MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 2 331 722–2 731 722 bp (400 000 bp)
+ strand − strand pks12 (Rv2048c) — requalified: type I polyketide synthase rbpA (Rv2050) — family_assigned: RNA polymerase-binding protein RbpA ppm1 (Rv2051c) — requalified: apolipoprotein N-acyltransferase Rv2052c (Rv2052c) — requalified: amidohydrolase fxsA (Rv2053c) — family_assigned: FxsA family protein Rv2054 (Rv2054) — family_assigned: dienelactone hydrolase family protein rpsR2 (Rv2055c) — requalified: 30S ribosomal protein S18 rpsN2 (Rv2056c) — requalified: 30S ribosomal protein S14 rpmB2 (Rv2058c) — requalified: 50S ribosomal protein L28 Rv2061c (Rv2061c) — requalified: PPOX class F420-dependent oxidoreductase cobN (Rv2062c) — family_assigned: cobaltochelatase subunit CobN cobG (Rv2064) — requalified: precorrin-3B synthase cobH (Rv2065) — requalified: precorrin-8X methylmutase cobIJ (Rv2066) — requalified: precorrin-2 C(20)-methyltransferase Rv2067c (Rv2067c) — requalified: class I SAM-dependent methyltransferase sigC (Rv2069) — requalified: RNA polymerase sigma factor SigC cobK (Rv2070c) — requalified: cobalt-precorrin-6A reductase cobM (Rv2071c) — requalified: precorrin-4 C(11)-methyltransferase cobL (Rv2072c) — requalified: bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cob Rv2073c (Rv2073c) — family_assigned: SDR family NAD(P)-dependent oxidoreductase Rv2074 (Rv2074) — requalified: F420-dependent biliverdin reductase Rv2075c (Rv2075c) — family_assigned: hypothetical protein Rv2077c (Rv2077c) — dark: hypothetical protein Rv2078 (Rv2078) — family_assigned: DUF2563 family protein Rv2079 (Rv2079) — family_assigned: alpha/beta hydrolase lppJ (Rv2080) — family_assigned: hypothetical protein Rv2081c (Rv2081c) — dark: hypothetical protein Rv2082 (Rv2082) — dark: DUF5631 domain-containing protein Rv2083 (Rv2083) — dark: hypothetical protein Rv2084 (Rv2084) — dark: hypothetical protein pknJ (Rv2088) — requalified: serine/threonine protein kinase PknJ pepE (Rv2089c) — family_assigned: Xaa-Pro peptidase family protein Rv2091c (Rv2091c) — family_assigned: DUF4333 domain-containing protein helY (Rv2092c) — requalified: RNA helicase tatC (Rv2093c) — family_assigned: twin-arginine translocase subunit TatC tatA (Rv2094c) — family_assigned: Sec-independent protein translocase subunit TatA pafC (Rv2095c) — family_assigned: YafY family protein pafB (Rv2096c) — family_assigned: YafY family protein pafA (Rv2097c) — requalified: Pup--protein ligase helZ (Rv2101) — requalified: DEAD/DEAH box helicase vapC37 (Rv2103c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB37 (Rv2104c) — requalified: antitoxin prcA (Rv2109c) — family_assigned: proteasome subunit alpha prcB (Rv2110c) — family_assigned: proteasome subunit beta Rv2113 (Rv2113) — family_assigned: integral membrane protein Rv2114 (Rv2114) — dark: hypothetical protein mpa (Rv2115c) — requalified: proteasome ATPase lppK (Rv2116) — family_assigned: hypothetical protein Rv2117 (Rv2117) — family_assigned: DUF503 domain-containing protein trmI (Rv2118c) — requalified: tRNA (adenine(58)-N(1))-methyltransferase TrmI Rv2119 (Rv2119) — family_assigned: RecB family exonuclease Rv2120c (Rv2120c) — family_assigned: glycine zipper 2TM domain-containing protein hisG (Rv2121c) — requalified: ATP phosphoribosyltransferase metH (Rv2124c) — requalified: methionine synthase Rv2125 (Rv2125) — family_assigned: PAC2 family protein