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Infect Drug Resist |
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Biochemistry |
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Front Microbiol |
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bioRxiv |
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Chem Biodivers |
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| Rapid Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis Using Real-Time PCR.
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| A Comparison of the Sensititre MycoTB Plate, the Bactec MGIT 960, and a Microarray-Based Molecular Assay for the Detection of Drug Resistance in Clinical Mycobacterium tuberculosis Isolates in Moscow, Russia.
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| Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana.
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Curr HIV Res |
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| Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells.
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| Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations.
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Diagn Microbiol Infect Dis |
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mBio |
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FEBS Lett |
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Indian J Med Microbiol |
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| Impact of isoniazid resistance on virulence of global and south Indian clinical isolates of Mycobacterium tuberculosis.
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Eur J Microbiol Immunol (Bp) |
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doi:10.1111/j.1365-2958.2011.07888.x
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Mol Microbiol |
2011 |
| Clinical data and molecular analysis of Mycobacterium tuberculosis isolates from drug-resistant tuberculosis patients in Goiás, Brazil.
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Mem Inst Oswaldo Cruz |
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| [Evaluation of GenoType MTBDRplus for the detection of multi-drug-resistant Mycobacterium tuberculosis strains].
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Kekkaku |
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| Characterization of mutations conferring extensive drug resistance to Mycobacterium tuberculosis isolates in Pakistan.
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Antimicrob Agents Chemother |
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| [Detection of genes associated with drug resistance in Mycobacterium tuberculosis strains isolated in Chile].
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Rev Med Chil |
2011 |
| Expression of Mycobacterium tuberculosis ferric uptake regulator A gene in Escherichia coli and generation of monoclonal antibodies to FurA.
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Hybridoma (Larchmt) |
2011 |
| Rapid detection of isoniazid, rifampin, and ofloxacin resistance in Mycobacterium tuberculosis clinical isolates using high-resolution melting analysis.
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J Clin Microbiol |
2011 |
| Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa.
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Clin Infect Dis |
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| Impaired fitness of Mycobacterium tuberculosis resistant isolates in a cell culture model of murine macrophages.
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J Antimicrob Chemother |
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| [The cluster and drug-resistant characteristics of Beijing genotype Mycobacterium tuberculosis in eastern rural China].
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| Multidrug-resistant tuberculosis presenting as a solitary splenic mass in an immunocompetent patient.
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Diagn Microbiol Infect Dis |
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| Study of Genetic Evolution in Mycobacterium tuberculosis Isolates from Patients with Active Pulmonary Tuberculosis in the Iran and Belarus.
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Open Microbiol J |
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| Rapid Detection of Isoniazid Resistance in Mycobacterium tuberculosis by a Single Multiplex Allele-specific Polymerase Chain Reaction Assay.
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Cell J |
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| Genotypic and phenotypic characteristics of tunisian isoniazid-resistant Mycobacterium tuberculosis strains.
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J Microbiol |
2011 |
| Survival of civilian and prisoner drug-sensitive, multi- and extensive drug- resistant tuberculosis cohorts prospectively followed in Russia.
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PLoS One |
2011 |
| Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.
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Antimicrob Agents Chemother |
2011 |
| Molecular characterization of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Kazakhstan.
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Jpn J Infect Dis |
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| [GenoType MTBDRplus assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis in Sichuan].
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Nan Fang Yi Ke Da Xue Xue Bao |
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| Improved rapid molecular diagnosis of multidrug-resistant tuberculosis using a new reverse hybridization assay, REBA MTB-MDR.
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J Med Microbiol |
2011 |
| Multiplex allele-specific polymerase chain reaction for detection of isoniazid resistance in Mycobacterium tuberculosis.
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Int J Tuberc Lung Dis |
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| Detection of mutations associated with multidrug-resistant Mycobacterium tuberculosis clinical isolates.
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FEMS Immunol Med Microbiol |
2011 |
| High level isoniazid resistance correlates with multiple mutation in the katG encoding catalase proxidase of pulmonary tuberculosis isolates from the frontier localities of Iran.
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Tuberk Toraks |
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| [Design and realization of a microarray data analysis platform].
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Nan Fang Yi Ke Da Xue Xue Bao |
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| Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations.
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Mutat Res |
2011 |
| First report of molecular detection of fluoroquinolone resistance-associated gyrA mutations in multidrug-resistant clinical Mycobacterium tuberculosis isolates in Kuwait.
doi:10.1186/1756-0500-4-123
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BMC Res Notes |
2011 |
| Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in South-Western Uganda.
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BMC Infect Dis |
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| Prevalence of mutations at codon 463 of katG gene in MDR and XDR clinical isolates of Mycobacterium tuberculosis in Belarus and application of the method in rapid diagnosis.
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Acta Microbiol Immunol Hung |
2011 |
| GenoType® MTBDRplus compared with conventional drug-susceptibility testing of Mycobacterium tuberculosis in a low-resistance locale.
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Future Microbiol |
2011 |
| Genetic variation of Mycobacterium tuberculosis circulating in Kharkiv Oblast, Ukraine.
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BMC Infect Dis |
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| Highest prevalence of the Mycobacterium tuberculosis Beijing genotype isolates in patients newly diagnosed with tuberculosis in the Novosibirsk oblast, Russian Federation.
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J Med Microbiol |
2011 |
| Rapid detection of multidrug-resistant Mycobacterium tuberculosis by multiplex allele-specific polymerase chain reaction.
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Int J Tuberc Lung Dis |
2011 |
| Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates from Xi'an, China.
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Microb Drug Resist |
2011 |
| inhA promoter mutations: a gateway to extensively drug-resistant tuberculosis in South Africa?
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Int J Tuberc Lung Dis |
2011 |
| Detection of novel coupled mutations in the katG gene (His276Met, Gln295His and Ser315Thr) in a multidrug-resistant Mycobacterium tuberculosis strain from Chennai, India, and insight into the molecular mechanism of isoniazid resistance using structural bioinformatics approaches.
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Int J Antimicrob Agents |
2011 |
| Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.
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Antimicrob Agents Chemother |
2011 |
| Mutation detection and accurate diagnosis of extensively drug-resistant tuberculosis: report from a tertiary care center in India.
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J Clin Microbiol |
2011 |
| Performance comparison of four methods for detecting multidrug-resistant Mycobacterium tuberculosis strains.
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Int J Tuberc Lung Dis |
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| Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.
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Mol Microbiol |
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| katG (SER 315 THR) gene mutation in isoniazid resistant Mycobacterium tuberculosis.
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Kathmandu Univ Med J (KUMJ) |
2011 |
| Toxicogenomic response of Mycobacterium bovis BCG to peracetic acid and a comparative analysis of the M. bovis BCG response to three oxidative disinfectants.
doi:10.1007/s00253-010-2931-6
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Appl Microbiol Biotechnol |
2011 |
| Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific polymerase chain reaction.
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Diagn Microbiol Infect Dis |
2011 |
| Molecular typing of Mycobacterium tuberculosis circulated in Moscow, Russian Federation.
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Eur J Clin Microbiol Infect Dis |
2011 |
| A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility.
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Epidemiol Infect |
2011 |
| Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis.
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Respir Res |
2010 |
| Correction to: M. tuberculosis Central Asian Strain 1 MDR isolates have more mutations in rpoB and katG genes compared with other genotypes.
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Scand J Infect Dis |
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| The management of tuberculosis: epidemiology, resistance and monitoring.
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Dan Med Bull |
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| [The effects of gene mutation related to drug resistance and drug efflux pump in extensively drug-resistant tuberculosis clinical isolates].
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Zhonghua Jie He He Hu Xi Za Zhi |
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| Rifampin-isoniazid oligonucleotide typing: an alternative format for rapid detection of multidrug-resistant Mycobacterium tuberculosis.
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J Clin Microbiol |
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| [Detection of wild type isolates and point mutations in genome of isoniazid-resistant Mycobacteria tuberculosis].
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Mol Biol (Mosk) |
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| High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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J Clin Microbiol |
2010 |
| Rapid detection of multidrug-resistant Mycobacterium tuberculosis by use of real-time PCR and high-resolution melt analysis.
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J Clin Microbiol |
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| Determinants of multidrug-resistant tuberculosis clusters, California, USA, 2004-2007.
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Emerg Infect Dis |
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| [Molecular genetic tools for etiologic diagnostics of disseminated lung tuberculosis].
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Zh Mikrobiol Epidemiol Immunobiol |
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| Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
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Antimicrob Agents Chemother |
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| Molecular characterization of drug-resistant Beijing family isolates of Mycobacterium tuberculosis from Tianjin, China.
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Biomed Environ Sci |
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| Use of the GenoType(R) MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda.
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BMC Clin Pathol |
2010 |
| One-tube loop-mediated isothermal amplification combined with restriction endonuclease digestion and ELISA for colorimetric detection of resistance to isoniazid, ethambutol and streptomycin in Mycobacterium tuberculosis isolates.
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J Microbiol Methods |
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| [Molecular characterization of drug-resistant and extensive-drug resistant isolates of Mycobacterium tuberculosis in Shenzhen of China].
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| KatG protein: a novel marker for differential diagnosis of Mycobacterium avium complex infection.
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Indian J Med Microbiol |
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| Detection of Mycobacterium tuberculosis resistance mutations to rifampin and isoniazid by real-time PCR.
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Indian J Med Microbiol |
2010 |
| A high prevalence of resistance in new tuberculosis cases of midwestern Brazil.
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Infect Genet Evol |
2010 |
| Comparison of antibody responses to seventeen antigens from Mycobacterium tuberculosis.
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Clin Chim Acta |
2010 |
| Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.
doi:10.1128/AAC.00453-10
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Antimicrob Agents Chemother |
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| Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.
doi:10.1074/jbc.M110.139428
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J Biol Chem |
2010 |
| M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates.
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Mol Microbiol |
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| Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana.
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Int J Med Microbiol |
2010 |
| Drug resistant Mycobacterium tuberculosis of the Beijing genotype does not spread in Sweden.
doi:10.1371/journal.pone.0010893
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PLoS One |
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| A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesis.
