MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 1 954 705–2 274 705 bp (320 000 bp)
+ strand − strand Rv1717 (Rv1717) — family_assigned: cupin domain-containing protein Rv1718 (Rv1718) — requalified: 3-keto-5-aminohexanoate cleavage protein Rv1719 (Rv1719) — family_assigned: IclR family transcriptional regulator vapC12 (Rv1720c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB12 (Rv1721c) — requalified: antitoxin Rv1722 (Rv1722) — requalified: biotin carboxylase Rv1723 (Rv1723) — requalified: serine hydrolase Rv1724c (Rv1724c) — dark: hypothetical protein Rv1725c (Rv1725c) — family_assigned: winged helix-turn-helix transcriptional regulator Rv1726 (Rv1726) — requalified: FAD-binding oxidoreductase Rv1727 (Rv1727) — family_assigned: TIGR03086 family metal-binding protein Rv1728c (Rv1728c) — requalified: glycoside hydrolase Rv1729c (Rv1729c) — requalified: class I SAM-dependent methyltransferase Rv1730c (Rv1730c) — family_assigned: serine hydrolase domain-containing protein gabD2 (Rv1731) — requalified: succinic semialdehyde dehydrogenase Rv1732c (Rv1732c) — family_assigned: thioredoxin family protein Rv1733c (Rv1733c) — family_assigned: hypothetical protein narX (Rv1736c) — family_assigned: respiratory nitrate reductase subunit gamma narK2 (Rv1737c) — requalified: nitrate transporter NarK Rv1738 (Rv1738) — family_assigned: DUF1876 domain-containing protein Rv1739c (Rv1739c) — family_assigned: SulP family inorganic anion transporter vapB34 (Rv1740) — family_assigned: type II toxin-antitoxin system VapB family antitoxin vapC34 (Rv1741) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv1742 (Rv1742) — family_assigned: hypothetical protein pknE (Rv1743) — requalified: serine/threonine protein kinase PknE Rv1744c (Rv1744c) — dark: hypothetical protein idi (Rv1745c) — requalified: isopentenyl-diphosphate Delta-isomerase pknF (Rv1746) — requalified: serine/threonine protein kinase PknF Rv1747 (Rv1747) — family_assigned: ATP-binding cassette domain-containing protein Rv1749c (Rv1749c) — family_assigned: DUF6790 family protein fadD1 (Rv1750c) — requalified: fatty-acid--CoA ligase FadD1 Rv1754c (Rv1754c) — requalified: DUF4185 domain-containing protein Rv1761c (Rv1761c) — family_assigned: DUF5073 family protein Rv1762c (Rv1762c) — family_assigned: heavy metal-binding domain-containing protein Rv1766 (Rv1766) — family_assigned: metal-sensitive transcriptional regulator Rv1767 (Rv1767) — family_assigned: carboxymuconolactone decarboxylase family protein Rv1769 (Rv1769) — requalified: amino acid deaminase/aldolase Rv1771 (Rv1771) — requalified: L-gulono-1%2C4-lactone dehydrogenase Rv1772 (Rv1772) — family_assigned: ANTAR domain-containing protein Rv1773c (Rv1773c) — family_assigned: IclR family transcriptional regulator Rv1774 (Rv1774) — requalified: FAD-binding oxidoreductase Rv1775 (Rv1775) — family_assigned: hypothetical protein Rv1776c (Rv1776c) — family_assigned: TetR/AcrR family transcriptional regulator Rv1778c (Rv1778c) — dark: hypothetical protein Rv1779c (Rv1779c) — dark: DUF4407 domain-containing protein Rv1780 (Rv1780) — family_assigned: hypothetical protein malQ (Rv1781c) — requalified: 4-alpha-glucanotransferase eccB5 (Rv1782) — family_assigned: type VII secretion system ESX-5 subunit EccB5 cyp143 (Rv1785c) — requalified: cytochrome P450 Rv1786 (Rv1786) — requalified: ferredoxin esxJ (Rv1038c) — requalified: type VII secretion system ESX-5 protein EsxJ Rv1794 (Rv1794) — family_assigned: ESX secretion-associated protein EspG eccD5 (Rv1795) — family_assigned: type VII secretion system ESX-5 subunit EccD5 mycP5 (Rv1796) — requalified: type VII secretion system ESX-5 serine protease mycosin MycP eccE5 (Rv1797) — family_assigned: type VII secretion system ESX-5 subunit EccE5 eccA5 (Rv1798) — family_assigned: type VII secretion system ESX-5 AAA family ATPase EccA5 lppT (Rv1799) — dark: hypothetical protein Rv1804c (Rv1804c) — requalified: DUF732 domain-containing protein mgtC (Rv1811) — family_assigned: MgtC/SapB family protein Rv1812c (Rv1812c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv1813c (Rv1813c) — family_assigned: DUF4189 domain-containing protein Rv1815 (Rv1815) — family_assigned: hypothetical protein Rv1817 (Rv1817) — family_assigned: FAD-binding protein bacA (Rv1819c) — family_assigned: vitamin B12 ABC transporter ATP-binding protein BacA ilvG (Rv1820) — requalified: acetolactate synthase pgsA2 (Rv1822) — family_assigned: CDP-alcohol phosphatidyltransferase family protein Rv1823 (Rv1823) — family_assigned: DUF881 domain-containing protein Rv1824 (Rv1824) — family_assigned: small basic family protein Rv1825 (Rv1825) — family_assigned: DUF881 domain-containing protein gcvH (Rv1826) — requalified: glycine cleavage system protein GcvH garA (Rv1827) — requalified: glycogen accumulation regulator GarA Rv1828 (Rv1828) — family_assigned: MerR family transcriptional regulator gcvB (Rv1832) — requalified: aminomethyl-transferring glycine dehydrogenase Rv1833c (Rv1833c) — requalified: haloalkane dehalogenase lipZ (Rv1834) — family_assigned: alpha/beta hydrolase Rv1835c (Rv1835c) — family_assigned: CocE/NonD family hydrolase Rv1836c (Rv1836c) — family_assigned: substrate-binding domain-containing protein glcB (Rv1837c) — requalified: malate synthase G vapC13 (Rv1838c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB13 (Rv1839c) — requalified: antitoxin Rv1841c (Rv1841c) — family_assigned: hemolysin family protein Rv1842c (Rv1842c) — family_assigned: hemolysin family protein guaB1 (Rv1843c) — family_assigned: GuaB1 family IMP dehydrogenase-related protein blaR (Rv1845c) — family_assigned: M56 family metallopeptidase blaI (Rv1846c) — requalified: transcriptional repressor BlaI Rv1847 (Rv1847) — family_assigned: PaaI family thioesterase ureA (Rv1848) — family_assigned: urease subunit gamma ureB (Rv1849) — family_assigned: urease subunit beta ureC (Rv1850) — family_assigned: urease subunit alpha ureF (Rv1851) — requalified: urease accessory protein UreF ureG (Rv1852) — requalified: urease accessory protein UreG ndh (Rv1854c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv1855c (Rv1855c) — requalified: LLM class F420-dependent oxidoreductase Rv1856c (Rv1856c) — family_assigned: SDR family oxidoreductase modA (Rv1857) — family_assigned: molybdate ABC transporter substrate-binding protein modB (Rv1858) — family_assigned: ABC transporter permease modC (Rv1859) — family_assigned: sulfate/molybdate ABC transporter ATP-binding protein Rv1861 (Rv1861) — family_assigned: GlsB/YeaQ/YmgE family stress response membrane protein adhA (Rv1862) — family_assigned: zinc-binding alcohol dehydrogenase family protein Rv1865c (Rv1865c) — family_assigned: SDR family oxidoreductase Rv1867 (Rv1867) — requalified: acetyl-CoA acetyltransferase Rv1868 (Rv1868) — family_assigned: NAD(P)H-binding protein Rv1869c (Rv1869c) — requalified: FAD-dependent oxidoreductase Rv1871c (Rv1871c) — family_assigned: nitroreductase family deazaflavin-dependent oxidoreductase lldD2 (Rv1872c) — requalified: quinone-dependent L-lactate dehydrogenase Rv1873 (Rv1873) — family_assigned: DUF1810 domain-containing protein Rv1875 (Rv1875) — requalified: PPOX class F420-dependent