metA Resolved · high auto-curated

H37Rv Rv3341 · MTBC0 mtbc0_003553 · 379 aa · 3753474–3754613 MTBC0 (+) · RefSeq NP_217858.1

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This gene (outlined) in its genomic context; arrows are neighbouring genes coloured by verdict. Click any gene to navigate. Pan and zoom in the full browser.

Annotation: from legacy to revised

Legacy (H37Rv / Mycobrowser)homoserine O-acetyltransferase
MTBC0 PGAP re-annotationhomoserine O-acetyltransferase
Revised (this work)Homoserine O-acetyltransferase. Pfam: Abhydrolase_1 (PF00561.27).
Functional category (TubercuList)intermediary metabolism and respiration

Auto-curated: this verdict and function were generated by rules from PGAP + Pfam + Foldseek and have not been hand-reviewed.

In the literature (TB corpus sweep) 2817 publications

2817 TB publications mention this gene. 2817 publications discuss this gene. Queried separately, 2828 records carry a M. tuberculosis context and 66 a non-TB mycobacterial context (species named in the 40-record verified sample: M. abscessus (19), M. leprae (13), M. marinum (4), M. smegmatis (4)). The three counts come from three distinct PubMed queries (each with its own context filter), so they neither partition the total nor need to add up to it.

5 of 2817: the most recently indexed records of the curated sweep at its date, not necessarily the most recent papers on this gene — the exhaustive list below is later and broader and may hold newer ones.
PublicationDate
Risk of Infections With Infliximab vs Adalimumab Among Children With Inflammatory Bowel Disease. doi:10.1001/jamanetworkopen.2026.22684 2026
Prevalence of extensively drug-resistant tuberculosis and drug resistance patterns in Asia and Africa (2000-2025): systematic review and meta-analysis. doi:10.1007/s15010-026-02822-x 2026
Prevalence and Predictors of Anxiety among Tuberculosis Patients in India: A Systematic Review and Meta-Analysis. doi:10.1007/s44197-026-00610-2 2026
Do Cellular Allografts Improve Spinal Fusion Enough to Justify Their Cost and Potential Risk? A Systematic Review of Efficacy, Safety, and Cost. doi:10.1227/neuprac.0000000000000266 2026
Conversational mHealth Platform Designed to Support Tuberculosis Treatment Adherence in Low-Income South African Patients: Pilot Cohort Study. doi:10.2196/85242 2026
3451 records returned by the alias sweep (a separate sweep from the 2817 above; both are shown, neither is exhaustive)

Searched as: Rv3341, metA, Mb3373, ML0682c, MMAR_1184, MSMEG_1651, MAB_3688 — each in conjunction with a mycobacterial context term. Swept 2026-09-07.