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J Am Chem Soc |
2010 |
| Detection of rpoB, katG and inhA gene mutations in Mycobacterium tuberculosis clinical isolates from Chongqing as determined by microarray.
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Clin Microbiol Infect |
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| Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.
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Int J Tuberc Lung Dis |
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| Recent progress in the identification and development of InhA direct inhibitors of Mycobacterium tuberculosis.
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Mini Rev Med Chem |
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| Isoniazid-resistant tuberculosis in Denmark: mutations, transmission and treatment outcome.
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J Infect |
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| KatG from Salmonella typhimurium is a peroxynitritase.
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FEBS Lett |
2010 |
| First insights into the genetic diversity of Mycobacterium tuberculosis isolates from HIV-infected Mexican patients and mutations causing multidrug resistance.
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BMC Microbiol |
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| Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.
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Antimicrob Agents Chemother |
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| A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis.
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J Biol Chem |
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| Extensive transmission of isoniazid resistant M. tuberculosis and its association with increased multidrug-resistant TB in two rural counties of eastern China: a molecular epidemiological study.
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BMC Infect Dis |
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| Evaluation of cost-effective total nucleic acids extraction protocols for cultured Mycobacterium tuberculosis; a comparison by PCR amplification of genes associated with drug resistance.
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BMC Res Notes |
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| Rapid detection of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis by high-resolution melting analysis.
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J Clin Microbiol |
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| Multidrug-resistant tuberculosis: treatment outcome in Denmark, 1992-2007.
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Scand J Infect Dis |
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| Genetic characterisation of drug-resistant Mycobacterium tuberculosis in rural China: a population-based study.
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| Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
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Protein Sci |
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| [THE SENSITIVITY AND SPECIFICITY OF THE MOLECULAR GENOTYPE MTBDRPL US ASSAY (HAIN LIFESCIENCE GMBH, GERMANY) FOR RAPID DIAGNOSIS OF DRUG SUSCEPTIBILITY IN MYCOBACTERIUM TUBERCULOSIS ON SPUTUM SPECIMENS].
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Tuberk Biolezni Legkih |
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| Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.
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Antimicrob Agents Chemother |
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| Mycobacterium tuberculosis spoligotypes in Monterrey, Mexico.
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J Clin Microbiol |
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| Cloning, expression and characterization of the catalase-peroxidase (KatG) gene from a fast-growing Mycobacterium sp. strain JC1 DSM 3803.
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J Biochem |
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| Clinical efficacy of direct DNA sequencing analysis on sputum specimens for early detection of drug-resistant Mycobacterium tuberculosis in a clinical setting.
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Chest |
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| Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101.
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J Clin Immunol |
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| Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
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Clin Microbiol Infect |
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| [Population-based molecular epidemiologic study of rifampicin-resistant tuberculosis in rural area of eastern China].
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Zhonghua Liu Xing Bing Xue Za Zhi |
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| High level association of mutation in KatG315 with MDR and XDR clinical isolates of Mycobacterium tuberculosis in Belarus.
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Acta Microbiol Immunol Hung |
2009 |
| Characterization of Molecular Evolution in Multi-Drug Resistant of Mycobacterium tuberculosis by rpoB Gene in Patient with Active Pulmonary Tuberculosis from Iranian Isolates.
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Int J Biomed Sci |
2009 |
| Microarray analysis of Mycobacterium bovis BCG revealed induction of iron acquisition related genes in response to hydrogen peroxide.
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Environ Sci Technol |
2009 |
| Detection of isoniazid and rifampicin resistance by sequencing of katG, inhA, and rpoB genes in Korea.
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Korean J Lab Med |
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| [Molecular genetic and bacteriological methods for the diagnosis of multidrug resistant M. tuberculosis].
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Tuberk Biolezni Legkih |
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| Ethionamide cross- and co-resistance in children with isoniazid-resistant tuberculosis.
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Int J Tuberc Lung Dis |
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| First documentation of isoniazid reversion in Mycobacterium tuberculosis.
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Int J Tuberc Lung Dis |
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| Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones.
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J Clin Microbiol |
2009 |
| In house colorimetric reverse hybridisation assay for detection of the mutation most frequently associated with resistance to isoniazid in Mycobacterium tuberculosis.
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Mem Inst Oswaldo Cruz |
2009 |
| Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex.
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J Bacteriol |
2009 |
| Molecular characterization of INH-resistant Mycobacterium tuberculosis isolates by PCR-RFLP and multiplex-PCR in North India.
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Infect Genet Evol |
2009 |
| Analysis of isoniazid, streptomycin and ethambutol resistance in Mycobacterium tuberculosis isolates from Morocco.
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J Infect Dev Ctries |
2009 |
| Isoniazid-resistant Mycobacterium tuberculosis strains arising from mutations in two different regions of the katG gene.
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J Bras Pneumol |
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| Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso.
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BMC Infect Dis |
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| Isoniazid and rifampicin resistance-associated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing.
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J Antimicrob Chemother |
2009 |
| Comparative growth pattern of multi drug resistance versus susceptible isolates of Mycobacterium tuberculosis in mice lungs.
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Indian J Med Res |
2009 |
| Epidemiologic characterization of culture positive Mycobacterium tuberculosis patients by katG-gyrA principal genetic grouping.
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J Mol Diagn |
2009 |
| Comparison of performance of two DNA line probe assays for rapid detection of multidrug-resistant isolates of Mycobacterium tuberculosis.
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Indian J Exp Biol |
2009 |
| Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates in Guangdong, China.
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Jpn J Infect Dis |
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| [Evaluation of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in clinical Mycobacterium tuberculosis complex clinical isolates].
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Mikrobiyol Bul |
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| Rolling circle amplification and multiplex allele-specific PCR for rapid detection of katG and inhA gene mutations in Mycobacterium tuberculosis.
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Int J Med Microbiol |
2009 |
| Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis.
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Infect Immun |
2009 |
| Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates.
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Antimicrob Agents Chemother |
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| Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance.
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J Antimicrob Chemother |
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| [Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains].
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Probl Tuberk Bolezn Legk |
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| Rapid, accurate determination of multidrug resistance in M. tuberculosis isolates and sputum using a biochip system.
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Int J Tuberc Lung Dis |
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| Mutations in rpoB and katG genes in Mycobacterium isolates from the Southeast of Mexico.
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Mem Inst Oswaldo Cruz |
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| Distinct role of specific tryptophans in facilitating electron transfer or as [Fe(IV)=O Trp(*)] intermediates in the peroxidase reaction of Bulkholderia pseudomallei catalase-peroxidase: a multifrequency EPR spectroscopy investigation.
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J Am Chem Soc |
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| Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada.
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J Antimicrob Chemother |
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| Comparison of two commercial assays for the characterization of rpoB mutations in Mycobacterium tuberculosis and description of new mutations conferring weak resistance to rifampicin.
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J Antimicrob Chemother |
2009 |
| Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis.
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J Clin Microbiol |
2009 |
| The clinical relevance of Mycobacterial pharmacogenetics.
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Tuberculosis (Edinb) |
2009 |
| Antibiotic resistance in Mycobacterium tuberculosis: peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG).
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J Biol Chem |
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| [Practical value of the TB-biochip MDR test system in the rapid identification of multidrug-resistant M. tuberculosis strains].
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Klin Lab Diagn |
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| Performance of the Genotype MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian Federation.
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BMC Clin Pathol |
2009 |
| In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type.
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PLoS One |
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| Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America.
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BMC Microbiol |
2009 |
| Genotypic detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis strains by DNA sequencing: a randomized trial.
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Ann Clin Microbiol Antimicrob |
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| Identification of Mycobacterium avium KatG protein (MAV_2753) as a possible serodiagnostic marker for MAC disease.
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J Infect |
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| Performance of MTBDR plus for detecting high/low levels of Mycobacterium tuberculosis resistance to isoniazid.
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Int J Tuberc Lung Dis |
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| An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG).
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J Biol Chem |
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| Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant.
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J Biol Chem |
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| Molecular identification of mutations associated with anti-tuberculosis drug resistance among strains of Mycobacterium tuberculosis.
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Int J Infect Dis |
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| Molecular detection of drug-resistant Mycobacterium tuberculosis with a scanning-frame oligonucleotide microarray.
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Methods Mol Biol |
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| Elucidating isoniazid resistance using molecular modeling.
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J Chem Inf Model |
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| M. tuberculosis Central Asian Strain 1 MDR isolates have more mutations in rpoB and katG genes compared with other genotypes.
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Scand J Infect Dis |
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| Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa.
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J Antimicrob Chemother |
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| At Baltic crossroads: a molecular snapshot of Mycobacterium tuberculosis population diversity in Kaliningrad, Russia.
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FEMS Immunol Med Microbiol |
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| Prospective evaluation of pyrosequencing for the rapid detection of isoniazid and rifampin resistance in clinical Mycobacterium tuberculosis isolates.
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Eur J Clin Microbiol Infect Dis |
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| Rapid speciation of 15 clinically relevant mycobacteria with simultaneous detection of resistance to rifampin, isoniazid, and streptomycin in Mycobacterium tuberculosis complex.
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Int J Infect Dis |
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| [Drug sensitivity in Mycobacterium tuberculosis versus its viability, cytotoxicity, genotype, and the course of the process in patients with pulmonary tuberculosis].
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Probl Tuberk Bolezn Legk |
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| [Distribution of mutations in the rpoB, katG, inhA, ahpC gene of rifampicin and isoniazid resistant M. tuberculosis strains isolated in Kyrgyz Republic].
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Mol Gen Mikrobiol Virusol |
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| The Metal-Dependent Regulators FurA and FurB from Mycobacterium Tuberculosis.
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Int J Mol Sci |
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| Molecular analysis of isoniazid resistance in different genotypes of Mycobacterium tuberculosis isolates from Iran.
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Microb Drug Resist |
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| T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis.
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J Immunol |
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| Prevalence and dissemination of the Ser315Thr substitution within the KatG enzyme in isoniazid-resistant strains of Mycobacterium tuberculosis isolated in Uruguay.
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J Med Microbiol |
2008 |
| Evaluation of new GenoType MTBDRplus for detection of resistance in cultures and direct specimens of Mycobacterium tuberculosis.
