MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 403 835–723 835 bp (320 000 bp)
+ strand − strand aspC (Rv0337c) — requalified: pyridoxal phosphate-dependent aminotransferase Rv0338c (Rv0338c) — requalified: heterodisulfide reductase-related iron-sulfur binding cluste iniR (Rv0339c) — family_assigned: isoniazid response ATPase/transcriptional regulator IniR Rv0340 (Rv0340) — family_assigned: Rv0340 family IniB-related protein iniB (Rv0341) — requalified: isoniazid-induced protein IniB iniC (Rv0343) — requalified: isoniazid-induced dynamin-like GTPase IniC lpqJ (Rv0344c) — family_assigned: hypothetical protein mosR (Rv0348) — family_assigned: hypoxia/intracellular survival transcriptional regulator Mos dnaK (Rv0350) — requalified: molecular chaperone DnaK grpE (Rv0351) — requalified: nucleotide exchange factor GrpE hspR (Rv0353) — family_assigned: heat shock transcriptional regulator HspR Rv0356c (Rv0356c) — family_assigned: PaaI family thioesterase purA (Rv0357c) — requalified: adenylosuccinate synthase Rv0358 (Rv0358) — requalified: peptidase M50 Rv0359 (Rv0359) — family_assigned: site-2 protease family protein Rv0361 (Rv0361) — family_assigned: hypothetical protein mgtE (Rv0362) — requalified: magnesium transporter fba (Rv0363c) — requalified: class II fructose-bisphosphate aldolase Rv0364 (Rv0364) — family_assigned: VTT domain-containing protein Rv0365c (Rv0365c) — family_assigned: glycoside hydrolase family 76 protein Rv0366c (Rv0366c) — family_assigned: zeta toxin family protein Rv0367c (Rv0367c) — family_assigned: hypothetical protein Rv0368c (Rv0368c) — family_assigned: VWA domain-containing protein Rv0370c (Rv0370c) — family_assigned: MoxR family ATPase Rv0371c (Rv0371c) — family_assigned: NTP transferase domain-containing protein Rv0372c (Rv0372c) — family_assigned: XdhC family protein Rv0373c (Rv0373c) — family_assigned: aerobic carbon-monoxide dehydrogenase large subunit Rv0374c (Rv0374c) — family_assigned: (2Fe-2S)-binding protein Rv0377 (Rv0377) — family_assigned: LysR family transcriptional regulator Rv0378 (Rv0378) — dark: hypothetical protein Rv0381c (Rv0381c) — dark: hypothetical protein ttfA (Rv0383c) — requalified: trehalose monomycolate transport factor TtfA Rv0385 (Rv0385) — requalified: FAD-binding oxidoreductase Rv0386 (Rv0386) — family_assigned: LuxR family transcriptional regulator purT (Rv0389) — requalified: phosphoribosylglycinamide formyltransferase 2 Rv0390 (Rv0390) — family_assigned: rhodanese-like domain-containing protein metZ (Rv0391) — requalified: O-succinylhomoserine sulfhydrylase ndhA (Rv0392c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0394c (Rv0394c) — requalified: hyaluronidase/chondrosulfatase Rv0395 (Rv0395) — dark: hypothetical protein Rv0396 (Rv0396) — dark: hypothetical protein Rv0398c (Rv0398c) — family_assigned: hypothetical protein lpqK (Rv0399c) — family_assigned: serine hydrolase domain-containing protein fadE7 (Rv0400c) — requalified: acyl-CoA dehydrogenase Rv0401 (Rv0401) — dark: DUF3054 domain-containing protein mmpL1 (Rv0402c) — requalified: RND transporter MmpL1 mmpS1 (Rv0403c) — family_assigned: MmpS family protein fgd1 (Rv0407) — requalified: glucose-6-phosphate dehydrogenase (coenzyme-F420) pta (Rv0408) — requalified: phosphate acetyltransferase ackA (Rv0409) — requalified: acetate kinase pknG (Rv0410c) — requalified: serine/threonine protein kinase PknG glnH (Rv0411c) — family_assigned: glutamate ABC transporter substrate-binding protein glnX (Rv0412c) — requalified: protein kinase G-activating protein GlnX thiE (Rv0414c) — requalified: thiamine phosphate