activity, structure-activity relationship and molecular docking studies of some novel indole-oxadiazole hybrids.
doi:10.1080/1062936X.2022.2032333
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SAR QSAR Environ Res |
2022 |
| Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
doi:10.1017/S095026882100279X
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Epidemiol Infect |
2022 |
| Clinical and Microbiological Characteristics of Mycobacterium kansasii Pulmonary Infections in China.
doi:10.1128/spectrum.01475-21
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Microbiol Spectr |
2022 |
| Phosphoproteomics of Mycobacterium-host interaction and inspirations for novel measures against tuberculosis.
doi:10.1016/j.cellsig.2021.110238
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Cell Signal |
2022 |
| Thermodynamic integration combined with molecular dynamic simulations to explore the cross-resistance mechanism of isoniazid and ethionamide.
doi:10.1002/prot.26295
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Proteins |
2022 |
| Clinical Features, Diagnosis, Management, and Outcomes of Idiopathic Pulmonary Fibrosis in Korea: Analysis of the Korea IPF Cohort (KICO) Registry.
doi:10.4046/trd.2021.0123
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Tuberc Respir Dis (Seoul) |
2022 |
| Antituberculosis, antioxidant and cytotoxicity profiles of quercetin: a systematic and cost-effective in silico and in vitro approach.
doi:10.1080/14786419.2021.2008387
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Nat Prod Res |
2022 |
| Clinical features and long-term treatment outcomes in choroidal tuberculoma.
doi:10.1007/s00417-021-05474-9
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Graefes Arch Clin Exp Ophthalmol |
2022 |
| Inhibition of Mycobacterium tuberculosis InhA by 3-nitropropanoic acid.
doi:10.1002/prot.26268
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Proteins |
2022 |
| Conventional and microwave-assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids.
doi:10.1002/ddr.21872
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Drug Dev Res |
2022 |
| Significance of the coexistence of non-codon 315 katG, inhA, and oxyR-ahpC intergenic gene mutations among isoniazid-resistant and multidrug-resistant isolates of Mycobacterium tuberculosis: a report of novel mutations.
doi:10.1080/20477724.2021.1928870
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Pathog Glob Health |
2022 |
| Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study.
doi:10.2174/1573406417666210324131951
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Med Chem |
2022 |
| Carfilzomib as a potential inhibitor of NADH-dependent enoyl-acyl carrier protein reductases of Klebsiella pneumoniae and Mycobacterium tuberculosis as a drug target enzyme: insights from molecular docking and molecular dynamics.
doi:10.1080/07391102.2020.1852966
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J Biomol Struct Dyn |
2022 |
| [Genetic structure of drug-resistant Mycobacterium tuberculosis strains in Peru based on haplotypes obtained from a line probe assay].
doi:10.17843/rpmesp.2021.384.7834
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Rev Peru Med Exp Salud Publica |
2021 |
| Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid.
doi:10.3390/ph14121302
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Pharmaceuticals (Basel) |
2021 |
| Integrative utility of long read sequencing-based whole genome analysis and phenotypic assay on differentiating isoniazid-resistant signature of Mycobacterium tuberculosis.
doi:10.1186/s12929-021-00783-x
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J Biomed Sci |
2021 |
| Putative extensive and pre-extensive drug resistant-tuberculosis associated with unusual genotypes on the Thailand-Myanmar border.
doi:10.1590/S1678-9946202163085
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Rev Inst Med Trop Sao Paulo |
2021 |
| Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
doi:10.3390/antibiotics10111367
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Antibiotics (Basel) |
2021 |
| The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.
doi:10.1186/s12864-021-08139-3
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BMC Genomics |
2021 |
| Correlation of inhA mutations and ethionamide susceptibility: Experience from national reference center for tuberculosis.
doi:10.4103/lungindia.lungindia_120_21
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Lung India |
2021 |
| Conventional and Microwave-Assisted Synthesis, Antitubercular Activity, and Molecular Docking Studies of Pyrazole and Oxadiazole Hybrids.
doi:10.1021/acsomega.1c04411
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ACS Omega |
2021 |
| Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study.
doi:10.1038/s41598-021-97559-y
|
Sci Rep |
2021 |
| Evaluation of Multidrug Resistant Loop-mediated Isothermal Amplification Assay for Detecting the Drug Resistance of Mycobacterium tuberculosis.