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Int J Tuberc Lung Dis |
2008 |
| Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis: a computer modelling approach.
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Chem Biol Drug Des |
2008 |
| Impact of distal side water and residue 315 on ligand binding to ferric Mycobacterium tuberculosis catalase-peroxidase (KatG).
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Biochemistry |
2008 |
| Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase.
doi:10.1021/bi800952b
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Biochemistry |
2008 |
| The alternative sigma factor SigF of Mycobacterium smegmatis is required for survival of heat shock, acidic pH and oxidative stress.
doi:10.1099/mic.0.2008/018044-0
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Microbiology (Reading) |
2008 |
| Phenotypic and genotypic characterization of drug-resistant Mycobacterium tuberculosis strains.
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Diagn Microbiol Infect Dis |
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| [Utility of gene analysis for evaluation of the current status of tuberculosis developing long after primary infection].
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Nihon Koshu Eisei Zasshi |
2008 |
| Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria.
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Infect Genet Evol |
2008 |
| Molecular characterization of drug-resistant mycobacterium tuberculosis isolates from Sichuan Province in china.
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Jpn J Infect Dis |
2008 |
| Genotypic analysis of isoniazid and rifampin resistance in drug-resistant clinical Mycobacterium tuberculosis complex isolates in southern Turkey.
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Jpn J Infect Dis |
2008 |
| The effect of oxidative stress on the mutation rate of Mycobacterium tuberculosis with impaired catalase/peroxidase function.
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J Antimicrob Chemother |
2008 |
| Multidrug-resistant tuberculosis in Lisbon, Portugal: a molecular epidemiological perspective.
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Microb Drug Resist |
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| [Fast identification of rifampicin-and isoniazid resistance of M. Tuberculosis strains by the "TB-biochip" test system].
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Georgian Med News |
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| Multidrug-resistant tuberculosis: rapid detection of resistance to rifampin and high or low levels of isoniazid in clinical specimens and isolates.
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Eur J Clin Microbiol Infect Dis |
2008 |
| Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in Japan.
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J Clin Microbiol |
2008 |
| Detection of mutation in isoniazid-resistant Mycobacterium tuberculosis isolates from tuberculosis patients in Belarus.
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Indian J Med Microbiol |
2008 |
| The katG mRNA of Mycobacterium tuberculosis and Mycobacterium smegmatis is processed at its 5' end and is stabilized by both a polypurine sequence and translation initiation.
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BMC Mol Biol |
2008 |
| Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR.
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Microb Drug Resist |
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| Molecular characterisation of isoniazid-resistant Mycobacterium tuberculosis isolated from new cases in Lagunes region (Côte d'Ivoire).
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Int J Antimicrob Agents |
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| Molecular genetics of drug-resistant Mycobacterium tuberculosis isolates in Finland, 1995-2004.
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Int J Tuberc Lung Dis |
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| Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis.
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J Antimicrob Chemother |
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| Determination of global protein turnover in stressed mycobacterium cells using hybrid-linear ion trap-fourier transform mass spectrometry.
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Anal Chem |
2008 |
| Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis.
doi:10.1128/JCM.01821-07
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J Clin Microbiol |
2008 |
| Prevalence of and molecular basis for tuberculosis drug resistance in the Republic of Georgia: validation of a QIAplex system for detection of drug resistance-related mutations.
doi:10.1128/AAC.01124-07
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Antimicrob Agents Chemother |
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| The tuberculosis prodrug isoniazid bound to activating peroxidases.
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J Biol Chem |
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| Genomic interrogation of ancestral Mycobacterium tuberculosis from south India.
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Infect Genet Evol |
2008 |
| Molecular analysis of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from India.
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Int J Antimicrob Agents |
2008 |
| Frequency and molecular characterization of isoniazid resistance in katG region of MDR isolates from tuberculosis patients in southern endemic border of Iran.
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Infect Genet Evol |
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| Two [Fe(IV)=O Trp*] intermediates in M. tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid.
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J Am Chem Soc |
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| The mechanism of isoniazid killing: clarity through the scope of genetics.
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Annu Rev Microbiol |
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| katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis isolates from Belarusian patients.
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Tuberk Toraks |
2007 |
| Multiple Mycobacterium antigens induce interferon-gamma production from sarcoidosis peripheral blood mononuclear cells.
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Clin Exp Immunol |
2007 |
| Drug susceptibility of Spanish Mycobacterium tuberculosis complex isolates from animals.
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Tuberculosis (Edinb) |
2007 |
| A novel genotypic test for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates by a multiplex probe array.
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J Appl Microbiol |
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| Antibiotic resistance and single-nucleotide polymorphism cluster grouping type in a multinational sample of resistant Mycobacterium tuberculosis isolates.
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Antimicrob Agents Chemother |
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| Molecular investigation of recurrent tuberculosis in patients from Rwanda.
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Int J Tuberc Lung Dis |
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| [Analysis of mutations of multidrug-resistant M. tuberculosis strains in patients with tuberculosis in the Kyrghyz Republic].
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Probl Tuberk Bolezn Legk |
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| Mass-spectrometry based minisequencing method for the rapid detection of drug resistance in Mycobacterium tuberculosis.
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J Microbiol Methods |
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| M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern Tanzania.
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BMC Microbiol |
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| Multiple mutations in katG and inhA identified in Thai isoniazid-resistant Mycobacterium tuberculosis isolates.
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Southeast Asian J Trop Med Public Health |
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| Evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimens.
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J Clin Microbiol |
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| Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing, China.
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| [Mechanism of drug resistance in M. tuberculosis and non-tuberculous acid-fast bacilli].
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Nihon Rinsho |
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| Molecular characteristics of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis isolates from the Russian Federation.
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J Antimicrob Chemother |
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| Isoniazid induces its own resistance in nonreplicating Mycobacterium tuberculosis.
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Antimicrob Agents Chemother |
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| PCR-restriction fragment length polymorphism for rapid, low-cost identification of isoniazid-resistant Mycobacterium tuberculosis.
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J Clin Microbiol |
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| Association of specific mutations in katG, rpoB, rpsL and rrs genes with spoligotypes of multidrug-resistant Mycobacterium tuberculosis isolates in Russia.
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Clin Microbiol Infect |
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| Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.
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J Antimicrob Chemother |
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| Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis.
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Curr Top Med Chem |
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| Molecular epidemiology and prevalence of mutations conferring rifampicin and isoniazid resistance in Mycobacterium tuberculosis strains from the southern Ukraine.
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Clin Microbiol Infect |
2007 |
| Characterization of the binding of isoniazid and analogues to Mycobacterium tuberculosis catalase-peroxidase.
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Biochemistry |
2007 |
| Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil.
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Mem Inst Oswaldo Cruz |
2007 |
| Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from central China.
doi:10.1007/s10528-006-9074-6
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Biochem Genet |
2007 |
| Autocatalytic formation of a covalent link between tryptophan 41 and the heme in ascorbate peroxidase.
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Biochemistry |
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| Molecular analysis of Mycobacterium tuberculosis causing multidrug-resistant tuberculosis meningitis.
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Int J Tuberc Lung Dis |
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| Redox intermediates in the catalase cycle of catalase-peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis.
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Biochemistry |
2007 |
| Hydrogen peroxide oxidation by catalase-peroxidase follows a non-scrambling mechanism.
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FEBS Lett |
2007 |
| Radical sites in Mycobacterium tuberculosis KatG identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electron transfer couplings.
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J Biol Chem |
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| Isoniazid's bactericidal activity ceases because of the emergence of resistance, not depletion of Mycobacterium tuberculosis in the log phase of growth.
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J Infect Dis |
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| Modification of the active site of Mycobacterium tuberculosis KatG after disruption of the Met-Tyr-Trp cross-linked adduct.
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J Inorg Biochem |
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| Association between Mycobacterium tuberculosis Beijing/W lineage strain infection and extrathoracic tuberculosis: Insights from epidemiologic and clinical characterization of the three principal genetic groups of M. tuberculosis clinical isolates.
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J Clin Microbiol |
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| Detection of multidrug resistance in Mycobacterium tuberculosis.
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J Clin Microbiol |
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| Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis.
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Infect Immun |
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| [Resistance-conferring mutations of Mycobacterium tuberculosis strains with low level resistance to isoniazid].
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Kekkaku |
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| High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
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ACS Chem Biol |
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| [Modern diagnosis of tuberculosis].
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Presse Med |
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| Mechanisms of action of isoniazid.
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Mol Microbiol |
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| [Mechanisms of action of and resistance to rifampicin and isoniazid in Mycobacterium tuberculosis: new information on old friends].
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Rev Argent Microbiol |
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| Use of smear-positive samples to assess the PCR-based genotype MTBDR assay for rapid, direct detection of the Mycobacterium tuberculosis complex as well as its resistance to isoniazid and rifampin.
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J Clin Microbiol |
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| Molecular characterisation of Mycobacterium tuberculosis isolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela.
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BMC Microbiol |
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| Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA.
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J Med Microbiol |
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| Performance of the genotype MTBDR line probe assay for detection of resistance to rifampin and isoniazid in strains of Mycobacterium tuberculosis with low- and high-level resistance.
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J Clin Microbiol |
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| [Efficiency of chemotherapy of destructive pulmonary tuberculosis, based on the results of rapid detection of drug sensitivity to isoniazid and rifampicin with the "TB-Biochip" test system].
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Probl Tuberk Bolezn Legk |
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Probl Tuberk Bolezn Legk |
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Pol J Microbiol |
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| Molecular characterization of mutation associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis isolates.
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Indian J Exp Biol |
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| Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
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Antimicrob Agents Chemother |
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| Public health impact of isoniazid-resistant Mycobacterium tuberculosis strains with a mutation at amino-acid position 315 of katG: a decade of experience in The Netherlands.
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Clin Microbiol Infect |
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| Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.
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Curr Pharm Des |
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| Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100.
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Arch Microbiol |
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| Rapid genotypic detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis directly in clinical specimens.
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J Clin Microbiol |
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| Use of genotype MTBDR assay for molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical strains isolated in Italy.
