MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 3 379 762–3 779 762 bp (400 000 bp)
+ strand − strand lppY (Rv2999) — family_assigned: DUF1259 domain-containing protein Rv3000 (Rv3000) — family_assigned: ABC transporter permease ilvC (Rv3001c) — requalified: ketol-acid reductoisomerase ilvN (Rv3002c) — family_assigned: acetolactate synthase small subunit Rv3005c (Rv3005c) — family_assigned: DoxX family protein lppZ (Rv3006) — family_assigned: sorbosone dehydrogenase family protein Rv3007c (Rv3007c) — family_assigned: flavin reductase family protein Rv3008 (Rv3008) — family_assigned: MgtC/SapB family protein gatB (Rv3009c) — family_assigned: Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB pfkA (Rv3010c) — requalified: ATP-dependent 6-phosphofructokinase gatA (Rv3011c) — family_assigned: Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA gatC (Rv3012c) — family_assigned: Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC Rv3013 (Rv3013) — family_assigned: amino acid-binding protein ligA (Rv3014c) — requalified: NAD-dependent DNA ligase LigA Rv3015c (Rv3015c) — requalified: methionine synthase lpqA (Rv3016) — family_assigned: sensor domain-containing protein esxQ (Rv3017c) — requalified: type VII secretion system ESX-3 effector EsxQ esxR (Rv3019c) — family_assigned: WXG100 family type VII secretion target Rv1047 (Rv1047) — family_assigned: IS256-like element IS1081 family transposase trmU (Rv3024c) — requalified: tRNA 2-thiouridine(34) synthase MnmA iscS (Rv3025c) — family_assigned: cysteine desulfurase family protein Rv3026c (Rv3026c) — family_assigned: lysophospholipid acyltransferase family protein Rv3027c (Rv3027c) — family_assigned: GNAT family N-acetyltransferase fixB (Rv3028c) — family_assigned: electron transfer flavoprotein subunit alpha/FixB family pro fixA (Rv3029c) — family_assigned: electron transfer flavoprotein subunit beta/FixA family prot Rv3030 (Rv3030) — family_assigned: methyltransferase domain-containing protein Rv3031 (Rv3031) — family_assigned: glycoside hydrolase family 57 protein Rv3032 (Rv3032) — requalified: glycogen synthase Rv3033 (Rv3033) — requalified: DUF4333 domain-containing protein TB22.2 (Rv3036c) — family_assigned: RsiV family protein Rv3038c (Rv3038c) — family_assigned: methyltransferase domain-containing protein echA17 (Rv3039c) — requalified: enoyl-CoA hydratase Rv3040c (Rv3040c) — requalified: NUDIX hydrolase Rv3041c (Rv3041c) — family_assigned: ABC transporter ATP-binding protein serB2 (Rv3042c) — requalified: phosphoserine phosphatase SerB ctaD (Rv3043c) — family_assigned: cytochrome c oxidase subunit I fecB (Rv3044) — family_assigned: iron-siderophore ABC transporter substrate-binding protein adhC (Rv3045) — requalified: NAD(P)-dependent alcohol dehydrogenase Rv3046c (Rv3046c) — family_assigned: DUF3349 domain-containing protein Rv3047c (Rv3047c) — dark: hypothetical protein Rv3049c (Rv3049c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv3050c (Rv3050c) — family_assigned: TetR/AcrR family transcriptional regulator nrdI (Rv3052c) — requalified: class Ib ribonucleoside-diphosphate reductase assembly flavo nrdH (Rv3053c) — requalified: redoxin NrdH Rv3054c (Rv3054c) — requalified: NADPH-dependent FMN reductase Rv3055 (Rv3055) — family_assigned: helix-turn-helix domain-containing protein dinP (Rv3056) — requalified: DNA polymerase IV Rv3057c (Rv3057c) — family_assigned: SDR family oxidoreductase Rv3058c (Rv3058c) — family_assigned: TetR/AcrR family transcriptional regulator cyp136 (Rv3059) — requalified: cytochrome P450 Rv3060c (Rv3060c) — family_assigned: FCD domain-containing protein fadE22 (Rv3061c) — requalified: acyl-CoA dehydrogenase ligB (Rv3062) — requalified: ATP-dependent DNA ligase cstA (Rv3063) — family_assigned: carbon starvation CstA family protein Rv3064c (Rv3064c) — family_assigned: DoxX family protein Rv3066 (Rv3066) — family_assigned: TetR/AcrR family transcriptional regulator pgmA (Rv3068c) — requalified: phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-depen crcB (Rv3069) — requalified: fluoride efflux transporter CrcB crcB (Rv3070) — requalified: fluoride efflux transporter CrcB Rv3071 (Rv3071) — family_assigned: DUF190 domain-containing protein Rv3073c (Rv3073c) — dark: DUF488 domain-containing protein Rv3074 (Rv3074) — family_assigned: DUF222 domain-containing protein Rv3075c (Rv3075c) — requalified: CoA ester lyase Rv3076 (Rv3076) — family_assigned: SRPBCC family protein hab (Rv3078) — requalified: hydrogenase Rv3079c (Rv3079c) — requalified: LLM class F420-dependent oxidoreductase pknK (Rv3080c) — requalified: serine/threonine protein kinase PknK Rv3081 (Rv3081) — requalified: nucleotidyltransferase virS (Rv3082c) — family_assigned: AraC family transcriptional regulator Rv3083 (Rv3083) — requalified: NAD(P)/FAD-dependent oxidoreductase lipR (Rv3084) — family_assigned: alpha/beta hydrolase Rv3085 (Rv3085) — family_assigned: SDR family NAD(P)-dependent oxidoreductase adhD (Rv3086) — requalified: NDMA-dependent alcohol dehydrogenase Rv3087 (Rv3087) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase tgs4 (Rv3088) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase fadD13 (Rv3089) — requalified: long-chain-fatty-acid--CoA ligase FadD13 Rv3090 (Rv3090) — family_assigned: SPFH domain-containing protein Rv3091 (Rv3091) — family_assigned: patatin-like phospholipase family protein Rv3092c (Rv3092c) — family_assigned: DUF808 domain-containing protein Rv3093c (Rv3093c) — requalified: LLM class F420-dependent oxidoreductase Rv3094c (Rv3094c) — family_assigned: acyl-CoA dehydrogenase family protein Rv3095 (Rv3095) — family_assigned: helix-turn-helix domain-containing protein Rv3096 (Rv3096) — requalified: 1%2C4-beta-xylanase Rv3098c (Rv3098c) — dark: hypothetical protein Rv3099c (Rv3099c) — family_assigned: maleylpyruvate isomerase family mycothiol-dependent enzyme smpB (Rv3100c) — family_assigned: SsrA-binding protein SmpB ftsX (Rv3101c) — requalified: permease-like cell division protein FtsX ftsE (Rv3102c) — family_assigned: cell division ATP-binding protein FtsE Rv3103c (Rv3103c) — dark: hypothetical protein Rv3104c (Rv3104c) — family_assigned: mechanosensitive ion channel family protein fprA (Rv3106) — requalified: ferredoxin--NADP(+) reductase FprA agpS (Rv3107c) — requalified: FAD-binding oxidoreductase Rv3113 (Rv3113) — family_assigned: HAD family hydrolase Rv3114 (Rv3114) — requalified: nucleoside deaminase Rv1199c (Rv1199c) — family_assigned: IS256-like element IS1081 family transposase cysA2 (Rv0815c) — requalified: sulfurtransferase Rv0814c (Rv0814c) — family_assigned: DUF1416 domain-containing protein Rv3120 (Rv3120) — requalified: class I SAM-dependent methyltransferase cyp141 (Rv3121) — requalified: cytochrome P450 Cyp141 Rv3123 (Rv3123) — family_assigned: hypothetical protein moaR1 (Rv3124) — family_assigned: transcriptional regulator MoaR1 Rv3127 (Rv3127) — requalified: NAD(P)H nitroreductase tgs1 (Rv3130c) — requalified: diacylglycerol O-acyltransferase Rv3131 (Rv3131) — requalified: NAD(P)H nitroreductase devS (Rv3132c) — requalified: two-component system sensor histidine kinase DevS devR (Rv3133c) — requalified: two-component system response regulator DevR Rv3134c (Rv3134c) — requalified: universal stress protein hisN (Rv3137) — requalified: histidinol-phosphatase pflA (Rv3138) — requalified: AmmeMemoRadiSam system radical SAM enzyme fadE24 (Rv3139) — family_assigned: acyl-CoA dehydrogenase family protein fadE23 (Rv3140) — family_assigned: acyl-CoA dehydrogenase family protein fadB4 (Rv3141) — family_assigned: NADPH:quinone oxidoreductase family protein Rv3142c (Rv3142c) — family_assigned: DUF6188 family protein Rv3143 (Rv3143) — requalified: response regulator nuoA (Rv3145) — family_assigned: NADH-quinone oxidoreductase subunit A nuoC (Rv3147) — family_assigned: NADH-quinone oxidoreductase subunit C nuoD (Rv3148) — family_assigned: NADH dehydrogenase (quinone) subunit D nuoE (Rv3149) — family_assigned: NADH-quinone oxidoreductase subunit NuoE nuoF (Rv3150) — family_assigned: NADH-quinone oxidoreductase subunit NuoF nuoG (Rv3151) — family_assigned: NADH-quinone oxidoreductase subunit G nuoH (Rv3152) — family_assigned: NADH-quinone oxidoreductase subunit NuoH nuoI (Rv3153) — family_assigned: NADH-quinone oxidoreductase subunit NuoI nuoJ (Rv3154) — family_assigned: NADH-quinone oxidoreductase subunit J nuoK (Rv3155) — family_assigned: NADH-quinone oxidoreductase subunit NuoK nuoL (Rv3156) — family_assigned: NADH-quinone oxidoreductase subunit L nuoM (Rv3157) — family_assigned: NADH-quinone oxidoreductase subunit M nuoN (Rv3158) — family_assigned: NADH-quinone oxidoreductase subunit NuoN Rv3160c (Rv3160c) — family_assigned: helix-turn-helix domain-containing protein Rv3161c (Rv3161c) — family_assigned: aromatic ring-hydroxylating dioxygenase subunit alpha Rv3162c (Rv3162c) — family_assigned: integral membrane protein Rv3163c (Rv3163c) — dark: DUF58 domain-containing protein moxR3 (Rv3164c) — family_assigned: MoxR family ATPase Rv3165c (Rv3165c) — dark: hypothetical protein Rv3166c (Rv3166c) — family_assigned: DUF4129 domain-containing protein Rv3167c (Rv3167c) — family_assigned: TetR/AcrR family transcriptional regulator Rv3168 (Rv3168) — family_assigned: phosphotransferase family protein Rv3169 (Rv3169) — family_assigned: hypothetical protein aofH (Rv3170) — family_assigned: flavin monoamine oxidase family protein Rv3173c (Rv3173c) — family_assigned: helix-turn-helix domain-containing protein Rv3174 (Rv3174) — family_assigned: SDR family oxidoreductase Rv3175 (Rv3175) — requalified: amidase Rv3177 (Rv3177) — family_assigned: alpha/beta hydrolase Rv3179 (Rv3179) — family_assigned: ATP-binding protein Rv3180c (Rv3180c) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv3181c (Rv3181c) — family_assigned: type II toxin-antitoxin system Phd/YefM family antitoxin Rv3182 (Rv3182) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin Rv3183 (Rv3183) — family_assigned: XRE family transcriptional regulator Rv3188 (Rv3188) — family_assigned: antitoxin Xre/MbcA/ParS toxin-binding domain-containing prot Rv3189 (Rv3189) — family_assigned: RES family NAD+ phosphorylase Rv3190c (Rv3190c) — dark: hypothetical protein Rv3191c (Rv3191c) — family_assigned: IS30 family transposase Rv3193c (Rv3193c) — family_assigned: UPF0182 family protein Rv3194c (Rv3194c) — family_assigned: PDZ domain-containing protein Rv3195 (Rv3195) — requalified: zinc-dependent metalloprotease Rv3197 (Rv3197) — family_assigned: AarF/ABC1/UbiB kinase family protein uvrD2 (Rv3198c) — requalified: ATP-dependent DNA helicase UvrD2 nudC (Rv3199c) — requalified: NAD(+) diphosphatase Rv3200c (Rv3200c) — family_assigned: potassium channel family protein adnB (Rv3201c) — requalified: ATP-dependent DNA helicase AdnB adnA (Rv3202c) — requalified: ATP-dependent DNA helicase AdnA Rv3204 (Rv3204) — family_assigned: MGMT family protein Rv3208 (Rv3208) — family_assigned: TetR/AcrR family transcriptional regulator Rv3209 (Rv3209) — family_assigned: MmpS family transport accessory protein Rv3210c (Rv3210c) — family_assigned: ferritin-like fold-containing protein rhlE (Rv3211) — requalified: DEAD/DEAH box helicase Rv3212 (Rv3212) — family_assigned: hypothetical protein Rv3213c (Rv3213c) — family_assigned: AAA family ATPase entC (Rv3215) — requalified: isochorismate synthase Rv3217c (Rv3217c) — dark: hypothetical protein Rv3218 (Rv3218) — family_assigned: diacylglycerol kinase family lipid kinase Rv3220c (Rv3220c) — family_assigned: histidine kinase N-terminal domain-containing protein TB7.3 (Rv3221c) — requalified: biotin/lipoyl-binding carrier protein Rv3222c (Rv3222c) — family_assigned: hypothetical protein sigH (Rv3223c) — family_assigned: sigma-70 family RNA polymerase sigma factor SigH Rv3224 (Rv3224) — requalified: NAD(P)-dependent oxidoreductase Rv3225c (Rv3225c) — family_assigned: bifunctional GNAT family N-acetyltransferase/aminoglycoside Rv3226c (Rv3226c) — requalified: SOS response-associated peptidase aroA (Rv3227) — requalified: 3-phosphoshikimate 1-carboxyvinyltransferase rsgA (Rv3228) — family_assigned: ribosome small subunit-dependent GTPase A Rv3230c (Rv3230c) — requalified: NADPH oxidoreductase Rv3231c (Rv3231c) — family_assigned: hypothetical protein Rv3237c (Rv3237c) — family_assigned: cation:proton antiporter regulatory subunit Rv3238c (Rv3238c) — family_assigned: isoprenylcysteine carboxylmethyltransferase family protein Rv3239c (Rv3239c) — requalified: MFS transporter raiA (Rv3241c) — requalified: ribosome-associated translation inhibitor RaiA Rv3242c (Rv3242c) — family_assigned: ComF family protein Rv3243c (Rv3243c) — family_assigned: LmeA family phospholipid-binding protein lpqB (Rv3244c) — requalified: MtrAB system accessory lipoprotein LpqB mtrB (Rv3245c) — requalified: two-component system sensor histidine kinase MtrB mtrA (Rv3246c) — requalified: two-component system response regulator MtrA tmk (Rv3247c) — requalified: dTMP kinase sahH (Rv3248c) — requalified: adenosylhomocysteinase Rv3249c (Rv3249c) — family_assigned: TetR family transcriptional regulator rubB (Rv3250c) — requalified: rubredoxin RubB rubA (Rv3251c) — requalified: rubredoxin alkB (Rv3252c) — requalified: alkane 1-monooxygenase Rv3253c (Rv3253c) — requalified: amino acid permease Rv3254 (Rv3254) — requalified: oxidoreductase manA (Rv3255c) — requalified: mannose-6-phosphate isomerase%2C class I Rv3256c (Rv3256c) — requalified: TobH protein pmmA (Rv3257c) — requalified: phosphomannomutase/phosphoglucomutase Rv3259 (Rv3259) — family_assigned: metallopeptidase family protein fbiA (Rv3261) — requalified: 2-phospho-L-lactate transferase fbiB (Rv3262) — requalified: coenzyme F420-0:L-glutamate ligase Rv3263 (Rv3263) — requalified: class I SAM-dependent methyltransferase rmlD (Rv3266c) — requalified: dTDP-4-dehydrorhamnose reductase lcp1 (Rv3267) — requalified: phosphotransferase Lcp1 Rv3269 (Rv3269) — family_assigned: DUF1490 family protein ctpC (Rv3270) — requalified: manganese-exporting P-type ATPase CtpC Rv3271c (Rv3271c) — requalified: cation transporter Rv3272 (Rv3272) — requalified: CoA transferase fadE25 (Rv3274c) — requalified: acyl-CoA dehydrogenase purE (Rv3275c) — requalified: 5-(carboxyamino)imidazole ribonucleotide mutase purK (Rv3276c) — requalified: 5-(carboxyamino)imidazole ribonucleotide