doi:10.3967/bes2021.085
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Biomed Environ Sci |
2021 |
| Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.
doi:10.2147/IDR.S320024
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Infect Drug Resist |
2021 |
| Emerging MDR-Mycobacterium avium subsp. avium in house-reared domestic birds as the first report in Egypt.
doi:10.1186/s12866-021-02287-y
|
BMC Microbiol |
2021 |
| 1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
doi:10.1021/acs.jmedchem.1c00837
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J Med Chem |
2021 |
| A Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical Trial.
doi:10.1164/rccm.202103-0534OC
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Am J Respir Crit Care Med |
2021 |
| Mycobacterium enoyl acyl carrier protein reductase (InhA): A key target for antitubercular drug discovery.
doi:10.1016/j.bioorg.2021.105242
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Bioorg Chem |
2021 |
| Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
doi:10.1016/j.heliyon.2021.e07566
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Heliyon |
2021 |
| Correlating genetic mutations with isoniazid phenotypic levels of resistance in Mycobacterium tuberculosis isolates from patients with drug-resistant tuberculosis in a high burden setting.
doi:10.1007/s10096-021-04316-0
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Eur J Clin Microbiol Infect Dis |
2021 |
| Characterization of rifampicin-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan.
doi:10.1038/s41598-021-93501-4
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Sci Rep |
2021 |
| Prevalence of drug resistance-conferring mutations associated with isoniazid- and rifampicin-resistant Mycobacterium tuberculosis in Ethiopia: a systematic review and meta-analysis.
doi:10.1016/j.jgar.2021.06.009
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J Glob Antimicrob Resist |
2021 |
| Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme.
doi:10.1080/14756366.2021.1919889
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J Enzyme Inhib Med Chem |
2021 |
| Rapid Molecular Diagnosis of Tuberculosis and Its Resistance to Rifampicin and Isoniazid with Automated MDR/MTB ELITe MGB(®) Assay.
doi:10.3390/antibiotics10070797
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Antibiotics (Basel) |
2021 |
| Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity.
doi:10.1016/j.ejmech.2021.113668
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Eur J Med Chem |
2021 |
| In silico identification of novel chemical compounds with antituberculosis activity for the inhibition of InhA and EthR proteins from Mycobacterium tuberculosis.
doi:10.1016/j.jctube.2021.100246
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J Clin Tuberc Other Mycobact Dis |
2021 |
| Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.
doi:10.1039/d0md00291g
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RSC Med Chem |
2021 |
| Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
doi:10.1016/j.csbj.2021.04.034
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Comput Struct Biotechnol J |
2021 |
| Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis.
doi:10.1128/AAC.00011-21
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Antimicrob Agents Chemother |
2021 |
| Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
doi:10.1038/s41598-021-88603-y
|
Sci Rep |
2021 |
| Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis.
doi:10.1016/j.ejmech.2021.113472
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Eur J Med Chem |
2021 |
| New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis.
doi:10.3390/ph14040361
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Pharmaceuticals (Basel) |
2021 |
| Molecular Characteristics and Drug Resistance of Mycobacterium tuberculosis Isolate Circulating in Shaanxi Province, Northwestern China.
doi:10.1089/mdr.2020.0496
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Microb Drug Resist |
2021 |
| Exploratory development of PCR-fluorescent probes in rapid detection of mutations associated with extensively drug-resistant tuberculosis.
doi:10.1007/s10096-021-04236-z
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Eur J Clin Microbiol Infect Dis |
2021 |
| Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition.
doi:10.1016/j.bmcl.2021.127984
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Bioorg Med Chem Lett |
2021 |
| Molecular epidemiology of Mycobacterium tuberculosis in adult Filipino TB-HIV co-infected patients.
doi:10.5588/ijtld.20.0878
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Int J Tuberc Lung Dis |
2021 |
| Value of routine whole genome sequencing for Mycobacterium tuberculosis drug resistance detection.
doi:10.1016/j.ijid.2021.03.033
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Int J Infect Dis |
2021 |
| A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure.
doi:10.1021/acsinfecdis.0c00437
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ACS Infect Dis |
2021 |
| Genotyping and Drug Susceptibility Patterns of M. Tuberculosis Isolated from HIV Seropositive Patients in Tehran Iran.