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J Clin Microbiol |
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| Evaluation of the Genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis isolates.
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J Clin Microbiol |
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| Mutations prevalent among rifampin- and isoniazid-resistant Mycobacterium tuberculosis isolates from a hospital in Vietnam.
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J Clin Microbiol |
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| Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis.
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PLoS Pathog |
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| [Evaluation of reasons of the MDR M. tuberculosis strains dissemination by analysis of the rifampicin and/or isoniazid resistant isolates].
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Mol Gen Mikrobiol Virusol |
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| Comparison of a conventional antimicrobial susceptibility assay to an oligonucleotide chip system for detection of drug resistance in Mycobacterium tuberculosis isolates.
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J Clin Microbiol |
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| Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.
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Nat Struct Mol Biol |
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| Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
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Biochemistry |
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| Catalase-peroxidase of Mycobacterium bovis BCG converts isoniazid to isonicotinamide, but not to isonicotinic acid: differentiation parameter between enzymes of Mycobacterium bovis BCG and Mycobacterium tuberculosis.
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Biochim Biophys Acta |
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| Rapid detection of specific gene mutations associated with isoniazid or rifampicin resistance in Mycobacterium tuberculosis clinical isolates using non-fluorescent low-density DNA microarrays.
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J Antimicrob Chemother |
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| Detection of the mutations in katG 315 and inhA -15 of Mycobacterium tuberculosis strains isolated from Chinese patients.
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Chin Med J (Engl) |
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| Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA.
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Antimicrob Agents Chemother |
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| Evaluation of the CombiChip Mycobacteria Drug-Resistance detection DNA chip for identifying mutations associated with resistance to isoniazid and rifampin in Mycobacterium tuberculosis.
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Diagn Microbiol Infect Dis |
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| Comparison of two commercially available DNA line probe assays for detection of multidrug-resistant Mycobacterium tuberculosis.
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J Clin Microbiol |
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| Use of a mycobacteriophage-based assay for rapid assessment of susceptibilities of Mycobacterium tuberculosis isolates to isoniazid and influence of resistance level on assay performance.
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J Clin Microbiol |
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| Temperature-mediated heteroduplex analysis for the detection of drug-resistant gene mutations in clinical isolates of Mycobacterium tuberculosis by denaturing HPLC, SURVEYOR nuclease.
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Microbes Infect |
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| The use of macroarrays for the identification of MDR Mycobacterium tuberculosis.
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J Microbiol Methods |
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| [A simple enzyme test for proving the resistance to isoniazid of Mycobacterium tuberculosis strains].
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Pneumologia |
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| Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I).
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Biochemistry |
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| Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China.
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J Clin Microbiol |
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| Molecular analysis of isoniazid, rifampin and streptomycin resistance in Mycobacterium tuberculosis isolates from patients with tuberculosis in Düzce, Turkey.
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Jpn J Infect Dis |
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| Rifampicin and isoniazid resistance mutations in Mycobacterium tuberculosis strains isolated from patients in Kazakhstan.
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Int J Tuberc Lung Dis |
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| [The characteristics of the sensitivity of Mycobacterium tuberculosis to rifampicin and isoniazid through determination of mutations in the genes rpoB, katG, inhA, oxyR, and kasA by different molecular biological assays].
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Probl Tuberk Bolezn Legk |
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| Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia.
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Antimicrob Agents Chemother |
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| Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG.
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Arch Pediatr |
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| Use of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis complex isolates.
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J Clin Microbiol |
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| [Anti-drug pattern of drug-resistant Mycobacterium tuberculosis and analysis of mutation in drug-target genes].
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Kansenshogaku Zasshi |
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| Microarray and allele specific PCR detection of point mutations in Mycobacterium tuberculosis genes associated with drug resistance.
doi:10.1016/j.mimet.2005.04.026
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J Microbiol Methods |
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| Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutol.
doi:10.1128/AAC.49.6.2218-2225.2005
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Antimicrob Agents Chemother |
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| Resonance Raman spectroscopy of Compound II and its decay in Mycobacterium tuberculosis catalase-peroxidase KatG and its isoniazid resistant mutant S315T.
doi:10.1016/j.jinorgbio.2005.03.016
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J Inorg Biochem |
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| Molecular analysis of isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates recovered from Barcelona.
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Microb Drug Resist |
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| Molecular characterization of isoniazid and rifampin resistance of Mycobacterium tuberculosis clinical isolates from Malatya, Turkey.
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Microb Drug Resist |
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| Comparison of drug resistance genotypes between Beijing and non-Beijing family strains of Mycobacterium tuberculosis in Korea.
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J Microbiol Methods |
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| Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress.
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J Biol Chem |
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| Direct detection in clinical samples of multiple gene mutations causing resistance of Mycobacterium tuberculosis to isoniazid and rifampicin using fluorogenic probes.
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J Antimicrob Chemother |
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| [Characterization of the katG, inhA, ahpC, kasA, and oxyR gene mutations in isoniazid-resistant and susceptible strain of Mycobacterium tuberculosis by automated DNA sequencing].
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Zhonghua Jie He He Hu Xi Za Zhi |
2005 |
| The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties.
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J Biol Chem |
2005 |
| Genetic diversity, determined on the basis of katG463 and gyrA95 polymorphisms, Spoligotyping, and IS6110 typing, of Mycobacterium tuberculosis complex isolates from Italy.
doi:10.1128/JCM.43.4.1617-1624.2005
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J Clin Microbiol |
2005 |
| Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates from England and Wales reveals the phylogenetic significance of the ahpC -46A polymorphism.
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Antimicrob Agents Chemother |
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| Development of a pyrosequencing approach for rapid screening of rifampin, isoniazid and ethambutol-resistant Mycobacterium tuberculosis.
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Int J Tuberc Lung Dis |
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Zh Mikrobiol Epidemiol Immunobiol |
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| Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis.
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J Exp Med |
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| Systematic molecular characterization of multidrug-resistant Mycobacterium tuberculosis complex isolates from Spain.
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J Clin Microbiol |
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| Use of fluorescence resonance energy transfer for rapid detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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Int J Tuberc Lung Dis |
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| Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany.
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Antimicrob Agents Chemother |
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| Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.
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Protein Sci |
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| Single-nucleotide polymorphism-based differentiation and drug resistance detection in Mycobacterium tuberculosis from isolates or directly from sputum.
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Clin Microbiol Infect |
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| Mutations responsible for Mycobacterium tuberculosis isoniazid resistance in Italy.
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Int J Tuberc Lung Dis |
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| Prevalence of katG Ser315 substitution and rpoB mutations in isoniazid-resistant Mycobacterium tuberculosis isolates from Brazil.
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Int J Tuberc Lung Dis |
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| Mycobacterium tuberculosis KatG(S315T) catalase-peroxidase retains all active site properties for proper catalytic function.
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Biochemistry |
2005 |
| New multiplex PCR for rapid detection of isoniazid-resistant Mycobacterium tuberculosis clinical isolates.
doi:10.1128/AAC.49.1.144-147.2005
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Antimicrob Agents Chemother |
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| Genotypic diversity among isoniazid-resistant isolates of Mycobacterium tuberculosis from Rashid hospital in Dubai, United Arab Emirates.
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Med Princ Pract |
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| Structural characterization of the Ser324Thr variant of the catalase-peroxidase (KatG) from Burkholderia pseudomallei.
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J Mol Biol |
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| (11)C-Labeled isoniazid.
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| [Molecular-genetic characteristics of Mycobacterium tuberculosis strains isolated in southern region of Ukraine].
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Tsitol Genet |
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| Isoniazid resistance and the future of drug-resistant tuberculosis.
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Microb Drug Resist |
2004 |
| Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.
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Microb Drug Resist |
2004 |
| Molecular epidemiology of drug-resistant Mycobacterium tuberculosis strains isolated from patients with pulmonary tuberculosis in Poland: a 1-year study.
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Int J Tuberc Lung Dis |
2004 |
| Dual-probe assay for rapid detection of drug-resistant Mycobacterium tuberculosis by real-time PCR.
doi:10.1128/JCM.42.11.5277-5285.2004
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J Clin Microbiol |
2004 |
| Characterization of drug-resistant isolates of Mycobacterium tuberculosis derived from Russian inmates.
|
Int J Tuberc Lung Dis |
2004 |
| Molecular strain identification of the Mycobacterium tuberculosis complex in archival tissue samples.
doi:10.1136/jcp.2003.015719
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J Clin Pathol |
2004 |
| Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis.
doi:10.3201/eid1009.040046
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Emerg Infect Dis |
2004 |
| PCR-RFLP analysis of a point mutation in codons 315 and 463 of the katG gene of Mycobacterium tuberculosis isolated from patients in Silesia, Poland.
names it
|
Pol J Microbiol |
2004 |
| Detection of mutations associated with isoniazid and rifampin resistance in Mycobacterium tuberculosis isolates from Samara Region, Russian Federation.
doi:10.1128/JCM.42.10.4498-4502.2004
|
J Clin Microbiol |
2004 |
| Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant.
doi:10.1186/1476-0711-3-18
|
Ann Clin Microbiol Antimicrob |
2004 |
| Detection of Mycobacterium tuberculosis genotypic groups by a duplex real-time PCR targeting the katG and gyrA genes.
doi:10.1016/j.mimet.2004.06.012
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|
J Microbiol Methods |
2004 |
| [KatG Ser3 15Thr mutation as the main reason of isoniazid resistance in Mycobacterium tuberculosis isolated in the Novosibirsk and Kemerovo Regions].
names it
|
Mol Gen Mikrobiol Virusol |
2004 |
| Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
doi:10.1128/AAC.48.9.3373-3381.2004
|
Antimicrob Agents Chemother |
2004 |
| [New technologies in the determination of drug susceptibility in Mycobacterium tuberculosis].
|
Probl Tuberk Bolezn Legk |
2004 |
| [Molecular identification of mycobacteria and detection of antibiotic resistance].
|
Ann Biol Clin (Paris) |
2004 |
| Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivo.
doi:10.1128/JB.186.16.5427-5431.2004
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J Bacteriol |
2004 |
| Catalase-peroxidases (KatG) exhibit NADH oxidase activity.