synthase Rv3278c (Rv3278c) — family_assigned: PH domain-containing protein birA (Rv3279c) — requalified: biotin--[acetyl-CoA-carboxylase] ligase accD5 (Rv3280) — family_assigned: acyl-CoA carboxylase subunit beta accE5 (Rv3281) — family_assigned: acyl-CoA carboxylase subunit epsilon Rv3282 (Rv3282) — requalified: nucleoside triphosphate pyrophosphatase sseA (Rv3283) — requalified: sulfurtransferase Rv3284 (Rv3284) — family_assigned: SufE family protein accA3 (Rv3285) — family_assigned: acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alph sigF (Rv3286c) — requalified: RNA polymerase sigma factor SigF rsbW (Rv3287c) — requalified: anti-sigma B factor RsbW Rv3289c (Rv3289c) — dark: hypothetical protein lat (Rv3290c) — requalified: L-lysine 6-transaminase lrpA (Rv3291c) — family_assigned: transcriptional regulator LrpA Rv3292 (Rv3292) — family_assigned: VOC family protein Rv3295 (Rv3295) — family_assigned: TetR/AcrR family transcriptional regulator lhr (Rv3296) — requalified: ATP-dependent helicase nei (Rv3297) — requalified: endonuclease VIII Nei2 lpqC (Rv3298c) — family_assigned: PHB depolymerase family esterase atsB (Rv3299c) — requalified: arylsulfatase AtsB Rv3300c (Rv3300c) — family_assigned: RluA family pseudouridine synthase phoY1 (Rv3301c) — requalified: phosphate signaling complex protein PhoU glpD2 (Rv3302c) — requalified: glycerol-3-phosphate dehydrogenase/oxidase lpdA (Rv3303c) — requalified: NAD(P)H-quinone dehydrogenase Rv3304 (Rv3304) — requalified: gamma-glutamylcyclotransferase deoD (Rv3307) — requalified: purine-nucleoside phosphorylase pmmB (Rv3308) — requalified: phospho-sugar mutase upp (Rv3309c) — requalified: uracil phosphoribosyltransferase sapM (Rv3310) — requalified: phosphatidylinositol-3-phosphatase Rv3311 (Rv3311) — family_assigned: primosomal protein Rv3312c (Rv3312c) — family_assigned: alpha/beta hydrolase add (Rv3313c) — requalified: adenosine deaminase deoA (Rv3314c) — requalified: thymidine phosphorylase cdd (Rv3315c) — requalified: cytidine deaminase sdhC (Rv3316) — family_assigned: succinate dehydrogenase%2C cytochrome b556 subunit sdhD (Rv3317) — family_assigned: succinate dehydrogenase hydrophobic membrane anchor subunit sdhA (Rv3318) — family_assigned: succinate dehydrogenase flavoprotein subunit sdhB (Rv3319) — family_assigned: succinate dehydrogenase iron-sulfur subunit vapC44 (Rv3320c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB44 (Rv3321c) — family_assigned: CopG family transcriptional regulator moaC3 (Rv3324c) — requalified: cyclic pyranopterin monophosphate synthase MoaC Rv3327 (Rv3327) — family_assigned: IS110 family transposase sigJ (Rv3328c) — family_assigned: sigma-70 family RNA polymerase sigma factor SigJ dacB1 (Rv3330) — requalified: D-alanyl-D-alanine carboxypeptidase DacB1 nagA (Rv3332) — requalified: N-acetylglucosamine-6-phosphate deacetylase prp1 (Rv3333c) — requalified: PDZ-interacting protease regulator Ppr1 Rv3334 (Rv3334) — family_assigned: hypoxia response transcriptional regulator yhjD (Rv3335c) — requalified: inner membrane protein YhjD trpS (Rv3336c) — requalified: tryptophan--tRNA ligase icd1 (Rv3339c) — requalified: NADP-dependent isocitrate dehydrogenase metC (Rv3340) — requalified: bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase metA (Rv3341) — requalified: homoserine O-acetyltransferase Rv3342 (Rv3342) — requalified: class I SAM-dependent methyltransferase Rv3346c (Rv3346c) — dark: DUF3017 domain-containing protein 3 392 kb 3 458 kb 3 524 kb 3 591 kb 3 658 kb 3 724 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.