MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 3 096 994–3 416 994 bp (320 000 bp)
+ strand − strand Rv2765 (Rv2765) — family_assigned: dienelactone hydrolase family protein Rv2767c (Rv2767c) — family_assigned: hypothetical protein Rv2771c (Rv2771c) — family_assigned: flavodoxin family protein Rv2772c (Rv2772c) — family_assigned: hypothetical protein dapB (Rv2773c) — requalified: 4-hydroxy-tetrahydrodipicolinate reductase Rv2774c (Rv2774c) — dark: hypothetical protein Rv2777c (Rv2777c) — requalified: metal-dependent hydrolase Rv2778c (Rv2778c) — family_assigned: SRPBCC family protein ald (Rv2780) — requalified: alanine dehydrogenase Rv2781c (Rv2781c) — requalified: nitronate monooxygenase pepR (Rv2782c) — family_assigned: pitrilysin family protein gpsI (Rv2783c) — requalified: polyribonucleotide nucleotidyltransferase lppU (Rv2784c) — dark: hypothetical protein Rv2787 (Rv2787) — family_assigned: AAA family ATPase sirR (Rv2788) — family_assigned: manganese-binding transcriptional regulator MntR fadE21 (Rv2789c) — family_assigned: acyl-CoA dehydrogenase family protein ltp1 (Rv2790c) — requalified: lipid-transfer protein truB (Rv2793c) — requalified: tRNA pseudouridine(55) synthase TruB pptT (Rv2794c) — requalified: 4'-phosphopantetheinyl transferase Rv2795c (Rv2795c) — requalified: metallophosphoesterase lppV (Rv2796c) — family_assigned: LppA family lipoprotein Rv2797c (Rv2797c) — family_assigned: alpha/beta hydrolase family protein Rv2798c (Rv2798c) — family_assigned: hypothetical protein Rv2800 (Rv2800) — family_assigned: CocE/NonD family hydrolase mazF9 (Rv2801c) — requalified: type II toxin-antitoxin system toxin endoribonuclease MazF9 Rv2802c (Rv2802c) — dark: DUF2293 domain-containing protein Rv2806 (Rv2806) — dark: hypothetical protein Rv2805 (Rv2805) — requalified: transposase Rv2808 (Rv2808) — requalified: hypothetical protein Rv2809 (Rv2809) — family_assigned: hypothetical protein Rv2811 (Rv2811) — family_assigned: hypothetical protein Rv2813 (Rv2813) — family_assigned: ExeA family protein cas2 (Rv2816c) — requalified: CRISPR-associated endonuclease Cas2 cas1 (Rv2817c) — requalified: CRISPR-associated endonuclease Cas1 csm5 (Rv2819c) — requalified: type III-A CRISPR-associated RAMP protein Csm5 csm4 (Rv2820c) — requalified: type III-A CRISPR-associated RAMP protein Csm4 csm3 (Rv2821c) — requalified: type III-A CRISPR-associated RAMP protein Csm3 csm2 (Rv2822c) — requalified: type III-A CRISPR-associated protein Csm2 cas10 (Rv2823c) — requalified: type III-A CRISPR-associated protein Cas10/Csm1 Rv2826c (Rv2826c) — family_assigned: nucleotidyl transferase AbiEii/AbiGii toxin family protein Rv2827c (Rv2827c) — family_assigned: type IV toxin-antitoxin system AbiEi family antitoxin Rv2828c (Rv2828c) — family_assigned: DUF1802 family protein vapC22 (Rv2829c) — family_assigned: PIN domain-containing protein vapB22 (Rv2830c) — family_assigned: type II toxin-antitoxin system prevent-host-death family ant echA16 (Rv2831) — requalified: enoyl-CoA hydratase ugpC (Rv2832c) — family_assigned: ABC transporter ATP-binding protein ugpB (Rv2833c) — family_assigned: ABC transporter substrate-binding protein ugpE (Rv2834c) — family_assigned: carbohydrate ABC transporter permease ugpA (Rv2835c) — family_assigned: sugar ABC transporter permease dinF (Rv2836c) — family_assigned: MATE family efflux transporter nrnA (Rv2837c) — requalified: bifunctional oligoribonuclease/PAP phosphatase NrnA rbfA (Rv2838c) — requalified: 30S ribosome-binding factor RbfA infB (Rv2839c) — requalified: translation initiation