MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 2 903 056–3 223 056 bp (320 000 bp)
+ strand − strand Rv2559c (Rv2559c) — requalified: replication-associated recombination protein A Rv2560 (Rv2560) — family_assigned: DUF2189 domain-containing protein Rv2563 (Rv2563) — family_assigned: ABC transporter permease glnQ (Rv2564) — family_assigned: ATP-binding cassette domain-containing protein Rv2565 (Rv2565) — family_assigned: patatin-like phospholipase family protein Rv2567 (Rv2567) — requalified: circularly permuted type 2 ATP-grasp protein Rv2568c (Rv2568c) — family_assigned: putative zinc-binding metallopeptidase Rv2569c (Rv2569c) — family_assigned: transglutaminase family protein Rv2570 (Rv2570) — family_assigned: MmcQ/YjbR family DNA-binding protein Rv2571c (Rv2571c) — family_assigned: aromatic acid exporter family protein aspS (Rv2572c) — requalified: aspartate--tRNA ligase Rv2574 (Rv2574) — family_assigned: SRPBCC family protein Rv2575 (Rv2575) — requalified: neutral zinc metallopeptidase Rv2576c (Rv2576c) — family_assigned: hypothetical protein Rv2577 (Rv2577) — family_assigned: metallophosphoesterase family protein Rv2578c (Rv2578c) — family_assigned: Rv2578c family radical SAM protein hisS (Rv2580c) — requalified: histidine--tRNA ligase Rv2581c (Rv2581c) — requalified: MBL fold metallo-hydrolase relA (Rv2583c) — family_assigned: RelA/SpoT family protein apt (Rv2584c) — requalified: adenine phosphoribosyltransferase Rv2585c (Rv2585c) — family_assigned: ABC transporter substrate-binding protein secF (Rv2586c) — family_assigned: protein translocase subunit SecF secD (Rv2587c) — family_assigned: protein translocase subunit SecD yajC (Rv2588c) — family_assigned: preprotein translocase subunit YajC gabT (Rv2589) — requalified: 4-aminobutyrate--2-oxoglutarate transaminase fadD9 (Rv2590) — requalified: carboxylic acid reductase ruvB (Rv2592c) — requalified: Holliday junction branch migration DNA helicase RuvB ruvA (Rv2593c) — requalified: Holliday junction branch migration protein RuvA ruvC (Rv2594c) — requalified: crossover junction endodeoxyribonuclease RuvC vapB40 (Rv2595) — family_assigned: AbrB/MazE/SpoVT family DNA-binding domain-containing protein vapC40 (Rv2596) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2597 (Rv2597) — dark: DUF4178 domain-containing protein Rv2598 (Rv2598) — family_assigned: DUF2617 family protein Rv2599 (Rv2599) — family_assigned: DUF4247 domain-containing protein vapC41 (Rv2602) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2603c (Rv2603c) — family_assigned: YebC/PmpR family DNA-binding transcriptional regulator snoP (Rv2604c) — family_assigned: pyridoxal 5'-phosphate synthase glutaminase subunit PdxT tesB2 (Rv2605c) — requalified: acyl-CoA thioesterase II snzP (Rv2606c) — family_assigned: pyridoxal 5'-phosphate synthase lyase subunit PdxS pdxH (Rv2607) — requalified: pyridoxamine 5'-phosphate oxidase Rv2609c (Rv2609c) — family_assigned: NUDIX domain-containing protein pimA (Rv2610c) — requalified: phosphatidyl-myo-inositol alpha-mannosyltransferase Rv2611c (Rv2611c) — requalified: phosphatidylinositol mannoside acyltransferase Rv2613c (Rv2613c) — requalified: ATP adenylyltransferase thrS (Rv2614c) — requalified: threonine--tRNA ligase Rv2616 (Rv2616) — family_assigned: DUF1990 family protein Rv2617c (Rv2617c) — family_assigned: DoxX family membrane protein Rv2619c (Rv2619c) — family_assigned: cupin domain-containing protein