PublicationJournalYear
Neuroradiological Findings in Central Nervous System Tuberculosis: A Systematic Review and Meta-analysis Comparing Adult and Pediatric Populations. doi:10.3174/ajnr.A9625 names it AJNR Am J Neuroradiol 2026
Diagnostic performance of third-generation sequencing for tuberculous pericarditis: a systematic review and meta-analysis protocol. doi:10.1136/bmjopen-2026-124499 names it BMJ Open 2026
The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-analysis. doi:10.1371/journal.pgph.0006704 names it PLOS Glob Public Health 2026
Immunotherapeutic effect of MIP vaccine along with multidrug therapy (MDT) in leprosy: A systematic review and meta-analysis. doi:10.25259/IJMR_538_2026 names it Indian J Med Res 2026
Health effects associated with alcohol consumption: a Burden of Proof study. doi:10.1038/s44360-026-00139-5 Nat Health 2026
Hypoxaemia and mortality in children with lower respiratory infection in low-income and middle-income countries: systematic review and meta-analysis. doi:10.1016/j.langlo.2026.104031 names it Lancet Glob Health 2026
Molecular Diagnostics for WHO Priority Bacterial Pathogens: A Bibliometric Mapping of Diagnostic Platforms, Resistance Markers, and Antimicrobial Resistance Research Trends. doi:10.1002/mbo3.70394 Microbiologyopen 2026
Sensitivity of chest X-ray from community screening: a meta-reanalysis of TB prevalence survey data. doi:10.5588/ijtld.25.0744 names it Int J Tuberc Lung Dis 2026
6-gingerol modulates lipid metabolism, insulin resistance, and inflammation in NAFLD: evidence from a preclinical meta-analysis. doi:10.3389/fnut.2026.1872764 names it Front Nutr 2026
Record linkage in tuberculosis epidemiological surveillance in Brazil: systematic methodological literature review. doi:10.1590/1980-549720260045 Rev Bras Epidemiol 2026
The Epidemiology of Pulmonary Hypertension in Sub-Saharan Africa-A Systematic Report. doi:10.1002/pul2.70388 Pulm Circ 2026
Algorithmic Determinants of Performance Heterogeneity in Whole-Genome Sequencing-Based Prediction of Drug Resistance in Mycobacterium tuberculosis: A Systematic Review and Meta-Analysis. doi:10.3390/microorganisms14081824 names it Microorganisms 2026
Food Intake and Nutrition in Children Undergoing Treatment for Pulmonary Tuberculosis: A Scoping Review. doi:10.3390/nu18162651 Nutrients 2026
Effect of Intravenous Magnesium on Postoperative Pain and Analgesic Outcomes in Patients Undergoing General Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. doi:10.3390/ph19081296 names it Pharmaceuticals (Basel) 2026
Hearing-Functioning Problems Across High-Burden Adult Health Conditions in Africa. doi:10.3390/ijerph23080974 Int J Environ Res Public Health 2026
Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part II: MRI/CT Features, Prediction Models, and the Role of PET/CT-A Narrative Review. doi:10.3390/diagnostics16162540 Diagnostics (Basel) 2026
Infectious Diseases and Pulmonary Arterial Hypertension: A Review. doi:10.1016/j.hlc.2026.06.015 Heart Lung Circ 2026
Viral suppression in models of care for improving engagement of antiretroviral therapy in postpartum women living with HIV. doi:10.1097/QAD.0000000000004603 AIDS 2026
Association between history of pulmonary tuberculosis and chronic obstructive pulmonary disease: a systematic review and meta-analysis. doi:10.3389/fmed.2026.1926128 names it Front Med (Lausanne) 2026
MIC-based tuberculosis drug susceptibility testing using Sensititre MYCOTB: a diagnostic accuracy meta-analysis. doi:10.1128/jcm.00813-26 names it J Clin Microbiol 2026
Long term nursing management of children with tuberculosis survivors: focus on sequelae prevention and improve quality of life. doi:10.1016/j.pedn.2026.08.002 J Pediatr Nurs 2026
The Impact of Conflict on Maternal and Child Health Services: A Scoping Review. doi:10.4103/npmj.npmj_511_25 Niger Postgrad Med J 2026
MetaOmixTools: A User-Friendly Web Suite for Meta-analysis of Ranked Features and Functional Enrichment. doi:10.34133/csbj.0157 names it Comput Struct Biotechnol J 2026
Measuring the composition and availability of human resources for health by sex in 204 countries and territories, 1990-2023, and workforce gaps for universal health coverage: a systematic analysis for the Global Burden of Disease Study 2023. doi:10.1016/S2468-2667(26)00145-3 Lancet Public Health 2026
Systematic Review and Meta-Analysis of Urine-Based Molecular Testing for Urogenital Tuberculosis. doi:10.56434/j.arch.esp.urol.20267906.114 names it Arch Esp Urol 2026
Programmatic effectiveness of tuberculosis preventive treatment for people with HIV in six high-tuberculosis-burden countries (PROTECT): a prospective cohort study and meta-analysis. doi:10.1016/S2352-3018(26)00140-2 names it Lancet HIV 2026
Artificial Intelligence and Machine Learning-based prediction of tuberculosis treatment failure: A systematic review and meta-analysis. doi:10.1371/journal.pone.0355124 names it PLoS One 2026
Factors influencing quality of life in patients with pulmonary tuberculosis: a protocol for a systematic review and meta-analysis. doi:10.1136/bmjopen-2026-116725 names it BMJ Open 2026
Efficacy of probiotic and synbiotic supplementation on antibiotic use duration and risk of postoperative infection in patients undergoing gastrointestinal and cancer-related surgery: An umbrella review of meta-analyses. doi:10.1016/j.clnesp.2026.105013 names it Clin Nutr ESPEN 2026
Mycobacteroides abscessus complex vertebral osteomyelitis and discitis of the thoracolumbar spine: a systematic review of management and outcomes with illustrative case. doi:10.3389/fcimb.2026.1867912 Front Cell Infect Microbiol 2026
Efficacy and safety of oral treatments for allergic rhinitis in children: A network meta-analysis. doi:10.1111/pai.70431 names it Pediatr Allergy Immunol 2026
Evaluating the risk of dapsone hypersensitivity syndrome in Nepalese Leprosy Patients via HLA-B* 13:01 screening using real-time PCR and comparative meta-analysis of international data. doi:10.1371/journal.pntd.0014568 names it PLoS Negl Trop Dis 2026
Utility of cell-free DNA in diagnosing tuberculous pleurisy: A systematic review and meta-analysis protocol. doi:10.1371/journal.pone.0355485 names it PLoS One 2026
Screening and tuberculosis preventive treatment among household contacts of drug-resistant tuberculosis patients: a scoping review. doi:10.1186/s12879-026-14056-1 BMC Infect Dis 2026
Efficacy and safety of airway clearance techniques in Chinese adult patients with pneumonia: a systematic review and meta-analysis. doi:10.3389/fmed.2026.1819629 names it Front Med (Lausanne) 2026
Pregnancy Outcomes in Patients with Tuberculosis: A Systematic Review and Meta-analysis. doi:10.59556/japi.74.1608 names it J Assoc Physicians India 2026
Comparing adherence strategies and facility DOT in TB care: a systematic review with meta-analysis. doi:10.5588/ijtld.25.0604 names it Int J Tuberc Lung Dis 2026
Co-managing the double burden: strategies for simultaneously tackling infectious and non-communicable diseases. doi:10.1186/s40249-026-01477-y Infect Dis Poverty 2026
Impact of NAT2 acetylation phenotype on toxicity in tuberculosis therapy: a systematic review and meta-analysis. doi:10.1080/14622416.2026.2710853 names it Pharmacogenomics 2026
Global Burden of Elevated LDL-C: Findings From the Global Burden of Disease Study 2023. doi:10.1001/jama.2026.8628 JAMA 2026
Factors associated with tuberculosis patient delay: a meta-analysis. doi:10.3389/fpubh.2026.1832410 names it Front Public Health 2026
Nurses' roles in facilitating parental involvement in pediatric tuberculosis care: A scoping review. doi:10.1016/j.pedn.2026.07.038 J Pediatr Nurs 2026
Efficacy and Safety of Corticosteroids in Tuberculous Meningitis: Systematic Review, Meta-Analysis, and Meta-Regression. doi:10.1002/brb3.71639 names it Brain Behav 2026
Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part I-Epidemiology, Clinical Features, Laboratory Markers, and Tissue-Based Diagnosis. doi:10.3390/diagnostics16142243 Diagnostics (Basel) 2026
Open-access genomic drug resistance prediction tools for Mycobacterium tuberculosis: a systematic review and meta-analysis. doi:10.1128/jcm.00321-26 names it J Clin Microbiol 2026
Beyond Cure: A Scoping Review of Post-Tuberculosis Long-Term Health Outcomes. doi:10.3390/tropicalmed11070203 Trop Med Infect Dis 2026
Deep learning-based detection of acid-fast bacilli in microscopy images: a systematic review. doi:10.1093/ajcp/aqag083 Am J Clin Pathol 2026
Overcoming catalytic barriers to reprogram acyltransferases for bis(2-hydroxyethyl) terephthalate hydrolysis. doi:10.1016/j.biortech.2026.135492 Bioresour Technol 2026
Effects of Virtual Reality Interventions on Anxiety and Depression in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. doi:10.2147/COPD.S605739 names it Int J Chron Obstruct Pulmon Dis 2026
Global, regional, and national burden of road injuries 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. doi:10.1016/S2468-2667(26)00141-6 Lancet Public Health 2026
Epidemiological characterization of uveitis in the elderly population: a systematic review and meta-analysis. doi:10.1007/s10792-026-04170-z names it Int Ophthalmol 2026
Tuberculosis in migrant children and adolescents in Europe: a joint TBnet and ptbnet systematic review and meta-analysis. doi:10.1016/j.cmi.2026.07.014 names it Clin Microbiol Infect 2026
Retinal neuroaxonal degeneration in NMOSD vs. MS and unaffected controls: A systematic review and meta-analysis of OCT biomarkers. doi:10.1016/j.msard.2026.107392 names it Mult Scler Relat Disord 2026
Calibration-aware genomic prediction of paratuberculosis serostatus in indigenous Turkish goats. doi:10.1038/s41598-026-62518-y Sci Rep 2026
Diagnostic accuracy of stool Xpert MTB/RIF assay for adult pulmonary tuberculosis: a systematic review and meta-analysis. doi:10.1186/s12879-026-14003-0 names it BMC Infect Dis 2026
Associated characteristics of multidrug-resistant tuberculosis (MDR-TB) cases in Sub-Saharan Africa: a systematic review and meta-analysis. doi:10.1186/s12879-026-14008-9 names it BMC Infect Dis 2026
Tuberculosis-Related Outcomes in Dermatologic Patients Receiving Systemic Therapy: A Systematic Review and Meta-Analysis. doi:10.1001/jamadermatol.2026.2365 names it JAMA Dermatol 2026
Bovine tuberculosis in the Middle East and North Africa: a systematic review and meta-analysis on prevalence and Mycobacterium bovis clonal complexes. doi:10.3389/fvets.2026.1861602 names it Front Vet Sci 2026
The impact on airborne isolation duration utilizing GeneXpert versus acid-fast bacilli smears to guide discontinuation among individuals with suspected pulmonary tuberculosis: a systematic review and meta-analysis. doi:10.1017/ice.2026.10486 names it Infect Control Hosp Epidemiol 2026