Rv2128 (Rv2128) — dark: hypothetical protein Rv2129c (Rv2129c) — family_assigned: SDR family oxidoreductase mshC (Rv2130c) — requalified: cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyra cysQ (Rv2131c) — requalified: 3'(2')%2C5'-bisphosphate nucleotidase CysQ Rv2132 (Rv2132) — family_assigned: ribbon-helix-helix protein%2C CopG family Rv2133c (Rv2133c) — family_assigned: SCO1664 family protein Rv2135c (Rv2135c) — family_assigned: histidine phosphatase family protein Rv2136c (Rv2136c) — requalified: undecaprenyl-diphosphate phosphatase lppL (Rv2138) — family_assigned: hypothetical protein pyrD (Rv2139) — requalified: quinone-dependent dihydroorotate dehydrogenase TB18.6 (Rv2140c) — family_assigned: YbhB/YbcL family Raf kinase inhibitor-like protein parE2 (Rv2142c) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin Rv2143 (Rv2143) — family_assigned: phosphoribosyltransferase family protein Rv2144c (Rv2144c) — dark: hypothetical protein wag31 (Rv2145c) — requalified: cell wall synthesis protein Wag31 Rv2146c (Rv2146c) — family_assigned: YggT family protein Rv2148c (Rv2148c) — family_assigned: YggS family pyridoxal phosphate-dependent enzyme ftsZ (Rv2150c) — requalified: cell division protein FtsZ ftsQ (Rv2151c) — requalified: cell division protein FtsQ murC (Rv2152c) — requalified: UDP-N-acetylmuramate--L-alanine ligase murG (Rv2153c) — requalified: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylgluc ftsW (Rv2154c) — family_assigned: putative lipid II flippase FtsW murD (Rv2155c) — requalified: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase murX (Rv2156c) — requalified: phospho-N-acetylmuramoyl-pentapeptide-transferase murF (Rv2157c) — requalified: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase murE (Rv2158c) — requalified: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopime Rv2159c (Rv2159c) — family_assigned: carboxymuconolactone decarboxylase family protein Rv2161c (Rv2161c) — family_assigned: TIGR03619 family F420-dependent LLM class oxidoreductase pbpB (Rv2163c) — requalified: D%2CD-transpeptidase PbpB Rv2164c (Rv2164c) — family_assigned: hypothetical protein rsmH (Rv2165c) — requalified: 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH mraZ (Rv2166c) — requalified: division/cell wall cluster transcriptional repressor MraZ Rv2169c (Rv2169c) — dark: DUF3040 domain-containing protein Rv2170 (Rv2170) — requalified: N-acetyltransferase lppM (Rv2171) — requalified: lipoprotein LppM Rv2172c (Rv2172c) — requalified: mycobacterial-type methylenetetrahydrofolate reductase idsA2 (Rv2173) — requalified: bifunctional (2E%2C6E)-farnesyl/geranyl diphosphate synthase mptA (Rv2174) — requalified: alpha-(1->6)-mannopyranosyltransferase A pknL (Rv2176) — requalified: protein kinase aroG (Rv2178c) — requalified: 3-deoxy-7-phosphoheptulonate synthase class II Rv2179c (Rv2179c) — requalified: polyadenylate-specific 3'-exoribonuclease AS Rv2180c (Rv2180c) — family_assigned: integral membrane protein Rv2181 (Rv2181) — requalified: alpha-(1-2)-phosphatidylinositol mannoside mannosyltransfera Rv2182c (Rv2182c) — family_assigned: lysophospholipid acyltransferase family protein Rv2183c (Rv2183c) — dark: hypothetical protein TB16.3 (Rv2185c) — family_assigned: SRPBCC family protein Rv2186c (Rv2186c) — requalified: polyketide cyclase / dehydrase and lipid transport fadD15 (Rv2187) — requalified: long-chain fatty acid--CoA ligase