oxidoreductase Rv1877 (Rv1877) — family_assigned: MDR family MFS transporter glnA3 (Rv1878) — family_assigned: glutamine synthetase family protein Rv1879 (Rv1879) — family_assigned: amidohydrolase family protein cyp140 (Rv1880c) — requalified: cytochrome P450 lppE (Rv1881c) — requalified: lipoprotein LpqH Rv1882c (Rv1882c) — family_assigned: SDR family oxidoreductase Rv1883c (Rv1883c) — family_assigned: SRPBCC family protein rpfC (Rv1884c) — requalified: resuscitation-promoting factor RpfC Rv1885c (Rv1885c) — requalified: chorismate mutase fbpB (Rv1886c) — requalified: diacylglycerol acyltransferase/mycolyltransferase Ag85B Rv1887 (Rv1887) — family_assigned: hypothetical protein Rv1891 (Rv1891) — dark: hypothetical protein Rv1892 (Rv1892) — family_assigned: hypothetical protein Rv1893 (Rv1893) — family_assigned: hypothetical protein Rv1894c (Rv1894c) — family_assigned: nitronate monooxygenase family protein Rv1896c (Rv1896c) — requalified: class I SAM-dependent methyltransferase dtd (Rv1897c) — requalified: D-aminoacyl-tRNA deacylase Rv1898 (Rv1898) — family_assigned: MTH1187 family thiamine-binding protein lipJ (Rv1900c) — family_assigned: adenylate/guanylate cyclase domain-containing protein cinA (Rv1901) — requalified: competence/damage-inducible protein A nanT (Rv1902c) — family_assigned: sialate:H+ symport family MFS transporter Rv1903 (Rv1903) — family_assigned: phage holin family protein Rv1904 (Rv1904) — requalified: anti-sigma factor antagonist aao (Rv1905c) — requalified: FAD-dependent oxidoreductase Rv1906c (Rv1906c) — family_assigned: hypothetical protein katG (Rv1908c) — requalified: catalase/peroxidase HPI furA (Rv1909c) — family_assigned: Fur family transcriptional regulator Rv1910c (Rv1910c) — family_assigned: YbhB/YbcL family Raf kinase inhibitor-like protein lppC (Rv1911c) — family_assigned: YbhB/YbcL family Raf kinase inhibitor-like protein fadB5 (Rv1912c) — family_assigned: medium chain dehydrogenase/reductase family protein Rv1913 (Rv1913) — requalified: MBL fold metallo-hydrolase Rv1914c (Rv1914c) — dark: hypothetical protein Rv1919c (Rv1919c) — family_assigned: SRPBCC family protein Rv1920 (Rv1920) — family_assigned: lysophospholipid acyltransferase family protein lppF (Rv1921c) — requalified: haloacid dehalogenase-like hydrolase Rv1922 (Rv1922) — requalified: serine hydrolase Rv1924c (Rv1924c) — family_assigned: hypothetical protein fadD31 (Rv1925) — requalified: fatty-acid--AMP ligase FAAL31/FadD31 mpt63 (Rv1926c) — requalified: immunoprotective protein Mpt63 Rv1927 (Rv1927) — family_assigned: YqjF family protein Rv1928c (Rv1928c) — family_assigned: SDR family oxidoreductase Rv1929c (Rv1929c) — family_assigned: TIGR03085 family metal-binding protein Rv1930c (Rv1930c) — requalified: glutamine amidotransferase tpx (Rv1932) — requalified: thiol peroxidase fadE18 (Rv1933c) — family_assigned: acyl-CoA dehydrogenase family protein fadE17 (Rv1934c) — requalified: acyl-CoA dehydrogenase echA13 (Rv1935c) — requalified: enoyl-CoA hydratase Rv1936 (Rv1936) — requalified: LLM class flavin-dependent oxidoreductase Rv1937 (Rv1937) — requalified: FAD-binding oxidoreductase ephB (Rv1938) — requalified: epoxide hydrolase EphB Rv1939 (Rv1939) — family_assigned: flavin reductase family protein Rv1941 (Rv1941) — family_assigned: SDR family oxidoreductase mazF5 (Rv1942c) — family_assigned: type II toxin-antitoxin system PemK/MazF family toxin mazE5 (Rv1943c) — requalified: type II toxin-antitoxin system antitoxin MazE5 Rv1944c (Rv1944c) — family_assigned: SEC-C domain-containing protein Rv1945 (Rv1945) — requalified: HNH