MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 3 804 530–4 204 530 bp (400 000 bp)
+ strand − strand spoU (Rv3366) — requalified: tRNA (cytidine(34)-2'-O)-methyltransferase Rv3368c (Rv3368c) — family_assigned: nitroreductase family protein Rv3371 (Rv3371) — requalified: diacylglycerol O-acyltransferase otsB2 (Rv3372) — requalified: trehalose-phosphatase amiD (Rv3375) — requalified: amidase Rv3376 (Rv3376) — family_assigned: HAD family phosphatase Rv3377c (Rv3377c) — requalified: type B diterpene cyclase Rv3378c (Rv3378c) — requalified: diterpene synthase idsB (Rv3383c) — family_assigned: polyprenyl synthetase family protein vapC46 (Rv3384c) — family_assigned: type II toxin-antitoxin system VapC family toxin htdY (Rv3389c) — requalified: 3-hydroxyacyl-thioester dehydratase HtdY lpqD (Rv3390) — family_assigned: histidine phosphatase family protein acrA1 (Rv3391) — family_assigned: SDR family oxidoreductase cmaA1 (Rv3392c) — requalified: cyclopropane mycolic acid synthase CmaA1 iunH (Rv3393) — requalified: nucleoside hydrolase IunH Rv3394c (Rv3394c) — family_assigned: DNA polymerase Y family protein Rv3395c (Rv3395c) — family_assigned: hypothetical protein guaA (Rv3396c) — requalified: glutamine-hydrolyzing GMP synthase phyA (Rv3397c) — requalified: presqualene diphosphate synthase HpnD Rv3400 (Rv3400) — family_assigned: beta-phosphoglucomutase family hydrolase Rv3401 (Rv3401) — family_assigned: glycoside hydrolase family 65 protein Rv3402c (Rv3402c) — family_assigned: DegT/DnrJ/EryC1/StrS family aminotransferase Rv3403c (Rv3403c) — family_assigned: FAD/NAD(P)-binding protein Rv3404c (Rv3404c) — requalified: dTDP-4-amino-4%2C6-dideoxyglucose formyltransferase Rv3405c (Rv3405c) — family_assigned: helix-turn-helix domain-containing protein Rv3406 (Rv3406) — requalified: alpha-ketoglutarate-dependent sulfate ester dioxygenase vapC47 (Rv3408) — family_assigned: type II toxin-antitoxin system VapC family toxin choD (Rv3409c) — requalified: cholesterol oxidase guaB3 (Rv3410c) — family_assigned: GuaB3 family IMP dehydrogenase-related protein guaB2 (Rv3411c) — requalified: IMP dehydrogenase Rv3412 (Rv3412) — dark: DUF5319 domain-containing protein rsdA (Rv3413c) — requalified: anti-sigma D factor RsdA Rv3415c (Rv3415c) — family_assigned: hypothetical protein whiB3 (Rv3416) — family_assigned: redox-responsive transcriptional regulator WhiB3 groEL1 (Rv3417c) — requalified: chaperonin GroEL gcp (Rv3419c) — family_assigned: tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex rimI (Rv3420c) — requalified: ribosomal protein S18-alanine N-acetyltransferase tsaB (Rv3421c) — family_assigned: tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex tsaE (Rv3422c) — family_assigned: tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex istB (Rv3427c) — family_assigned: IS21-like element ISMt2 family helper ATPase IstB Rv3424c (Rv3424c) — dark: hypothetical protein gadB (Rv3432c) — requalified: glutamate decarboxylase Rv3433c (Rv3433c) — requalified: NAD(P)H-hydrate dehydratase Rv3434c (Rv3434c) — family_assigned: rhomboid-like protein Rv3435c (Rv3435c) — family_assigned: DUF4436 domain-containing protein glmS (Rv3436c) — requalified: glutamine--fructose-6-phosphate transaminase (isomerizing) Rv3437 (Rv3437) — dark: DUF2510 domain-containing protein Rv3438 (Rv3438) — family_assigned: alpha/beta hydrolase Rv3439c (Rv3439c) — family_assigned: hypothetical protein Rv3440c (Rv3440c) — family_assigned: hypothetical protein mrsA (Rv3441c) — requalified: phosphoglucosamine mutase rpsI (Rv3442c) — requalified: 30S ribosomal protein S9 