doi:10.2174/1570162X19666210226125335
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Curr HIV Res |
2021 |
| Drug Resistance Conferring Mutation and Genetic Diversity of Mycobacterium tuberculosis Isolates in Tuberculosis Lymphadenitis Patients; Ethiopia.
doi:10.2147/IDR.S298683
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Infect Drug Resist |
2021 |
| The Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology.
doi:10.2147/IDR.S268799
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Infect Drug Resist |
2021 |
| Molecular Docking Suggests the Targets of Anti-Mycobacterial Natural Products.
doi:10.3390/molecules26020475
|
Molecules |
2021 |
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Front Microbiol |
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| A rapid identification technique for drug-resistant Mycobacterium tuberculosis isolates using mismatch specific cleavage enzyme.
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| InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis.
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| Effective pragmatic approach of diagnosis of multidrug-resistant tuberculosis by high-resolution melt curve assay.
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| Molecular mechanism of the synergistic activity of ethambutol and isoniazid against Mycobacterium tuberculosis.
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| Whole-genome sequencing and single nucleotide polymorphisms in multidrug-resistant clinical isolates of Mycobacterium tuberculosis from the Philippines.
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PLoS One |
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| Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations Not Detectable by Common Molecular Tests.
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| Ultrasound Assisted Synthesis of 4-(Benzyloxy)-N-(3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl) Benzamide as Challenging Anti-Tubercular Scaffold.
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Molecules |
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| Structure-based design of some isonicotinic acid hydrazide analogues as potential antitubercular agents.
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Malawi Med J |
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| Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.
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| Synthesis, In silico Molecular Docking and Pharmacokinetic Studies, In vitro Antimycobacterial and Antimicrobial Studies of New Imidozolones Clubbed with Thiazolidinedione.
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Front Microbiol |
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| Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
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| Determining Genotypic Drug Resistance by Ion Semiconductor Sequencing With the Ion AmpliSeq™ TB Panel in Multidrug-Resistant Mycobacterium tuberculosis Isolates.
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J Glob Antimicrob Resist |
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| Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.
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J Clin Microbiol |
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| Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study.
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Lancet Infect Dis |
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| Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
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| Next-Generation Sequencing for Characterizing Drug Resistance-Conferring Mycobacterium tuberculosis Genes from Clinical Isolates in the Ukraine.
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| Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.
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| Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.
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| Rational design of isonicotinic acid hydrazide derivatives with antitubercular activity: Machine learning, molecular docking, synthesis and biological testing.
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| Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole.
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| Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.
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| Molecular characterization of mutations associated with resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients from high prevalence tuberculosis city in Morocco.
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| Drug Susceptibility Profiling and Genetic Determinants of Drug Resistance in Mycobacterium kansasii.
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Tuberculosis (Edinb) |
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| Differences in rpoB, katG and inhA mutations between new and previously treated tuberculosis cases using the GenoType MTBDRplus assay.
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Infect Genet Evol |
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| An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors.
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ChemMedChem |
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| Genetic and phenotypic characterizations of drug-resistant Mycobacterium tuberculosis isolates in Cheonan, Korea.
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| Activity-based classification circumvents affinity prediction problems for pyrrolidine carboxamide inhibitors of InhA.
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| Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
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Microb Genom |
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| Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis.
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Korean J Intern Med |
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| Design, synthesis, and pharmacological evaluation of fluorinated azoles as anti-tubercular agents.
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| Triclosan and its derivatives as antimycobacterial active agents.
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| Molecular drug resistance profiles of Mycobacterium tuberculosis from sputum specimens using ion semiconductor sequencing.
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| Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge.
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J Clin Microbiol |
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| Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.
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| Highly Sensitive Detection of Isoniazid Heteroresistance in Mycobacterium tuberculosis by DeepMelt Assay.
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| Emerging resistant clones of Mycobacterium tuberculosis in a spatiotemporal context.
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| Design and synthesis of 9H-fluorenone based 1,2,3-triazole analogues as Mycobacterium tuberculosis InhA inhibitors.
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Chem Biol Drug Des |
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| Analysis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis isolates in Morocco using GenoType(®) MTBDRplus assay.
