MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 2 738 836–3 058 836 bp (320 000 bp)
+ strand − strand Rv2417c (Rv2417c) — family_assigned: DegV family protein octT (Rv2418c) — requalified: diglucosylglycerate octanoyltransferase gpgP (Rv2419c) — requalified: glucosyl-3-phosphoglycerate phosphatase rsfS (Rv2420c) — requalified: ribosome silencing factor Rv2422 (Rv2422) — family_assigned: hypothetical protein Rv2423 (Rv2423) — requalified: class I SAM-dependent methyltransferase Rv2425c (Rv2425c) — family_assigned: VWA domain-containing protein Rv2426c (Rv2426c) — family_assigned: MoxR family ATPase proA (Rv2427c) — requalified: glutamate-5-semialdehyde dehydrogenase ahpC (Rv2428) — requalified: peroxiredoxin AhpC ahpD (Rv2429) — requalified: alkyl hydroperoxide reductase Rv2432c (Rv2432c) — dark: hypothetical protein nrtS (Rv2433c) — requalified: nitrate/nitrite transporter NrtS Rv2434c (Rv2434c) — requalified: mechanosensitive ion channel Rv2435c (Rv2435c) — family_assigned: adenylate/guanylate cyclase domain-containing protein rbsK (Rv2436) — requalified: ribokinase RbsK Rv2437 (Rv2437) — family_assigned: isoprenylcysteine carboxylmethyltransferase family protein nadE (Rv2438c) — requalified: NAD(+) synthase proB (Rv2439c) — requalified: glutamate 5-kinase obg (Rv2440c) — requalified: GTPase ObgE rpmA (Rv2441c) — requalified: 50S ribosomal protein L27 rplU (Rv2442c) — requalified: 50S ribosomal protein L21 dctA (Rv2443) — family_assigned: cation:dicarboxylase symporter family transporter rne (Rv2444c) — family_assigned: Rne/Rng family ribonuclease ndkA (Rv2445c) — requalified: nucleoside-diphosphate kinase Rv2446c (Rv2446c) — dark: DUF4233 domain-containing protein folC (Rv2447c) — requalified: bifunctional tetrahydrofolate synthase/dihydrofolate synthas Rv2449c (Rv2449c) — family_assigned: trans-acting enoyl reductase family protein rpfE (Rv2450c) — requalified: resuscitation-promoting factor protein RpfE Rv2451 (Rv2451) — dark: hypothetical protein Rv2452c (Rv2452c) — dark: hypothetical protein mobA (Rv2453c) — requalified: molybdenum cofactor guanylyltransferase Rv2454c (Rv2454c) — family_assigned: 2-oxoacid:ferredoxin oxidoreductase subunit beta Rv2455c (Rv2455c) — family_assigned: 2-oxoacid:acceptor oxidoreductase subunit alpha Rv2456c (Rv2456c) — requalified: MFS transporter clpX (Rv2457c) — family_assigned: ATP-dependent Clp protease ATP-binding subunit ClpX mmuM (Rv2458) — requalified: homocysteine S-methyltransferase jefA (Rv2459) — requalified: multidrug efflux pump JefA clpP2 (Rv2460c) — family_assigned: ATP-dependent CLP protease proteolytic subunit ClpP2 tig (Rv2462c) — requalified: trigger factor lipP (Rv2463) — family_assigned: serine hydrolase domain-containing protein Rv2464c (Rv2464c) — family_assigned: Fpg/Nei family DNA glycosylase Rv2466c (Rv2466c) — family_assigned: Rv2466c family mycothiol-dependent reductase Rv2469c (Rv2469c) — requalified: HNH endonuclease glbO (Rv2470) — requalified: group 2 truncated hemoglobin GlbO aglA (Rv2471) — family_assigned: glycoside hydrolase family 13 protein Rv2472 (Rv2472) — dark: hypothetical protein Rv2473 (Rv2473) — dark: hypothetical protein Rv2474c (Rv2474c) — family_assigned: hypothetical protein Rv2475c (Rv2475c) — family_assigned: thioesterase family protein gdh (Rv2476c) — requalified: NAD-glutamate