Risk of Infections With Infliximab vs Adalimumab Among Children With Inflammatory Bowel Disease. doi:10.1001/jamanetworkopen.2026.22684 JAMA Netw Open 2026
Prevalence of extensively drug-resistant tuberculosis and drug resistance patterns in Asia and Africa (2000-2025): systematic review and meta-analysis. doi:10.1007/s15010-026-02822-x names it Infection 2026
Prevalence and Predictors of Anxiety among Tuberculosis Patients in India: A Systematic Review and Meta-Analysis. doi:10.1007/s44197-026-00610-2 names it J Epidemiol Glob Health 2026
Do Cellular Allografts Improve Spinal Fusion Enough to Justify Their Cost and Potential Risk? A Systematic Review of Efficacy, Safety, and Cost. doi:10.1227/neuprac.0000000000000266 Neurosurg Pract 2026
Conversational mHealth Platform Designed to Support Tuberculosis Treatment Adherence in Low-Income South African Patients: Pilot Cohort Study. doi:10.2196/85242 JMIR Form Res 2026
Molecular epidemiology of Mycobacterium tuberculosis in the Middle East and North Africa: A systematic review and meta-analysis. doi:10.1016/j.ijid.2026.108967 names it Int J Infect Dis 2026
Challenges and Barriers in Implementation of National Tuberculosis Elimination Program Guidelines at Nutrition Rehabilitation Centers in India: A Systematic Review. doi:10.1007/s44197-026-00538-7 J Epidemiol Glob Health 2026
Diagnostic accuracy of artificial intelligence for tuberculosis detection from cough sounds: a systematic review and meta-analysis. doi:10.3389/frai.2026.1774125 names it Front Artif Intell 2026
Predictors of Recurrence Following Bronchial Artery Embolisation (BAE) for Haemoptysis: A Systematic Review and Evidence Synthesis Analyses Using SWiM Guidelines. doi:10.1007/s00270-026-04520-5 Cardiovasc Intervent Radiol 2026
Effects of coenzyme Q10 on oxidative stress biomarkers in printing workers with low-level exposure to toluene and xylene: a randomized, double-blind, placebo-controlled crossover clinical trial. doi:10.1038/s41598-026-61025-4 Sci Rep 2026
Epidemiology of bovine tuberculosis in Tanzania: Systematic review and meta-analysis. doi:10.1371/journal.pntd.0014459 names it PLoS Negl Trop Dis 2026
Rational Design, Synthesis, Molecular Docking, and Evaluation of Thioridazine-modified Tetrahydrocarbazole Derivatives as Antitubercular Agents. doi:10.2174/0127724344447896260611074636 Recent Adv Antiinfect Drug Discov 2026
A Systematic Review and Meta-analysis on Innovative Approaches in Tuberculosis Diagnosis: Challenges and Future Directions. doi:10.21106/IJMA_29_2025 names it Int J MCH AIDS 2026
Interferon-gamma release assays versus tuberculin skin test for latent tuberculosis infection positivity among healthcare workers and first responders: a systematic review and meta-analysis. doi:10.1016/j.ijid.2026.108949 names it Int J Infect Dis 2026
Measuring scientific coherence between global neglected tropical disease research and population health indicators: a 25-year meta-research study. doi:10.3389/frma.2026.1766718 names it Front Res Metr Anal 2026
Anemia burden in tuberculosis patients across Southeast Asia: a systematic review and meta-analysis. doi:10.1186/s12890-026-04404-x names it BMC Pulm Med 2026
Integrative multi-omics analysis identifies SELL and PRF1 as key immune biomarkers and therapeutic targets in tuberculosis. doi:10.1007/s00210-026-05606-0 Naunyn Schmiedebergs Arch Pharmacol 2026
Vaccination policies for healthcare personnel in Europe, 2026. doi:10.1016/j.vaccine.2026.128839 Vaccine 2026
Correction: Antigen-specific Th1 cytokine markers and protection against tuberculosis: a systematic review and meta-analysis stratified by progression to active disease and sustained IGRA conversion. doi:10.3389/fcimb.2026.1838266 names it Front Cell Infect Microbiol 2026
Evolution of evidence on vitamin D supplementation in tuberculosis: A comprehensive umbrella review of nine systematic reviews. doi:10.1016/j.jctube.2026.100625 J Clin Tuberc Other Mycobact Dis 2026
A systematic review and meta-analysis of steroid use for treatment of TB meningitis. doi:10.5588/ijtld.25.0588 names it Int J Tuberc Lung Dis 2026
Epidemiology and risk factors of multidrug-resistant tuberculosis in Saudi Arabia: a systematic review and meta-analysis. doi:10.3389/fpubh.2026.1824576 names it Front Public Health 2026
Resistance to Linezolid and Pretomanid in the Era of Modern Drug-Resistant Tuberculosis Treatment in South Africa: A Systematic Review and Meta-Analysis. doi:10.3390/antibiotics15060543 names it Antibiotics (Basel) 2026
The Impact of HIV Viral Suppression and Immune Status on Rifampicin-Resistant Tuberculosis Outcomes: A Systematic Review and Meta-Analysis Protocol. doi:10.3390/tropicalmed11060160 names it Trop Med Infect Dis 2026
The role of digital health interventions for adults with tuberculosis: a network meta-analysis of randomized controlled trials. doi:10.3389/fmed.2026.1840258 names it Front Med (Lausanne) 2026
Integrating health literacy, health promotion, and digital health in tuberculosis prevention: An ecosystemic competency framework and CIMO-based systematic review. doi:10.14202/vetworld.2026.1888-1899 Vet World 2026
Cough biomarkers for diagnosis and monitoring of respiratory disease: a systematic review. doi:10.1183/16000617.0288-2025 Eur Respir Rev 2026
Clinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis. doi:10.1007/s13318-026-01017-x names it Eur J Drug Metab Pharmacokinet 2026
Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy. doi:10.1136/jcp-2026-210685 J Clin Pathol 2026
Ocular TB as the only manifestation of TB: diagnostic uncertainty and treatment thresholds. doi:10.1007/s10792-026-04134-3 Int Ophthalmol 2026
Sensitivity of Tuberculosis Infection Diagnostic Tests Among Different Populations: A Systematic Review and Meta-analysis. doi:10.1093/ofid/ofag345 names it Open Forum Infect Dis 2026
Non-pharmacological therapies for patients with lymphangioleiomyomatosis: a systematic review and meta-analysis. doi:10.3389/fresc.2026.1819549 names it Front Rehabil Sci 2026
Fluoroquinolones for TB preventive treatment of contacts exposed to persons with multidrug-resistant TB: a systematic review and meta-analysis. doi:10.5588/ijtldopen.26.0019 names it IJTLD Open 2026
Prognostic Performance of C-Reactive Protein for Tuberculosis Outcome: Protocol for a Systematic Review and Meta-Analysis. doi:10.2196/80744 names it JMIR Res Protoc 2026
Viral hepatitis co-infections with tuberculosis in India: A systematic review and meta-analysis. doi:10.25259/IJMR_3570_2025 names it Indian J Med Res 2026
Neuro-ophthalmic complications of tuberculosis and its treatment: a systematic review and meta-analysis. doi:10.3389/fopht.2026.1818640 names it Front Ophthalmol (Lausanne) 2026
Efficacy and Safety Outcomes of Bacteriophage Therapy for Resistant Bacterial Infections. doi:10.7759/cureus.108749 Cureus 2026
The current state of demographic subgroup reporting for commercially available AI for radiology: a scoping review. doi:10.1007/s00330-026-12652-y Eur Radiol 2026
Accuracy of ELISA for the detection of paratuberculosis in cattle: A systematic review and meta-analysis. doi:10.3168/jds.2025-27531 names it J Dairy Sci 2026
Time to sputum culture conversion and its predictors among drug-resistant tuberculosis patients in Ethiopia: a systematic review and meta-analysis. doi:10.1016/j.ijid.2026.108877 names it Int J Infect Dis 2026
Impact of diabetes mellitus on drug-resistant tuberculosis across resistance categories: a systematic review and meta-analysis. doi:10.7189/jogh.16.04170 names it J Glob Health 2026
A genome-wide association study of young onset Parkinson's disease in European ancestry. doi:10.64898/2026.06.03.26354799 medRxiv 2026
Long-Term Outcomes Following Bacterial Meningitis in Childhood: A Systematic Review and Meta-Analysis. doi:10.1111/jpc.70469 names it J Paediatr Child Health 2026
Recurrence Risk and Functional Outcomes of Total Knee Arthroplasty in Tuberculous Arthritis: A Systematic Review and Meta-Analysis. doi:10.1007/s43465-026-01763-9 names it Indian J Orthop 2026
Cause of Death and Risk of Death for People Living With HIV Admitted to Hospital: A Systematic Review and Meta-Analysis. doi:10.1002/jia2.70134 names it J Int AIDS Soc 2026
Illicit substance use and its impact on tuberculosis care engagement: A systematic review and Meta-analysis of prevalence. doi:10.1016/j.jctube.2026.100620 names it J Clin Tuberc Other Mycobact Dis 2026
Characterizing isoniazid preventive therapy uptake among people living with human immunodeficiency virus in Tanzania, a resource-constrained setting with a high tuberculosis burden: A systematic review and meta-analysis. doi:10.1016/j.ijregi.2026.100908 names it IJID Reg 2026
Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study. doi:10.1111/cea.70355 Clin Exp Allergy 2026
Clinical effectiveness of three months once-weekly Isoniazid and Rifapentine regimen for treatment of Latent TB Infection: a systematic review and meta-analysis. doi:10.1186/s12879-026-13607-w names it BMC Infect Dis 2026
WHO estimates of the global, regional, and national burden of 42 foodborne infectious and chemical hazards, 2000-21: an updated data synthesis. doi:10.1016/j.langlo.2026.103994 Lancet Glob Health 2026
Proportions of M. Intracellulare and M. Avium among non-tuberculous mycobacteria isolates in China: A Systematic review and Meta-Analysis. doi:10.1016/j.jctube.2026.100600 names it J Clin Tuberc Other Mycobact Dis 2026
Global burden of enteric infectious diseases, diarrhoeal diseases, and corresponding aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. doi:10.1016/S1473-3099(26)00194-5 Lancet Infect Dis 2026
TB risk during treatment with biological agents and Janus kinase inhibitors: an umbrella review. doi:10.5588/ijtld.25.0518 Int J Tuberc Lung Dis 2026
Prevalence of latent tuberculosis infection among healthcare workers in Saudi Arabia: a systematic review and meta-analysis. doi:10.1186/s12889-026-27751-0 names it BMC Public Health 2026
Multimorbidity and the risk of post-tuberculosis lung disease: a systematic review and meta-analysis. doi:10.1136/bmjgh-2025-020365 names it BMJ Glob Health 2026
Correction: Impact of alcohol consumption, substance use, and smoking on treatment outcomes in tuberculosis: a systematic review and meta-analysis. doi:10.1186/s13643-026-03210-0 names it Syst Rev 2026
Efficacy and Safety of High-Dose Rifampicin in the Management of Tuberculosis Meningitis: A Systematic Review and Meta-Analysis. doi:10.7759/cureus.107718 names it Cureus 2026
Multidimensional determinants of BCG-induced false-positivity in tuberculin skin testing: a global meta-analysis of 242 studies. doi:10.1183/16000617.0204-2025 names it Eur Respir Rev 2026
Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations. doi:10.1186/s13073-026-01670-6 Genome Med 2026