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| Cell wall permeability assisted virtual screening to identify potential direct InhA inhibitors of Mycobacterium tuberculosis and their biological evaluation.
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| Detection of First-Line Drug Resistance Mutations and Drug-Protein Interaction Dynamics from Tuberculosis Patients in South India.
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Microb Drug Resist |
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| Epidemiology and clinical outcomes of tuberculosis among homeless persons visiting emergency department in public hospital.
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| Hybrid Docking-QSAR Studies of 1, 4-dihydropyridine-3, 5-Dicarboxamides as Potential Antitubercular Agents.
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Curr Comput Aided Drug Des |
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| Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis.
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Chem Sci |
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| Molecular Characterization of Prothionamide-Resistant Mycobacterium tuberculosis Isolates in Southern China.
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Front Microbiol |
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| Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.
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Front Cell Infect Microbiol |
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| A QSAR and molecular modelling study towards new lead finding: polypharmacological approach to Mycobacterium tuberculosis.
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Open Med Chem J |
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| Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety.
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Chem Cent J |
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| Variants of katG, inhA and nat genes are not associated with mutations in efflux pump genes (mmpL3 and mmpL7) in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from India.
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| Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.
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| Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.
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Front Pharmacol |
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| Chemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives: Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis.
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Bioorg Chem |
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| Multiple receptor conformers based molecular docking study of fluorine enhanced ethionamide with mycobacterium enoyl ACP reductase (InhA).
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| Low Frequency of Acquired Isoniazid and Rifampicin Resistance in Rifampicin-Susceptible Pulmonary Tuberculosis in a Setting of High HIV-1 Infection and Tuberculosis Coprevalence.
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| Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis.
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Mol Biol (Mosk) |
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| Use of Genotype MTBDRplus Assay for Diagnosis of Multidrug-Resistant Tuberculosis in Nepal.
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| Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity.
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Molecules |
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| Relation of Mycobacterium tuberculosis mutations at katG315 and inhA-15 with drug resistance profile, genetic background, and clustering in Argentina.
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| Molecular screening of multidrug-resistance tuberculosis by a designated public health laboratory in Taiwan.
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Lett Appl Microbiol |
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| Genetic diversity of Mycobacterium tuberculosis and transmission associated with first-line drug resistance: a first analysis in Jalisco, Mexico.
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J Glob Antimicrob Resist |
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| Frequency of multi-drug resistance and mutations in Mycobacterium tuberculosis isolates from Punjab state of India.
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| Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only.
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BMC Genomics |
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Comp Funct Genomics |
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Scand J Infect Dis |
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| Molecular analysis of isoniazid resistance in different genotypes of Mycobacterium tuberculosis isolates from Iran.
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J Mol Graph Model |
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Diagn Microbiol Infect Dis |
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| Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria.
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Acc Chem Res |
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J Struct Biol |
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| Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis.
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Curr Drug Targets |
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Mem Inst Oswaldo Cruz |
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| Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
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Mol Cell Probes |
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Curr Pharm Des |
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PLoS Pathog |
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Nat Struct Mol Biol |
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| Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
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| Detection of the mutations in katG 315 and inhA -15 of Mycobacterium tuberculosis strains isolated from Chinese patients.
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| GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.
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Cell |
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| The first chemical synthesis of the core structure of the benzoylhydrazine-NAD adduct, a competitive inhibitor of the Mycobacterium tuberculosis enoyl reductase.
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J Org Chem |
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| Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia.
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| Molecular analysis of isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates recovered from Barcelona.
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Microb Drug Resist |
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| Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities.
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Biophys J |
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Infect Immun |
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| Direct detection in clinical samples of multiple gene mutations causing resistance of Mycobacterium tuberculosis to isoniazid and rifampicin using fluorogenic probes.
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| HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis.
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Tuberculosis (Edinb) |
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| Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates from England and Wales reveals the phylogenetic significance of the ahpC -46A polymorphism.
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Org Biomol Chem |
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| Protein-protein interactions within the Fatty Acid Synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability.
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Mol Microbiol |
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| The effects of urokinase instillation therapy via percutaneous transthoracic catheter in loculated tuberculous pleural effusion: a randomized prospective study.
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Yonsei Med J |
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| Detection of mutations associated with isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates from Samara Region, Russian Federation.