Rv2620c (Rv2620c) — dark: hypothetical protein Rv2621c (Rv2621c) — family_assigned: helix-turn-helix domain-containing protein Rv2622 (Rv2622) — family_assigned: methyltransferase domain-containing protein TB31.7 (Rv2623) — requalified: universal stress protein TB31.7 Rv2625c (Rv2625c) — family_assigned: site-2 protease family protein hrp1 (Rv2626c) — requalified: hypoxic response protein Hrp1 Rv2627c (Rv2627c) — family_assigned: alpha/beta hydrolase Rv2629 (Rv2629) — family_assigned: hypothetical protein Rv2630 (Rv2630) — requalified: archease Rv2632c (Rv2632c) — family_assigned: DUF1876 domain-containing protein Rv2633c (Rv2633c) — requalified: non-heme di-iron catalase Rv2635 (Rv2635) — requalified: hypothetical protein Rv2636 (Rv2636) — family_assigned: chloramphenicol phosphotransferase CPT family protein dedA (Rv2637) — family_assigned: DedA family protein Rv2638 (Rv2638) — requalified: anti-sigma factor antagonist Rv2639c (Rv2639c) — family_assigned: YnfA family protein Rv2640c (Rv2640c) — family_assigned: Rv2640c family ArsR-like transcriptional regulator cadI (Rv2641) — requalified: cadmium-induced metalloenzyme CadI Rv2642 (Rv2642) — family_assigned: metalloregulator ArsR/SmtB family transcription factor arsC (Rv2643) — family_assigned: ACR3 family arsenite efflux transporter Rv2645 (Rv2645) — family_assigned: hypothetical protein Rv2646 (Rv2646) — requalified: tyrosine-type recombinase/integrase Rv2650c (Rv2650c) — requalified: phage major capsid protein Rv2651c (Rv2651c) — family_assigned: HK97 family phage prohead protease Rv2653c (Rv2653c) — requalified: type II toxin-antitoxin system toxin Rv2654c (Rv2654c) — requalified: type II toxin-antitoxin system antitoxin Rv2655c (Rv2655c) — family_assigned: DUF3631 domain-containing protein Rv2656c (Rv2656c) — dark: DUF2742 domain-containing protein Rv2657c (Rv2657c) — family_assigned: helix-turn-helix domain-containing protein Rv2658c (Rv2658c) — family_assigned: hypothetical protein Rv2659c (Rv2659c) — requalified: tyrosine-type recombinase/integrase Rv2660c (Rv2660c) — dark: hypothetical protein Rv2661c (Rv2661c) — dark: hypothetical protein Rv2662 (Rv2662) — dark: hypothetical protein Rv2663 (Rv2663) — requalified: hypothetical protein Rv2664 (Rv2664) — family_assigned: hypothetical protein Rv2665 (Rv2665) — requalified: arginine RICH protein Rv2668 (Rv2668) — family_assigned: hypothetical protein Rv2669 (Rv2669) — requalified: N-acetyltransferase zapE (Rv2670c) — requalified: cell division protein ZapE ribD (Rv2671) — requalified: bifunctional diaminohydroxyphosphoribosylaminopyrimidine dea Rv2672 (Rv2672) — requalified: alpha/beta fold hydrolase aftC (Rv2673) — requalified: arabinofuranan 3-O-arabinosyltransferase msrB (Rv2674) — requalified: peptide-methionine (R)-S-oxide reductase MsrB Rv2675c (Rv2675c) — requalified: class I SAM-dependent methyltransferase hemQ (Rv2676c) — requalified: hydrogen peroxide-dependent heme synthase hemE (Rv2678c) — requalified: uroporphyrinogen decarboxylase echA15 (Rv2679) — family_assigned: enoyl-CoA hydratase/isomerase family protein Rv2680 (Rv2680) — dark: DUF3000 domain-containing protein Rv2681 (Rv2681) — requalified: ribonuclease D arsA (Rv2684) — family_assigned: ArsB/NhaD family transporter Rv2686c (Rv2686c) — family_assigned: fluoroquinolones efflux ABC transporter permease Rv2687c (Rv2687c) — family_assigned: fluoroquinolone transporter permease Rv2688c (Rv2688c) — family_assigned: ABC transporter ATP-binding protein Rv2689c (Rv2689c) — requalified: class I SAM-dependent RNA methyltransferase Rv2693c (Rv2693c) — dark: DUF3159 domain-containing protein Rv2694c (Rv2694c) — family_assigned: OB-fold nucleic acid binding domain-containing protein Rv2695 (Rv2695) — requalified: alpha/beta fold hydrolase Rv2696c (Rv2696c) — dark: DUF3710 domain-containing protein Rv2698 (Rv2698) — dark: DUF3093 domain-containing protein Rv2699c (Rv2699c) — dark: DUF4193 domain-containing protein cei (Rv2700) — requalified: envelope integrity protein Cei suhB (Rv2701c) — requalified: inositol-1-monophosphatase SuhB ppgK (Rv2702) — family_assigned: ROK family protein sigA (Rv2703) — requalified: RNA polymerase sigma factor Rv2704 (Rv2704) — family_assigned: RidA family protein Rv2705c (Rv2705c) — family_assigned: DUF952 domain-containing protein Rv2706c (Rv2706c) — dark: hypothetical protein Rv2707 (Rv2707) — family_assigned: YihY/virulence factor BrkB family protein Rv2709 (Rv2709) — dark: DUF3099 domain-containing protein sigB (Rv2710) — family_assigned: sigma-70 family RNA polymerase sigma factor SigB ideR (Rv2711) — family_assigned: iron-dependent transcriptional regulator IdeR Rv2712c (Rv2712c) — dark: DUF4192 domain-containing protein sthA (Rv2713) — requalified: Si-specific NAD(P)(+) transhydrogenase Rv2714 (Rv2714) — family_assigned: PAC2 family protein Rv2715 (Rv2715) — family_assigned: alpha/beta hydrolase Rv2716 (Rv2716) — family_assigned: PhzF family phenazine biosynthesis protein Rv2717c (Rv2717c) — family_assigned: FABP family protein nrdR (Rv2718c) — family_assigned: transcriptional regulator NrdR chiZ (Rv2719c) — requalified: cell wall hydrolase ChiZ lexA (Rv2720) — requalified: transcriptional repressor LexA Rv2721c (Rv2721c) — family_assigned: LGFP repeat-containing protein Rv2722 (Rv2722) — dark: hypothetical protein Rv2723 (Rv2723) — family_assigned: TerC/Alx family metal homeostasis membrane protein fadE20 (Rv2724c) — family_assigned: acyl-CoA dehydrogenase family protein dapF (Rv2726c) — requalified: diaminopimelate epimerase miaA (Rv2727c) — requalified: tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA Rv2728c (Rv2728c) — family_assigned: hypothetical protein Rv2729c (Rv2729c) — family_assigned: DMT family transporter Rv2730 (Rv2730) — dark: hypothetical protein Rv2731 (Rv2731) — family_assigned: DUF349 domain-containing protein Rv2732c (Rv2732c) — family_assigned: hypothetical protein miaB (Rv2733c) — requalified: tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase Rv2734 (Rv2734) — family_assigned: DUF5131 family protein Rv2735c (Rv2735c) — requalified: three-Cys-motif partner protein TcmP recX (Rv2736c) — requalified: recombination regulator RecX recA (Rv2737c) — requalified: intein-containing recombinase RecA Rv2738c (Rv2738c) — family_assigned: DUF3046 domain-containing protein Rv2739c (Rv2739c) — requalified: glycosyltransferase ephG (Rv2740) — requalified: epoxide hydrolase Rv2743c (Rv2743c) — family_assigned: hypothetical protein clgR (Rv2745c) — family_assigned: transcriptional regulator ClgR argA (Rv2747) — requalified: amino-acid N-acetyltransferase ftsK (Rv2748c) — requalified: DNA translocase FtsK Rv2749 (Rv2749) — family_assigned: putative quinol monooxygenase Rv2750 (Rv2750) — family_assigned: Rv2750 family mycofactocin-dependent SDR oxidoreductase Rv2751 (Rv2751) — requalified: class I SAM-dependent methyltransferase