doi:10.1074/jbc.M406374200
names it
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J Biol Chem |
2004 |
| Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis.
doi:10.1128/AAC.48.8.3006-3009.2004
names it
|
Antimicrob Agents Chemother |
2004 |
| Purification and characterization of Mycobacterium tuberculosis KatG, KatG(S315T), and Mycobacterium bovis KatG(R463L).
doi:10.1016/j.pep.2004.04.018
names it
|
Protein Expr Purif |
2004 |
| Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress.
doi:10.1128/AAC.48.7.2424-2430.2004
|
Antimicrob Agents Chemother |
2004 |
| Genetic polymorphism in Mycobacterium tuberculosis isolates from patients with chronic multidrug-resistant tuberculosis.
doi:10.1086/421501
|
J Infect Dis |
2004 |
| Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical strains isolated in the Philippines.
doi:10.1016/j.ijantimicag.2003.09.032
|
Int J Antimicrob Agents |
2004 |
| Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland.
doi:10.1128/JCM.42.6.2425-2431.2004
|
J Clin Microbiol |
2004 |
| Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.
doi:10.1016/j.abb.2004.04.017
|
Arch Biochem Biophys |
2004 |
| Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst.
doi:10.1111/j.1365-2958.2004.04078.x
names it
|
Mol Microbiol |
2004 |
| Identification of MDR-TB Beijing/W and other Mycobacterium tuberculosis genotypes in Nairobi, Kenya.
|
Int J Tuberc Lung Dis |
2004 |
| [Detection of KatG 315 gene mutation associated with isoniazid resistance in Mycobacterium tuberculosis by template-directed dye-terminator incorporation with fluorescence polarization detection technology].
names it
|
Zhonghua Jie He He Hu Xi Za Zhi |
2004 |
| Contribution of AGC to ACC and other mutations at codon 315 of the katG gene in isoniazid-resistant Mycobacterium tuberculosis isolates from the Middle East.
doi:10.1016/j.ijantimicag.2003.10.004
names it
|
Int J Antimicrob Agents |
2004 |
| Superoxide reactivity of KatG: insights into isoniazid resistance pathways in TB.
doi:10.1021/ja031728t
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|
J Am Chem Soc |
2004 |
| Newer diagnostic modalities for tuberculosis.
doi:10.1007/BF02724274
|
Indian J Pediatr |
2004 |
| Direct detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis in auramine-rhodamine-positive sputum specimens by real-time PCR.
doi:10.1128/JCM.42.4.1585-1589.2004
|
J Clin Microbiol |
2004 |
| Recovery of Mycobacterium avium subspecies paratuberculosis from the natural host for the extraction and analysis in vivo-derived RNA.
doi:10.1016/j.mimet.2004.01.010
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J Microbiol Methods |
2004 |
| Antimicrobial susceptibility determined by the E test, Löwenstein-Jensen proportion, and DNA sequencing methods among Mycobacterium tuberculosis isolates discrepancies, preliminary results.
doi:10.1590/s0074-02762004000100019
|
Mem Inst Oswaldo Cruz |
2004 |
| Genetic characterization of the Guinea-Bissau family of Mycobacterium tuberculosis complex strains.
doi:10.1016/j.micinf.2003.12.006
|
Microbes Infect |
2004 |
| [Study on isoniazid-resistant Mycobacterium tuberculosis isolates by multiple-polymerase chain reaction-single strand conformation polymorphism].
|
Zhonghua Jie He He Hu Xi Za Zhi |
2004 |
| Study of resistance to anti-tuberculosis drugs in five districts of Equatorial Guinea: rates, risk factors, genotyping of gene mutations and molecular epidemiology.
|
Int J Tuberc Lung Dis |
2004 |
| Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
doi:10.1016/j.abb.2003.11.021
|
Arch Biochem Biophys |
2004 |
| An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
doi:10.1039/b313592f
|
Chem Commun (Camb) |
2004 |
| Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients.
doi:10.1099/jmm.0.05471-0
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|
J Med Microbiol |
2004 |
| Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates from Monterrey, Mexico.
doi:10.1099/jmm.0.05343-0
|
J Med Microbiol |
2004 |
| Evidence for radical formation at Tyr-353 in Mycobacterium tuberculosis catalase-peroxidase (KatG).
doi:10.1074/jbc.M311884200
names it
|
J Biol Chem |
2004 |
| Molecular fingerprinting of multidrug-resistant Mycobacterium tuberculosis strains in Beirut reveals genetic diversity and father to daughter transmission.
|
J Med Liban |
2003 |
| [Establishment of a method with micro-channel electrophoresis for detecting the mutations of isoniazid-resistant genes in Mycobacterium tuberculosis].
|
Zhonghua Jie He He Hu Xi Za Zhi |
2003 |
| Typing of Mycobacterium tuberculosis strains resistant to rifampicin and isoniazid by molecular biological methods.
doi:10.1023/b:bebm.0000008981.63290.ef
|
Bull Exp Biol Med |
2003 |
| [Identification of Mycobacterium tuberculosis strains and a simultaneous identification of their drug resistance by the hybridization method on oligonucleotide microchips].
|
Mol Gen Mikrobiol Virusol |
2003 |
| Elevation of Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999 to species rank as Mycobacterium caprae comb. nov., sp. nov.
doi:10.1099/ijs.0.02532-0
|
Int J Syst Evol Microbiol |
2003 |
| ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates.
doi:10.1128/AAC.47.12.3799-3805.2003
names it
|
Antimicrob Agents Chemother |
2003 |
| The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.
doi:10.1073/pnas.2235848100
|
Proc Natl Acad Sci U S A |
2003 |
| Koch's bacillus - a look at the first isolate of Mycobacterium tuberculosis from a modern perspective.
doi:10.1099/mic.0.26654-0
|
Microbiology (Reading) |
2003 |
| Biosynthetic specificity of the rhamnosyltransferase gene of Mycobacterium avium serovar 2 as determined by allelic exchange mutagenesis.
doi:10.1099/mic.0.26565-0
|
Microbiology (Reading) |
2003 |
| Prevalence of Beijing genotype in Latvian multidrug-resistant Mycobacterium tuberculosis isolates.
|
Int J Tuberc Lung Dis |
2003 |
| Molecular analysis of isoniazid resistance in Mycobacterium tuberculosis isolates recovered from South Korea.
doi:10.1016/s0732-8893(03)00132-9
|
Diagn Microbiol Infect Dis |
2003 |
| Detection of isoniazid and rifampin resistance in Mycobacterium tuberculosis strains by single-strand conformation polymorphism analysis and restriction fragment length polymorphism.
|
New Microbiol |
2003 |
| Detection of resistance to isoniazid by denaturing gradient-gel electrophoresis DNA sequencing in Mycobacterium tuberculosis clinical isolates.
|
New Microbiol |
2003 |
| Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP.
doi:10.1099/jmm.0.05223-0
names it
|
J Med Microbiol |
2003 |
| Detection of a point mutation associated with high-level isoniazid resistance in Mycobacterium tuberculosis by using real-time PCR technology with 3'-minor groove binder-DNA probes.
doi:10.1128/JCM.41.10.4630-4635.2003
|
J Clin Microbiol |
2003 |
| Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis.
doi:10.1128/JCM.41.9.4471-4474.2003
names it
|
J Clin Microbiol |
2003 |
| Mycobacterium tuberculosis FurA autoregulates its own expression.
doi:10.1128/JB.185.18.5357-5362.2003
|
J Bacteriol |
2003 |
| Rapid formation of compound II and a tyrosyl radical in the Y229F mutant of Mycobacterium tuberculosis catalase-peroxidase disrupts catalase but not peroxidase function.
doi:10.1074/jbc.M304757200
|
J Biol Chem |
2003 |
| Characterization of the Manila family of Mycobacterium tuberculosis.
doi:10.1128/JCM.41.6.2723-2726.2003
|
J Clin Microbiol |
2003 |
| The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics.
doi:10.1074/jbc.M303747200
|
J Biol Chem |
2003 |
| Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania.
doi:10.1128/AAC.47.6.2009-2011.2003
|
Antimicrob Agents Chemother |
2003 |
| A novel thiocationic liposomal formulation of antisense oligonucleotides with activity against Mycobacterium tuberculosis.
doi:10.1080/00365540310000102
|
Scand J Infect Dis |
2003 |
| 1H and 13C NMR characterization of hemiamidal isoniazid-NAD(H) adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis.
doi:10.1002/chem.200204637
|
Chemistry |
2003 |
| Frequency of mutations in rpoB and codons 315 and 463 of katG in rifampin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates from northeast Mexico.
doi:10.1089/107662903764736328
names it
|
Microb Drug Resist |
2003 |
| Conformational differences in Mycobacterium tuberculosis catalase-peroxidase KatG and its S315T mutant revealed by resonance Raman spectroscopy.
doi:10.1021/bi026992y
names it
|
Biochemistry |
2003 |
| Improved real-time PCR for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
doi:10.1016/s0732-8893(02)00521-7
|
Diagn Microbiol Infect Dis |
2003 |
| Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
doi:10.1074/jbc.M302435200
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J Biol Chem |
2003 |
| Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis.
doi:10.1128/AAC.47.4.1241-1250.2003
|
Antimicrob Agents Chemother |
2003 |
| Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution.
doi:10.1016/s0022-2836(03)00122-0
names it
|
J Mol Biol |
2003 |
| Reduced affinity for Isoniazid in the S315T mutant of Mycobacterium tuberculosis KatG is a key factor in antibiotic resistance.
doi:10.1074/jbc.M300326200
names it
|
J Biol Chem |
2003 |
| Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians.
doi:10.1099/mic.0.25961-0
|
Microbiology (Reading) |
2003 |
| Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.
doi:10.1128/AAC.47.2.670-675.2003
names it
|
Antimicrob Agents Chemother |
2003 |
| Deciphering an outbreak of drug-resistant Mycobacterium tuberculosis.
doi:10.1128/JCM.41.1.67-72.2003
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J Clin Microbiol |
2003 |
| Analysis of heme structural heterogeneity in Mycobacterium tuberculosis catalase-peroxidase (KatG).