The effect of Lippia Citriodora (LC) extract on cardiometabolic risk factors: a systematic review and meta-analysis. doi:10.1038/s41387-026-00420-2 names it Nutr Diabetes 2026
Prevalence and risk factors of bovine tuberculosis in dairy cattle, 2020-2025: A systematic review and meta-analysis of available literature. doi:10.1016/j.prevetmed.2026.106920 names it Prev Vet Med 2026
Differences in tuberculosis prevalence by sex in low- and middle-income countries over 1993-2025: A systematic review and meta-analysis. doi:10.1371/journal.pmed.1005114 names it PLoS Med 2026
Updated trends in the global prevalence and burden of mental disorders, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. doi:10.1016/S0140-6736(26)00519-2 Lancet 2026
Effectiveness and Safety of Contemporary Drug Regimens for Multidrug- and Extensively Drug-resistant Tuberculosis in Children and Adolescents: A Global Systematic Review and Meta-analysis. doi:10.1097/INF.0000000000005269 names it Pediatr Infect Dis J 2026
Systematic review and meta-analysis of predictive accuracy of prognostic models for poor treatment outcome of drug resistance tuberculosis. doi:10.1038/s41598-026-53145-8 names it Sci Rep 2026
Correction: Meta-analysis of tuberculosis incidence and risk in cancer patients treated with immune checkpoint inhibitors. doi:10.3389/fonc.2026.1866448 names it Front Oncol 2026
Durable viral suppression in the dolutegravir era: a data-enabled, risk-stratified model for integrated HIV care in Uganda. doi:10.3389/fpubh.2026.1794681 Front Public Health 2026
N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR). doi:10.3389/fmed.2026.1810363 Front Med (Lausanne) 2026
Adjunctive linezolid in patients with tuberculous meningitis for the prevention of mortality or neurologic disability: a meta-analysis of randomized controlled trials. doi:10.1186/s12879-026-13604-z names it BMC Infect Dis 2026
Accuracy of nanopore sequencing technology for rapid diagnosis of tuberculous mediastinal and hilar lymphadenopathy using endobronchial ultrasound-guided transbronchial needle aspiration specimens: protocol for a systematic review and meta-analysis. doi:10.1136/bmjopen-2025-116013 names it BMJ Open 2026
Treatment outcomes and associated factors among persons with pulmonary tuberculosis in Morocco: a systematic review and meta-analysis. doi:10.1186/s12879-026-13586-y names it BMC Infect Dis 2026
Tuberculosis in children who are HIV-exposed uninfected. doi:10.1097/QAD.0000000000004543 AIDS 2026
Risk factors for drug-induced liver injury in tuberculosis patients: a meta-analysis and systematic review. doi:10.3389/fmed.2026.1834524 names it Front Med (Lausanne) 2026
Efficacy and safety of drug therapies for treating tuberculous meningitis: a network meta-analysis. doi:10.3855/jidc.21300 names it J Infect Dev Ctries 2026
Tuberculosis in the South America's homeless: a systematic review of social determinants, control strategies and health equity. doi:10.1590/1980-220X-REEUSP-2025-0222en Rev Esc Enferm USP 2026
Lung function impairment in children post-tuberculosis treatment: a systematic review and meta-analysis. doi:10.3389/fped.2026.1753683 names it Front Pediatr 2026
Meta-Analysis of Transcriptomic Datasets Reveals Key Immune Gene Profiles and Signaling Pathways in Bos taurus. doi:10.1002/age.70117 names it Anim Genet 2026
Prevalence and determinants of drug-resistant pulmonary tuberculosis in the MENA region: a systematic review and meta-analysis. doi:10.1136/bmjresp-2025-003887 names it BMJ Open Respir Res 2026
Global prevalence and risk factors of bovine tuberculosis in cattle: a systematic review and meta-analysis. doi:10.3389/fvets.2026.1820176 names it Front Vet Sci 2026
Vaccine development against Mycobacterium tuberculosis: a PRISMA-guided systematic review of conventional and computational multi-epitope approaches. doi:10.7774/cevr.2026.15.e15 Clin Exp Vaccine Res 2026
Global Status of Ethambutol Resistance in Mycobacterium tuberculosis Clinical Isolates: An Updated Systematic Review and Meta-Analysis. doi:10.1177/10766294261448630 names it Microb Drug Resist 2026
Prevalence of tuberculosis infection among pregnant women: a systematic review protocol. doi:10.11124/JBIES-25-00114 JBI Evid Synth 2026
C-reactive protein as a predictor of mortality in tuberculosis: systematic review and meta-analysis. doi:10.1186/s12879-026-13462-9 names it BMC Infect Dis 2026
Incidence and Predictors of Mortality Among Adults on Antiretroviral Therapy in Ethiopia: A Systematic Review and Meta-Analysis. doi:10.1007/s44197-026-00568-1 names it J Epidemiol Glob Health 2026
Association of Macrophage Migration Inhibitory Factor-794 CATT Microsatellite Polymorphism With Tuberculosis Risk: A Systematic Review and Meta-Analysis. doi:10.1155/pm/8413702 names it Pulm Med 2026
Idiopathic pulmonary fibrosis risk loci in East Asian populations mirror those of European populations. doi:10.1093/ajrccm/aamag152 Am J Respir Crit Care Med 2026
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(no title indexed) 2016
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A review of exotic animal disease in Great Britain and in Scotland specifically between 1938 and 2007. doi:10.1371/journal.pone.0022066 PLoS One 2011
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The role of coinfections in HIV epidemic trajectory and positive prevention: a systematic review and meta-analysis. doi:10.1097/QAD.0b013e3283491e3e names it AIDS 2011
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Factors associated with patient and health care system delay in diagnosis and treatment for TB in sub-Saharan African countries with high burdens of TB and HIV. doi:10.1111/j.1365-3156.2010.02718.x Trop Med Int Health 2011
Diagnostic accuracy of T-cell interferon-γ release assays in tuberculous pleurisy: a meta-analysis. doi:10.1111/j.1440-1843.2011.01941.x names it Respirology 2011
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(no title indexed) 2011
Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials. doi:10.1093/rheumatology/keq343 names it Rheumatology (Oxford) 2011
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Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals. doi:10.2147/clep.s9242 names it Clin Epidemiol 2010
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IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. doi:10.1007/s00439-010-0872-x Hum Genet 2010
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The relation between different dimensions of alcohol consumption and burden of disease: an overview. doi:10.1111/j.1360-0443.2010.02899.x Addiction 2010
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Mycobacterium vaccae vaccine to prevent tuberculosis in high risk people: a meta-analysis. doi:10.1016/j.jinf.2010.02.005 names it J Infect 2010
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SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis. names it Int J Tuberc Lung Dis 2006
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Routine surgery in addition to chemotherapy for treating spinal tuberculosis. doi:10.1002/14651858.CD004532.pub2 Cochrane Database Syst Rev 2006
Current perspectives on drug susceptibility testing of Mycobacterium tuberculosis complex: the automated nonradiometric systems. doi:10.1128/JCM.44.1.20-28.2006 J Clin Microbiol 2006
Risk factors for multidrug resistant tuberculosis in Europe: a systematic review. doi:10.1136/thx.2005.045963 Thorax 2006
Long term safety of etanercept in elderly subjects with rheumatic diseases. doi:10.1136/ard.2005.035287 Ann Rheum Dis 2006
Metabolism of fluoranthene by Mycobacterium sp. strain AP1. doi:10.1007/s00253-005-0120-9 Appl Microbiol Biotechnol 2006
Mycobacterium ulcerans disease. Bull World Health Organ 2005
Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk. names it Int J Tuberc Lung Dis 2005
In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression. doi:10.1186/1471-2180-5-55 names it BMC Microbiol 2005
Tuberculosis treatment outcomes in Europe: a systematic review. doi:10.1183/09031936.05.00103504 Eur Respir J 2005
Lung cancer in Asian women-the environment and genes. doi:10.1111/j.1440-1843.2005.00723.x Respirology 2005
Metabolism of fluoranthene by mycobacterial strains isolated by their ability to grow in fluoranthene or pyrene. doi:10.1007/s10295-005-0022-y J Ind Microbiol Biotechnol 2005
Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs. Int J Tuberc Lung Dis 2005
A note on variance estimation in random effects meta-regression. doi:10.1081/BIP-200067915 names it J Biopharm Stat 2005
A commercial line probe assay for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis. doi:10.1186/1471-2334-5-62 names it BMC Infect Dis 2005
Fluoroquinolones for treating tuberculosis. doi:10.1002/14651858.CD004795.pub2 Cochrane Database Syst Rev 2005
Bacteriophage- based tests for the detection of Mycobacterium tuberculosis in clinical specimens: a systematic review and meta- analysis. doi:10.1186/1471-2334-5-59 names it BMC Infect Dis 2005
Bacteriophage-based assays for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis: a meta-analysis. doi:10.1016/j.jinf.2005.05.017 names it J Infect 2005
Degradation of benz[a]anthracene by Mycobacterium vanbaalenii strain PYR-1. doi:10.1007/s10532-004-7217-1 Biodegradation 2005
Short-course therapy with rifampin plus isoniazid, compared with standard therapy with isoniazid, for latent tuberculosis infection: a meta-analysis. doi:10.1086/427802 names it Clin Infect Dis 2005
Air cleaning technologies: an evidence-based analysis. Ont Health Technol Assess Ser 2005
The BCG controversy: a reappraisal of the protective effect against tuberculosis and leprosy. Indian J Public Health 2004
The accuracy and reliability of nucleic acid amplification tests in the diagnosis of tuberculosis. Natl Med J India 2004
Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. doi:10.1016/S1473-3099(04)01206-X Lancet Infect Dis 2004
[Systematic assessment on the improvement of tuberculosis case detection through general hospital-based tuberculosis patients transferring system in China]. Zhonghua Liu Xing Bing Xue Za Zhi 2004
In vitro and in vivo activities of new rifamycin derivatives against mycobacterial infections. doi:10.2174/1381612043383287 Curr Pharm Des 2004
The classic caries clinical trial: constraints and opportunities. doi:10.1177/154405910408301s02 J Dent Res 2004
A new group of potential antituberculotics: hydrochlorides of piperidinylalkyl esters of alkoxy-substituted phenylcarbamic acids. doi:10.1007/BF02931041 Folia Microbiol (Praha) 2004
Antituberculosis agents X. Synthesis and evaluation of in vitro antituberculosis activity of 2-(5-nitro-2-furyl)- and 2-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazole derivatives. doi:10.1007/BF02980122 Arch Pharm Res 2004