rnj (Rv2752c) — requalified: ribonuclease J dapA (Rv2753c) — requalified: 4-hydroxy-tetrahydrodipicolinate synthase thyX (Rv2754c) — requalified: FAD-dependent thymidylate synthase hsdM (Rv2756c) — requalified: class I SAM-dependent DNA methyltransferase vapC21 (Rv2757c) — requalified: type II toxin-antitoxin system toxin ribonuclease C21 vapB21 (Rv2758c) — family_assigned: type II toxin-antitoxin system VapB family antitoxin vapC42 (Rv2759c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB42 (Rv2760c) — family_assigned: type II toxin-antitoxin system VapB family antitoxin hsdS (Rv2761c) — family_assigned: restriction endonuclease subunit S Rv2762c (Rv2762c) — family_assigned: winged helix-turn-helix domain-containing protein qcrA (Rv2195) — requalified: hypothetical protein dfrA (Rv2763c) — requalified: dihydrofolate reductase Rv2765 (Rv2765) — family_assigned: dienelactone hydrolase family protein Rv2767c (Rv2767c) — family_assigned: hypothetical protein Rv2771c (Rv2771c) — family_assigned: flavodoxin family protein Rv2772c (Rv2772c) — family_assigned: hypothetical protein dapB (Rv2773c) — requalified: 4-hydroxy-tetrahydrodipicolinate reductase Rv2774c (Rv2774c) — dark: hypothetical protein Rv2777c (Rv2777c) — requalified: metal-dependent hydrolase Rv2778c (Rv2778c) — family_assigned: SRPBCC family protein ald (Rv2780) — requalified: alanine dehydrogenase Rv2781c (Rv2781c) — requalified: nitronate monooxygenase pepR (Rv2782c) — family_assigned: pitrilysin family protein gpsI (Rv2783c) — requalified: polyribonucleotide nucleotidyltransferase lppU (Rv2784c) — dark: hypothetical protein Rv2787 (Rv2787) — family_assigned: AAA family ATPase sirR (Rv2788) — family_assigned: manganese-binding transcriptional regulator MntR fadE21 (Rv2789c) — family_assigned: acyl-CoA dehydrogenase family protein ltp1 (Rv2790c) — requalified: lipid-transfer protein truB (Rv2793c) — requalified: tRNA pseudouridine(55) synthase TruB pptT (Rv2794c) — requalified: 4'-phosphopantetheinyl transferase Rv2795c (Rv2795c) — requalified: metallophosphoesterase lppV (Rv2796c) — family_assigned: LppA family lipoprotein Rv2797c (Rv2797c) — family_assigned: alpha/beta hydrolase family protein Rv2798c (Rv2798c) — family_assigned: hypothetical protein Rv2800 (Rv2800) — family_assigned: CocE/NonD family hydrolase mazF9 (Rv2801c) — requalified: type II toxin-antitoxin system toxin endoribonuclease MazF9 Rv2802c (Rv2802c) — dark: DUF2293 domain-containing protein Rv2806 (Rv2806) — dark: hypothetical protein Rv2805 (Rv2805) — requalified: transposase Rv2808 (Rv2808) — requalified: hypothetical protein Rv2809 (Rv2809) — family_assigned: hypothetical protein Rv2811 (Rv2811) — family_assigned: hypothetical protein Rv2813 (Rv2813) — family_assigned: ExeA family protein cas2 (Rv2816c) — requalified: CRISPR-associated endonuclease Cas2 cas1 (Rv2817c) — requalified: CRISPR-associated endonuclease Cas1 csm5 (Rv2819c) — requalified: type III-A CRISPR-associated RAMP protein Csm5 csm4 (Rv2820c) — requalified: type III-A CRISPR-associated RAMP protein Csm4 csm3 (Rv2821c) — requalified: type III-A CRISPR-associated RAMP protein Csm3 csm2 (Rv2822c) — requalified: type III-A CRISPR-associated protein Csm2 cas10 (Rv2823c) — requalified: type III-A CRISPR-associated protein Cas10/Csm1 Rv2826c (Rv2826c) — family_assigned: nucleotidyl transferase AbiEii/AbiGii toxin family protein Rv2827c (Rv2827c) — family_assigned: type IV