rplM (Rv3443c) — requalified: 50S ribosomal protein L13 esxT (Rv3444c) — family_assigned: WXG100 family type VII secretion target esxU (Rv3445c) — requalified: type VII secretion system ESX-4 protein EsxU Rv3446c (Rv3446c) — family_assigned: type VII secretion-associated protein eccC4 (Rv3447c) — family_assigned: type VII secretion system ESX-4 FtsK/SpoIIIE family ATPase E eccD4 (Rv3448) — family_assigned: type VII secretion system ESX-4 subunit EccD4 mycP4 (Rv3449) — requalified: type VII secretion system ESX-4 serine protease mycosin MycP eccB4 (Rv3450c) — family_assigned: type VII secretion system ESX-4 subunit EccB4 cut3 (Rv3451) — family_assigned: cutinase family protein cut4 (Rv3452) — requalified: cutinase Cut4 rplQ (Rv3456c) — requalified: 50S ribosomal protein L17 rpoA (Rv3457c) — family_assigned: DNA-directed RNA polymerase subunit alpha rpsD (Rv3458c) — requalified: 30S ribosomal protein S4 rpsK (Rv3459c) — requalified: 30S ribosomal protein S11 rpsM (Rv3460c) — requalified: 30S ribosomal protein S13 rpmJ (Rv3461c) — requalified: 50S ribosomal protein L36 Rv3463 (Rv3463) — requalified: LLM class F420-dependent oxidoreductase rmlB (Rv3464) — requalified: dTDP-glucose 4%2C6-dehydratase rmlC (Rv3465) — requalified: dTDP-4-dehydrorhamnose 3%2C5-epimerase mhpE (Rv3469c) — requalified: 4-hydroxy-2-oxovalerate aldolase ilvB2 (Rv3470c) — family_assigned: thiamine pyrophosphate-binding protein Rv3472 (Rv3472) — family_assigned: nuclear transport factor 2 family protein Rv3480c (Rv3480c) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase Rv3481c (Rv3481c) — family_assigned: GAP family protein Rv3482c (Rv3482c) — dark: DUF2510 domain-containing protein Rv3483c (Rv3483c) — family_assigned: LppP/LprE family lipoprotein cpsA (Rv3484) — family_assigned: LCP family protein Rv3486 (Rv3486) — family_assigned: DoxX family protein Rv3488 (Rv3488) — family_assigned: PadR family transcriptional regulator Rv3489 (Rv3489) — family_assigned: hypothetical protein otsA (Rv3490) — requalified: trehalose-6-phosphate synthase Rv3491 (Rv3491) — family_assigned: hypothetical protein Rv3492c (Rv3492c) — requalified: Mce associated protein Rv3493c (Rv3493c) — requalified: mammalian cell entry protein mce4F (Rv3494c) — family_assigned: virulence factor Mce family protein lprN (Rv3495c) — family_assigned: Mce family lipoprotein LprN mce4D (Rv3496c) — family_assigned: virulence factor Mce family protein mce4C (Rv3497c) — family_assigned: virulence factor Mce family protein mce4B (Rv3498c) — family_assigned: virulence factor Mce family protein yrbE4B (Rv3500c) — family_assigned: ABC transporter permease yrbE4A (Rv3501c) — family_assigned: ABC transporter permease Rv3502c (Rv3502c) — requalified: 3-oxoacyl-ACP reductase fdxD (Rv3503c) — requalified: ferredoxin fadE26 (Rv3504) — requalified: acyl-CoA dehydrogenase fadE27 (Rv3505) — family_assigned: acyl-CoA dehydrogenase family protein fadD17 (Rv3506) — requalified: long-chain-fatty-acid--CoA ligase FadD17 ilvX (Rv3509c) — family_assigned: acetolactate synthase large subunit Rv3510c (Rv3510c) — family_assigned: amidohydrolase family protein echA19 (Rv3516) — family_assigned: crotonase/enoyl-CoA hydratase family protein Rv3517 (Rv3517) — family_assigned: hypothetical protein cyp142 (Rv3518c) — requalified: steroid C26-monooxygenase Cyp142 Rv3519 (Rv3519) — family_assigned: acetoacetate decarboxylase family protein ltp4 (Rv3522) — family_assigned: thiolase domain-containing protein ltp3 (Rv3523) — family_assigned: thiolase domain-containing protein Rv3524 (Rv3524) — family_assigned: NHL repeat-containing