Meta-analysis of BACTEC MGIT 960 and BACTEC 460 TB, with or without solid media, for detection of mycobacteria. doi:10.1128/JCM.42.5.2321-2325.2004 names it J Clin Microbiol 2004
Nucleic acid amplification tests in the diagnosis of tuberculous pleuritis: a systematic review and meta-analysis. doi:10.1186/1471-2334-4-6 names it BMC Infect Dis 2004
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. doi:10.1021/jm030438k J Med Chem 2004
Nucleic acid amplification tests for diagnosis of tuberculous meningitis. doi:10.1016/s1473-3099(03)00852-1 Lancet Infect Dis 2004
Intradermal BCG: partial protection against tuberculosis in children: unproven efficacy of multipuncture administration. Prescrire Int 2003
Nucleic acid amplification tests for tuberculous meningitis: a systematic review of diagnostic accuracy. Natl Med J India 2003
Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages. doi:10.1111/j.1365-2133.2003.05557.x Br J Dermatol 2003
Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. doi:10.1016/s1473-3099(03)00772-2 names it Lancet Infect Dis 2003
Improved tests for a random effects meta-regression with a single covariate. doi:10.1002/sim.1482 names it Stat Med 2003
Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a meta-analysis. names it Int J Tuberc Lung Dis 2003
Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV. doi:10.1002/14651858.CD003108 Cochrane Database Syst Rev 2003
Diagnostic value of adenosine deaminase in tuberculous pleural effusion: a meta-analysis. doi:10.1258/000456303766477011 names it Ann Clin Biochem 2003
Assessment by meta-analysis of PCR for diagnosis of smear-negative pulmonary tuberculosis. doi:10.1128/JCM.41.7.3233-3240.2003 names it J Clin Microbiol 2003
Atypical mycobacterial infection, starvation and effect of BCG vaccination on tuberculin skin test. doi:10.1136/thorax.58.4.367-a Thorax 2003
Mycobacterium vaccae immunotherapy for treating tuberculosis. doi:10.1002/14651858.CD001166 Cochrane Database Syst Rev 2003
Respiratory effects of environmental pollution: epidemiological data. Monaldi Arch Chest Dis 2002
Antitubercular isoniazid and drug resistance of Mycobacterium tuberculosis--a review. doi:10.1002/ardp.200290005 Arch Pharm (Weinheim) 2002
Interventions for treating tuberculous pericarditis. doi:10.1002/14651858.CD000526 Cochrane Database Syst Rev 2002
Mycobacterium tuberculosis susceptibility in Saudi Arabia. Saudi Med J 2002
Size isn't everything. doi:10.1002/sim.1284 Stat Med 2002
A meta-analysis of the effect of Bacille Calmette Guérin vaccination on tuberculin skin test measurements. doi:10.1136/thorax.57.9.804 names it Thorax 2002
Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis: a systematic review. doi:10.3201/eid0805.020002 Emerg Infect Dis 2002
Utilization of mixtures of polycyclic aromatic hydrocarbons by bacteria isolated from contaminated sediment. doi:10.1111/j.1574-6941.2002.tb00960.x FEMS Microbiol Ecol 2002
Investigation of environmental and host-related risk factors for tuberculosis in Africa. I. Methodological aspects of a combined design. doi:10.1093/aje/155.11.1066 Am J Epidemiol 2002
Meta-analysis of the impact of HIV on the infectiousness of tuberculosis: methodological concerns. doi:10.1086/339951 names it Clin Infect Dis 2002
[What place for BCG vaccination in France?]. doi:10.1016/s0929-693x(01)00685-6 Arch Pediatr 2002
Advanced methods in meta-analysis: multivariate approach and meta-regression. doi:10.1002/sim.1040 names it Stat Med 2002
Tuberculous meningitis: is a 6-month treatment regimen sufficient? Int J Tuberc Lung Dis 2001
The impact of human immunodeficiency virus type 1 on infectiousness of tuberculosis: a meta-analysis. doi:10.1086/324352 names it Clin Infect Dis 2001
[Where do we stand with BCG vaccination programme in Japan?]. Kekkaku 2001
Spinal tuberculosis (Pott's disease): its clinical presentation, surgical management, and outcome. A survey study on 694 patients. doi:10.1007/pl00011973 Neurosurg Rev 2001
Diabetes Mellitus and Tuberculosis. 2000
Preparing patients to travel abroad safely. Part 2: Updating vaccinations. Can Fam Physician 2000
Preventing tuberculosis with bacillus Calmette-Guérin vaccine: a meta-analysis of the literature. doi:10.1086/314072 names it Clin Infect Dis 2000
Applying experiences from trials of bacille Calmette-Guérin vaccine. doi:10.1086/313886 Clin Infect Dis 2000
Randomized, controlled trials, observational studies, and the hierarchy of research designs. doi:10.1056/NEJM200006223422507 N Engl J Med 2000
Regimens of less than six months for treating tuberculosis. doi:10.1002/14651858.CD001362 Cochrane Database Syst Rev 2000
Directly observed therapy and treatment adherence. doi:10.1016/S0140-6736(00)02124-3 Lancet 2000
A meta-analysis of antimycobacterial therapy for Crohn's disease. doi:10.1111/j.1572-0241.2000.01842.x names it Am J Gastroenterol 2000
Shortening the duration of treatment for cervical tuberculous lymphadenitis. doi:10.1183/09031936.00.15119200 Eur Respir J 2000
Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives. doi:10.1016/s0014-827x(99)00084-1 names it Farmaco 1999
Does aging modify pulmonary tuberculosis?: A meta-analytical review. doi:10.1378/chest.116.4.961 names it Chest 1999
A comparison of C/B ratios from studies using receiver operating characteristic curve analysis. doi:10.1016/s0895-4356(99)00075-x J Clin Epidemiol 1999
Tuberculosis. West J Med 1999
Glucocorticoids in central nervous system bacterial infection. doi:10.1001/archneur.56.7.796 Arch Neurol 1999
Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials. doi:10.1097/00002030-199903110-00009 names it AIDS 1999
Effect of preventive treatment for tuberculosis in adults infected with HIV: systematic review of randomised placebo controlled trials. doi:10.1136/bmj.317.7159.625 BMJ 1998
Key enzymes for the degradation of benzoate, m- and p-hydroxybenzoate by some members of the order Actinomycetales. J Basic Microbiol 1998
Approximate hierarchical modelling of discrete data in epidemiology. doi:10.1177/096228029800700105 Stat Methods Med Res 1998
Does the efficacy of BCG decline with time since vaccination? Int J Tuberc Lung Dis 1998
A new 4-nitrotoluene degradation pathway in a Mycobacterium strain. doi:10.1128/AEM.64.2.446-452.1998 Appl Environ Microbiol 1998
[BCG vaccines for the prevention of tuberculosis in the world]. Kekkaku 1997
Characterization of the initiator tRNA gene locus and identification of a strong promoter from Mycobacterium tuberculosis. doi:10.1099/00221287-143-11-3591 Microbiology (Reading) 1997
Variation of chest radiographic patterns in pulmonary tuberculosis by degree of human immunodeficiency virus-related immunosuppression. The Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). The AIDS Clinical Trials Group (ACTG). doi:10.1086/514546 Clin Infect Dis 1997
Simple robust procedures for combining risk differences in sets of 2 x 2 tables. doi:10.1002/sim.4780151402 Stat Med 1996
The role of BCG vaccine in the prevention and control of tuberculosis in the United States. A joint statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices. MMWR Recomm Rep 1996
[Update on the BGC vaccine. Indications for use in Europe and in developing countries]. Med Trop (Mars) 1996
The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature. names it Pediatrics 1995
Geographic latitude and the efficacy of bacillus Calmette-Guérin vaccine. doi:10.1093/clinids/20.4.982 Clin Infect Dis 1995
A random-effects regression model for meta-analysis. doi:10.1002/sim.4780140406 names it Stat Med 1995
Bacille Calmette-Guérin vaccination for the prevention of tuberculosis in health care workers. doi:10.1093/clinids/20.1.136 Clin Infect Dis 1995
Relationship between bacille Calmette-Guérin (BCG) strains and the efficacy of BCG vaccine in the prevention of tuberculosis. doi:10.1093/clinids/20.1.126 Clin Infect Dis 1995
BCG immunization: review of past experience, current use, and future prospects. Curr Clin Top Infect Dis 1995
Corticosteroids and peptic ulcer: meta-analysis of adverse events during steroid therapy. doi:10.1111/j.1365-2796.1994.tb00855.x names it J Intern Med 1994
Efficacy of BCG vaccine. JAMA 1994
Efficacy of BCG vaccine. doi:10.1001/jama.1994.03520100029015 JAMA 1994
Efficacy of BCG vaccine. doi:10.1001/jama.272.10.765b JAMA 1994
Field trials of tuberculosis vaccines: how could we have done them better? doi:10.1016/0197-2456(94)90042-6 Control Clin Trials 1994
Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. names it JAMA 1994
Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysis. doi:10.1093/ije/22.6.1154 names it Int J Epidemiol 1993
Fatal isoniazid-induced hepatitis. Its risk during chemoprophylaxis. West J Med 1993
Immunotherapy of lung cancer. Semin Oncol 1993
[Benefits of corticosteroids in the treatment of Horton's disease and rhizomelic pseudopolyarthritis: advantages and inconveniences. A meta-analysis]. doi:10.1016/s0248-8663(05)81208-1 names it Rev Med Interne 1992
[Glucocorticoids and infection]. Schweiz Med Wochenschr 1992
Toxic hepatitis with isoniazid and rifampin. A meta-analysis. doi:10.1378/chest.99.2.465 names it Chest 1991
Adenosine deaminase in the diagnosis of tuberculous pleural effusions. A report of 218 patients and review of the literature. doi:10.1378/chest.99.2.355 Chest 1991
[The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. names it Med Clin (Barc) 1990
Mineralization of phenanthrene by a Mycobacterium sp. doi:10.1128/aem.54.4.937-944.1988 Appl Environ Microbiol 1988
[Medico-social aspects of the diseases of Piedmont agricultural workers during the second half of the 19th century. II]. Minerva Med 1984
[Considerations on the meta-herpetic keratitis (author's transl)]. names it Klin Monbl Augenheilkd 1978
Comparison of specificities of humoral and cellular immune response to haptens. doi:10.1002/eji.1830051107 Eur J Immunol 1975
[Historical comments on the etiopathogenesi of scrofula in the middle of the 19th century]. Riv Stor Med 1969
[POSTOPERATIVE RESULTS OF PARTIAL NEPHRECTOMY FOR TUBERCULOSIS 8 YEARS AFTER THE OPERATION]. Hell Cheirourgike 1963
[The concept of para-tuberculosis of meta-tuberculosis in the light of some recent pharmacological data]. names it Therapie 1958
[Tuberculostatic activity of ortho- and meta-substituted thioureas]. doi:10.1007/BF02162528 names it Experientia 1956
[Metadiaphyseal tuberculous foci in the long bones in adolescents]. Vestn Rentgenol Radiol 1955
[Pulmonary surgery: meta-pneumothoracic operations]. names it Policlinico Prat 1951
[The problem of tuberculosis contagion as viewed in the first half of the 19th century]. Arch Tisiol Mal Appar Respir 1950
[Tuberculosis of the lower half of the lung in adults]. Riv Patol Clin Tuberc 1947

