Rv1930c Resolved · medium auto-curated
H37Rv Rv1930c · MTBC0 mtbc0_002044 ·
174 aa · 2201034–2201558 (-) ·
RefSeq NP_216446.1
Annotation: from legacy to revised
| Legacy (H37Rv / Mycobrowser) | hypothetical protein |
|---|---|
| MTBC0 PGAP re-annotation | glutamine amidotransferase |
| Revised (this work) | Glutamine amidotransferase. |
Auto-curated: this verdict and function were generated by rules from PGAP + Pfam + Foldseek and have not been hand-reviewed.
Curated reference (UniProt)
| UniProt |
P95284
TrEMBL · unreviewed
· Predicted
|
|---|---|
| UniProt name | Glutamine amidotransferase |
Functional vocabulary (eggNOG-mapper, orthology transfer)
| COG category |
S Function unknown
|
|---|---|
| eggNOG description | DJ-1 PfpI family |
| Orthologous group | COG0693 |
Orthology-based transfer (eggNOG 5.0.2, diamond). EC/KO/GO/CAZy are computed annotations, not manual curation; cross-check against the primary literature before treating a specific reaction as established.
Domains (Pfam, hmmscan --cut_ga)
No Pfam-A domain above the gathering threshold (or not yet scanned).
Functional interaction network (STRING v12, guilt-by-association)
Closest characterised functional partner: Rv1931c (transcriptional regulator), high confidence from genomic context alone (score 935 excluding text-mining). This association is the citable seed of a function hypothesis for this hypothetical protein.
| Partner | Product | Score | No text-mining | Channels (≥400) |
|---|---|---|---|---|
Rv1931c |
transcriptional regulator | 935 | 935 ctx | neighborhood:863 cooccurence:539 |
Rv1929c hyp |
hypothetical protein | 770 | 770 ctx | neighborhood:770 |
Rv1932 tpx |
2-Cys peroxiredoxin | 763 | 764 ctx | neighborhood:764 |
Rv1928c |
short-chain type dehydrogenase/reductase | 648 | 647 ctx | neighborhood:636 |
Rv0554 bpoC |
non-heme bromoperoxidase BpoC | 596 | 597 ctx | neighborhood:544 |
Rv0553 menC |
muconate cycloisomerase | 548 | 548 ctx | neighborhood:544 |
Rv0556 |
transmembrane protein | 544 | 544 ctx | neighborhood:544 |
Rv0555 menD |
bifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase | 544 | 544 ctx | neighborhood:544 |
Rv2720 lexA |
repressor LexA | 471 | 448 | |
Rv2703 sigA |
RNA polymerase sigma factor SigA | 491 | 432 | |
Rv2710 sigB |
RNA polymerase sigma factor SigB | 491 | 432 | |
Rv0517 |
acyltransferase | 428 | 428 ctx | cooccurence:425 |
Rv2043c pncA |
pyrazinamidase/nicotinamidase PncA | 425 | 426 | coexpression:404 |
Rv2511 orn |
oligoribonuclease | 481 | 153 | textmining:413 |
Rv3286c sigF |
RNA polymerase sigma factor SigF | 484 | 47 | textmining:481 |
STRING combines evidence channels (neighborhood, fusion, cooccurrence, coexpression, experimental, database, text-mining) into a 0–1000 score. The ctx badge marks edges carried by the genomic-context channels (conserved neighborhood, fusion, phylogenetic co-occurrence), which are independent of orthology and structure and the strongest signal for an unknown gene. The no text-mining column recomputes the score from data alone, so a link that does not depend on the literature is visible. Association is a function hypothesis, not proof: corroborate with the operon context and the primary literature before assigning a function.
Evidence
- Legacy H37Rv annotation: hypothetical protein
- MTBC0 PGAP product: glutamine amidotransferase
- (auto-curated by rules from PGAP + Pfam + Foldseek; not hand-reviewed)
Sources
- Ancestral sequence & coordinates: Harrison LB et al. (2024), An imputed ancestral reference genome for the MTBC, doi:10.1101/2023.09.07.556366
- Product annotation: NCBI PGAP on MTBC0; legacy from H37Rv NC_000962.3 (RefSeq NP_216446.1)
- Domains: Pfam-A via hmmscan --cut_ga — none above threshold
- Sequence-level signal: ESM Atlas (EvolutionaryScale × BioHub) — exploratory
- Controlled vocabulary: eggNOG-mapper 2.1.12 (Cantalapiedra et al. 2021,
doi:10.1093/molbev/msab293), eggNOG 5.0 DB
(Huerta-Cepas et al. 2019) — OG
COG0693 - Curated reference: UniProt P95284 (TrEMBL, unreviewed; Predicted)
- Interaction network: STRING v12.0 (Szklarczyk et al. 2023,
doi:10.1093/nar/gkac1000), taxon 83332, CC-BY 4.0 —
16 functional partner(s); context anchor
Rv1931c - Primary literature: none located yet; annotation rests on the domain/homology sources above.
Ancestral MTBC0 protein sequence
>mtbc0_002044|Rv1930c| MTQIAFVAYPGVTALDVVGPYEVLRNLPHAQVRFVWLRGRRATSHWLTLPALKAFGAIPVADERIVHQDNIVTSAGVSAGLDLALWLAGQLGGEARAKAIQLAIEYDPQPPFDSGHMSKASPTTKAAATALLSKDSAKPANLTAATLLAWERALAAVQSRRRKRQPVGAQARRP