endonuclease signature motif containing protein lppG (Rv1946c) — family_assigned: lipoprotein Rv1947 (Rv1947) — family_assigned: hypothetical protein Rv1948c (Rv1948c) — family_assigned: hypothetical protein Rv1950c (Rv1950c) — dark: hypothetical protein Rv1951c (Rv1951c) — dark: hypothetical protein vapB14 (Rv1952) — requalified: antitoxin Rv1954c (Rv1954c) — requalified: hypothetical protein higB (Rv1955) — requalified: type II toxin-antitoxin system toxin HigB higA (Rv1956) — requalified: type II toxin-antitoxin system antitoxin HigA Rv1957 (Rv1957) — requalified: SecB-like chaperone Rv1958c (Rv1958c) — dark: hypothetical protein parE1 (Rv1959c) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin parD1 (Rv1960c) — family_assigned: type II toxin-antitoxin system ParD family antitoxin Rv1961 (Rv1961) — family_assigned: hypothetical protein vapC35 (Rv1962c) — family_assigned: type II toxin-antitoxin system VapC family toxin mce3R (Rv1963c) — family_assigned: TetR family transcriptional regulator Mce3R yrbE3A (Rv1964) — family_assigned: ABC transporter permease yrbE3B (Rv1965) — family_assigned: ABC transporter permease mce3B (Rv1967) — family_assigned: virulence factor Mce family protein mce3C (Rv1968) — family_assigned: virulence factor Mce family protein mce3D (Rv1969) — family_assigned: virulence factor Mce family protein lprM (Rv1970) — family_assigned: Mce family lipoprotein LprM mce3F (Rv1971) — family_assigned: MlaD family protein Rv1972 (Rv1972) — requalified: Mce associated membrane protein Rv1973 (Rv1973) — family_assigned: hypothetical protein Rv1974 (Rv1974) — family_assigned: DUF732 domain-containing protein Rv1975 (Rv1975) — family_assigned: CAP domain-containing protein Rv1976c (Rv1976c) — family_assigned: NYN domain-containing protein Rv1977 (Rv1977) — family_assigned: M48 family metallopeptidase Rv1978 (Rv1978) — requalified: class I SAM-dependent methyltransferase Rv1979c (Rv1979c) — family_assigned: APC family permease mpt64 (Rv1980c) — requalified: immunoprotective protein Mpt64 vapC36 (Rv1982c) — family_assigned: type II toxin-antitoxin system VapC family toxin cfp21 (Rv1984c) — requalified: cutinase Cfp21 Rv1985c (Rv1985c) — family_assigned: ArgP/LysG family DNA-binding transcriptional regulator lysE (Rv1986) — requalified: L-lysine exporter Rv1987 (Rv1987) — family_assigned: cellulose-binding protein Rv1989c (Rv1989c) — family_assigned: RES family NAD+ phosphorylase Rv1990c (Rv1990c) — family_assigned: antitoxin Xre/MbcA/ParS toxin-binding domain-containing prot mazF6 (Rv1991c) — requalified: type II toxin-antitoxin system toxin endoribonuclease MazF6 ctpG (Rv1992c) — requalified: cation transporter ATPase CptG Rv1993c (Rv1993c) — family_assigned: DUF1490 family protein cmtR (Rv1994c) — family_assigned: Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regu Rv1995 (Rv1995) — family_assigned: hemerythrin domain-containing protein Rv1996 (Rv1996) — requalified: universal stress protein ctpF (Rv1997) — requalified: cation-transporting P-type ATPase Rv1998c (Rv1998c) — family_assigned: isocitrate lyase/phosphoenolpyruvate mutase family protein Rv1999c (Rv1999c) — family_assigned: APC family permease Rv2000 (Rv2000) — family_assigned: FAD/NAD(P)-binding protein Rv2001 (Rv2001) — requalified: acyl-[acyl-carrier-protein] thioesterase fabG3 (Rv2002) — family_assigned: SDR family oxidoreductase Rv2004c (Rv2004c) — family_assigned: AAA family ATPase Rv2005c (Rv2005c) — requalified: universal stress protein 1 980 kb 2 033 kb 2 086 kb 2 140 kb 2 194 kb 2 247 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.