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| Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
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J Clin Microbiol |
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| Direct detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis in auramine-rhodamine-positive sputum specimens by real-time PCR.
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J Clin Microbiol |
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| Antimicrobial susceptibility determined by the E test, Löwenstein-Jensen proportion, and DNA sequencing methods among Mycobacterium tuberculosis isolates discrepancies, preliminary results.
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Mem Inst Oswaldo Cruz |
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| Identification of a Mycobacterium tuberculosis strain with stable, low-level resistance to isoniazid.
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| Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes.
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Protein Expr Purif |
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| An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
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Chem Commun (Camb) |
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| In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid.
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| ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates.
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Antimicrob Agents Chemother |
2003 |
| The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion.
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Respirology |
2003 |
| The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.
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Proc Natl Acad Sci U S A |
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| A real-time PCR assay for detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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J Microbiol Methods |
2003 |
| Molecular analysis of isoniazid resistance in Mycobacterium tuberculosis isolates recovered from South Korea.
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Diagn Microbiol Infect Dis |
2003 |
| Detection of resistance to isoniazid by denaturing gradient-gel electrophoresis DNA sequencing in Mycobacterium tuberculosis clinical isolates.
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New Microbiol |
2003 |
| Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis.
doi:10.1128/JCM.41.9.4471-4474.2003
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J Clin Microbiol |
2003 |
| Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis.
doi:10.1128/AAC.47.9.2903-2913.2003
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Antimicrob Agents Chemother |
2003 |
| Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania.
doi:10.1128/AAC.47.6.2009-2011.2003
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Antimicrob Agents Chemother |
2003 |
| 1H and 13C NMR characterization of hemiamidal isoniazid-NAD(H) adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis.
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Chemistry |
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| Esophageal tuberculosis manifesting as submucosal abscess.
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AJR Am J Roentgenol |
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| Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.
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Biochemistry |
2003 |
| Improved real-time PCR for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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Diagn Microbiol Infect Dis |
2003 |
| Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
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J Biol Chem |
2003 |
| Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis.
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Antimicrob Agents Chemother |
2003 |
| Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
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J Biol Chem |
2003 |
| Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.
doi:10.1128/AAC.47.2.670-675.2003
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Antimicrob Agents Chemother |
2003 |
| The TB structural genomics consortium: providing a structural foundation for drug discovery.
doi:10.2174/1568005023342551
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Curr Drug Targets Infect Disord |
2002 |
| Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: dominance of the beijing strain family.
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Emerg Infect Dis |
2002 |
| Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
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Mol Microbiol |
2002 |
| Tuberculous subdeltoid bursitis with rice bodies.
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Yonsei Med J |
2002 |
| Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis.
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Curr Pharm Biotechnol |
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| Agonodepsides a and B: two new depsides from a filamentous fungus F7524.
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J Nat Prod |
2002 |
| Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.
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J Mol Biol |
2002 |
| Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
doi:10.1128/AAC.46.7.2137-2144.2002
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Antimicrob Agents Chemother |
2002 |
| The InhA2 metalloprotease of Bacillus thuringiensis strain 407 is required for pathogenicity in insects infected via the oral route.
doi:10.1128/JB.184.12.3296-3304.2002
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J Bacteriol |
2002 |
| Mycobacterium tuberculosis genes induced during infection of human macrophages.
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Infect Immun |
2002 |
| Rifampin and isoniazid resistance associated mutations in Mycobacterium tuberculosis clinical isolates in Seville, Spain.
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Int J Tuberc Lung Dis |
2002 |
| NADH interactions with WT- and S94A-acyl carrier protein reductase from Mycobacterium tuberculosis: an ab initio study.
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Proteins |
2002 |
| Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
doi:10.1128/AAC.46.2.443-450.2002
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Antimicrob Agents Chemother |
2002 |
| A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts.
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Chembiochem |
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Ann Pharm Fr |
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| Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.
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Antimicrob Agents Chemother |
2001 |
| Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.
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Antimicrob Agents Chemother |
2001 |
| Differential expression of mycobacterial proteins following phagocytosis by macrophages.
doi:10.1099/00221287-147-2-459
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Microbiology (Reading) |
2001 |
| Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.
