MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

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+ strand − strand Rv2205c (Rv2205c) — requalified: glycerate kinase Rv2206 (Rv2206) — family_assigned: DUF3043 domain-containing protein cobT (Rv2207) — requalified: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosylt cobS (Rv2208) — requalified: adenosylcobinamide-GDP ribazoletransferase Rv2209 (Rv2209) — requalified: MFS transporter ilvE (Rv2210c) — requalified: branched-chain amino acid aminotransferase Rv2212 (Rv2212) — requalified: adenylyl cyclase pepB (Rv2213) — requalified: leucyl aminopeptidase ephD (Rv2214c) — family_assigned: SDR family oxidoreductase dlaT (Rv2215) — requalified: 2-oxoglutarate dehydrogenase%2C E2 component%2C dihydrolipoa Rv2216 (Rv2216) — family_assigned: TIGR01777 family oxidoreductase lipB (Rv2217) — requalified: lipoyl(octanoyl) transferase LipB lipA (Rv2218) — requalified: lipoyl synthase Rv2219 (Rv2219) — family_assigned: DUF4191 domain-containing protein glnA1 (Rv2220) — requalified: type I glutamate--ammonia ligase glnE (Rv2221c) — requalified: bifunctional [glutamine synthetase] adenylyltransferase/[glu glnA2 (Rv2222c) — family_assigned: glutamine synthetase family protein caeB (Rv2223c) — requalified: carboxylesterase CaeB caeA (Rv2224c) — requalified: carboxylesterase CaeA panB (Rv2225) — requalified: 3-methyl-2-oxobutanoate hydroxymethyltransferase Rv2226 (Rv2226) — family_assigned: CYTH and CHAD domain-containing protein Rv2229c (Rv2229c) — family_assigned: zinc ribbon domain-containing protein Rv2230c (Rv2230c) — requalified: Nif3-like dinuclear metal center hexameric protein ptpA (Rv2234) — requalified: protein-tyrosine-phosphatase Rv2235 (Rv2235) — family_assigned: SURF1 family protein cobD (Rv2236c) — requalified: cobalamin biosynthesis protein ahpE (Rv2238c) — requalified: peroxiredoxin AhpE Rv2240c (Rv2240c) — family_assigned: hypothetical protein Rv2242 (Rv2242) — family_assigned: PucR family transcriptional regulator fabD (Rv2243) — requalified: malonyl CoA-acyl carrier protein transacylase acpM (Rv2244) — requalified: meromycolate extension acyl carrier protein AcpM kasA (Rv2245) — requalified: 3-oxoacyl-ACP synthase KasA accD6 (Rv2247) — family_assigned: acyl-CoA carboxylase subunit beta glpD1 (Rv2249c) — requalified: glycerol-3-phosphate dehydrogenase/oxidase Rv2250c (Rv2250c) — family_assigned: TetR/AcrR family transcriptional regulator Rv2252 (Rv2252) — requalified: diacylglycerol kinase Rv2253 (Rv2253) — family_assigned: hypothetical protein Rv2254c (Rv2254c) — family_assigned: LysE family transporter Rv2257c (Rv2257c) — family_assigned: serine hydrolase domain-containing protein Rv2258c (Rv2258c) — requalified: class I SAM-dependent methyltransferase mscR (Rv2259) — requalified: S-(hydroxymethyl)mycothiol dehydrogenase Rv2260 (Rv2260) — requalified: MBL fold metallo-hydrolase Rv2263 (Rv2263) — family_assigned: SDR family oxidoreductase Rv2264c (Rv2264c) — family_assigned: Hsp70 family protein Rv2265 (Rv2265) — requalified: MFS transporter cyp124 (Rv2266) — requalified: methyl-branched lipid omega-hydroxylase Cyp124 Rv2267c (Rv2267c) — requalified: sulfotransferase cyp128 (Rv2268c) — requalified: cytochrome P450 Rv2269c (Rv2269c) — family_assigned: hypothetical protein lppN (Rv2270) — family_assigned: hypothetical protein Rv2271 (Rv2271) — dark: DUF2695 domain-containing protein Rv2272 (Rv2272) — family_assigned: YidH family protein Rv2273 (Rv2273) — dark: DUF202 domain-containing protein mazF8 (Rv2274c) — requalified: toxin cyp121 (Rv2276) — requalified: mycocyclosin synthase Cyp121 pitB (Rv2281) — requalified: anion permease Rv2282c (Rv2282c) — family_assigned: LysR family transcriptional regulator Rv2283 (Rv2283) — dark: hypothetical protein lipM (Rv2284) — family_assigned: alpha/beta hydrolase Rv2285 (Rv2285) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase Rv2286c (Rv2286c) — family_assigned: DsbA family protein Rv2288 (Rv2288) — dark: hypothetical protein cdh (Rv2289) — requalified: CDP-diacylglycerol diphosphatase lppO (Rv2290) — requalified: lipoprotein LpqH sseB (Rv2291) — requalified: sulfurtransferase Rv2294 (Rv2294) — family_assigned: MalY/PatB family protein Rv2295 (Rv2295) — family_assigned: CbrC family protein Rv2296 (Rv2296) — requalified: haloalkane dehalogenase Rv2297 (Rv2297) — dark: hypothetical protein Rv2298 (Rv2298) — requalified: aldo/keto reductase htpG (Rv2299c) — requalified: molecular chaperone HtpG cut2 (Rv2301) — family_assigned: cutinase family protein Rv2302 (Rv2302) — family_assigned: DUF1918 domain-containing protein Rv2303c (Rv2303c) — family_assigned: amidohydrolase family protein Rv2304c (Rv2304c) — dark: hypothetical protein Rv2305 (Rv2305) — family_assigned: hypothetical protein Rv2307c (Rv2307c) — family_assigned: alpha/beta hydrolase Rv2308 (Rv2308) — family_assigned: DUF433 domain-containing protein Rv2312 (Rv2312) — dark: hypothetical protein Rv2313c (Rv2313c) — family_assigned: carboxymuconolactone decarboxylase family protein Rv2314c (Rv2314c) — family_assigned: TldD/PmbA family protein Rv2315c (Rv2315c) — family_assigned: TldD/PmbA family protein uspA (Rv2316) — family_assigned: sugar ABC transporter permease uspC (Rv2318) — family_assigned: sugar ABC transporter substrate-binding protein Rv2319c (Rv2319c) — requalified: universal stress protein rocE (Rv2320c) — requalified: amino acid permease Rv2324 (Rv2324) — family_assigned: Lrp/AsnC family transcriptional regulator Rv2325c (Rv2325c) — family_assigned: CbiQ family ECF transporter T component Rv2327 (Rv2327) — family_assigned: MarR family winged helix-turn-helix transcriptional regulato narK1 (Rv2329c) — requalified: nitrate/nitrite transporter lppP (Rv2330c) — family_assigned: LppP/LprE family lipoprotein Rv2331 (Rv2331) — family_assigned: hypothetical protein mez (Rv2332) — requalified: NAD-dependent malic enzyme stp (Rv2333c) — requalified: multidrug resistance protein Stp tyzA (Rv2336) — requalified: hypothetical protein tyzC (Rv2337c) — requalified: hypothetical protein moeW (Rv2338c) — family_assigned: ThiF family adenylyltransferase mmpL9 (Rv2339) — requalified: RND transporter MmpL9 cysE (Rv2335) — requalified: serine O-acetyltransferase lppQ (Rv2341) — dark: hypothetical protein Rv2342 (Rv2342) — family_assigned: hypothetical protein dnaG (Rv2343c) — requalified: DNA primase dgt (Rv2344c) — requalified: deoxyguanosinetriphosphate triphosphohydrolase Rv2345 (Rv2345) — family_assigned: TPM domain-containing protein esxO (Rv2346c) — requalified: type VII secretion system effector EsxO esxP (Rv2347c) — requalified: type VII secretion system ESX-5 protein EsxJ Rv2348c (Rv2348c) — family_assigned: hypothetical protein plcC (Rv2349c) — requalified: phospholipase C glyS (Rv2357c) — requalified: glycine--tRNA ligase smtB (Rv2358) — family_assigned: metalloregulator ArsR/SmtB family transcription factor zur (Rv2359) — requalified: zinc uptake transcriptional repressor Zur Rv2360c (Rv2360c) — family_assigned: hypothetical protein Rv2361c (Rv2361c) — requalified: decaprenyl diphosphate synthase recO (Rv2362c) — requalified: DNA repair protein RecO amiA2 (Rv2363) — requalified: amidase Rv2365c (Rv2365c) — requalified: cytidine deaminase Rv2366c (Rv2366c) — family_assigned: hemolysin family protein Rv2369c (Rv2369c) — dark: hypothetical protein Rv2370c (Rv2370c) — family_assigned: PucR family transcriptional regulator Rv2372c (Rv2372c) — requalified: 16S rRNA (uracil(1498)-N(3))-methyltransferase dnaJ2 (Rv2373c) — requalified: molecular chaperone DnaJ hrcA (Rv2374c) — requalified: heat-inducible transcriptional repressor HrcA Rv2375 (Rv2375) — family_assigned: type II toxin-antitoxin system VapB family antitoxin cfp2 (Rv2376c) — requalified: Low molecular weight antigen MTB12 mbtH (Rv2377c) — requalified: mycobactin NRPS accessory protein MbtH mbtG (Rv2378c) — requalified: NADPH-dependent L-lysine N(6)-monooxygenase MbtG mbtD (Rv2381c) — requalified: mycobactin polyketide synthase MbtD mbtC (Rv2382c) — requalified: polyketide synthetase MbtC mbtB (Rv2383c) — requalified: phenyloxazoline synthase MbtB mbtA (Rv2384) — requalified: bifunctional salicyl-AMP ligase/salicyl-S-ArCP synthetase Mb Rv2387 (Rv2387) — family_assigned: sodium-dependent bicarbonate transport family permease rpfD (Rv2389c) — requalified: resuscitation-promoting factor protein RpfD Rv2390c (Rv2390c) — family_assigned: hypothetical protein cysH (Rv2392) — requalified: phosphoadenylyl-sulfate reductase ggtB (Rv2394) — family_assigned: gamma-glutamyltransferase family protein Rv2395 (Rv2395) — family_assigned: oligopeptide transporter%2C OPT family cysW (Rv2398c) — family_assigned: sulfate ABC transporter permease subunit CysW cysT (Rv2399c) — family_assigned: sulfate ABC transporter permease subunit CysT subI (Rv2400c) — family_assigned: sulfate ABC transporter substrate-binding protein Rv2401 (Rv2401) — dark: hypothetical protein lppR (Rv2403c) — family_assigned: sensor domain-containing protein lepA (Rv2404c) — requalified: translation elongation factor 4 Rv2406c (Rv2406c) — family_assigned: CBS domain-containing protein Rv2407 (Rv2407) — family_assigned: Rv2407 family type 3 sulfatase Rv2409c (Rv2409c) — family_assigned: transglutaminase family protein Rv2410c (Rv2410c) — family_assigned: alpha-E domain-containing protein Rv2411c (Rv2411c) — requalified: circularly permuted type 2 ATP-grasp protein rpsT (Rv2412) — requalified: 30S ribosomal protein S20 Rv2413c (Rv2413c) — family_assigned: DNA polymerase III subunit delta Rv2414c (Rv2414c) — family_assigned: ComEC/Rec2 family competence protein Rv2415c (Rv2415c) — family_assigned: ComEA family DNA-binding protein Rv2417c (Rv2417c) — family_assigned: DegV family protein octT (Rv2418c) — requalified: diglucosylglycerate octanoyltransferase gpgP (Rv2419c) — requalified: glucosyl-3-phosphoglycerate phosphatase rsfS (Rv2420c) — requalified: ribosome silencing factor Rv2422 (Rv2422) — family_assigned: hypothetical protein Rv2423 (Rv2423) — requalified: class I SAM-dependent methyltransferase Rv2425c (Rv2425c) — family_assigned: VWA domain-containing protein Rv2426c (Rv2426c) — family_assigned: MoxR family ATPase proA (Rv2427c) — requalified: glutamate-5-semialdehyde dehydrogenase ahpC (Rv2428) — requalified: peroxiredoxin AhpC ahpD (Rv2429) — requalified: alkyl hydroperoxide reductase Rv2432c (Rv2432c) — dark: hypothetical protein nrtS (Rv2433c) — requalified: nitrate/nitrite transporter NrtS Rv2434c (Rv2434c) — requalified: mechanosensitive ion channel Rv2435c (Rv2435c) — family_assigned: adenylate/guanylate cyclase domain-containing protein rbsK (Rv2436) — requalified: ribokinase RbsK Rv2437 (Rv2437) — family_assigned: isoprenylcysteine carboxylmethyltransferase family protein nadE (Rv2438c) — requalified: NAD(+) synthase proB (Rv2439c) — requalified: glutamate 5-kinase obg (Rv2440c) — requalified: GTPase ObgE rpmA (Rv2441c) — requalified: 50S ribosomal protein L27 rplU (Rv2442c) — requalified: 50S ribosomal protein L21 dctA (Rv2443) — family_assigned: cation:dicarboxylase symporter family transporter rne (Rv2444c) — family_assigned: Rne/Rng family ribonuclease ndkA (Rv2445c) — requalified: nucleoside-diphosphate kinase Rv2446c (Rv2446c) — dark: DUF4233 domain-containing protein folC (Rv2447c) — requalified: bifunctional tetrahydrofolate synthase/dihydrofolate synthas Rv2449c (Rv2449c) — family_assigned: trans-acting enoyl reductase family protein rpfE (Rv2450c) — requalified: resuscitation-promoting factor protein RpfE Rv2451 (Rv2451) — dark: hypothetical protein Rv2452c (Rv2452c) — dark: hypothetical protein mobA (Rv2453c) — requalified: molybdenum cofactor guanylyltransferase Rv2454c (Rv2454c) — family_assigned: 2-oxoacid:ferredoxin oxidoreductase subunit beta Rv2455c (Rv2455c) — family_assigned: 2-oxoacid:acceptor oxidoreductase subunit alpha Rv2456c (Rv2456c) — requalified: MFS transporter clpX (Rv2457c) — family_assigned: ATP-dependent Clp protease ATP-binding subunit ClpX mmuM (Rv2458) — requalified: homocysteine S-methyltransferase jefA (Rv2459) — requalified: multidrug efflux pump JefA clpP2 (Rv2460c) — family_assigned: ATP-dependent CLP protease proteolytic subunit ClpP2 tig (Rv2462c) — requalified: trigger factor lipP (Rv2463) — family_assigned: serine hydrolase domain-containing protein Rv2464c (Rv2464c) — family_assigned: Fpg/Nei family DNA glycosylase Rv2466c (Rv2466c) — family_assigned: Rv2466c family mycothiol-dependent reductase Rv2469c (Rv2469c) — requalified: HNH endonuclease glbO (Rv2470) — requalified: group 2 truncated hemoglobin GlbO aglA (Rv2471) — family_assigned: glycoside hydrolase family 13 protein Rv2472 (Rv2472) — dark: hypothetical protein Rv2473 (Rv2473) — dark: hypothetical protein Rv2474c (Rv2474c) — family_assigned: hypothetical protein Rv2475c (Rv2475c) — family_assigned: thioesterase family protein gdh (Rv2476c) — requalified: NAD-glutamate dehydrogenase ettA (Rv2477c) — requalified: energy-dependent translational throttle protein EttA Rv2481c (Rv2481c) — family_assigned: hypothetical protein plsB2 (Rv2482c) — requalified: glycerol-3-phosphate 1-O-acyltransferase plsC (Rv2483c) — family_assigned: HAD-IB family hydrolase Rv2484c (Rv2484c) — family_assigned: wax ester/triacylglycerol synthase family O-acyltransferase lipQ (Rv2485c) — family_assigned: alpha/beta hydrolase 2 514 kb 2 568 kb 2 622 kb 2 675 kb 2 728 kb 2 782 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.