pimB (Rv2188c) — requalified: GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monom Rv2189c (Rv2189c) — dark: hypothetical protein ripC (Rv2190c) — requalified: peptidoglycan hydrolase RipC trpD (Rv2192c) — requalified: anthranilate phosphoribosyltransferase ctaE (Rv2193) — family_assigned: heme-copper oxidase subunit III qcrC (Rv2194) — requalified: cytochrome c qcrB (Rv2196) — family_assigned: cytochrome bc complex cytochrome b subunit mmpS3 (Rv2198c) — family_assigned: MmpS family transport accessory protein Rv2199c (Rv2199c) — family_assigned: cytochrome c oxidase subunit 4 ctaC (Rv2200c) — family_assigned: cytochrome c oxidase subunit II asnB (Rv2201) — requalified: asparagine synthase (glutamine-hydrolyzing) adoK (Rv2202c) — family_assigned: carbohydrate kinase family protein Rv2203 (Rv2203) — dark: hypothetical protein Rv2204c (Rv2204c) — requalified: iron-sulfur cluster assembly accessory protein Rv2205c (Rv2205c) — requalified: glycerate kinase Rv2206 (Rv2206) — family_assigned: DUF3043 domain-containing protein cobT (Rv2207) — requalified: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosylt cobS (Rv2208) — requalified: adenosylcobinamide-GDP ribazoletransferase Rv2209 (Rv2209) — requalified: MFS transporter ilvE (Rv2210c) — requalified: branched-chain amino acid aminotransferase Rv2212 (Rv2212) — requalified: adenylyl cyclase pepB (Rv2213) — requalified: leucyl aminopeptidase ephD (Rv2214c) — family_assigned: SDR family oxidoreductase dlaT (Rv2215) — requalified: 2-oxoglutarate dehydrogenase%2C E2 component%2C dihydrolipoa Rv2216 (Rv2216) — family_assigned: TIGR01777 family oxidoreductase lipB (Rv2217) — requalified: lipoyl(octanoyl) transferase LipB lipA (Rv2218) — requalified: lipoyl synthase Rv2219 (Rv2219) — family_assigned: DUF4191 domain-containing protein glnA1 (Rv2220) — requalified: type I glutamate--ammonia ligase glnE (Rv2221c) — requalified: bifunctional [glutamine synthetase] adenylyltransferase/[glu glnA2 (Rv2222c) — family_assigned: glutamine synthetase family protein caeB (Rv2223c) — requalified: carboxylesterase CaeB caeA (Rv2224c) — requalified: carboxylesterase CaeA panB (Rv2225) — requalified: 3-methyl-2-oxobutanoate hydroxymethyltransferase Rv2226 (Rv2226) — family_assigned: CYTH and CHAD domain-containing protein Rv2229c (Rv2229c) — family_assigned: zinc ribbon domain-containing protein Rv2230c (Rv2230c) — requalified: Nif3-like dinuclear metal center hexameric protein ptpA (Rv2234) — requalified: protein-tyrosine-phosphatase Rv2235 (Rv2235) — family_assigned: SURF1 family protein cobD (Rv2236c) — requalified: cobalamin biosynthesis protein ahpE (Rv2238c) — requalified: peroxiredoxin AhpE Rv2240c (Rv2240c) — family_assigned: hypothetical protein Rv2242 (Rv2242) — family_assigned: PucR family transcriptional regulator fabD (Rv2243) — requalified: malonyl CoA-acyl carrier protein transacylase acpM (Rv2244) — requalified: meromycolate extension acyl carrier protein AcpM kasA (Rv2245) — requalified: 3-oxoacyl-ACP synthase KasA accD6 (Rv2247) — family_assigned: acyl-CoA carboxylase subunit beta glpD1 (Rv2249c) — requalified: glycerol-3-phosphate dehydrogenase/oxidase Rv2250c (Rv2250c) — family_assigned: TetR/AcrR family transcriptional regulator Rv2252 (Rv2252) — requalified: diacylglycerol kinase Rv2253 (Rv2253) — family_assigned: hypothetical protein Rv2254c (Rv2254c) — family_assigned: LysE family transporter