factor IF-2 nusA (Rv2841c) — requalified: transcription termination factor NusA rimP (Rv2842c) — requalified: ribosome maturation factor RimP Rv2843 (Rv2843) — family_assigned: hypothetical protein Rv2844 (Rv2844) — family_assigned: ferritin-like domain-containing protein proS (Rv2845c) — requalified: proline--tRNA ligase efpA (Rv2846c) — requalified: multidrug efflux MFS transporter EfpA cysG (Rv2847c) — requalified: uroporphyrinogen-III C-methyltransferase cobB (Rv2848c) — requalified: cobyrinate a%2Cc-diamide synthase Rv2850c (Rv2850c) — family_assigned: magnesium chelatase subunit D family protein Rv2851c (Rv2851c) — family_assigned: GNAT family N-acetyltransferase mqo (Rv2852c) — requalified: malate dehydrogenase (quinone) Rv2854 (Rv2854) — family_assigned: alpha/beta hydrolase nicT (Rv2856) — family_assigned: HoxN/HupN/NixA family nickel/cobalt transporter Rv2857c (Rv2857c) — requalified: 3-oxoacyl-ACP reductase Rv2859c (Rv2859c) — requalified: gamma-glutamyl-gamma-aminobutyrate hydrolase glnA4 (Rv2860c) — family_assigned: glutamine synthetase family protein Rv2862c (Rv2862c) — family_assigned: DUF1707 domain-containing protein vapC23 (Rv2863) — family_assigned: type II toxin-antitoxin system VapC family toxin Rv2864c (Rv2864c) — family_assigned: penicillin-binding protein relF (Rv2865) — requalified: type II toxin-antitoxin system antitoxin RelF relG (Rv2866) — family_assigned: type II toxin-antitoxin system RelE/ParE family toxin Rv2867c (Rv2867c) — family_assigned: GNAT family N-acetyltransferase gcpE (Rv2868c) — requalified: flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphos rip (Rv2869c) — requalified: zinc metalloprotease Rip dxr (Rv2870c) — requalified: 1-deoxy-D-xylulose-5-phosphate reductoisomerase vapB43 (Rv2871) — family_assigned: ribbon-helix-helix domain-containing protein vapC43 (Rv2872) — family_assigned: type II toxin-antitoxin system VapC family toxin mpt83 (Rv2873) — requalified: cell surface glycolipoprotein Mpt83 mpt70 (Rv2875) — family_assigned: fasciclin domain-containing protein mpt53 (Rv2878c) — requalified: protein disulfide oxidoreductase cdsA (Rv2881c) — requalified: phosphatidate cytidylyltransferase frr (Rv2882c) — requalified: ribosome recycling factor pyrH (Rv2883c) — requalified: UMP kinase Rv2887 (Rv2887) — family_assigned: MarR family transcriptional regulator amiC (Rv2888c) — requalified: amidase tsf (Rv2889c) — requalified: translation elongation factor Ts rpsB (Rv2890c) — requalified: 30S ribosomal protein S2 Rv2893 (Rv2893) — requalified: LLM class F420-dependent oxidoreductase xerC (Rv2894c) — requalified: tyrosine recombinase XerC viuB (Rv2895c) — requalified: siderophore-interacting protein dprA (Rv2896c) — requalified: DNA-processing protein DprA Rv2897c (Rv2897c) — family_assigned: YifB family Mg chelatase-like AAA ATPase Rv2898c (Rv2898c) — family_assigned: YraN family protein fdhD (Rv2899c) — requalified: formate dehydrogenase accessory sulfurtransferase FdhD fdhF (Rv2900c) — family_assigned: FdhF/YdeP family oxidoreductase Rv2901c (Rv2901c) — dark: DUF2469 domain-containing protein rnhB (Rv2902c) — requalified: ribonuclease HII lepB (Rv2903c) — requalified: signal peptidase I rplS (Rv2904c) — requalified: 50S ribosomal protein L19 lppW (Rv2905) — family_assigned: hypothetical protein trmD (Rv2906c) — requalified: tRNA (guanosine(37)-N1)-methyltransferase TrmD rimM (Rv2907c) — requalified: ribosome maturation factor RimM Rv2908c (Rv2908c) — family_assigned: RNA-binding protein rpsP (Rv2909c) — requalified: 30S ribosomal protein S16 Rv2912c (Rv2912c) — family_assigned: TetR/AcrR family transcriptional regulator Rv2913c (Rv2913c) — family_assigned: amidohydrolase family protein pknI (Rv2914c) — requalified: serine/threonine protein kinase PknI Rv2915c (Rv2915c) — family_assigned: amidohydrolase family protein ffh (Rv2916c) — requalified: signal recognition particle protein glnD (Rv2918c) — requalified: [protein-PII] uridylyltransferase glnB (Rv2919c) — family_assigned: nitrogen regulatory protein P-II amt (Rv2920c) — requalified: ammonium transporter ftsY (Rv2921c) — requalified: signal recognition particle-docking protein FtsY smc (Rv2922c) — requalified: chromosome segregation protein SMC Rv2923c (Rv2923c) — family_assigned: OsmC family protein fpg (Rv2924c) — requalified: DNA-formamidopyrimidine glycosylase rnc (Rv2925c) — requalified: ribonuclease III sepIVA (Rv2927c) — requalified: cell division protein SepIVA tesA (Rv2928) — requalified: thioesterase TesA Rv2929 (Rv2929) — family_assigned: hypothetical protein fadD26 (Rv2930) — requalified: long-chain-fatty-acid--AMP ligase FAAL26/FadD26 ppsA (Rv2931) — requalified: phthiocerol type I polyketide synthase PpsA ppsB (Rv2932) — requalified: phthiocerol type I polyketide synthase PpsB ppsC (Rv2933) — requalified: phthiocerol type I polyketide synthase PpsC ppsD (Rv2934) — requalified: phthiocerol type I polyketide synthase PpsD ppsE (Rv2935) — requalified: phthiocerol type I polyketide synthase PpsE drrA (Rv2936) — family_assigned: daunorubicin ABC transporter ATP-binding protein DrrA drrB (Rv2937) — family_assigned: daunorubicin ABC transporter permease DrrB drrC (Rv2938) — family_assigned: ABC transporter permease papA5 (Rv2939) — requalified: phthiocerol/phthiodiolone dimycocerosyl transferase mas (Rv2940c) — requalified: mycocerosate synthase fadD28 (Rv2941) — requalified: fatty-acid--AMP ligase FAAL28/FadD28 mmpL7 (Rv2942) — requalified: phthiocerol dimycocerosate RND transporter MmpL7 lppX (Rv2945c) — requalified: LppX_LprAFG lipoprotein fadD22 (Rv2948c) — requalified: p-hydroxybenzoic acid--AMP ligase FadD22 Rv2949c (Rv2949c) — family_assigned: chorismate pyruvate-lyase family protein Rv2951c (Rv2951c) — requalified: phthiodiolone/phenolphthiodiolone dimycocerosates ketoreduct Rv2952 (Rv2952) — requalified: phthiotriol/phenolphthiotriol dimycocerosates methyltransfer Rv2953 (Rv2953) — requalified: trans-acting enoyl reductase Rv2954c (Rv2954c) — requalified: [2%2C4-di-O-methyl-alpha-L-fucopyranosyl-(1->3)-alpha-L-rham Rv2955c (Rv2955c) — requalified: [2-O-methyl-alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyran Rv2956 (Rv2956) — requalified: [alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3) Rv2957 (Rv2957) — requalified: PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c (Rv2958c) — requalified: PGL/p-HBAD biosynthesis glycosyltransferase Rv2959c (Rv2959c) — requalified: rhamnosyl O-methyltransferase Rv2960c (Rv2960c) — dark: hypothetical protein Rv2962c (Rv2962c) — requalified: PGL/p-HBAD biosynthesis rhamnosyltransferase Rv2963 (Rv2963) — requalified: permease purU (Rv2964) — requalified: formyltetrahydrofolate deformylase kdtB (Rv2965c) — requalified: pantetheine-phosphate adenylyltransferase rsmD (Rv2966c) — requalified: 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD pca (Rv2967c) — requalified: pyruvate carboxylase Rv2968c (Rv2968c) — family_assigned: vitamin K epoxide reductase family protein Rv2969c (Rv2969c) — requalified: mycothiol-dependent reductase lipN (Rv2970c) — requalified: lipase/esterase LipN Rv2971 (Rv2971) — requalified: aldo/keto reductase Rv2972c (Rv2972c) — family_assigned: HNH endonuclease family protein recG (Rv2973c) — requalified: ATP-dependent DNA helicase RecG ung (Rv2976c) — requalified: uracil-DNA glycosylase thiL (Rv2977c) — requalified: thiamine-phosphate kinase tnpB (Rv2978c) — family_assigned: IS607 family element RNA-guided endonuclease TnpB Rv2979c (Rv2979c) — family_assigned: IS607 family transposase Rv2980 (Rv2980) — dark: DUF3515 domain-containing protein ddlA (Rv2981c) — requalified: D-alanine--D-alanine ligase DdlA gpdA2 (Rv2982c) — requalified: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase cofC (Rv2983) — requalified: 2-phospho-L-lactate guanylyltransferase ppk1 (Rv2984) — requalified: RNA degradosome polyphosphate kinase mutT1 (Rv2985) — requalified: NUDIX hydrolase hupB (Rv2986c) — family_assigned: DNA-binding protein HupB leuD (Rv2987c) — family_assigned: 3-isopropylmalate dehydratase small subunit leuC (Rv2988c) — family_assigned: 3-isopropylmalate dehydratase large subunit Rv2989 (Rv2989) — family_assigned: IclR family transcriptional regulator Rv2990c (Rv2990c) — requalified: class I SAM-dependent methyltransferase Rv2991 (Rv2991) — requalified: PPOX class F420-dependent oxidoreductase leuB (Rv2995c) — requalified: 3-isopropylmalate dehydrogenase Rv2997 (Rv2997) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv2998 (Rv2998) — dark: hypothetical protein lppY (Rv2999) — family_assigned: DUF1259 domain-containing protein Rv3000 (Rv3000) — family_assigned: ABC transporter permease ilvC (Rv3001c) — requalified: ketol-acid reductoisomerase ilvN (Rv3002c) — family_assigned: acetolactate synthase small subunit Rv3005c (Rv3005c) — family_assigned: DoxX family protein lppZ (Rv3006) — family_assigned: sorbosone dehydrogenase family protein Rv3007c (Rv3007c) — family_assigned: flavin reductase family protein Rv3008 (Rv3008) — family_assigned: MgtC/SapB family protein gatB (Rv3009c) — family_assigned: Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB pfkA (Rv3010c) — requalified: ATP-dependent 6-phosphofructokinase gatA (Rv3011c) — family_assigned: Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA gatC (Rv3012c) — family_assigned: Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC Rv3013 (Rv3013) — family_assigned: amino acid-binding protein ligA (Rv3014c) — requalified: NAD-dependent DNA ligase LigA Rv3015c (Rv3015c) — requalified: methionine synthase lpqA (Rv3016) — family_assigned: sensor domain-containing protein esxQ (Rv3017c) — requalified: type VII secretion system ESX-3 effector EsxQ esxR (Rv3019c) — family_assigned: WXG100 family type VII secretion target Rv1047 (Rv1047) — family_assigned: IS256-like element IS1081 family transposase trmU (Rv3024c) — requalified: tRNA 2-thiouridine(34) synthase MnmA iscS (Rv3025c) — family_assigned: cysteine desulfurase family protein Rv3026c (Rv3026c) — family_assigned: lysophospholipid acyltransferase family protein Rv3027c (Rv3027c) — family_assigned: GNAT family N-acetyltransferase fixB (Rv3028c) — family_assigned: electron transfer flavoprotein subunit alpha/FixB family pro fixA (Rv3029c) — family_assigned: electron transfer flavoprotein subunit beta/FixA family prot Rv3030 (Rv3030) — family_assigned: methyltransferase domain-containing protein Rv3031 (Rv3031) — family_assigned: glycoside hydrolase family 57 protein Rv3032 (Rv3032) — requalified: glycogen synthase Rv3033 (Rv3033) — requalified: DUF4333 domain-containing protein 3 103 kb 3 156 kb 3 210 kb 3 264 kb 3 317 kb 3 370 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.