protein Rv3525c (Rv3525c) — family_assigned: gamma carbonic anhydrase family protein kshA (Rv3526) — family_assigned: 3-ketosteroid-9-alpha-hydroxylase subunit KshA Rv3527 (Rv3527) — family_assigned: hypothetical protein Rv3528c (Rv3528c) — family_assigned: hypothetical protein Rv3529c (Rv3529c) — requalified: TLR2-mediated response inhibitor Rv3530c (Rv3530c) — family_assigned: SDR family oxidoreductase Rv3531c (Rv3531c) — family_assigned: hypothetical protein hsaF (Rv3534c) — requalified: 4-hydroxy-2-oxovalerate aldolase hsaG (Rv3535c) — requalified: acetaldehyde dehydrogenase (acetylating) hsaE (Rv3536c) — requalified: 2-keto-4-pentenoate hydratase kstD (Rv3537) — requalified: 3-oxosteroid 1-dehydrogenase ltp2 (Rv3540c) — requalified: lipid-transfer protein chsH1 (Rv3541c) — family_assigned: 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratas chsH2 (Rv3542c) — family_assigned: 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratas fadE29 (Rv3543c) — requalified: acyl-CoA dehydrogenase FadE29 fadE28 (Rv3544c) — requalified: acyl-CoA dehydrogenase FadE28 fadA5 (Rv3546) — requalified: steroid 3-ketoacyl-CoA thiolase ddn (Rv3547) — requalified: deazaflavin-dependent nitroreductase Ddn Rv3548c (Rv3548c) — family_assigned: SDR family oxidoreductase Rv3549c (Rv3549c) — family_assigned: SDR family oxidoreductase echA20 (Rv3550) — family_assigned: enoyl-CoA hydratase family protein Rv3551 (Rv3551) — family_assigned: CoA transferase subunit A Rv3552 (Rv3552) — family_assigned: CoA-transferase subunit beta Rv3553 (Rv3553) — requalified: nitronate monooxygenase fdxB (Rv3554) — requalified: fatty acid desaturase Rv3555c (Rv3555c) — family_assigned: DUF559 domain-containing protein fadA6 (Rv3556c) — requalified: acetyl-CoA C-acetyltransferase kstR2 (Rv3557c) — family_assigned: TetR family transcriptional regulator KstR2 Rv3559c (Rv3559c) — family_assigned: SDR family oxidoreductase fadE30 (Rv3560c) — family_assigned: acyl-CoA dehydrogenase family protein fadD3 (Rv3561) — requalified: 3-((3aS%2C4S%2C7aS)-7a-methyl-1%2C5-dioxo-octahydro-1H-inden fadE31 (Rv3562) — family_assigned: acyl-CoA dehydrogenase family protein fadE32 (Rv3563) — family_assigned: acyl-CoA dehydrogenase family protein fadE33 (Rv3564) — family_assigned: acyl-CoA dehydrogenase family protein aspB (Rv3565) — requalified: pyridoxal phosphate-dependent aminotransferase hsaB (Rv3567c) — family_assigned: flavin-dependent monooxygenase reductase subunit HsaB hsaC (Rv3568c) — requalified: iron-dependent extradiol dioxygenase HsaC hsaD (Rv3569c) — requalified: alpha/beta fold hydrolase hsaA (Rv3570c) — family_assigned: flavin-dependent monooxygenase oxygenase subunit HsaA kshB (Rv3571) — family_assigned: 3-ketosteroid-9-alpha-hydroxylase reductase subunit Rv3572 (Rv3572) — family_assigned: hypothetical protein fadE34 (Rv3573c) — requalified: acyl-CoA dehydrogenase kstR (Rv3574) — family_assigned: cholesterol catabolism transcriptional regulator KstR Rv3575c (Rv3575c) — family_assigned: LacI family DNA-binding transcriptional regulator arsB2 (Rv3578) — requalified: arsenic transport integral membrane protein ArsB rlmB (Rv3579c) — requalified: 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB ispF (Rv3581c) — requalified: 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase ispD (Rv3582c) — requalified: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase carD (Rv3583c) — requalified: RNA polymerase-binding transcription factor CarD lpqE (Rv3584) — family_assigned: hypothetical protein radA (Rv3585) — requalified: DNA repair protein RadA disA (Rv3586) — requalified: DNA integrity scanning diadenylate cyclase DisA Rv3587c (Rv3587c) — family_assigned: hypothetical protein canB (Rv3588c) — requalified: beta-carbonic anhydrase CanB mutY (Rv3589) — requalified: A/G-specific adenine glycosylase Rv3591c (Rv3591c) — family_assigned: alpha/beta hydrolase mhuD (Rv3592) — requalified: mycobilin-forming heme oxygenase MhuD lpqF (Rv3593) — requalified: serine hydrolase Rv3594 (Rv3594) — requalified: N-acetylmuramoyl-L-alanine amidase lsr2 (Rv3597c) — requalified: histone-like nucleoid-structuring protein Lsr2 lysS (Rv3598c) — requalified: lysine--tRNA ligase Rv3600c (Rv3600c) — requalified: type III pantothenate kinase panD (Rv3601c) — requalified: aspartate 1-decarboxylase panC (Rv3602c) — requalified: pantoate--beta-alanine ligase Rv3603c (Rv3603c) — family_assigned: Rossmann-like and DUF2520 domain-containing protein Rv3604c (Rv3604c) — dark: DUF6779 domain-containing protein Rv3605c (Rv3605c) — family_assigned: DUF3180 domain-containing protein folK (Rv3606c) — requalified: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphok folE (Rv3609c) — requalified: GTP cyclohydrolase I FolE ftsH (Rv3610c) — requalified: ATP-dependent zinc metalloprotease FtsH Rv3612c (Rv3612c) — dark: hypothetical protein Rv3613c (Rv3613c) — family_assigned: hypothetical protein espD (Rv3614c) — requalified: type VII secretion system ESX-1 target EspD espC (Rv3615c) — requalified: type VII secretion system ESX-1 filament-forming target EspC espA (Rv3616c) — requalified: type VII secretion system ESX-1 target EspA ephA (Rv3617) — requalified: epoxide hydrolase EphA Rv3618 (Rv3618) — requalified: LLM class flavin-dependent oxidoreductase esxI (Rv1037c) — requalified: type VII secretion system ESX-5 protein EsxL esxW (Rv3620c) — requalified: type VII secretion system protein EsxW lpqG (Rv3623) — family_assigned: SIMPL domain-containing protein hpt (Rv3624c) — requalified: hypoxanthine phosphoribosyltransferase mesJ (Rv3625c) — requalified: tRNA lysidine(34) synthetase TilS Rv3626c (Rv3626c) — requalified: zinc-dependent metalloprotease dacB (Rv3627c) — requalified: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endop ppa (Rv3628) — requalified: inorganic diphosphatase Rv3629c (Rv3629c) — family_assigned: DUF475 domain-containing protein Rv3630 (Rv3630) — family_assigned: hypothetical protein Rv3631 (Rv3631) — family_assigned: glycosyltransferase family 2 protein Rv3632 (Rv3632) — family_assigned: DUF2304 domain-containing protein Rv3633 (Rv3633) — family_assigned: phytanoyl-CoA dioxygenase family protein galE1 (Rv3634c) — requalified: UDP-glucose 4-epimerase Rv3635 (Rv3635) — family_assigned: hypothetical protein Rv3638 (Rv3638) — family_assigned: ATP-binding protein Rv3640c (Rv3640c) — family_assigned: IS256-like element IS1553 family transposase fic (Rv3641c) — family_assigned: Fic/DOC family protein Rv3642c (Rv3642c) — family_assigned: antitoxin VbhA family protein Rv3643 (Rv3643) — family_assigned: hypothetical protein Rv3644c (Rv3644c) — family_assigned: DNA polymerase III subunit delta' Rv3645 (Rv3645) — family_assigned: adenylate/guanylate cyclase domain-containing protein topA (Rv3646c) — requalified: type I DNA topoisomerase Rv3647c (Rv3647c) — family_assigned: hypothetical protein cspA (Rv3648c) — requalified: cold shock protein CspA Rv3649 (Rv3649) — requalified: DEAD/DEAH box helicase Rv3651 (Rv3651) — family_assigned: DUF5628 domain-containing protein Rv3655c (Rv3655c) — requalified: apoptosis inhibitor Rv3656c (Rv3656c) — dark: DUF4244 domain-containing protein Rv3658c (Rv3658c) — family_assigned: type II secretion system F family protein ssd (Rv3660c) — requalified: septum site-determining protein Ssd Rv3661 (Rv3661) — family_assigned: HAD-IB family hydrolase Rv3662c (Rv3662c) — requalified: oxidoreductase dppD (Rv3663c) — family_assigned: ABC transporter ATP-binding protein dppB (Rv3665c) — family_assigned: ABC transporter permease dppA (Rv3666c) — family_assigned: ABC transporter substrate-binding protein acs (Rv3667) — requalified: acetate--CoA ligase Rv3668c (Rv3668c) — requalified: protease Rv3669 (Rv3669) — family_assigned: phage holin family protein ephE (Rv3670) — family_assigned: alpha/beta hydrolase marP (Rv3671c) — requalified: acid resistance serine protease MarP Rv3672c (Rv3672c) — requalified: CoA pyrophosphatase nth (Rv3674c) — requalified: endonuclease III Rv3675 (Rv3675) — dark: hypothetical protein crp (Rv3676) — family_assigned: cAMP-activated global transcriptional regulator CRP Rv3677c (Rv3677c) — requalified: MBL fold metallo-hydrolase Rv3678c (Rv3678c) — family_assigned: RidA family protein Rv3679 (Rv3679) — family_assigned: ArsA family ATPase Rv3680 (Rv3680) — family_assigned: ArsA family ATPase whiB4 (Rv3681c) — family_assigned: transcriptional regulator WhiB4 Rv3683 (Rv3683) — requalified: metallophosphoesterase cyp137 (Rv3685c) — requalified: cytochrome P450 Rv3686c (Rv3686c) — dark: hypothetical protein rsfB (Rv3687c) — family_assigned: STAS domain-containing protein Rv3688c (Rv3688c) — family_assigned: GatB/YqeY domain-containing protein Rv3690 (Rv3690) — family_assigned: DUF4129 domain-containing protein moxR2 (Rv3692) — family_assigned: MoxR family ATPase Rv3693 (Rv3693) — family_assigned: DUF58 domain-containing protein Rv3694c (Rv3694c) — requalified: stage II sporulation protein M Rv3695 (Rv3695) — family_assigned: RDD family protein glpK (Rv3696c) — requalified: glycerol kinase GlpK vapC48 (Rv3697c) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv3699 (Rv3699) — requalified: class I SAM-dependent methyltransferase egtE (Rv3700c) — requalified: ergothioneine biosynthesis PLP-dependent enzyme EgtE egtD (Rv3701c) — requalified: L-histidine N(alpha)-methyltransferase egtC (Rv3702c) — requalified: ergothioneine biosynthesis protein EgtC etgB (Rv3703c) — requalified: ergothioneine biosynthesis protein EgtB gshA (Rv3704c) — requalified: ergothioneine biosynthesis glutamate--cysteine ligase EgtA Rv3705c (Rv3705c) — family_assigned: sensor domain-containing protein Rv3706c (Rv3706c) — family_assigned: hypothetical protein asd (Rv3708c) — requalified: aspartate-semialdehyde dehydrogenase ask (Rv3709c) — requalified: aspartate kinase leuA (Rv3710) — requalified: 2-isopropylmalate synthase dnaQ (Rv3711c) — family_assigned: DEDDh family exonuclease Rv3712 (Rv3712) — family_assigned: Mur ligase family protein cobQ2 (Rv3713) — requalified: type 1 glutamine amidotransferase Rv3714c (Rv3714c) — family_assigned: hypothetical protein recR (Rv3715c) — requalified: recombination mediator RecR Rv3716c (Rv3716c) — family_assigned: YbaB/EbfC family nucleoid-associated protein Rv3718c (Rv3718c) — family_assigned: SRPBCC family protein dnaZX (Rv3721c) — family_assigned: DNA polymerase III subunits gamma/tau Rv3722c (Rv3722c) — requalified: aminotransferase lucA (Rv3723) — requalified: lipid uptake coordinator LucA Rv3726 (Rv3726) — requalified: zinc-binding dehydrogenase Rv3727 (Rv3727) — requalified: FAD-dependent oxidoreductase Rv3728 (Rv3728) — requalified: MFS transporter 3 857 kb 3 924 kb 3 990 kb 4 056 kb 4 123 kb 4 190 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.