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Mol Microbiol |
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J UOEH |
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| Genomic mutations in the katG, inhA and aphC genes are useful for the prediction of isoniazid resistance in Mycobacterium tuberculosis isolates from Kwazulu Natal, South Africa.
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Tuber Lung Dis |
2000 |
| Activation of the pro-drug ethionamide is regulated in mycobacteria.
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J Biol Chem |
2000 |
| Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.
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Biochemistry |
2000 |
| Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.
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J Bacteriol |
2000 |
| Orientation of coenzyme A substrates, nicotinamide and active site functional groups in (Di)enoyl-coenzyme A reductases.
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Biochemistry |
2000 |
| Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea.
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Int J Tuberc Lung Dis |
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Probl Tuberk |
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| InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II.
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Microbiology (Reading) |
2000 |
| Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of inha inhibitor.
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J Biol Chem |
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| Molecular mechanisms of drug resistance in Mycobacterium tuberculosis clinical isolates.
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Chin Med J (Engl) |
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| Molecular analysis of rifampin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in Seville, Spain.
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Tuber Lung Dis |
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| Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.
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Biochemistry |
1999 |
| Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
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J Biol Chem |
1999 |
| Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).
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J Clin Microbiol |
1999 |
| Application of molecular methods for detection and transmission analysis of mycobacterium tuberculosis drug resistance in patients attending a reference hospital in Italy.
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J Infect Dis |
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| Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis.
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Biochem J |
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| Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.
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Antimicrob Agents Chemother |
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| Mechanisms of isoniazid resistance in Mycobacterium tuberculosis.
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| Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
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| Mechanisms for isoniazid action and resistance.
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| The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
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Microbiology (Reading) |
1998 |
| Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
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J Infect Dis |
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| Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.
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Emerg Infect Dis |
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| NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.
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J Bacteriol |
1998 |
| Determination of a 15437 bp nucleotide sequence around the inhA gene of Mycobacterium avium and similarity analysis of the products of putative ORFs.
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Microbiology (Reading) |
1998 |
| The rapid diagnosis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis--a molecular story.
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| Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
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| New scoring system using tumor markers in diagnosing patients with moderate pericardial effusions.
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Int J Cardiol |
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| Usefulness of Mycobacterium tuberculosis genomic mutations in the genes katG and inhA for the prediction of isoniazid resistance.
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| Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities.
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Antimicrob Agents Chemother |
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| Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level.
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J Clin Microbiol |
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| Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis.
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J Infect Dis |
1996 |
| katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.
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Antimicrob Agents Chemother |
1996 |
| Determination of the primary target for isoniazid in mycobacterial mycolic acid biosynthesis with Mycobacterium aurum A+.
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Biochem J |
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| Transcatheter instillation of urokinase into loculated pleural effusion: analysis of treatment effect.
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AJR Am J Roentgenol |
1996 |
| ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex.
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Mol Microbiol |
1996 |
| Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family.
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JAMA |
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| Evaluation of inhA gene and catalase-peroxidase gene among isoniazid-sensitive and resistant Mycobacterium tuberculosis isolates.
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Mol Cell Probes |
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| Molecular mechanisms of drug resistance in Mycobacterium tuberculosis.
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| The structure and function of the isoniazid target in M. tuberculosis.
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| Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.
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J Infect Dis |
1996 |
| Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
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Antimicrob Agents Chemother |
1995 |
| Antimicrobial agent resistance in mycobacteria: molecular genetic insights.
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Clin Microbiol Rev |
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| Enoyl-acyl-carrier-protein reductase and Mycobacterium tuberculosis InhA do not conserve the Tyr-Xaa-Xaa-Xaa-Lys motif in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases and Drosophila alcohol dehydrogenase.
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Biochem J |
1995 |
| Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
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Biochemistry |
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| Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.
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| Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis.
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Mol Microbiol |
1995 |
| Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.
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Mol Microbiol |
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| inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
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Science |
1994 |
| Physical delineation of the minimal chromosomal segment encompassing the murine host resistance locus Bcg.
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Genomics |
1993 |
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Genomics |
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Probl Tuberk |
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Beitr Klin Tuberk Spezif Tuberkuloseforsch |
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Praxis |
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Med Monatsschr |
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Arzneimittelforschung |
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Med Klin |
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Beitr Klin Tuberk Spezif Tuberkuloseforsch |
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Dtsch Med J |
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Praxis |
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