doi:10.1074/jbc.M208256200
names it
|
J Biol Chem |
2003 |
| Exploring the structure and function of the mycobacterial KatG protein using trans-dominant mutants.
doi:10.1128/AAC.47.1.188-195.2003
names it
|
Antimicrob Agents Chemother |
2003 |
| [Study on drug-resistance of Mycobacterium tuberculosis isolated from coal workers with silico-tuberculosis].
|
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi |
2002 |
| [Diagnosed tuberculosis using specific DNA probe hybridization methods].
|
Rinsho Byori |
2002 |
| [Rapid screening of katG gene mutation in isoniazid-resistant Mycobacterium tuberculosis].
doi:10.3785/j.issn.1008-9292.2002.03.011
names it
|
Zhejiang Da Xue Xue Bao Yi Xue Ban |
2002 |
| Phylogenetic reconstruction within Mycobacterium tuberculosis Beijing genotype in northwestern Russia.
doi:10.1016/s0923-2508(02)01374-8
|
Res Microbiol |
2002 |
| Molecular fingerprinting of isoniazid-resistant Mycobacterium tuberculosis isolates from chest diseases hospital in Kuwait.
doi:10.1111/j.1348-0421.2002.tb02762.x
|
Microbiol Immunol |
2002 |
| Improving bacteriological diagnosis of tuberculosis.
|
Indian J Pediatr |
2002 |
| [Clinical application and evaluation of the detection of five drugs resistance genes in Mycobacterium tuberculosis].
|
Zhonghua Jie He He Hu Xi Za Zhi |
2002 |
| Crystallization and preliminary X-ray analysis of the catalase-peroxidase KatG from Burkholderia pseudomallei.
doi:10.1107/s0907444902017869
names it
|
Acta Crystallogr D Biol Crystallogr |
2002 |
| Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: dominance of the beijing strain family.
doi:10.3201/eid0811.020507
|
Emerg Infect Dis |
2002 |
| Prevalence of S315T mutation within the katG gene in isoniazid-resistant clinical Mycobacterium tuberculosis isolates from Dubai and Beirut.
names it
|
Int J Tuberc Lung Dis |
2002 |
| Mutations in the rpoB and katG genes leading to drug resistance in Mycobacterium tuberculosis in Latvia.
doi:10.1128/JCM.40.10.3789-3792.2002
names it
|
J Clin Microbiol |
2002 |
| Identification and characterization of tyrosyl radical formation in Mycobacterium tuberculosis catalase-peroxidase (KatG).
doi:10.1074/jbc.M207916200
names it
|
J Biol Chem |
2002 |
| Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans.
doi:10.1128/IAI.70.9.4955-4960.2002
names it
|
Infect Immun |
2002 |
| Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis.
doi:10.1128/AAC.46.9.2804-2810.2002
|
Antimicrob Agents Chemother |
2002 |
| Oxidative stress increases susceptibility of Mycobacterium tuberculosis to isoniazid.
doi:10.1128/AAC.46.9.2765-2771.2002
|
Antimicrob Agents Chemother |
2002 |
| Variations in the occurrence of the S315T mutation within the katG gene in isoniazid-resistant clinical Mycobacterium tuberculosis isolates from Kuwait.
doi:10.1089/107662902760190644
names it
|
Microb Drug Resist |
2002 |
| Detection of isoniazid-resistant Mycobacterium tuberculosis strains by a multiplex allele-specific PCR assay targeting katG codon 315 variation.
doi:10.1128/JCM.40.7.2509-2512.2002
names it
|
J Clin Microbiol |
2002 |
| Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
doi:10.1128/AAC.46.7.2137-2144.2002
|
Antimicrob Agents Chemother |
2002 |
| Temperature-mediated heteroduplex analysis performed by using denaturing high-performance liquid chromatography to identify sequence polymorphisms in Mycobacterium tuberculosis complex organisms.
doi:10.1128/JCM.40.5.1610-1616.2002
|
J Clin Microbiol |
2002 |
| High prevalence of KatG Ser315Thr substitution among isoniazid-resistant Mycobacterium tuberculosis clinical isolates from northwestern Russia, 1996 to 2001.
doi:10.1128/AAC.46.5.1417-1424.2002
names it
|
Antimicrob Agents Chemother |
2002 |
| Rifampin and isoniazid resistance associated mutations in Mycobacterium tuberculosis clinical isolates in Seville, Spain.
|
Int J Tuberc Lung Dis |
2002 |
| Peptide nucleic acid probe detection of mutations in Mycobacterium tuberculosis genes associated with drug resistance.
doi:10.2144/02323st01
|
Biotechniques |
2002 |
| The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design.
doi:10.1074/jbc.M200864200
|
J Biol Chem |
2002 |
| New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis.
doi:10.1128/JCM.40.3.988-995.2002
|
J Clin Microbiol |
2002 |
| Direct voltammetry and catalysis with Mycobacterium tuberculosis catalase-peroxidase, peroxidases, and catalase in lipid films.
doi:10.1021/ac010701u
|
Anal Chem |
2002 |
| Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
doi:10.1128/AAC.46.2.443-450.2002
|
Antimicrob Agents Chemother |
2002 |
| Characterization of the W321F mutant of Mycobacterium tuberculosis catalase-peroxidase KatG.
doi:10.1110/ps.09902
names it
|
Protein Sci |
2002 |
| Typing of drug resistant isolates of Mycobacterium tuberculosis from India using the IS6110 element reveals substantive polymorphism.
doi:10.1016/s1567-1348(01)00014-4
|
Infect Genet Evol |
2001 |
| [Studies on mutation of isoniazid resistant genes in M. tuberculosis].
|
Hunan Yi Ke Da Xue Xue Bao |
2001 |
| A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts.
doi:10.1002/1439-7633(20011203)2:12<877::AID-CBIC877>3.0.CO;2-V
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Chembiochem |
2001 |
| [Sequencing of inhA in drug-resistant Mycobacterium tuberculosis isolates].
|
Zhonghua Jie He He Hu Xi Za Zhi |
2001 |
| [The mechanism of action of isoniazid. A chemical model of activation].
|
Ann Pharm Fr |
2001 |
| Inter- and intramolecular domain interactions of the catalase-peroxidase KatG from M. tuberculosis.
doi:10.1016/s0014-5793(01)03179-9
names it
|
FEBS Lett |
2001 |
| Transcriptional regulation of furA and katG upon oxidative stress in Mycobacterium smegmatis.
doi:10.1128/JB.183.23.6801-6806.2001
names it
|
J Bacteriol |
2001 |
| Mycobacterium tuberculosis phylogeny reconstruction based on combined numerical analysis with IS1081, IS6110, VNTR, and DR-based spoligotyping suggests the existence of two new phylogeographical clades.
doi:10.1007/s002390010255
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J Mol Evol |
2001 |
| Evaluation of katG codon 315 mutations among isoniazid sensitive and resistant mycobacterium tuberculosis isolates from Thailand.
names it
|
J Med Assoc Thai |
2001 |
| Identification and characterization of mycobacterial proteins differentially expressed under standing and shaking culture conditions, including Rv2623 from a novel class of putative ATP-binding proteins.
doi:10.1128/IAI.69.9.5777-5785.2001
|
Infect Immun |
2001 |
| Identification of catalase-like activity from Mycobacterium leprae and the relationship between catalase and isonicotinic acid hydrazide (INH).
doi:10.1099/0022-1317-50-8-675
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J Med Microbiol |
2001 |
| Secondary structure prediction and structure-specific sequence analysis of single-stranded DNA.
doi:10.1093/nar/29.15.3248
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Nucleic Acids Res |
2001 |
| Evidence for isoniazid-dependent free radical generation catalyzed by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T).
doi:10.1021/bi002614m
names it
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Biochemistry |
2001 |
| Characterization of isoniazid-resistant strains of Mycobacterium tuberculosis on the basis of phenotypic properties and mutations in katG.
doi:10.1007/pl00011272
names it
|
Eur J Clin Microbiol Infect Dis |
2001 |
| Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.
doi:10.1128/AAC.45.7.2157-2159.2001
|
Antimicrob Agents Chemother |
2001 |
| Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis.
doi:10.1046/j.1365-2958.2001.02427.x
names it
|
Mol Microbiol |
2001 |
| Carbon monoxide adducts of KatG and KatG(S315T) as probes of the heme site and isoniazid binding.
doi:10.1021/bi010369g
names it
|
Biochemistry |
2001 |
| Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages.
doi:10.1128/JB.183.13.4033-4039.2001
names it
|
J Bacteriol |
2001 |
| Characterization of IS6110 restriction fragment length polymorphism patterns and mechanisms of antimicrobial resistance for multidrug-resistant isolates of Mycobacterium tuberculosis from a major reference hospital in Assiut, Egypt.
doi:10.1128/JCM.39.6.2330-2334.2001
|
J Clin Microbiol |
2001 |
| Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.
doi:10.1128/AAC.45.6.1645-1648.2001
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Antimicrob Agents Chemother |
2001 |
| Heteroresistance in Mycobacterium tuberculosis.
|
Int J Tuberc Lung Dis |
2001 |
| The susceptibility of Mycobacterium tuberculosis to isoniazid and the Arg-->Leu mutation at codon 463 of katG are not associated.
doi:10.1128/JCM.39.4.1591-1594.2001
names it
|
J Clin Microbiol |
2001 |
| Active site structure of the catalase-peroxidases from Mycobacterium tuberculosis and Escherichia coli by extended X-ray absorption fine structure analysis.
doi:10.1016/s0167-4838(00)00221-1
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Biochim Biophys Acta |
2001 |
| The molecular peculiarities of catalase-peroxidases.
doi:10.1016/s0014-5793(01)02237-2
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FEBS Lett |
2001 |
| Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG.
doi:10.1111/j.1365-2958.2001.02321.x
names it
|
Mol Microbiol |
2001 |
| Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity.
doi:10.1042/0264-6021:3540209
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Biochem J |
2001 |
| Transmission dynamics and molecular characterization of Mycobacterium tuberculosis isolates with low copy numbers of IS6110.