Title+abstract index only: a paper that names this gene solely in its body text, a figure legend or a supplement is invisible here. That is why this list sits beside the curated layer rather than replacing it - Rv0007's characterisation, found by a full-text sweep, returns zero in this one. Absence from this list is not absence from the literature. Source: PubMed E-utilities sweep (esearch + esummary), every alias of the gene searched in conjunction with a mycobacterial context term; ambiguous common-word aliases excluded. phase198, 2026-09-06.

This layer CITES the literature and adds context; it does not change the verdict or the function stated elsewhere in this fiche. This distinguishes a gene that is dark because nobody has looked from one that is dark despite having been studied. Source: PubMed (whole): H37Rv locus tag + GENE NAME + ortholog identifiers (Mb…, MMAR_…, MSMEG_…, ML…, MAB_…), under a mycobacterial context filter; hits verified against the abstract text. Species-context counts distinguish M. tuberculosis literature from literature on other mycobacteria. phase76/phase77, 2026-07-13.

Genomic-neighbour overlap (structural caveat) co-directional · 0 % of gene

NeighbourRv3342 (Rv3342, + strand)
Overlap4 bp, 0 % of this gene's length

co-directional overlap: ordinary (e.g. shared stop/start codons in an operon), not the Rv2438A-type artefact P20.1, derived from GFF3 gene coordinates, 2026-08-03.

Conditional expression context (iModulons)

Member of 1 independently-modulated gene set(s): SigH (sigH).

iModulon membership (independently-modulated gene sets from a 647-sample RNA-seq compendium): the conditional co-expression context. Co-expression is a regulatory context, NOT a molecular function. Source: iModulonDB / modulome_mtb (Yoo 2022).

CRISPRi vulnerability

Vulnerability index -7.50 (95% CI -7.79 to -7.21). A more negative index = more vulnerable to knockdown (better drug-target quality); indicative threshold VI ≤ -6 = highly vulnerable.

Quantitative CRISPRi knockdown, graded (finer than binary Tn-seq essentiality). Source: CRISPRi vulnerability index (Bosch 2021, supplementary Table S2 'mmc3.xlsx', bulk import via Europe PMC -- supersedes the per-gene pebble.rockefeller.edu scrape of phase46_crispri_vulnerability.py).

Legacy record & comparison (Mycobrowser)

Mycobrowser functionCatalyzes acylation of L-homoserine. Involved in biosynthesis of methionine; HTA variant; first step [catalytic activity: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine].
Mycobrowser EC 2.3.1.31 · agrees with the atlas

The legacy Mycobrowser record is shown for verification. Mycobrowser is no longer maintained; its EC numbers predate recent nomenclature revisions, so a class change usually reflects re-numbering, not a conflict.

Orthologues (reciprocal best hits across mycobacteria)

M. bovis Mb3373 · 100.0% identity
M. leprae ML0682c · 85.0% identity
M. marinum MMAR_1184 · 85.5% identity
M. smegmatis MSMEG_1651 · 78.8% identity
M. orygis RJtmp_003445 · 100.0% identity
M. abscessus MAB_3688 · 76.5% identity

Reciprocal-best-hit orthologues (DIAMOND) against the Mycobrowser reference proteomes. A missing species is informative: e.g. a gene absent from M. leprae was likely lost in its reductive genome evolution. Locus tags link to Mycobrowser.

Curated reference (UniProt)

UniProt P9WJY9 SwissProt · reviewed · Evidence at protein level
UniProt nameHomoserine O-acetyltransferase
EC (curated) EC 2.3.1.31
Curated functionTransfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

Functional vocabulary (eggNOG-mapper, orthology transfer)

COG category E Amino acid transport and metabolism
Preferred namemetXA
eggNOG descriptionTransfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Orthologous groupCOG2021
EC number EC 2.3.1.31
KEGG orthology K00641
KEGG pathways map00270, map01100, map01130
Gene Ontology (49) GO:0000096, GO:0000097, GO:0003674, GO:0003824, GO:0004414, GO:0005575, GO:0005623, GO:0005886, GO:0006082, GO:0006520, GO:0006555, GO:0006790 +37 more

Orthology-based transfer (eggNOG 5.0.2, diamond). EC/KO/GO/CAZy are computed annotations, not manual curation; cross-check against the primary literature before treating a specific reaction as established.

Conservation & selection (intra-MTBC, 142 601 strains, snapshot of 2026-09-29)

pN/pS 0.548 · quasi-invariant (5 sites), pN/pS underpowered
Polymorphic sites (≥ 0.1% of strains) 2 synonymous, 3 missense, 0 nonsense, 0 frameshift

pN/pS from segregating SNPs (singletons removed) normalised by possible sites. Low pN/pS = purifying selection (a strong signal that a "hypothetical" is a real, constrained gene). A high pN/pS is ambiguous: relaxed constraint or positive selection (drug resistance, antigenic variation) inflate it; e.g. rpoB/katG/pncA score high here for resistance, not loss of function. A clonal disruption (one allele over a clade) suggests lineage pseudogenisation; a convergent one (many independent alleles) is typical of resistance loss-of-function.

