MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 900 951–1 220 951 bp (320 000 bp)
+ strand − strand purL (Rv0803) — family_assigned: phosphoribosylformylglycinamidine synthase subunit PurL Rv0804 (Rv0804) — family_assigned: CPBP family intramembrane glutamic endopeptidase cpdA (Rv0805) — requalified: 3'%2C5'-cyclic adenosine monophosphate phosphodiesterase Cpd cpsY (Rv0806c) — family_assigned: stealth family protein Rv0807 (Rv0807) — family_assigned: sterol carrier family protein purM (Rv0809) — requalified: phosphoribosylformylglycinamidine cyclo-ligase Rv0811c (Rv0811c) — family_assigned: folate-binding protein YgfZ Rv0813c (Rv0813c) — family_assigned: FABP family protein thiX (Rv0816c) — family_assigned: thioredoxin family protein lmeA (Rv0817c) — requalified: mannan chain length control protein LmeA Rv0818 (Rv0818) — requalified: response regulator transcription factor mshD (Rv0819) — requalified: mycothiol synthase phoT (Rv0820) — family_assigned: phosphate ABC transporter ATP-binding protein PstB phoY2 (Rv0821c) — requalified: phosphate signaling complex protein PhoU Rv0822c (Rv0822c) — family_assigned: LCP family protein dusB (Rv0823c) — requalified: tRNA dihydrouridine synthase DusB Rv0825c (Rv0825c) — family_assigned: TetR/AcrR family transcriptional regulator Rv0826 (Rv0826) — family_assigned: oxygenase MpaB family protein kmtR (Rv0827c) — requalified: Ni(II)/Co(II)-sensing metalloregulatory transcriptional repr Rv0830 (Rv0830) — requalified: class I SAM-dependent methyltransferase Rv0831c (Rv0831c) — family_assigned: TIGR04255 family protein lpqQ (Rv0835) — family_assigned: sensor domain-containing protein Rv0837c (Rv0837c) — family_assigned: type IV toxin-antitoxin system AbiEi family antitoxin lpqR (Rv0838) — family_assigned: M15 family metallopeptidase Rv0839 (Rv0839) — family_assigned: methyltransferase domain-containing protein pip (Rv0840c) — family_assigned: proline-specific peptidase family protein Rv0842 (Rv0842) — requalified: MFS transporter Rv0843 (Rv0843) — family_assigned: thiamine pyrophosphate-dependent dehydrogenase E1 component narL (Rv0844c) — requalified: two-component system response regulator NarL mmcO (Rv0846c) — requalified: multicopper oxidase MmcO lpqS (Rv0847) — requalified: lipoprotein LpqS Rv0849 (Rv0849) — requalified: MFS transporter Rv0851c (Rv0851c) — family_assigned: SDR family NAD(P)-dependent oxidoreductase Rv0852 (Rv0852) — requalified: fatty-acid--CoA ligase pdc (Rv0853c) — requalified: alpha-keto-acid decarboxylase Rv0854 (Rv0854) — family_assigned: SRPBCC family protein far (Rv0855) — requalified: fatty-acid-CoA racemase dapC (Rv0858c) — requalified: pyridoxal phosphate-dependent aminotransferase fadA (Rv0859) — requalified: acetyl-CoA C-acetyltransferase fadB (Rv0860) — requalified: fatty oxidation protein FadB Rv0862c (Rv0862c) — family_assigned: helicase-associated domain-containing protein Rv0863 (Rv0863) — family_assigned: hypothetical protein moaC2 (Rv0864) — requalified: cyclic pyranopterin monophosphate synthase MoaC mog (Rv0865) — family_assigned: MogA/MoaB family molybdenum cofactor biosynthesis protein moaE2 (Rv0866) — family_assigned: molybdopterin synthase subunit MoaE2 rpfA (Rv0867c) — requalified: resuscitation-promoting factor protein RpfA moaD2 (Rv0868c) — family_assigned: molybdopterin synthase subunit MoaD2 moaA2 (Rv0869c) — requalified: GTP 3'%2C8-cyclase MoaA Rv0870c (Rv0870c) — family_assigned: YccF domain-containing protein cspB (Rv0871) — requalified: cold-shock protein fadE10 (Rv0873) — family_assigned: acyl-CoA dehydrogenase family protein Rv0874c (Rv0874c) — family_assigned: FIST C-terminal domain-containing protein Rv0875c (Rv0875c) — dark: DUF2771 domain-containing protein Rv0876c (Rv0876c) — requalified: MFS transporter Rv0877 (Rv0877) — dark: DUF3027 domain-containing protein Rv0879c (Rv0879c) — family_assigned: DUF2530 domain-containing protein Rv0880 (Rv0880) — family_assigned: MarR family transcriptional regulator Rv0881 (Rv0881) — requalified: RNA methyltransferase Rv0882 (Rv0882) — dark: DUF2537 domain-containing protein sepH (Rv0883c) — requalified: septation protein SepH serC (Rv0884c) — requalified: phosphoserine transaminase Rv0885 (Rv0885) — requalified: diiron oxygenase fprB (Rv0886) — requalified: FAD-dependent oxidoreductase Rv0887c (Rv0887c) — family_assigned: VOC family protein spmT (Rv0888) — requalified: sphingomyelinase citA (Rv0889c) — requalified: citrate synthase 2 Rv0892 (Rv0892) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0893c (Rv0893c) — requalified: class I SAM-dependent methyltransferase Rv0894 (Rv0894) — family_assigned: hypothetical protein gltA2 (Rv0896) — requalified: citrate synthase Rv0897c (Rv0897c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0898c (Rv0898c) — family_assigned: DUF2630 family protein arfA (Rv0899) — family_assigned: peptidoglycan-binding protein ArfA arfB (Rv0900) — family_assigned: hypothetical protein arfC (Rv0901) — family_assigned: hypothetical protein prrB (Rv0902c) — requalified: two-component system sensor histidine kinase PrrB prrA (Rv0903c) — requalified: two-component system response regulator PrrA accD3 (Rv0904c) — family_assigned: carboxyl transferase domain-containing protein echA6 (Rv0905) — requalified: enoyl-CoA hydratase Rv0906 (Rv0906) — requalified: MBL fold metallo-hydrolase ctpE (Rv0908) — requalified: cation-translocating P-type ATPase Rv0909 (Rv0909) — requalified: antitoxin Rv0910 (Rv0910) — family_assigned: SRPBCC family protein Rv0911 (Rv0911) — family_assigned: VOC family protein Rv0912 (Rv0912) — dark: hypothetical protein Rv0913c (Rv0913c) — family_assigned: carotenoid oxygenase family protein Rv0914c (Rv0914c) — requalified: acetyl-CoA acetyltransferase betP (Rv0917) — family_assigned: BCCT family transporter Rv0918 (Rv0918) — family_assigned: DUF1778 domain-containing protein Rv0919 (Rv0919) — family_assigned: GNAT family N-acetyltransferase Rv0920c (Rv0920c) — family_assigned: IS256-like element IS1554 family transposase Rv0921 (Rv0921) — family_assigned: IS607-like element IS1535 family transposase tnpB (Rv0922) — family_assigned: IS607 family element RNA-guided endonuclease TnpB Rv0923c (Rv0923c) — family_assigned: poly-gamma-glutamate hydrolase family protein Rv0925c (Rv0925c) — family_assigned: flavodoxin family protein Rv0926c (Rv0926c) — requalified: diacylglycerol kinase Rv0927c (Rv0927c) — family_assigned: SDR family oxidoreductase pstC2 (Rv0929) — family_assigned: phosphate ABC transporter permease subunit PstC pknD (Rv0931c) — requalified: serine/threonine protein kinase PknD pstB (Rv0933) — family_assigned: phosphate ABC transporter ATP-binding protein pstA2 (Rv0936) — family_assigned: phosphate ABC transporter permease PstA mku (Rv0937c) — requalified: Ku protein ligD (Rv0938) — requalified: ATP-dependent DNA ligase Rv0939 (Rv0939) — family_assigned: fumarylacetoacetate hydrolase family protein Rv0940c (Rv0940c) — family_assigned: TIGR03619 family