doi:10.1128/JCM.39.1.217-221.2001
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J Clin Microbiol |
2001 |
| Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.
doi:10.1016/s1201-9712(00)90075-4
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Int J Infect Dis |
2000 |
| The DNA-binding characteristics of the Streptomyces reticuli regulator FurS depend on the redox state of its cysteine residues.
doi:10.1007/s004380000328
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Mol Gen Genet |
2000 |
| Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in the Netherlands.
doi:10.1086/317598
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J Infect Dis |
2000 |
| [Molecular mechanisms of multidrug resistance in Mycobacterium tuberculosis].
doi:10.7888/juoeh.22.269
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J UOEH |
2000 |
| Cloning, expression, and characterization of the katG gene, encoding catalase-peroxidase, from the polycyclic aromatic hydrocarbon-degrading bacterium Mycobacterium sp. strain PYR-1.
doi:10.1128/AEM.66.10.4300-4304.2000
names it
|
Appl Environ Microbiol |
2000 |
| Redox potential measurements of the Mycobacterium tuberculosis heme protein KatG and the isoniazid-resistant enzyme KatG(S315T): insights into isoniazid activation.
doi:10.1021/bi001239v
names it
|
Biochemistry |
2000 |
| Use of real-time PCR and fluorimetry for rapid detection of rifampin and isoniazid resistance-associated mutations in Mycobacterium tuberculosis.
doi:10.1128/JCM.38.9.3194-3199.2000
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J Clin Microbiol |
2000 |
| Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.
doi:10.1073/pnas.97.17.9677
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Proc Natl Acad Sci U S A |
2000 |
| Mycobacterium tuberculosis H37Rv comparative gene-expression analysis in synthetic medium and human macrophage.
doi:10.1016/s0378-1119(00)00249-3
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Gene |
2000 |
| Spectroscopic comparison of the heme active sites in WT KatG and its S315T mutant.
doi:10.1021/bi0006870
names it
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Biochemistry |
2000 |
| Catalase-peroxidase (Mycobacterium tuberculosis KatG) catalysis and isoniazid activation.
doi:10.1021/bi0005815
names it
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Biochemistry |
2000 |
| Genomic mutations in the katG, inhA and aphC genes are useful for the prediction of isoniazid resistance in Mycobacterium tuberculosis isolates from Kwazulu Natal, South Africa.
doi:10.1054/tuld.1999.0231
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Tuber Lung Dis |
2000 |
| The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.
doi:10.1016/s1286-4579(00)00359-2
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Microbes Infect |
2000 |
| Identification of drug-resistantMycobacterium tuberculosis by single strand conformation polymorphism and cleavase fragment length polymorphism.
doi:10.1007/BF02883734
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Indian J Clin Biochem |
2000 |
| Activation of the pro-drug ethionamide is regulated in mycobacteria.
doi:10.1074/jbc.M003744200
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J Biol Chem |
2000 |
| Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.
doi:10.1128/JB.182.14.4059-4067.2000
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J Bacteriol |
2000 |
| Modulation of the activities of catalase-peroxidase HPI of Escherichia coli by site-directed mutagenesis.
doi:10.1021/bi0000059
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Biochemistry |
2000 |
| Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis.
doi:10.1128/AAC.44.5.1296-1301.2000
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Antimicrob Agents Chemother |
2000 |
| [Molecular mechanisms of mycobacterium tuberculosis strains resistance to rifampicin and isoniazid].
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Probl Tuberk |
2000 |
| The immunogenicity of single and combination DNA vaccines against tuberculosis.
doi:10.1016/s0264-410x(99)00540-x
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Vaccine |
2000 |
| Characterization of Mycobacterium tuberculosis isolates from patients in Houston, Texas, by spoligotyping.
doi:10.1128/JCM.38.2.669-676.2000
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J Clin Microbiol |
2000 |
| Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of inha inhibitor.
doi:10.1074/jbc.275.4.2520
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J Biol Chem |
2000 |
| Molecular mechanisms of drug resistance in Mycobacterium tuberculosis clinical isolates.
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Chin Med J (Engl) |
1999 |
| Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy.
doi:10.1054/tuld.1999.0222
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Tuber Lung Dis |
1999 |
| Molecular analysis of rifampin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in Seville, Spain.
doi:10.1054/tuld.1998.0195
|
Tuber Lung Dis |
1999 |
| AhpC, oxidative stress and drug resistance in Mycobacterium tuberculosis.
doi:10.1002/biof.5520100219
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Biofactors |
1999 |
| High-dose isoniazid therapy for isoniazid-resistant murine Mycobacterium tuberculosis infection.
doi:10.1128/AAC.43.12.2922
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Antimicrob Agents Chemother |
1999 |
| The Mycobacterium tuberculosis mysB gene product is a functional equivalent of the Escherichia coli sigma factor, KatF.
doi:10.1016/s0378-1119(99)00430-8
|
Gene |
1999 |
| Molecular characterization of mycobacteria isolated from seals.
doi:10.1099/00221287-145-9-2519
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Microbiology (Reading) |
1999 |
| The Mycobacterium tuberculosis katG promoter region contains a novel upstream activator.
doi:10.1099/00221287-145-9-2507
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Microbiology (Reading) |
1999 |
| Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents.
doi:10.1099/13500872-145-8-2011
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Microbiology (Reading) |
1999 |
| Culture-independent prediction of isoniazid resistance in Mycobacterium tuberculosis by katG gene analysis directly from sputum samples.
doi:10.1016/s1084-8592(99)80038-1
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Mol Diagn |
1999 |
| Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences.
doi:10.1128/IAI.67.9.4780-4786.1999
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Infect Immun |
1999 |
| Mycobacterium tuberculosis subsp. caprae subsp. nov.: a taxonomic study of a new member of the Mycobacterium tuberculosis complex isolated from goats in Spain.
doi:10.1099/00207713-49-3-1263
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Int J Syst Bacteriol |
1999 |
| Phenotypic and genotypic characterization of Mycobacterium africanum isolates from West Africa.
doi:10.1128/JCM.37.6.1921-1926.1999
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J Clin Microbiol |
1999 |
| Molecular epidemiologic evaluation of transmissibility and virulence of Mycobacterium tuberculosis.
doi:10.1128/JCM.37.6.1764-1770.1999
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J Clin Microbiol |
1999 |
| The mycelium-associated Streptomyces reticuli catalase-peroxidase, its gene and regulation by FurS.
doi:10.1099/13500872-145-3-549
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Microbiology (Reading) |
1999 |
| Mycobacterium tuberculosis KatG is a peroxynitritase.
doi:10.1006/bbrc.1999.0358
names it
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Biochem Biophys Res Commun |
1999 |
| Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).
doi:10.1128/JCM.37.4.998-1003.1999
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J Clin Microbiol |
1999 |
| Application of molecular methods for detection and transmission analysis of mycobacterium tuberculosis drug resistance in patients attending a reference hospital in Italy.
doi:10.1086/314677
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J Infect Dis |
1999 |
| Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis.
names it
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Biochem J |
1999 |
| Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro.
doi:10.1128/IAI.67.1.74-79.1999
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Infect Immun |
1999 |
| Mechanisms of isoniazid resistance in Mycobacterium tuberculosis.
doi:10.1016/s1368-7646(98)80028-9
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Drug Resist Updat |
1998 |
| [Study on the mutations of ahpC genes in M. tuberculosis isoniazid-resistant isolates].
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Zhonghua Jie He He Hu Xi Za Zhi |
1998 |
| [Molecular biology of KatG gene and isoniazid resistence in Mycobacterium tuberculosis].
names it
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Zhonghua Jie He He Hu Xi Za Zhi |
1998 |
| [Relationship between catalase activity, KatG gene and isoniazid-resistance in M. tuberculosis].
names it
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Zhonghua Jie He He Hu Xi Za Zhi |
1998 |
| Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru.
doi:10.1054/tuld.1998.0013
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Tuber Lung Dis |
1998 |
| Protective role of the Mycobacterium smegmatis IdeR against reactive oxygen species and isoniazid toxicity.
doi:10.1054/tuld.1998.0011
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Tuber Lung Dis |
1998 |
| Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
doi:10.1054/tuld.1998.0002
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Tuber Lung Dis |
1998 |
| Comparative Evaluation of Cleavase Fragment Length Polymorphism With PCR-SSCP and PCR-RFLP to Detect Antimicrobial Agent Resistance in Mycobacterium tuberculosis.
doi:10.154/MODI00300081
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Mol Diagn |
1998 |
| Mechanisms for isoniazid action and resistance.
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Novartis Found Symp |
1998 |
| [Mechanisms of drug-resistance in mycobacteria].
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Nihon Rinsho |
1998 |
| [Multidrug-resistant tuberculosis. 2. Mechanisms of drug-resistance in Mycobacterium tuberculosis--genetic mechanisms of drug-resistance].
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Kekkaku |
1998 |
| Evidence for differential binding of isoniazid by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T).
doi:10.1021/bi982023k
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Biochemistry |
1998 |
| Mechanism of isoniazid uptake in Mycobacterium tuberculosis.
doi:10.1099/00221287-144-9-2539
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Microbiology (Reading) |
1998 |
| Site-directed mutagenesis and virulence assessment of the katG gene of Mycobacterium intracellulare.
doi:10.1046/j.1365-2958.1998.00982.x
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Mol Microbiol |
1998 |
| Significance of ahpC promoter mutations for the prediction of isoniazid resistance in Mycobacterium tuberculosis.
doi:10.1007/BF01691135
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Eur J Clin Microbiol Infect Dis |
1998 |
| A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia.
doi:10.1128/AAC.42.9.2443
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Antimicrob Agents Chemother |
1998 |
| Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.
doi:10.1128/JB.180.18.4856-4864.1998
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J Bacteriol |
1998 |
| Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
doi:10.1086/515362
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J Infect Dis |
1998 |
| NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.
doi:10.1128/JB.180.9.2459-2467.1998
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J Bacteriol |
1998 |
| Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium.
doi:10.1046/j.1365-2958.1998.00774.x
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Mol Microbiol |
1998 |
| Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs.
doi:10.1086/515254
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J Infect Dis |
1998 |
| Role of superoxide in catalase-peroxidase-mediated isoniazid action against mycobacteria.
doi:10.1128/AAC.42.3.709
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Antimicrob Agents Chemother |
1998 |
| The rapid diagnosis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis--a molecular story.
doi:10.1099/00222615-47-3-189
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J Med Microbiol |
1998 |
| [Study on the molecular mechanism of multi-drug resistance in clinical isolates of Mycobacterium tuberculosis].