Outgroup conservation (beyond the MTBC) Actinomycetia

M. canettii dN/dS (deep-divergence selection) 0.0 (low power) · 3 consensus substitution(s)
low power (3 canettii-consensus substitution(s)); present in M. canettii but dN/dS not reliable
Limitation: dN/dS mixes fixed canettii-H37Rv divergence with intra-canettii polymorphism, and is not polarised (the per-gene repolarisation is not viable: 79 % of the consensus SPDI lie outside the polarised table).
Genus-wide presence (~53 non-MTBC Mycobacterium) present in 53/53 (100%) · mean identity 85.1% · 4/4 closest MTBAP relatives
conserved across the genus (present in 53/53 non-MTBC Mycobacterium genomes, incl. distant relatives) — an ancient core gene predating the genus radiation
Phylostratum (deepest detected homolog) MTBC-specific → Mycobacterium → Mycobacteriaceae → Corynebacteriales → Actinomycetia → Bacteria
detected in 8/13 non-Mycobacterium reference genomes (down to Actinomycetia) · mean identity 61.1%
detected across the class Actinomycetia (beyond Corynebacteriales) but not outside the phylum — an Actinobacteria-level ancient gene

Two orthogonal outgroup signals. M. canettii (the immediate outgroup) gives a deep-divergence dN/dS (a low value confirms a constrained, real gene; shown as confident only at ≥8 substitutions, else flagged low-power). Genus-wide presence/absence (tblastn vs assembled non-MTBC genomes) places the gene on the ancient-core ↔ MTBC-specific axis: a gene absent even from the closest MTBAP relatives is a candidate MTBC-specific innovation (possible host-adaptation factor, to confirm by synteny). The phylostratum extends that axis outside the genus (tblastn vs 13 reference genomes spanning Mycobacteriaceae → Corynebacteriales → Actinomycetia → outside the phylum): it is the deepest clade in which a homolog is still detected, i.e. a proxy for gene age. Read it with the null model in mind: a shallow (young) stratum can also reflect homology-detection failure for short or fast-evolving ORFs, so it is a descriptive axis, not a proof of novelty.

Essentiality (transposon mutagenesis) essential

DeJesus 2017 callES · essential
What the call meansessential: insertions absent across the whole ORF
TA sites (Himar1) 15 in the ORF — 15 in the essential state, 0 growth-defect, 0 non-essential, 0 growth-advantage. Saturation 0.000, mean read count 0. A region of the protein devoid of TA sites is invisible to this assay: nothing can be inferred about it, in either direction.
All 15 sites lie in this ORF alone (no overlapping CDS shares any), so the call is attributable to this gene.

Genome-wide Himar1 transposon essentiality in H37Rv (DeJesus 2017). An essential call (ES/ESD/GD) is strong, independent evidence that a "hypothetical" locus encodes a functional, selectively required gene — orthogonal to intra-species conservation.

Chemical-genetic target & druggability (PROSPECT) hypomorph tool strain

This gene is part of the PROSPECT collection of TetON transcriptional-knockdown (hypomorph) strains of essential M. tuberculosis genes, built as a sensitised background for chemical-genetic mechanism-of-action deconvolution. Being in the panel means the gene is an essential / vulnerable target for which a validated knockdown tool strain exists.

Hypomorph strainmetA TetOn 6.3 (TetON promoter 6)
Baseline knockdown fitness2.558 median doublings (across 6 screen pool(s)) — fewer doublings = stronger growth defect on knockdown
Used in target deconvolutionyes (informs phenotypic-cluster / MOA assignment)

Panel membership reflects essentiality/vulnerability and the availability of a genetic tool, not a specific molecular function; it never changes the verdict here. Source: Bond AN et al., Nat Commun 2025;16:9673 (doi:10.1038/s41467-025-64662-x); PROSPECT chemical-genetic platform.

Mutant phenotypes (conditional Tn-seq, MtbTnDB) in-vivo phenotype

Conditionlog2FCqEffect
fitness in mouse infection, day 10 (in vivo) -2.380.041 required
fitness in mouse infection, day 45 (in vivo) -2.380.02 required

Conditional fitness of transposon-disruption mutants across 2 significant condition(s) (|log2FC|≥1, q≤0.05), from the standardized MtbTnDB compendium. A negative log2FC means the mutant is depleted — the gene contributes to fitness in that condition. An in-vivo defect for a "hypothetical" is strong evidence it matters for infection, even without a known molecular function. Disruption (Tn insertion), not a clean deletion; genetic-interaction screens excluded.

Proteomics (mass spectrometry) detected

MS detectiondetected in 9 of 16 independent MS datasets
Integrated abundance16.8 ppm · rank 2436/3519 (30.8th percentile)

Detection by mass spectrometry is direct, experimental evidence that the protein product exists — orthogonal to sequence conservation and to Tn-seq essentiality, and especially decisive for a "hypothetical" locus. Read the dataset count as abundance, not as replication. Measured across this atlas (3,491 detected proteins), the number of datasets a protein appears in tracks its abundance almost monotonically: median 1.2 ppm at 1 dataset of 16, 27 ppm at 10, 392 ppm at 15, 1,325 ppm at 16 — three orders of magnitude. A high count therefore says the protein is abundant more than it says several independent experiments confirmed it. What the count does establish, at any value, is that the product exists.

Predicted localisation (DeepTMHMM + lipobox) no export signal, no TM helix

Predictionno signal peptide, no TM helix (DeepTMHMM class GLOB)
DeepTMHMM classGLOB

A verified absence of signals, which is not a compartment. No Sec/Tat signal peptide, no transmembrane helix and no lipobox were found on this sequence. The predictor reports topology and export signals; it does not measure where the protein ends up, so this page draws no cytoplasmic conclusion from it. In M. tuberculosis that reservation is not theoretical: the 12 Esx paralogues of this atlas — EsxA/ESAT-6 and EsxB/CFP-10 among them, the best-established secreted proteins of the species — carry this very call, because substrates of the type VII (ESX) secretion system leave no recognisable signal. « Secreted » and « no signal peptide » are true together here.

Transmembrane topology and signal peptide from DeepTMHMM (deep-learning reference predictor); lipoproteins from a (myco)bacterial lipobox motif. A sequence-based prediction of subcellular context.

Physico-chemical properties (computed, ProtParam)

Length379 aa
Molecular weight39.8 kDa
Theoretical pI5.39
GRAVY-0.066 (hydrophilic)
Aliphatic index93.5
Aromaticity0.053
Instability index32.8 (stable)

Computed from the ancestral MTBC0 sequence with the ExPASy ProtParam method (Biopython). Descriptive biophysical context: a positive GRAVY flags a hydrophobic (often membrane) protein, a high instability index (>40) predicts a short in-vitro half-life, an extreme pI hints at compartment or binding partner.

Domains (Pfam, hmmscan --cut_ga)

PfamAccessioni-EvalueResiduesDescription
Abhydrolase_1PF00561.27 4.6e-1952–356 alpha/beta hydrolase fold

3D structure (interactive — Mol*/pdbe-molstar)

Experimental structure 7ryt (PDBe), the strongest available structural evidence for this gene. Drag to rotate, scroll to zoom; hetero-groups (ligands, ions, waters hidden by default) shown as sticks.

Experimental structures (Protein Data Bank) 3 solved

PDBMethodResolutionCoverage
7ryt X-ray diffraction 2.67 Å 97%
8f2l X-ray diffraction 2.89 Å 97%
6pux X-ray diffraction 1.9 Å 96%

Experimentally solved structures mapped from the UniProt accession via PDBe/SIFTS (3 total; up to 8 shown, ranked by sequence coverage then resolution). An experimental structure is direct proof of the folded product and the strongest structural evidence — superseding the predicted ESMFold/AlphaFold models below for any covered region.

Structural search (AlphaFold DB model, Foldseek vs PDB — genome-wide) pLDDT 96.3

PDB hitprobTM (aln)TM (query)TM (target)Seq. id.Cov. q / tE-valueDescription
7ryt-assembly1_B 1.00 1.00 0.96 0.99 100% 97% / 100% 5.6e-78 sig 7ryt-assembly1_B Crystal structure of Mycobacterium tuberculosis acetylated Homoserine transacetylase with Coenzyme A
6pux-assembly1_B 1.00 1.00 0.95 0.99 100% 96% / 100% 1.4e-76 sig 6pux-assembly1_B Homoserine transacetylase MetX from Mycobacterium tuberculosis
6ioh-assembly1_B 1.00 1.00 0.96 0.99 80% 96% / 100% 1.1e-68 sig 6ioh-assembly1_B Crystal structure of Homoserine O-acetyltransferase in complex with Homoserine from Mycobacterium smegmatis ATCC 19420
5w8p-assembly1_B 1.00 0.98 0.95 0.98 76% 96% / 100% 2.5e-67 sig 5w8p-assembly1_B Homoserine transacetylase MetX from Mycobacterium abscessus
5w8o-assembly1_B 1.00 0.99 0.90 0.99 75% 93% / 99% 3.1e-63 sig 5w8o-assembly1_B Homoserine transacetylase MetX from Mycobacterium hassiacum

Foldseek search of the AlphaFold DB model (mean pLDDT 96.3, gated at 70) against the PDB — a genome-wide extension of the ESMFold dark-gene search that also covers proteins beyond the single-sequence length limit. Confident structural neighbours (E < 0.01) shown.

