MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

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+ strand − strand Rv1977 (Rv1977) — family_assigned: M48 family metallopeptidase Rv1978 (Rv1978) — requalified: class I SAM-dependent methyltransferase Rv1979c (Rv1979c) — family_assigned: APC family permease mpt64 (Rv1980c) — requalified: immunoprotective protein Mpt64 vapC36 (Rv1982c) — family_assigned: type II toxin-antitoxin system VapC family toxin cfp21 (Rv1984c) — requalified: cutinase Cfp21 Rv1985c (Rv1985c) — family_assigned: ArgP/LysG family DNA-binding transcriptional regulator lysE (Rv1986) — requalified: L-lysine exporter Rv1987 (Rv1987) — family_assigned: cellulose-binding protein Rv1989c (Rv1989c) — family_assigned: RES family NAD+ phosphorylase Rv1990c (Rv1990c) — family_assigned: antitoxin Xre/MbcA/ParS toxin-binding domain-containing prot mazF6 (Rv1991c) — requalified: type II toxin-antitoxin system toxin endoribonuclease MazF6 ctpG (Rv1992c) — requalified: cation transporter ATPase CptG Rv1993c (Rv1993c) — family_assigned: DUF1490 family protein cmtR (Rv1994c) — family_assigned: Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regu Rv1995 (Rv1995) — family_assigned: hemerythrin domain-containing protein Rv1996 (Rv1996) — requalified: universal stress protein ctpF (Rv1997) — requalified: cation-transporting P-type ATPase Rv1998c (Rv1998c) — family_assigned: isocitrate lyase/phosphoenolpyruvate mutase family protein Rv1999c (Rv1999c) — family_assigned: APC family permease Rv2000 (Rv2000) — family_assigned: FAD/NAD(P)-binding protein Rv2001 (Rv2001) — requalified: acyl-[acyl-carrier-protein] thioesterase fabG3 (Rv2002) — family_assigned: SDR family oxidoreductase Rv2004c (Rv2004c) — family_assigned: AAA family ATPase Rv2005c (Rv2005c) — requalified: universal stress protein fdxA (Rv2007c) — family_assigned: ferredoxin family protein vapC15 (Rv2010) — family_assigned: PIN domain nuclease Rv2011c (Rv2011c) — family_assigned: MarR family winged helix-turn-helix transcriptional regulato Rv2015c (Rv2015c) — requalified: HNH endonuclease signature motif containing protein Rv2016 (Rv2016) — dark: hypothetical protein Rv2017 (Rv2017) — family_assigned: ImmA/IrrE family metallo-endopeptidase Rv2018 (Rv2018) — family_assigned: DUF433 domain-containing protein Rv2019 (Rv2019) — family_assigned: hypothetical protein Rv2021c (Rv2021c) — family_assigned: XRE family transcriptional regulator Rv2022c (Rv2022c) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin Rv2023c (Rv2023c) — dark: hypothetical protein Rv2025c (Rv2025c) — family_assigned: cation diffusion facilitator family transporter Rv2026c (Rv2026c) — requalified: universal stress protein dosT (Rv2027c) — requalified: two-component system sensor histidine kinase DosT Rv2028c (Rv2028c) — requalified: universal stress protein pfkB (Rv2029c) — family_assigned: 1-phosphofructokinase family hexose kinase Rv2030c (Rv2030c) — family_assigned: erythromycin esterase family protein hspX (Rv2031c) — requalified: alpha-crystallin HspX acg (Rv2032) — family_assigned: FMN-binding protein Acg Rv2033c (Rv2033c) — family_assigned: DUF3097 domain-containing protein Rv2034 (Rv2034) — family_assigned: metalloregulator ArsR/SmtB family transcription factor Rv2035 (Rv2035) — family_assigned: SRPBCC family protein Rv2036 (Rv2036) — family_assigned: maleylpyruvate isomerase family mycothiol-dependent enzyme Rv2037c (Rv2037c) — family_assigned: patatin-like phospholipase family protein ugpC (Rv2038c) — family_assigned: sn-glycerol-3-phosphate ABC transporter ATP-binding protein Rv2039c (Rv2039c) — family_assigned: carbohydrate ABC