dehydrogenase ettA (Rv2477c) — requalified: energy-dependent translational throttle protein EttA Rv2481c (Rv2481c) — family_assigned: hypothetical protein plsB2 (Rv2482c) — requalified: glycerol-3-phosphate 1-O-acyltransferase plsC (Rv2483c) — family_assigned: HAD-IB family hydrolase Rv2484c (Rv2484c) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase lipQ (Rv2485c) — family_assigned: alpha/beta hydrolase echA14 (Rv2486) — requalified: enoyl-CoA hydratase Rv2489c (Rv2489c) — dark: hypothetical protein Rv2491 (Rv2491) — family_assigned: TIGR00725 family protein Rv2492 (Rv2492) — requalified: hypothetical protein vapB38 (Rv2493) — requalified: antitoxin vapC38 (Rv2494) — family_assigned: type II toxin-antitoxin system VapC family toxin bkdC (Rv2495c) — family_assigned: dihydrolipoamide acetyltransferase family protein bkdB (Rv2496c) — family_assigned: 3-methyl-2-oxobutanoate dehydrogenase subunit beta bkdA (Rv2497c) — family_assigned: pyruvate dehydrogenase (acetyl-transferring) E1 component su citE (Rv2498c) — family_assigned: citrate (pro-3S)-lyase subunit beta Rv2499c (Rv2499c) — family_assigned: MaoC family dehydratase fadE19 (Rv2500c) — family_assigned: acyl-CoA dehydrogenase family protein accA1 (Rv2501c) — family_assigned: acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alph accD1 (Rv2502c) — family_assigned: acetyl-/propionyl-CoA carboxylase subunit beta scoB (Rv2503c) — family_assigned: succinyl-CoA--3-ketoacid CoA transferase subunit B scoA (Rv2504c) — family_assigned: succinyl-CoA--3-ketoacid CoA transferase subunit A fadD35 (Rv2505c) — family_assigned: AMP-binding protein Rv2506 (Rv2506) — family_assigned: TetR/AcrR family transcriptional regulator Rv2507 (Rv2507) — family_assigned: MmpS family transport accessory protein Rv2508c (Rv2508c) — requalified: MFS transporter cmrA (Rv2509) — requalified: mycolate reductase Rv2510c (Rv2510c) — family_assigned: DUF853 domain-containing protein orn (Rv2511) — requalified: oligoribonuclease Rv2513 (Rv2513) — dark: hypothetical protein Rv2514c (Rv2514c) — family_assigned: DUF4411 family protein Rv2515c (Rv2515c) — family_assigned: XRE family transcriptional regulator Rv2516c (Rv2516c) — dark: hypothetical protein Rv2517c (Rv2517c) — dark: hypothetical protein ldtB (Rv2518c) — requalified: L%2CD-transpeptidase LdtMt2 Rv2520c (Rv2520c) — dark: DUF3618 domain-containing protein bcp (Rv2521) — requalified: thioredoxin-dependent thiol peroxidase Rv2522c (Rv2522c) — requalified: dipeptidase acpS (Rv2523c) — requalified: holo-ACP synthase fas (Rv2524c) — requalified: fatty acid synthase fas Rv2525c (Rv2525c) — family_assigned: DUF1906 domain-containing protein vapB17 (Rv2526) — family_assigned: type II toxin-antitoxin system VapB family antitoxin vapC17 (Rv2527) — family_assigned: PIN domain-containing protein mrr (Rv2528c) — requalified: restriction endonuclease vapC39 (Rv2530c) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2532c (Rv2532c) — requalified: antitermination protein NusB nusB (Rv2533c) — requalified: transcription antitermination factor NusB pepQ (Rv2535c) — family_assigned: Xaa-Pro peptidase family protein Rv2536 (Rv2536) — family_assigned: B-4DMT family transporter aroD (Rv2537c) — requalified: type II 3-dehydroquinate dehydratase aroB (Rv2538c) — requalified: 3-dehydroquinate synthase aroK (Rv2539c) — requalified: shikimate kinase AroK aroF (Rv2540c) — requalified: chorismate synthase Rv2542 (Rv2542) — family_assigned: alpha/beta hydrolase family protein lppA (Rv2543) — family_assigned: LppA family lipoprotein lppB (Rv2544) — family_assigned: LppA family lipoprotein vapB18 (Rv2545) — family_assigned: type II toxin-antitoxin system VapB family antitoxin vapC18 (Rv2546) — family_assigned: PIN domain nuclease vapB19 (Rv2547) — family_assigned: CopG family transcriptional regulator vapC19 (Rv2548) — family_assigned: type II toxin-antitoxin system VapC family toxin vapC20 (Rv2549c) — requalified: type II toxin-antitoxin system toxin 23S rRNA-specific endon vapB20 (Rv2550c) — requalified: type II toxin-antitoxin system antitoxin VapB20 Rv2551c (Rv2551c) — family_assigned: A24 family peptidase aroE (Rv2552c) — requalified: shikimate dehydrogenase mltG (Rv2553c) — requalified: endolytic transglycosylase MltG ruvX (Rv2554c) — requalified: Holliday junction resolvase RuvX alaS (Rv2555c) — requalified: alanine--tRNA ligase Rv2556c (Rv2556c) — requalified: secondary thiamine-phosphate synthase enzyme YjbQ Rv2559c (Rv2559c) — requalified: replication-associated recombination protein A Rv2560 (Rv2560) — family_assigned: DUF2189 domain-containing protein Rv2563 (Rv2563) — family_assigned: ABC transporter permease glnQ (Rv2564) — family_assigned: ATP-binding cassette domain-containing protein Rv2565 (Rv2565) — family_assigned: patatin-like phospholipase family protein Rv2567 (Rv2567) — requalified: circularly permuted type 2 ATP-grasp protein Rv2568c (Rv2568c) — family_assigned: putative zinc-binding metallopeptidase Rv2569c (Rv2569c) — family_assigned: transglutaminase family protein Rv2570 (Rv2570) — family_assigned: MmcQ/YjbR family DNA-binding protein Rv2571c (Rv2571c) — family_assigned: aromatic acid exporter family protein aspS (Rv2572c) — requalified: aspartate--tRNA ligase Rv2574 (Rv2574) — family_assigned: SRPBCC family protein Rv2575 (Rv2575) — requalified: neutral zinc metallopeptidase Rv2576c (Rv2576c) — family_assigned: hypothetical protein Rv2577 (Rv2577) — family_assigned: metallophosphoesterase family protein Rv2578c (Rv2578c) — family_assigned: Rv2578c family radical SAM protein hisS (Rv2580c) — requalified: histidine--tRNA ligase Rv2581c (Rv2581c) — requalified: MBL fold metallo-hydrolase relA (Rv2583c) — family_assigned: RelA/SpoT family protein apt (Rv2584c) — requalified: adenine phosphoribosyltransferase Rv2585c (Rv2585c) — family_assigned: ABC transporter substrate-binding protein secF (Rv2586c) — family_assigned: protein translocase subunit SecF secD (Rv2587c) — family_assigned: protein translocase subunit SecD yajC (Rv2588c) — family_assigned: preprotein translocase subunit YajC gabT (Rv2589) — requalified: 4-aminobutyrate--2-oxoglutarate transaminase fadD9 (Rv2590) — requalified: carboxylic acid reductase ruvB (Rv2592c) — requalified: Holliday junction branch migration DNA helicase RuvB ruvA (Rv2593c) — requalified: Holliday junction branch migration protein RuvA ruvC (Rv2594c) — requalified: crossover junction endodeoxyribonuclease RuvC vapB40 (Rv2595) — family_assigned: AbrB/MazE/SpoVT family DNA-binding domain-containing protein vapC40 (Rv2596) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2597 (Rv2597) — dark: DUF4178 domain-containing protein Rv2598 (Rv2598) — family_assigned: DUF2617 family protein Rv2599 (Rv2599) — family_assigned: DUF4247 domain-containing protein vapC41 (Rv2602) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2603c (Rv2603c) — family_assigned: YebC/PmpR family DNA-binding transcriptional regulator snoP (Rv2604c) — family_assigned: pyridoxal 5'-phosphate synthase glutaminase subunit PdxT tesB2 (Rv2605c) — requalified: acyl-CoA thioesterase II snzP (Rv2606c) — family_assigned: pyridoxal 5'-phosphate synthase lyase subunit PdxS pdxH (Rv2607) — requalified: pyridoxamine 5'-phosphate oxidase Rv2609c (Rv2609c) — family_assigned: NUDIX domain-containing protein pimA (Rv2610c) — requalified: phosphatidyl-myo-inositol alpha-mannosyltransferase Rv2611c (Rv2611c) — requalified: phosphatidylinositol mannoside acyltransferase Rv2613c (Rv2613c) — requalified: ATP adenylyltransferase thrS (Rv2614c) — requalified: threonine--tRNA ligase Rv2616 (Rv2616) — family_assigned: DUF1990 family protein Rv2617c (Rv2617c) — family_assigned: DoxX family membrane protein Rv2619c (Rv2619c) — family_assigned: cupin domain-containing protein Rv2620c (Rv2620c) — dark: hypothetical protein Rv2621c (Rv2621c) — family_assigned: helix-turn-helix domain-containing protein Rv2622 (Rv2622) — family_assigned: methyltransferase domain-containing protein TB31.7 (Rv2623) — requalified: universal stress protein TB31.7 Rv2625c (Rv2625c) — family_assigned: site-2 protease family protein hrp1 (Rv2626c) — requalified: hypoxic response protein Hrp1 Rv2627c (Rv2627c) — family_assigned: alpha/beta hydrolase Rv2629 (Rv2629) — family_assigned: hypothetical protein Rv2630 (Rv2630) — requalified: archease Rv2632c (Rv2632c) — family_assigned: DUF1876 domain-containing protein Rv2633c (Rv2633c) — requalified: non-heme di-iron catalase Rv2635 (Rv2635) — requalified: hypothetical protein Rv2636 (Rv2636) — family_assigned: chloramphenicol phosphotransferase CPT family protein dedA (Rv2637) — family_assigned: DedA family protein Rv2638 (Rv2638) — requalified: anti-sigma factor antagonist Rv2639c (Rv2639c) — family_assigned: YnfA family protein Rv2640c (Rv2640c) — family_assigned: Rv2640c family ArsR-like transcriptional regulator cadI (Rv2641) — requalified: cadmium-induced metalloenzyme CadI Rv2642 (Rv2642) — family_assigned: metalloregulator ArsR/SmtB family transcription factor arsC (Rv2643) — family_assigned: ACR3 family arsenite efflux transporter Rv2645 (Rv2645) — family_assigned: hypothetical protein Rv2646 (Rv2646) — requalified: tyrosine-type recombinase/integrase Rv2650c (Rv2650c) — requalified: phage major capsid protein Rv2651c (Rv2651c) — family_assigned: HK97 family phage prohead protease Rv2653c (Rv2653c) — requalified: type II toxin-antitoxin system toxin Rv2654c (Rv2654c) — requalified: type II toxin-antitoxin system antitoxin Rv2655c (Rv2655c) — family_assigned: DUF3631 domain-containing protein Rv2656c (Rv2656c) — dark: DUF2742 domain-containing protein Rv2657c (Rv2657c) — family_assigned: helix-turn-helix domain-containing protein Rv2658c (Rv2658c) — family_assigned: hypothetical protein Rv2659c (Rv2659c) — requalified: tyrosine-type recombinase/integrase Rv2660c (Rv2660c) — dark: hypothetical protein Rv2661c (Rv2661c) — dark: hypothetical protein Rv2662 (Rv2662) — dark: hypothetical protein Rv2663 (Rv2663) — requalified: hypothetical protein Rv2664 (Rv2664) — family_assigned: hypothetical protein Rv2665 (Rv2665) — requalified: arginine RICH protein Rv2668 (Rv2668) — family_assigned: hypothetical protein Rv2669 (Rv2669) — requalified: N-acetyltransferase zapE (Rv2670c) — requalified: cell division protein ZapE ribD (Rv2671) — requalified: bifunctional diaminohydroxyphosphoribosylaminopyrimidine dea Rv2672 (Rv2672) — requalified: alpha/beta fold hydrolase aftC (Rv2673) — requalified: arabinofuranan 3-O-arabinosyltransferase msrB (Rv2674) — requalified: peptide-methionine (R)-S-oxide reductase MsrB Rv2675c (Rv2675c) — requalified: class I SAM-dependent methyltransferase hemQ (Rv2676c) — requalified: hydrogen peroxide-dependent heme synthase hemE (Rv2678c) — requalified: uroporphyrinogen decarboxylase echA15 (Rv2679) — family_assigned: enoyl-CoA hydratase/isomerase family protein Rv2680 (Rv2680) — dark: DUF3000 domain-containing protein Rv2681 (Rv2681) — requalified: ribonuclease D arsA (Rv2684) — family_assigned: ArsB/NhaD family transporter Rv2686c (Rv2686c) — family_assigned: fluoroquinolones efflux ABC transporter permease Rv2687c (Rv2687c) — family_assigned: fluoroquinolone transporter permease Rv2688c (Rv2688c) — family_assigned: ABC transporter ATP-binding protein Rv2689c (Rv2689c) — requalified: class I SAM-dependent RNA methyltransferase Rv2693c (Rv2693c) — dark: DUF3159 domain-containing protein Rv2694c (Rv2694c) — family_assigned: OB-fold nucleic acid binding domain-containing protein Rv2695 (Rv2695) — requalified: alpha/beta fold hydrolase Rv2696c (Rv2696c) — dark: DUF3710 domain-containing protein Rv2698 (Rv2698) — dark: DUF3093 domain-containing protein Rv2699c (Rv2699c) — dark: DUF4193 domain-containing protein cei (Rv2700) — requalified: envelope integrity protein Cei suhB (Rv2701c) — requalified: inositol-1-monophosphatase SuhB ppgK (Rv2702) — family_assigned: ROK family protein sigA (Rv2703) — requalified: RNA polymerase sigma factor Rv2704 (Rv2704) — family_assigned: RidA family protein Rv2705c (Rv2705c) — family_assigned: DUF952 domain-containing protein Rv2706c (Rv2706c) — dark: hypothetical protein Rv2707 (Rv2707) — family_assigned: YihY/virulence factor BrkB family protein Rv2709 (Rv2709) — dark: DUF3099 domain-containing protein sigB (Rv2710) — family_assigned: sigma-70 family RNA polymerase sigma factor SigB ideR (Rv2711) — family_assigned: iron-dependent transcriptional regulator IdeR Rv2712c (Rv2712c) — dark: DUF4192 domain-containing protein sthA (Rv2713) — requalified: Si-specific NAD(P)(+) transhydrogenase Rv2714 (Rv2714) — family_assigned: PAC2 family protein Rv2715 (Rv2715) — family_assigned: alpha/beta hydrolase Rv2716 (Rv2716) — family_assigned: PhzF family phenazine biosynthesis protein Rv2717c (Rv2717c) — family_assigned: FABP family protein nrdR (Rv2718c) — family_assigned: transcriptional regulator NrdR chiZ (Rv2719c) — requalified: cell wall hydrolase ChiZ lexA (Rv2720) — requalified: transcriptional repressor LexA Rv2721c (Rv2721c) — family_assigned: LGFP repeat-containing protein Rv2722 (Rv2722) — dark: hypothetical protein Rv2723 (Rv2723) — family_assigned: TerC/Alx family metal homeostasis membrane protein fadE20 (Rv2724c) — family_assigned: acyl-CoA dehydrogenase family protein 2 782 kb 2 836 kb 2 889 kb 2 942 kb 2 996 kb 3 050 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.