toxin-antitoxin system AbiEi family antitoxin Rv2828c (Rv2828c) — family_assigned: DUF1802 family protein vapC22 (Rv2829c) — family_assigned: PIN domain-containing protein vapB22 (Rv2830c) — family_assigned: type II toxin-antitoxin system prevent-host-death family ant echA16 (Rv2831) — requalified: enoyl-CoA hydratase ugpC (Rv2832c) — family_assigned: ABC transporter ATP-binding protein ugpB (Rv2833c) — family_assigned: ABC transporter substrate-binding protein ugpE (Rv2834c) — family_assigned: carbohydrate ABC transporter permease ugpA (Rv2835c) — family_assigned: sugar ABC transporter permease dinF (Rv2836c) — family_assigned: MATE family efflux transporter nrnA (Rv2837c) — requalified: bifunctional oligoribonuclease/PAP phosphatase NrnA rbfA (Rv2838c) — requalified: 30S ribosome-binding factor RbfA infB (Rv2839c) — requalified: translation initiation factor IF-2 nusA (Rv2841c) — requalified: transcription termination factor NusA rimP (Rv2842c) — requalified: ribosome maturation factor RimP Rv2843 (Rv2843) — family_assigned: hypothetical protein Rv2844 (Rv2844) — family_assigned: ferritin-like domain-containing protein proS (Rv2845c) — requalified: proline--tRNA ligase efpA (Rv2846c) — requalified: multidrug efflux MFS transporter EfpA cysG (Rv2847c) — requalified: uroporphyrinogen-III C-methyltransferase cobB (Rv2848c) — requalified: cobyrinate a%2Cc-diamide synthase Rv2850c (Rv2850c) — family_assigned: magnesium chelatase subunit D family protein Rv2851c (Rv2851c) — family_assigned: GNAT family N-acetyltransferase mqo (Rv2852c) — requalified: malate dehydrogenase (quinone) Rv2854 (Rv2854) — family_assigned: alpha/beta hydrolase nicT (Rv2856) — family_assigned: HoxN/HupN/NixA family nickel/cobalt transporter Rv2857c (Rv2857c) — requalified: 3-oxoacyl-ACP reductase Rv2859c (Rv2859c) — requalified: gamma-glutamyl-gamma-aminobutyrate hydrolase glnA4 (Rv2860c) — family_assigned: glutamine synthetase family protein Rv2862c (Rv2862c) — family_assigned: DUF1707 domain-containing protein vapC23 (Rv2863) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2864c (Rv2864c) — family_assigned: penicillin-binding protein relF (Rv2865) — requalified: type II toxin-antitoxin system antitoxin RelF relG (Rv2866) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin Rv2867c (Rv2867c) — family_assigned: GNAT family N-acetyltransferase gcpE (Rv2868c) — requalified: flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphos rip (Rv2869c) — requalified: zinc metalloprotease Rip dxr (Rv2870c) — requalified: 1-deoxy-D-xylulose-5-phosphate reductoisomerase vapB43 (Rv2871) — family_assigned: ribbon-helix-helix domain-containing protein vapC43 (Rv2872) — family_assigned: type II toxin-antitoxin system VapC family toxin mpt83 (Rv2873) — requalified: cell surface glycolipoprotein Mpt83 mpt70 (Rv2875) — family_assigned: fasciclin domain-containing protein mpt53 (Rv2878c) — requalified: protein disulfide oxidoreductase cdsA (Rv2881c) — requalified: phosphatidate cytidylyltransferase frr (Rv2882c) — requalified: ribosome recycling factor pyrH (Rv2883c) — requalified: UMP kinase Rv2887 (Rv2887) — family_assigned: MarR family transcriptional regulator amiC (Rv2888c) — requalified: amidase tsf (Rv2889c) — requalified: translation elongation factor Ts rpsB (Rv2890c) — requalified: 30S ribosomal protein S2 2 942 kb 2 996 kb 3 050 kb 3 103 kb 3 156 kb 3 210 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.