transporter permease Rv2040c (Rv2040c) — family_assigned: sugar ABC transporter permease Rv2041c (Rv2041c) — family_assigned: sugar ABC transporter substrate-binding protein Rv2042c (Rv2042c) — family_assigned: ketosteroid isomerase family protein pncA (Rv2043c) — requalified: pyrazinamidase PncA lppI (Rv2046) — family_assigned: hypothetical protein Rv2047c (Rv2047c) — family_assigned: sugar epimerase family protein pks12 (Rv2048c) — requalified: type I polyketide synthase pks12 rbpA (Rv2050) — family_assigned: RNA polymerase-binding protein RbpA ppm1 (Rv2051c) — requalified: apolipoprotein N-acyltransferase Rv2052c (Rv2052c) — requalified: amidohydrolase fxsA (Rv2053c) — family_assigned: FxsA family protein Rv2054 (Rv2054) — family_assigned: dienelactone hydrolase family protein rpsR2 (Rv2055c) — requalified: 30S ribosomal protein S18 rpsN2 (Rv2056c) — requalified: 30S ribosomal protein S14 rpmB2 (Rv2058c) — requalified: 50S ribosomal protein L28 Rv2061c (Rv2061c) — requalified: PPOX class F420-dependent oxidoreductase cobN (Rv2062c) — family_assigned: cobaltochelatase subunit CobN cobG (Rv2064) — requalified: precorrin-3B synthase cobH (Rv2065) — requalified: precorrin-8X methylmutase cobIJ (Rv2066) — requalified: precorrin-2 C(20)-methyltransferase Rv2067c (Rv2067c) — requalified: class I SAM-dependent methyltransferase sigC (Rv2069) — requalified: RNA polymerase sigma factor SigC cobK (Rv2070c) — requalified: cobalt-precorrin-6A reductase cobM (Rv2071c) — requalified: precorrin-4 C(11)-methyltransferase cobL (Rv2072c) — requalified: bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cob Rv2073c (Rv2073c) — family_assigned: SDR family NAD(P)-dependent oxidoreductase Rv2074 (Rv2074) — requalified: F420-dependent biliverdin reductase Rv2075c (Rv2075c) — family_assigned: hypothetical protein Rv2077c (Rv2077c) — dark: hypothetical protein Rv2078 (Rv2078) — family_assigned: DUF2563 family protein Rv2079 (Rv2079) — family_assigned: alpha/beta hydrolase lppJ (Rv2080) — family_assigned: hypothetical protein Rv2081c (Rv2081c) — dark: hypothetical protein Rv2082 (Rv2082) — dark: DUF5631 domain-containing protein Rv2083 (Rv2083) — dark: hypothetical protein Rv2084 (Rv2084) — dark: hypothetical protein pknJ (Rv2088) — requalified: serine/threonine protein kinase PknJ pepE (Rv2089c) — family_assigned: Xaa-Pro peptidase family protein Rv2091c (Rv2091c) — family_assigned: DUF4333 domain-containing protein helY (Rv2092c) — requalified: RNA helicase tatC (Rv2093c) — family_assigned: twin-arginine translocase subunit TatC tatA (Rv2094c) — family_assigned: Sec-independent protein translocase subunit TatA pafC (Rv2095c) — family_assigned: YafY family protein pafB (Rv2096c) — family_assigned: YafY family protein pafA (Rv2097c) — requalified: Pup--protein ligase helZ (Rv2101) — requalified: DEAD/DEAH box helicase vapC37 (Rv2103c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB37 (Rv2104c) — requalified: antitoxin prcA (Rv2109c) — family_assigned: proteasome subunit alpha prcB (Rv2110c) — family_assigned: proteasome subunit beta Rv2113 (Rv2113) — family_assigned: integral membrane protein Rv2114 (Rv2114) — dark: hypothetical protein mpa (Rv2115c) — requalified: proteasome ATPase lppK (Rv2116) — family_assigned: hypothetical protein Rv2117 (Rv2117) — family_assigned: DUF503 domain-containing protein trmI (Rv2118c) — requalified: tRNA (adenine(58)-N(1))-methyltransferase TrmI Rv2119 (Rv2119) — family_assigned: RecB family exonuclease Rv2120c (Rv2120c) — family_assigned: glycine zipper 2TM domain-containing protein hisG (Rv2121c) — requalified: ATP phosphoribosyltransferase metH (Rv2124c) — requalified: methionine synthase Rv2125 (Rv2125) — family_assigned: PAC2 family protein Rv2128 (Rv2128) — dark: hypothetical protein Rv2129c (Rv2129c) — family_assigned: SDR family oxidoreductase mshC (Rv2130c) — requalified: cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyra cysQ (Rv2131c) — requalified: 3'(2')%2C5'-bisphosphate nucleotidase CysQ Rv2132 (Rv2132) — family_assigned: ribbon-helix-helix protein%2C CopG family Rv2133c (Rv2133c) — family_assigned: SCO1664 family protein Rv2135c (Rv2135c) — family_assigned: histidine phosphatase family protein Rv2136c (Rv2136c) — requalified: undecaprenyl-diphosphate phosphatase lppL (Rv2138) — family_assigned: hypothetical protein pyrD (Rv2139) — requalified: quinone-dependent dihydroorotate dehydrogenase TB18.6 (Rv2140c) — family_assigned: YbhB/YbcL family Raf kinase inhibitor-like protein parE2 (Rv2142c) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin Rv2143 (Rv2143) — family_assigned: phosphoribosyltransferase family protein Rv2144c (Rv2144c) — dark: hypothetical protein wag31 (Rv2145c) — requalified: cell wall synthesis protein Wag31 Rv2146c (Rv2146c) — family_assigned: YggT family protein Rv2148c (Rv2148c) — family_assigned: YggS family pyridoxal phosphate-dependent enzyme ftsZ (Rv2150c) — requalified: cell division protein FtsZ ftsQ (Rv2151c) — requalified: cell division protein FtsQ murC (Rv2152c) — requalified: UDP-N-acetylmuramate--L-alanine ligase murG (Rv2153c) — requalified: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylgluc ftsW (Rv2154c) — family_assigned: putative lipid II flippase FtsW murD (Rv2155c) — requalified: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase murX (Rv2156c) — requalified: phospho-N-acetylmuramoyl-pentapeptide-transferase murF (Rv2157c) — requalified: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase murE (Rv2158c) — requalified: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopime Rv2159c (Rv2159c) — family_assigned: carboxymuconolactone decarboxylase family protein Rv2161c (Rv2161c) — family_assigned: TIGR03619 family F420-dependent LLM class oxidoreductase pbpB (Rv2163c) — requalified: D%2CD-transpeptidase PbpB Rv2164c (Rv2164c) — family_assigned: hypothetical protein rsmH (Rv2165c) — requalified: 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH mraZ (Rv2166c) — requalified: division/cell wall cluster transcriptional repressor MraZ Rv2169c (Rv2169c) — dark: DUF3040 domain-containing protein Rv2170 (Rv2170) — requalified: N-acetyltransferase lppM (Rv2171) — requalified: lipoprotein LppM Rv2172c (Rv2172c) — requalified: mycobacterial-type methylenetetrahydrofolate reductase idsA2 (Rv2173) — requalified: bifunctional (2E%2C6E)-farnesyl/geranyl diphosphate synthase mptA (Rv2174) — requalified: alpha-(1->6)-mannopyranosyltransferase A pknL (Rv2176) — requalified: protein kinase aroG (Rv2178c) — requalified: 3-deoxy-7-phosphoheptulonate synthase class II Rv2179c (Rv2179c) — requalified: polyadenylate-specific 3'-exoribonuclease AS Rv2180c (Rv2180c) — family_assigned: integral membrane protein Rv2181 (Rv2181) — requalified: alpha-(1-2)-phosphatidylinositol mannoside mannosyltransfera Rv2182c (Rv2182c) — family_assigned: lysophospholipid acyltransferase family protein Rv2183c (Rv2183c) — dark: hypothetical protein TB16.3 (Rv2185c) — family_assigned: SRPBCC family protein Rv2186c (Rv2186c) — requalified: polyketide cyclase / dehydrase and lipid transport fadD15 (Rv2187) — requalified: long-chain fatty acid--CoA ligase pimB (Rv2188c) — requalified: GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monom Rv2189c (Rv2189c) — dark: hypothetical protein ripC (Rv2190c) — requalified: peptidoglycan hydrolase RipC trpD (Rv2192c) — requalified: anthranilate phosphoribosyltransferase ctaE (Rv2193) — family_assigned: heme-copper oxidase subunit III qcrC (Rv2194) — requalified: cytochrome c qcrB (Rv2196) — family_assigned: cytochrome bc complex cytochrome b subunit mmpS3 (Rv2198c) — family_assigned: MmpS family transport accessory protein Rv2199c (Rv2199c) — family_assigned: cytochrome c oxidase subunit 4 ctaC (Rv2200c) — family_assigned: cytochrome c oxidase subunit II asnB (Rv2201) — requalified: asparagine synthase (glutamine-hydrolyzing) adoK (Rv2202c) — family_assigned: carbohydrate kinase family protein Rv2203 (Rv2203) — dark: hypothetical protein Rv2204c (Rv2204c) — requalified: iron-sulfur cluster assembly accessory protein Rv2205c (Rv2205c) — requalified: glycerate kinase Rv2206 (Rv2206) — family_assigned: DUF3043 domain-containing protein cobT (Rv2207) — requalified: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosylt cobS (Rv2208) — requalified: adenosylcobinamide-GDP ribazoletransferase Rv2209 (Rv2209) — requalified: MFS transporter ilvE (Rv2210c) — requalified: branched-chain amino acid aminotransferase Rv2212 (Rv2212) — requalified: adenylyl cyclase pepB (Rv2213) — requalified: leucyl aminopeptidase ephD (Rv2214c) — family_assigned: SDR family oxidoreductase dlaT (Rv2215) — requalified: 2-oxoglutarate dehydrogenase%2C E2 component%2C dihydrolipoa Rv2216 (Rv2216) — family_assigned: TIGR01777 family oxidoreductase lipB (Rv2217) — requalified: lipoyl(octanoyl) transferase LipB lipA (Rv2218) — requalified: lipoyl synthase Rv2219 (Rv2219) — family_assigned: DUF4191 domain-containing protein glnA1 (Rv2220) — requalified: type I glutamate--ammonia ligase glnE (Rv2221c) — requalified: bifunctional [glutamine synthetase] adenylyltransferase/[glu glnA2 (Rv2222c) — family_assigned: glutamine synthetase family protein caeB (Rv2223c) — requalified: carboxylesterase CaeB caeA (Rv2224c) — requalified: carboxylesterase CaeA panB (Rv2225) — requalified: 3-methyl-2-oxobutanoate hydroxymethyltransferase Rv2226 (Rv2226) — family_assigned: CYTH and CHAD domain-containing protein Rv2229c (Rv2229c) — family_assigned: zinc ribbon domain-containing protein Rv2230c (Rv2230c) — requalified: Nif3-like dinuclear metal center hexameric protein ptpA (Rv2234) — requalified: protein-tyrosine-phosphatase Rv2235 (Rv2235) — family_assigned: SURF1 family protein cobD (Rv2236c) — requalified: cobalamin biosynthesis protein ahpE (Rv2238c) — requalified: peroxiredoxin AhpE Rv2240c (Rv2240c) — family_assigned: hypothetical protein Rv2242 (Rv2242) — family_assigned: PucR family transcriptional regulator fabD (Rv2243) — requalified: malonyl CoA-acyl carrier protein transacylase acpM (Rv2244) — requalified: meromycolate extension acyl carrier protein AcpM kasA (Rv2245) — requalified: 3-oxoacyl-ACP synthase KasA accD6 (Rv2247) — family_assigned: acyl-CoA carboxylase subunit beta glpD1 (Rv2249c) — requalified: glycerol-3-phosphate dehydrogenase/oxidase Rv2250c (Rv2250c) — family_assigned: TetR/AcrR family transcriptional regulator Rv2252 (Rv2252) — requalified: diacylglycerol kinase Rv2253 (Rv2253) — family_assigned: hypothetical protein Rv2254c (Rv2254c) — family_assigned: LysE family transporter Rv2257c (Rv2257c) — family_assigned: serine hydrolase domain-containing protein Rv2258c (Rv2258c) — requalified: class I SAM-dependent methyltransferase mscR (Rv2259) — requalified: S-(hydroxymethyl)mycothiol dehydrogenase Rv2260 (Rv2260) — requalified: MBL fold metallo-hydrolase 2 247 kb 2 300 kb 2 354 kb 2 408 kb 2 461 kb 2 514 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.