Rv2257c (Rv2257c) — family_assigned: serine hydrolase domain-containing protein Rv2258c (Rv2258c) — requalified: class I SAM-dependent methyltransferase mscR (Rv2259) — requalified: S-(hydroxymethyl)mycothiol dehydrogenase Rv2260 (Rv2260) — requalified: MBL fold metallo-hydrolase Rv2263 (Rv2263) — family_assigned: SDR family oxidoreductase Rv2264c (Rv2264c) — family_assigned: Hsp70 family protein Rv2265 (Rv2265) — requalified: MFS transporter cyp124 (Rv2266) — requalified: methyl-branched lipid omega-hydroxylase Cyp124 Rv2267c (Rv2267c) — requalified: sulfotransferase cyp128 (Rv2268c) — requalified: cytochrome P450 Rv2269c (Rv2269c) — family_assigned: hypothetical protein lppN (Rv2270) — family_assigned: hypothetical protein Rv2271 (Rv2271) — dark: DUF2695 domain-containing protein Rv2272 (Rv2272) — family_assigned: YidH family protein Rv2273 (Rv2273) — dark: DUF202 domain-containing protein mazF8 (Rv2274c) — requalified: toxin cyp121 (Rv2276) — requalified: mycocyclosin synthase Cyp121 pitB (Rv2281) — requalified: anion permease Rv2282c (Rv2282c) — family_assigned: LysR family transcriptional regulator Rv2283 (Rv2283) — dark: hypothetical protein lipM (Rv2284) — family_assigned: alpha/beta hydrolase Rv2285 (Rv2285) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase Rv2286c (Rv2286c) — family_assigned: DsbA family protein Rv2288 (Rv2288) — dark: hypothetical protein cdh (Rv2289) — requalified: CDP-diacylglycerol diphosphatase lppO (Rv2290) — requalified: lipoprotein LpqH sseB (Rv2291) — requalified: sulfurtransferase Rv2294 (Rv2294) — family_assigned: MalY/PatB family protein Rv2295 (Rv2295) — family_assigned: CbrC family protein Rv2296 (Rv2296) — requalified: haloalkane dehalogenase Rv2297 (Rv2297) — dark: hypothetical protein Rv2298 (Rv2298) — requalified: aldo/keto reductase htpG (Rv2299c) — requalified: molecular chaperone HtpG cut2 (Rv2301) — family_assigned: cutinase family protein Rv2302 (Rv2302) — family_assigned: DUF1918 domain-containing protein Rv2303c (Rv2303c) — family_assigned: amidohydrolase family protein Rv2304c (Rv2304c) — dark: hypothetical protein Rv2305 (Rv2305) — family_assigned: hypothetical protein Rv2307c (Rv2307c) — family_assigned: alpha/beta hydrolase Rv2308 (Rv2308) — family_assigned: DUF433 domain-containing protein Rv2312 (Rv2312) — dark: hypothetical protein Rv2313c (Rv2313c) — family_assigned: carboxymuconolactone decarboxylase family protein Rv2314c (Rv2314c) — family_assigned: TldD/PmbA family protein Rv2315c (Rv2315c) — family_assigned: TldD/PmbA family protein uspA (Rv2316) — family_assigned: sugar ABC transporter permease uspC (Rv2318) — family_assigned: sugar ABC transporter substrate-binding protein Rv2319c (Rv2319c) — requalified: universal stress protein rocE (Rv2320c) — requalified: amino acid permease Rv2324 (Rv2324) — family_assigned: Lrp/AsnC family transcriptional regulator Rv2325c (Rv2325c) — family_assigned: CbiQ family ECF transporter T component Rv2327 (Rv2327) — family_assigned: MarR family winged helix-turn-helix transcriptional regulato narK1 (Rv2329c) — requalified: nitrate/nitrite transporter lppP (Rv2330c) — family_assigned: LppP/LprE family lipoprotein Rv2331 (Rv2331) — family_assigned: hypothetical protein mez (Rv2332) — requalified: NAD-dependent malic enzyme stp (Rv2333c) — requalified: multidrug resistance protein Stp tyzA (Rv2336) — requalified: hypothetical protein tyzC (Rv2337c) — requalified: hypothetical protein moeW (Rv2338c) — family_assigned: ThiF family adenylyltransferase mmpL9 (Rv2339) — requalified: RND transporter MmpL9 cysE (Rv2335) — requalified: serine O-acetyltransferase lppQ (Rv2341) — dark: hypothetical protein Rv2342 (Rv2342) — family_assigned: hypothetical protein dnaG (Rv2343c) — requalified: DNA primase dgt (Rv2344c) — requalified: deoxyguanosinetriphosphate triphosphohydrolase Rv2345 (Rv2345) — family_assigned: TPM domain-containing protein esxO (Rv2346c) — requalified: type VII secretion system effector EsxO esxP (Rv2347c) — requalified: type VII secretion system ESX-5 protein EsxJ Rv2348c (Rv2348c) — family_assigned: hypothetical protein plcC (Rv2349c) — requalified: phospholipase C glyS (Rv2357c) — requalified: glycine--tRNA ligase smtB (Rv2358) — family_assigned: metalloregulator ArsR/SmtB family transcription factor zur (Rv2359) — requalified: zinc uptake transcriptional repressor Zur Rv2360c (Rv2360c) — family_assigned: hypothetical protein Rv2361c (Rv2361c) — requalified: decaprenyl diphosphate synthase recO (Rv2362c) — requalified: DNA repair protein RecO amiA2 (Rv2363) — requalified: amidase Rv2365c (Rv2365c) — requalified: cytidine deaminase Rv2366c (Rv2366c) — family_assigned: hemolysin family protein Rv2369c (Rv2369c) — dark: hypothetical protein Rv2370c (Rv2370c) — family_assigned: PucR family transcriptional regulator Rv2372c (Rv2372c) — requalified: 16S rRNA (uracil(1498)-N(3))-methyltransferase dnaJ2 (Rv2373c) — requalified: molecular chaperone DnaJ hrcA (Rv2374c) — requalified: heat-inducible transcriptional repressor HrcA Rv2375 (Rv2375) — family_assigned: type II toxin-antitoxin system VapB family antitoxin cfp2 (Rv2376c) — requalified: Low molecular weight antigen MTB12 mbtH (Rv2377c) — requalified: mycobactin NRPS accessory protein MbtH mbtG (Rv2378c) — requalified: NADPH-dependent L-lysine N(6)-monooxygenase MbtG mbtD (Rv2381c) — requalified: mycobactin polyketide synthase MbtD mbtC (Rv2382c) — requalified: polyketide synthetase MbtC mbtB (Rv2383c) — requalified: phenyloxazoline synthase MbtB mbtA (Rv2384) — requalified: bifunctional salicyl-AMP ligase/salicyl-S-ArCP synthetase Mb Rv2387 (Rv2387) — family_assigned: sodium-dependent bicarbonate transport family permease rpfD (Rv2389c) — requalified: resuscitation-promoting factor protein RpfD Rv2390c (Rv2390c) — family_assigned: hypothetical protein cysH (Rv2392) — requalified: phosphoadenylyl-sulfate reductase ggtB (Rv2394) — family_assigned: gamma-glutamyltransferase family protein Rv2395 (Rv2395) — family_assigned: oligopeptide transporter%2C OPT family cysW (Rv2398c) — family_assigned: sulfate ABC transporter permease subunit CysW cysT (Rv2399c) — family_assigned: sulfate ABC transporter permease subunit CysT subI (Rv2400c) — family_assigned: sulfate ABC transporter substrate-binding protein Rv2401 (Rv2401) — dark: hypothetical protein lppR (Rv2403c) — family_assigned: sensor domain-containing protein lepA (Rv2404c) — requalified: translation elongation factor 4 Rv2406c (Rv2406c) — family_assigned: CBS domain-containing protein Rv2407 (Rv2407) — family_assigned: Rv2407 family type 3 sulfatase Rv2409c (Rv2409c) — family_assigned: transglutaminase family protein Rv2410c (Rv2410c) — family_assigned: alpha-E domain-containing protein 2 394 kb 2 460 kb 2 527 kb 2 594 kb 2 660 kb 2 726 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.