F420-dependent LLM class oxidoreductase Rv0941c (Rv0941c) — family_assigned: STAS domain-containing protein Rv0942 (Rv0942) — dark: hypothetical protein Rv0943c (Rv0943c) — dark: hypothetical protein pgi (Rv0946c) — requalified: glucose-6-phosphate isomerase Rv0948c (Rv0948c) — requalified: chorismate mutase Rv0950c (Rv0950c) — family_assigned: M23 family metallopeptidase sucC (Rv0951) — family_assigned: ADP-forming succinate--CoA ligase subunit beta Rv0953c (Rv0953c) — requalified: LLM class F420-dependent oxidoreductase Rv0954 (Rv0954) — requalified: DUF5336 domain-containing protein Rv0955 (Rv0955) — family_assigned: DUF6350 family protein purN (Rv0956) — requalified: phosphoribosylglycinamide formyltransferase purH (Rv0957) — requalified: bifunctional phosphoribosylaminoimidazolecarboxamide formylt Rv0958 (Rv0958) — family_assigned: ATP-binding protein Rv0959 (Rv0959) — family_assigned: VWA domain-containing protein vapC9 (Rv0960) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv0961 (Rv0961) — dark: hypothetical protein lprP (Rv0962c) — family_assigned: LppA family lipoprotein Rv0965c (Rv0965c) — family_assigned: hypothetical protein Rv0966c (Rv0966c) — dark: DUF1707 domain-containing protein csoR (Rv0967) — requalified: copper-sensing transcriptional repressor CsoR Rv0968 (Rv0968) — family_assigned: DUF1490 family protein ctpV (Rv0969) — requalified: copper-translocating P-type ATPase Rv0970 (Rv0970) — family_assigned: DUF5134 domain-containing protein echA7 (Rv0971c) — family_assigned: enoyl-CoA hydratase family protein fadE12 (Rv0972c) — requalified: acyl-CoA dehydrogenase accA2 (Rv0973c) — family_assigned: biotin carboxylase N-terminal domain-containing protein accD2 (Rv0974c) — family_assigned: acyl-CoA carboxylase subunit beta fadE13 (Rv0975c) — family_assigned: acyl-CoA dehydrogenase family protein Rv0976c (Rv0976c) — family_assigned: acyclic terpene utilization AtuA family protein Rv0979c (Rv0979c) — dark: hypothetical protein mprA (Rv0981) — requalified: two-component system response regulator MprA mprB (Rv0982) — requalified: two-component system sensor histidine kinase MprB pepD (Rv0983) — requalified: serine protease PepD moaB2 (Rv0984) — family_assigned: MogA/MoaB family molybdenum cofactor biosynthesis protein mscL (Rv0985c) — requalified: large-conductance mechanosensitive channel protein MscL Rv0986 (Rv0986) — family_assigned: ABC transporter ATP-binding protein Rv0987 (Rv0987) — family_assigned: FtsX-like permease family protein Rv0988 (Rv0988) — family_assigned: lipocalin-like domain-containing protein grcC2 (Rv0989c) — requalified: polyprenyl-diphosphate synthase GrcC Rv0990c (Rv0990c) — family_assigned: SAF domain-containing protein Rv0991c (Rv0991c) — family_assigned: FmdB family zinc ribbon protein Rv0992c (Rv0992c) — requalified: 5-formyltetrahydrofolate cyclo-ligase galU (Rv0993) — requalified: UTP--glucose-1-phosphate uridylyltransferase Rv0996 (Rv0996) — family_assigned: hypothetical protein Rv0998 (Rv0998) — family_assigned: GNAT family N-acetyltransferase arcA (Rv1001) — requalified: arginine deiminase Rv1002c (Rv1002c) — requalified: dolichyl-phosphate-mannose--protein mannosyltransferase rsmI (Rv1003) — requalified: 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Rv1004c (Rv1004c) — family_assigned: hypothetical protein Rv1006 (Rv1006) — family_assigned: hypothetical protein metS (Rv1007c) — requalified: methionine--tRNA ligase ksgA (Rv1010) — requalified: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltra Rv1012 (Rv1012) — dark: hypothetical protein pks16 (Rv1013) — requalified: fatty acyl-AMP ligase pth (Rv1014c) — requalified: aminoacyl-tRNA hydrolase rplY (Rv1015c) — requalified: 50S ribosomal protein L25/general stress protein Ctc prsA (Rv1017c) — requalified: ribose-phosphate diphosphokinase glmU (Rv1018c) — requalified: bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosa Rv1019 (Rv1019) — family_assigned: TetR/AcrR family transcriptional regulator mfd (Rv1020) — requalified: transcription-repair coupling factor Rv1021 (Rv1021) — requalified: nucleoside triphosphate pyrophosphohydrolase lpqU (Rv1022) — requalified: lytic murein transglycosylase eno (Rv1023) — requalified: phosphopyruvate hydratase Rv1024 (Rv1024) — family_assigned: septum formation initiator family protein ppx2 (Rv1026) — requalified: exopolyphosphatase Ppx2 kdpE (Rv1027c) — requalified: two-component system response regulator KdpE kdpD (Rv1028c) — requalified: sensor histidine kinase KdpD kdpA (Rv1029) — family_assigned: potassium-transporting ATPase subunit KdpA kdpB (Rv1030) — family_assigned: potassium-transporting ATPase subunit KdpB kdpC (Rv1031) — family_assigned: K(+)-transporting ATPase subunit C trcS (Rv1032c) — family_assigned: HAMP domain-containing sensor histidine kinase trcR (Rv1033c) — requalified: two-component system response regulator TrcR Rv1043c (Rv1043c) — requalified: serine protease Rv1044 (Rv1044) — family_assigned: type IV toxin-antitoxin system AbiEi family antitoxin domain Rv1045 (Rv1045) — family_assigned: nucleotidyl transferase AbiEii/AbiGii toxin family protein Rv1048c (Rv1048c) — dark: hypothetical protein Rv1049 (Rv1049) — requalified: oxidation-sensing regulator MosR Rv1050 (Rv1050) — family_assigned: SDR family oxidoreductase Rv1056 (Rv1056) — family_assigned: DUF427 domain-containing protein Rv1057 (Rv1057) — family_assigned: YncE family protein fadD14 (Rv1058) — requalified: long-chain fatty acid--CoA ligase Rv1059 (Rv1059) — requalified: dihydrodipicolinate reductase Rv1060 (Rv1060) — family_assigned: SRPBCC family protein Rv1061 (Rv1061) — requalified: class II glutamine amidotransferase Rv1062 (Rv1062) — family_assigned: patatin-like phospholipase family protein Rv1063c (Rv1063c) — family_assigned: patatin family protein lpqV (Rv1064c) — requalified: lipoprotein LpqV Rv1065 (Rv1065) — family_assigned: cysteine dioxygenase family protein Rv1066 (Rv1066) — family_assigned: rhodanese-like domain-containing protein Rv1069c (Rv1069c) — family_assigned: alpha/beta-hydrolase family protein echA8 (Rv1070c) — requalified: enoyl-CoA hydratase echA9 (Rv1071c) — family_assigned: enoyl-CoA hydratase/isomerase family protein Rv1072 (Rv1072) — family_assigned: Bax inhibitor-1/YccA family protein Rv1073 (Rv1073) — family_assigned: hypothetical protein fadA3 (Rv1074c) — requalified: acetyl-CoA C-acetyltransferase Rv1075c (Rv1075c) — family_assigned: SGNH/GDSL hydrolase family protein pra (Rv1078) — family_assigned: RDD family protein metB (Rv1079) — requalified: cystathionine gamma-synthase Rv1081c (Rv1081c) — dark: DUF4307 domain-containing protein mca (Rv1082) — requalified: mycothiol conjugate amidase Mca Rv1083 (Rv1083) — dark: hypothetical protein Rv1084 (Rv1084) — family_assigned: thioredoxin domain-containing protein Rv1085c (Rv1085c) — family_assigned: hemolysin III family protein 910 kb 963 kb 1 016 kb 1 070 kb 1 124 kb 1 177 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.