synthase thiO (Rv0415) — requalified: glycine oxidase ThiO thiS (Rv0416) — requalified: sulfur carrier protein ThiS thiG (Rv0417) — requalified: thiazole synthase lpqL (Rv0418) — family_assigned: M28 family metallopeptidase lpqM (Rv0419) — requalified: neutral zinc metallopeptidase Rv0421c (Rv0421c) — family_assigned: alpha/beta family hydrolase thiC (Rv0423c) — requalified: phosphomethylpyrimidine synthase ThiC Rv0424c (Rv0424c) — dark: hypothetical protein ctpH (Rv0425c) — requalified: cation-translocating P-type ATPase Rv0426c (Rv0426c) — dark: hypothetical protein Rv0428c (Rv0428c) — family_assigned: GNAT family N-acetyltransferase def (Rv0429c) — requalified: peptide deformylase napA (Rv0430) — requalified: DUF3263 domain-containing protein sodC (Rv0432) — family_assigned: superoxide dismutase family protein Rv0433 (Rv0433) — requalified: glutamate--cysteine ligase Rv0434 (Rv0434) — family_assigned: LON peptidase substrate-binding domain-containing protein Rv0435c (Rv0435c) — family_assigned: AAA family ATPase pssA (Rv0436c) — requalified: CDP-diacylglycerol--serine O-phosphatidyltransferase psd (Rv0437c) — requalified: phosphatidylserine decarboxylase Rv0439c (Rv0439c) — family_assigned: SDR family NAD(P)-dependent oxidoreductase groEL2 (Rv0440) — requalified: chaperonin GroEL Rv0441c (Rv0441c) — family_assigned: pyridoxamine 5'-phosphate oxidase family protein Rv0443 (Rv0443) — requalified: mycothiol transferase rskA (Rv0444c) — requalified: anti-sigma-K factor RskA sigK (Rv0445c) — family_assigned: sigma-70 family RNA polymerase sigma factor SigK Rv0446c (Rv0446c) — family_assigned: DUF1295 domain-containing protein ufaA1 (Rv0447c) — requalified: class I SAM-dependent methyltransferase Rv0449c (Rv0449c) — requalified: NAD(P)/FAD-dependent oxidoreductase mmpS4 (Rv0451c) — requalified: siderophore RND transporter accessory protein MmpS4 Rv0452 (Rv0452) — family_assigned: TetR family transcriptional regulator Rv0455c (Rv0455c) — family_assigned: DUF5078 domain-containing protein echA2 (Rv0456c) — family_assigned: crotonase/enoyl-CoA hydratase family protein Rv0457c (Rv0457c) — family_assigned: prolyl oligopeptidase family protein Rv0458 (Rv0458) — family_assigned: aldehyde dehydrogenase family protein Rv0459 (Rv0459) — family_assigned: DUF779 domain-containing protein lpdC (Rv0462) — requalified: dihydrolipoyl dehydrogenase Rv0463 (Rv0463) — dark: hypothetical protein Rv0464c (Rv0464c) — family_assigned: carboxymuconolactone decarboxylase family protein ramB (Rv0465c) — family_assigned: acetate metabolism transcriptional regulator RamB Rv0466 (Rv0466) — requalified: acyl-[acyl-carrier-protein] thioesterase fadB2 (Rv0468) — requalified: 3-hydroxybutyryl-CoA dehydrogenase FadB2 Rv0471c (Rv0471c) — requalified: 1%2C4-dihydroxy-2-naphthoate prenyltransferase Rv0472c (Rv0472c) — family_assigned: TetR/AcrR family transcriptional regulator Rv0473 (Rv0473) — dark: DUF445 domain-containing protein Rv0474 (Rv0474) — family_assigned: helix-turn-helix transcriptional regulator hbhA (Rv0475) — requalified: heparin-binding hemagglutinin HbhA Rv0477 (Rv0477) — dark: DUF2599 domain-containing protein deoC (Rv0478) — requalified: deoxyribose-phosphate aldolase Rv0479c (Rv0479c) — family_assigned: DUF2993 domain-containing protein Rv0480c (Rv0480c) — family_assigned: carbon-nitrogen hydrolase family protein Rv0481c (Rv0481c) — family_assigned: DUF2505 domain-containing protein murB (Rv0482) — requalified: UDP-N-acetylmuramate dehydrogenase lprQ (Rv0483) — requalified: L%2CD-transpeptidase LdtMt5 Rv0484c (Rv0484c) — family_assigned: SDR family oxidoreductase Rv0485 (Rv0485) — family_assigned: transcriptional regulator mshA (Rv0486) — requalified: D-inositol-3-phosphate glycosyltransferase Rv0487 (Rv0487) — family_assigned: YbjN domain-containing protein senX3 (Rv0490) — requalified: two-component system sensor histidine kinase SenX3 Rv0492c (Rv0492c) — family_assigned: GMC family oxidoreductase Rv0497 (Rv0497) — family_assigned: hypothetical protein Rv0498 (Rv0498) — requalified: sugar phosphate isomerase/epimerase Rv0499 (Rv0499) — family_assigned: thioesterase family protein galE2 (Rv0501) — family_assigned: SDR family oxidoreductase Rv0502 (Rv0502) — family_assigned: lysophospholipid acyltransferase family protein cmaA2 (Rv0503c) — requalified: cyclopropane mycolic acid synthase CmaA2 Rv0504c (Rv0504c) — family_assigned: MaoC family dehydratase N-terminal domain-containing protein mmpS2 (Rv0506) — family_assigned: MmpS family protein mmpL2 (Rv0507) — requalified: RND transporter MmpL2 Rv0508 (Rv0508) — family_assigned: glutaredoxin family protein hemA (Rv0509) — requalified: glutamyl-tRNA reductase hemC (Rv0510) — requalified: hydroxymethylbilane synthase hemB (Rv0512) — requalified: porphobilinogen synthase Rv0513 (Rv0513) — family_assigned: DUF3093 domain-containing protein Rv0514 (Rv0514) — dark: hypothetical protein oprA (Rv0516c) — requalified: osmosensory protein OprA Rv0518 (Rv0518) — family_assigned: SGNH/GDSL hydrolase family protein Rv0523c (Rv0523c) — family_assigned: nitroreductase family deazaflavin-dependent oxidoreductase hemL (Rv0524) — requalified: glutamate-1-semialdehyde 2%2C1-aminomutase Rv0525 (Rv0525) — family_assigned: histidine phosphatase family protein Rv0528 (Rv0528) — requalified: cytochrome c biogenesis protein ResB ccsA (Rv0529) — requalified: c-type cytochrome biogenesis protein CcsB Rv0530 (Rv0530) — family_assigned: MinD/ParA family protein Rv0531 (Rv0531) — family_assigned: DUF4229 domain-containing protein fabH (Rv0533c) — requalified: beta-ketoacyl-ACP synthase III menA (Rv0534c) — requalified: 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase Rv0537c (Rv0537c) — dark: hypothetical protein ptrp (Rv0538) — family_assigned: hypothetical protein Rv0540 (Rv0540) — family_assigned: DUF2064 domain-containing protein Rv0541c (Rv0541c) — family_assigned: integral membrane protein menE (Rv0542c) — requalified: o-succinylbenzoate--CoA ligase Rv0543c (Rv0543c) — family_assigned: DUF3349 domain-containing protein Rv0544c (Rv0544c) — family_assigned: hypothetical protein pitA (Rv0545c) — requalified: anion permease Rv0546c (Rv0546c) — family_assigned: VOC family protein Rv0547c (Rv0547c) — family_assigned: SDR family oxidoreductase vapC3 (Rv0549c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB3 (Rv0550c) — family_assigned: type II toxin-antitoxin system CcdA family antitoxin fadD8 (Rv0551c) — requalified: fatty-acid--CoA ligase FadD8 Rv0552 (Rv0552) — requalified: amidohydrolase menC (Rv0553) — requalified: o-succinylbenzoate synthase bpoC (Rv0554) — family_assigned: alpha/beta hydrolase menD (Rv0555) — requalified: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxyli Rv0556 (Rv0556) — family_assigned: DUF3592 domain-containing protein Rv0559c (Rv0559c) — family_assigned: DUF732 domain-containing protein menJ (Rv0561c) — requalified: menaquinone reductase grcC1 (Rv0562) — requalified: polyprenyl-diphosphate synthase GrcC htpX (Rv0563) — requalified: zinc metalloprotease HtpX gpdA1 (Rv0564c) — requalified: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Rv0565c (Rv0565c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0566c (Rv0566c) — family_assigned: YajQ family cyclic di-GMP-binding protein Rv0567 (Rv0567) — requalified: methyltransferase cyp135B1 (Rv0568) — requalified: cytochrome P450 Rv0569 (Rv0569) — family_assigned: DUF1918 domain-containing protein nrdZ (Rv0570) — requalified: adenosylcobalamin-dependent ribonucleoside-diphosphate reduc Rv0571c (Rv0571c) — family_assigned: phosphoribosyltransferase family protein Rv0572c (Rv0572c) — family_assigned: hypothetical protein pncB2 (Rv0573c) — requalified: nicotinate phosphoribosyltransferase Rv0574c (Rv0574c) — family_assigned: CapA family protein Rv0575c (Rv0575c) — requalified: FAD-binding domain Rv0576 (Rv0576) — family_assigned: TIGR03086 family metal-binding protein TB27.3 (Rv0577) — family_assigned: VOC family protein Rv0579 (Rv0579) — family_assigned: Mut7-C RNAse domain-containing protein Rv0580c (Rv0580c) — requalified: mycobacterial cell wall protein Rv0580c vapB26 (Rv0581) — requalified: type II toxin-antitoxin system antitoxin VapB26 vapC26 (Rv0582) — requalified: type II toxin-antitoxin system toxin ribonuclease C26 lpqN (Rv0583c) — family_assigned: LpqN/LpqT family lipoprotein Rv0584 (Rv0584) — family_assigned: GH92 family glycosyl hydrolase Rv0585c (Rv0585c) — family_assigned: lysylphosphatidylglycerol synthase transmembrane domain-cont mce2R (Rv0586) — family_assigned: FadR family transcriptional regulator Mce2R yrbE2A (Rv0587) — family_assigned: ABC transporter permease Rv0588 (Rv0588) — family_assigned: ABC transporter permease mce2C (Rv0591) — family_assigned: virulence factor Mce family protein mce2D (Rv0592) — family_assigned: virulence factor Mce family protein mce2F (Rv0594) — family_assigned: MlaD family protein vapC4 (Rv0595c) — requalified: type II toxin-antitoxin system toxin ribonuclease C4 vapB4 (Rv0596c) — requalified: type II toxin-antitoxin system antitoxin VapB4 Rv0597c (Rv0597c) — family_assigned: ATP-binding protein vapC27 (Rv0598c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB27 (Rv0599c) — requalified: type II toxin-antitoxin system antitoxin VapB27 Rv0603 (Rv0603) — family_assigned: hypothetical protein lpqO (Rv0604) — family_assigned: DUF1259 domain-containing protein Rv0605 (Rv0605) — family_assigned: IS607-like element IS1536 family transposase vapB28 (Rv0608) — family_assigned: type II toxin-antitoxin system VapB family antitoxin vapC28 (Rv0609) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv0610c (Rv0610c) — family_assigned: hypothetical protein Rv0611c (Rv0611c) — family_assigned: DUF4926 domain-containing protein Rv0612 (Rv0612) — family_assigned: hypothetical protein Rv0613c (Rv0613c) — family_assigned: SEC-C domain-containing protein Rv0614 (Rv0614) — dark: hypothetical protein Rv0615 (Rv0615) — family_assigned: hypothetical protein vapC29 (Rv0617) — requalified: type II toxin-antitoxin system ribonuclease VapC29 galK (Rv0620) — requalified: galactokinase Rv0622 (Rv0622) — dark: DUF732 domain-containing protein vapB30 (Rv0623) — requalified: type II toxin-antitoxin system antitoxin VapB30 vapC30 (Rv0624) — requalified: type II toxin-antitoxin system toxin ribonuclease C30 Rv0625c (Rv0625c) — family_assigned: TVP38/TMEM64 family protein vapB5 (Rv0626) — family_assigned: type II toxin-antitoxin system Phd/YefM family antitoxin vapC5 (Rv0627) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv0628c (Rv0628c) — family_assigned: FIST N-terminal domain-containing protein recD (Rv0629c) — family_assigned: exodeoxyribonuclease V subunit alpha 428 kb 482 kb 535 kb 588 kb 642 kb 696 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.