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Zhonghua Jie He He Hu Xi Za Zhi |
1997 |
| Molecular techniques in the diagnosis of drug-resistant tuberculosis.
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Ann Acad Med Singap |
1997 |
| [Rapid diagnosis of tuberculosis].
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Kekkaku |
1997 |
| Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis.
doi:10.1074/jbc.272.50.31265
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J Biol Chem |
1997 |
| MTC28, a novel 28-kilodalton proline-rich secreted antigen specific for the Mycobacterium tuberculosis complex.
doi:10.1128/iai.65.12.4951-4957.1997
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Infect Immun |
1997 |
| katGI and katGII encode two different catalases-peroxidases in Mycobacterium fortuitum.
doi:10.1128/jb.179.22.6880-6886.1997
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J Bacteriol |
1997 |
| Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electrospray mass spectrometry.
doi:10.1128/iai.65.11.4515-4524.1997
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Infect Immun |
1997 |
| Lack of clinical significance for the common arginine-to-leucine substitution at codon 463 of the katG gene in isoniazid-resistant Mycobacterium tuberculosis in Singapore.
doi:10.1086/517320
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J Infect Dis |
1997 |
| Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
doi:10.1128/AAC.41.9.2057
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Antimicrob Agents Chemother |
1997 |
| Recombinant Mycobacterium tuberculosis KatG(S315T) is a competent catalase-peroxidase with reduced activity toward isoniazid.
doi:10.1086/514096
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J Infect Dis |
1997 |
| Usefulness of Mycobacterium tuberculosis genomic mutations in the genes katG and inhA for the prediction of isoniazid resistance.
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Int J Tuberc Lung Dis |
1997 |
| Expression or possession of catalase gene does not alter the capacity of M. smegmatis to survive within human macrophages.
doi:10.1080/15216549700203281
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Biochem Mol Biol Int |
1997 |
| Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa.
doi:10.1128/AAC.41.7.1601
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Antimicrob Agents Chemother |
1997 |
| Influence of Mycobacterium tuberculosis catalase gene (KatG) expression on nitric oxide production and the intracellular growth of transfected Mycobacterium smegmatis strains within murine macrophages.
doi:10.1080/15216549700202511
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Biochem Mol Biol Int |
1997 |
| Detection of resistance to isoniazid, rifampin, and streptomycin in clinical isolates of Mycobacterium tuberculosis by molecular methods.
doi:10.1093/clinids/24.5.894
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Clin Infect Dis |
1997 |
| Nucleotide sequence of the Mycobacterium leprae katG region.
doi:10.1128/jb.179.9.3053-3057.1997
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J Bacteriol |
1997 |
| On the catalase-peroxidase gene, katG, of Mycobacterium leprae and the implications for treatment of leprosy with isoniazid.
doi:10.1111/j.1574-6968.1997.tb10340.x
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FEMS Microbiol Lett |
1997 |
| Isoniazid resistance and the point mutation of codon 463 of katG gene of Mycobacterium tuberculosis.
doi:10.3346/jkms.1997.12.2.92
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J Korean Med Sci |
1997 |
| Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
doi:10.1128/iai.65.4.1395-1401.1997
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Infect Immun |
1997 |
| Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities.
doi:10.1128/AAC.41.3.600
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Antimicrob Agents Chemother |
1997 |
| Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level.
doi:10.1128/jcm.35.3.719-723.1997
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J Clin Microbiol |
1997 |
| Use of polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis to detect a point mutation in the catalase-peroxidase gene (katG) of Mycobacterium tuberculosis.
doi:10.1006/mcpr.1996.0077
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Mol Cell Probes |
1997 |
| Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis.
doi:10.1074/jbc.272.5.2834
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J Biol Chem |
1997 |
| [Relationship between INH-resistance and katG mutation in M. tuberculosis].
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Zhonghua Jie He He Hu Xi Za Zhi |
1996 |
| Differentiation of bacterial 16S rRNA genes and intergenic regions and Mycobacterium tuberculosis katG genes by structure-specific endonuclease cleavage.
doi:10.1128/jcm.34.12.3129-3137.1996
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J Clin Microbiol |
1996 |
| In search of tuberculosis virulence genes.
doi:10.1016/0966-842x(96)10066-4
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Trends Microbiol |
1996 |
| Life without KatG.
doi:10.1016/0966-842x(96)30030-9
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Trends Microbiol |
1996 |
| Presence of katG gene in resistant Mycobacterium tuberculosis.
doi:10.1136/jcp.49.11.945
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J Clin Pathol |
1996 |
| Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance.
doi:10.1046/j.1365-2958.1996.00133.x
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Mol Microbiol |
1996 |
| An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response.
doi:10.1046/j.1365-2958.1996.1461511.x
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Mol Microbiol |
1996 |
| Analysis of isoniazid-resistant transposon mutants of Mycobacterium smegmatis.
doi:10.1111/j.1574-6968.1996.tb08507.x
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FEMS Microbiol Lett |
1996 |
| katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.
doi:10.1128/AAC.40.9.2187
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Antimicrob Agents Chemother |
1996 |
| Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.
doi:10.1126/science.272.5268.1641
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Science |
1996 |
| katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis are not infrequent.
doi:10.1128/AAC.40.6.1572
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Antimicrob Agents Chemother |
1996 |
| Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis.
doi:10.1016/0378-1119(95)00841-1
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Gene |
1996 |
| Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family.
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JAMA |
1996 |
| Evaluation of inhA gene and catalase-peroxidase gene among isoniazid-sensitive and resistant Mycobacterium tuberculosis isolates.
doi:10.1006/mcpr.1996.0001
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Mol Cell Probes |
1996 |
| The katE gene, which encodes the catalase HPII of Mycobacterium avium.
doi:10.1046/j.1365-2958.1996.352876.x
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Mol Microbiol |
1996 |
| Molecular mechanisms of drug resistance in Mycobacterium tuberculosis.
doi:10.1146/annurev.bi.65.070196.001243
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Annu Rev Biochem |
1996 |
| Molecular biology in medicine: laboratory diagnosis of tuberculosis.
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Ann Acad Med Singap |
1996 |
| Host-mediated modification of PvuII restriction in Mycobacterium tuberculosis.
doi:10.1128/jb.178.1.78-84.1996
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J Bacteriol |
1996 |
| Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.
doi:10.1093/infdis/173.1.196
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J Infect Dis |
1996 |
| KatG sequence deletion is not the major cause of isoniazid resistance in Japanese and Yemeni Mycobacterium tuberculosis isolates.
doi:10.1006/mcpr.1995.0066
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Mol Cell Probes |
1995 |
| Comparison of isoniazid oxidation catalyzed by bacterial catalase-peroxidases and horseradish peroxidase.
doi:10.1006/abbi.1995.0065
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Arch Biochem Biophys |
1995 |
| Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
doi:10.1128/AAC.39.11.2472
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Antimicrob Agents Chemother |
1995 |
| Antimicrobial agent resistance in mycobacteria: molecular genetic insights.
doi:10.1128/CMR.8.4.496
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Clin Microbiol Rev |
1995 |
| Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare.
doi:10.1128/AAC.39.10.2276
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Antimicrob Agents Chemother |
1995 |
| Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation.
doi:10.1074/jbc.270.38.22290
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J Biol Chem |
1995 |
| Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria.
doi:10.1073/pnas.92.14.6625
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Proc Natl Acad Sci U S A |
1995 |
| Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis.
doi:10.1128/iai.63.4.1427-1433.1995
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Infect Immun |
1995 |
| Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.
doi:10.1093/infdis/171.4.954
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J Infect Dis |
1995 |
| Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis.
doi:10.1128/AAC.39.3.750
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Antimicrob Agents Chemother |
1995 |
| Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis.
doi:10.1111/j.1365-2958.1995.tb02276.x
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Mol Microbiol |
1995 |
| Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.
doi:10.1093/infdis/171.1.240
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J Infect Dis |
1995 |
| Catalase expression, katG, and MIC of isoniazid for Mycobacterium tuberculosis isolates from São Paulo, Brazil.
doi:10.1093/infdis/171.1.237
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J Infect Dis |
1995 |
| Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.
doi:10.1111/j.1365-2958.1995.tb02238.x
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Mol Microbiol |
1995 |
| PCR amplification of variable sequence upstream of katG gene to subdivide strains of Mycobacterium tuberculosis complex.
doi:10.1128/jcm.32.12.3070-3071.1994
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J Clin Microbiol |
1994 |
| Strain variation in the katG region of Mycobacterium tuberculosis.
doi:10.1111/j.1365-2958.1994.tb01291.x
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Mol Microbiol |
1994 |
| Molecular genetics of drug resistance in Mycobacterium tuberculosis.
doi:10.1093/jac/34.3.313
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J Antimicrob Chemother |
1994 |
| Effects of peroxides on susceptibilities of Escherichia coli and Mycobacterium smegmatis to isoniazid.
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Antimicrob Agents Chemother |
1994 |
| Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study.
doi:10.1016/s0140-6736(94)91338-2
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Lancet |
1994 |
| Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates.
doi:10.1093/infdis/169.5.1162
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J Infect Dis |
1994 |
| Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City.
doi:10.1093/infdis/168.4.1063
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J Infect Dis |
1993 |
| Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid.
doi:10.1128/AAC.37.10.2251
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Antimicrob Agents Chemother |
1993 |
| Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.
doi:10.1128/jb.175.13.4255-4259.1993
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J Bacteriol |
1993 |
| Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations.
doi:10.1111/j.1365-2958.1993.tb01596.x
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Mol Microbiol |
1993 |
| Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum.
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Res Microbiol |
1992 |
| The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.
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Nature |
1992 |