Genomic context (neighbours & predicted operon) operon of 3

Upstream (5' on genome)metC (+ strand, 11 bp gap)
Downstream (3' on genome)Rv3342 (+ strand, -4 bp gap)
Predicted operon metC · metA · Rv3342

Neighbours from the H37Rv annotation (+ strand). The operon is predicted by co-directional intergenic distance (same strand, gaps ≤50 bp) — a transcription-unit hypothesis, not a mapped TSS. For a "hypothetical", co-transcription with a characterised operon is a concrete functional lead (complements the STRING neighborhood channel below).

Published operon evidence (two independent sources)

Roback 2007 (logistic regression: distance + expression correlation, 474 microarrays) operon of 2: metA · Rv3342 — disagrees with the distance heuristic above
REMap 2016 (RNA-seq coverage continuity, CDC1551, tag MT3444) exponential phase: operon of 3, Rv3340 · Rv3341 · Rv3342 (coverage 46.28)
stationary phase: operon of 3, Rv3340 · Rv3341 · Rv3342 (coverage 28.08) — agrees with the distance heuristic above

Two independent published operon maps, cited alongside the distance heuristic above: an association corroborating or contradicting the heuristic, never proof of shared function. REMap's RNA-seq coverage continuity is the most direct of the three signals; Roback's logistic regression and the intergenic-distance heuristic are statistical proxies.

Functional interaction network (STRING v12, guilt-by-association)

Explore full network →

Node colour = verdict, dashed = still uncharacterised; edge colour = evidence (green experimental, orange genomic-context, grey co-expression), width ∝ score. Click a partner to open its page; "Explore full network" to walk the graph.

Closest characterised functional partner: metC (O-acetylhomoserine sulfhydrylase), high confidence (score 999, all STRING channels except text-mining; the partner is chosen on its genomic-context evidence). The pair is recorded in a curated database (pathway or complex membership) for M. tuberculosis genes themselves (score ≥ 200): a curated association, not a measurement in this organism.

Showing the 15 strongest of this gene's 34 partners at medium confidence (15 at high confidence). The table is an extract, not a neighbourhood: across the proteome the real median degree is 34 while the served median is 15, so no hub, degree distribution or centrality may be read on this table. None of the 34 partners rests on an interaction measured in M. tuberculosis itself.

PartnerProductScoreNo text-miningChannels (≥400)
Rv3340 metC curated O-acetylhomoserine sulfhydrylase 999 999 ctx neighborhood:872 cooccurence:499 coexpression:817 database:900 textmining:648
Rv3342 methyltransferase 984 984 ctx neighborhood:881 coexpression:868
Rv1294 thrA curated homoserine dehydrogenase 951 944 database:900
Rv0391 metZ curated O-succinylhomoserine sulfhydrylase 957 931 database:900 textmining:409
Rv1079 metB curated cystathionine gamma-synthase 952 922 database:900 textmining:419
Rv1559 ilvA curated threonine dehydratase IlvA 845 829 database:800
Rv1077 cbs curated cystathionine beta-synthase 836 811 database:800
Rv1093 glyA1 curated serine hydroxymethyltransferase 824 803 database:800
Rv3042c serB2 curated phosphoserine phosphatase SerB 811 803 database:800
Rv0070c glyA2 curated serine hydroxymethyltransferase 823 801 database:800
Rv1612 trpB curated tryptophan synthase subunit beta 810 801 database:800
Rv1613 trpA curated tryptophan synthase subunit alpha 801 801 database:800
Rv0069c sdaA curated L-serine dehydratase 800 801 database:800
Rv0436c pssA curated CDP-diacylglycerol--serine O-phosphatidyltransferase 800 800 database:800
Rv2124c metH methionine synthase 818 651 coexpression:456 textmining:501

STRING combines evidence channels (neighborhood, fusion, cooccurrence, coexpression, experimental, database, text-mining) into a 0–1000 score. The ctx badge marks edges carried by the genomic-context channels (conserved neighborhood, fusion, phylogenetic co-occurrence), which are independent of orthology and structure and the strongest signal for an unknown gene. The no text-mining column recomputes the score from data alone, so a link that does not depend on the literature is visible. Association is a function hypothesis, not proof: corroborate with the operon context and the primary literature before assigning a function.

Where the experimental evidence comes from, and why it matters here. STRING's experimental channel fuses interactions measured in M. tuberculosis with interactions measured in another organism and transferred to this pair by orthology. The two are not equivalent for this atlas, whose standing rule is that better studied elsewhere is not a function established in M. tuberculosis. Measured on the served network: of the 38 229 partner pairs shown across the atlas, 13 483 partner rows carry a non-zero experimental channel, and only 106 pairs rest on an interaction measured in M. tuberculosis itself — 0.3 % of the network. Those 106 are long-established complexes (ESX-1/ESAT-6, RNA polymerase with CarD and RbpA, the Pup–Mpa proteasome, gyrase, Emb, GarA with PknB and PknG, the Rel modules); no still-uncharacterised gene is among them. The reason is not a gap in this atlas but in the literature: there is almost no experimental interactome of this bacterium, IntAct holding 134 curated protein pairs for a ~4 000-gene proteome. A exp (transferred) badge is therefore a lead, never a measurement, and an absence of badge is not evidence that the pair does not interact.

Evidence

  • Legacy H37Rv annotation: homoserine O-acetyltransferase
  • MTBC0 PGAP product: homoserine O-acetyltransferase
  • Pfam (hmmscan --cut_ga): Abhydrolase_1 PF00561.27 (E=5e-19)
  • (auto-curated by rules from PGAP + Pfam + Foldseek; not hand-reviewed)

Sources

  • Ancestral sequence & coordinates: Harrison LB et al. (2024), An imputed ancestral reference genome for the MTBC, doi:10.1101/2023.09.07.556366
  • Product annotation: NCBI PGAP on MTBC0; legacy from H37Rv NC_000962.3 (RefSeq NP_217858.1)
  • Domains: Pfam-A via hmmscan --cut_ga — Abhydrolase_1 (PF00561.27)
  • Sequence-level signal: ESM Atlas (EvolutionaryScale × BioHub) — exploratory
  • Controlled vocabulary: eggNOG-mapper 2.1.12 (Cantalapiedra et al. 2021, doi:10.1093/molbev/msab293), eggNOG 5.0 DB (Huerta-Cepas et al. 2019) — OG COG2021
  • Curated reference: UniProt P9WJY9 (SwissProt, reviewed; Evidence at protein level)
  • Intra-MTBC selection: pN/pS and disruption from SPDI variants of 142 601 MTBC strains (this work, local collection vs H37Rv NC_000962.3)
  • Genome-wide structure: AlphaFold DB model (Jumper et al. 2021, doi:10.1038/s41586-021-03819-2; Varadi et al. 2024, doi:10.1093/nar/gkad1011) searched vs PDB with Foldseek (mean pLDDT 96.3)
  • Interaction network: STRING v12.0 (Szklarczyk et al. 2023, doi:10.1093/nar/gkac1000), taxon 83332, CC-BY 4.0 — 34 functional partner(s); context anchor metC
  • Essentiality: genome-wide transposon mutagenesis in H37Rv — DeJesus et al. 2017 (mBio, doi:10.1128/mBio.02133-16, CC BY)
  • Proteomics: integrated mass-spectrometry abundance from PaxDb 5.0 (Huang et al. 2023, doi:10.1016/j.mcpro.2023.100640), taxon 83332 — weighted average of 16 datasets, incl. Schubert et al. 2013 (doi:10.1016/j.chom.2013.04.008) and Albrethsen et al. 2013 (doi:10.1074/mcp.M112.018846)
  • Functional category: TubercuList scheme (Cole et al. 1998, doi:10.1038/31159), via Mycobrowser (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006)
  • Orthologues: reciprocal best hits (DIAMOND, Buchfink et al. 2021, doi:10.1038/s41592-021-01101-x) against Mycobrowser release 5 reference proteomes
  • Experimental structures: PDBe/SIFTS UniProt→PDB mapping (Dana et al. 2019, doi:10.1093/nar/gky1114)
  • Genomic context / operon: H37Rv annotation; operon predicted by co-directional intergenic distance (Salgado et al. 2000, doi:10.1073/pnas.030539397)
  • Mutant phenotypes: standardized Tn-seq compendium MtbTnDB (Jinich et al. 2025, doi:10.1111/mmi.15370), aggregating many primary Tn-seq studies across conditions
  • Physico-chemical properties: ExPASy ProtParam method via Biopython (Gasteiger et al. 2005), computed from the MTBC0 sequence
  • Predicted localisation: DeepTMHMM (Hallgren et al. 2022, doi:10.1101/2022.04.08.487609) for transmembrane topology and signal peptide
  • Primary literature: none located yet; annotation rests on the domain/homology sources above.

Ancestral MTBC0 protein sequence

>mtbc0_003553|Rv3341|metA
MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR