MTBC Gene Atlas

Genome browser

Linear view of the M. tuberculosis complex genome (MTBC0 ancestral coordinates, H37Rv locus tags). Each arrow is a gene, pointing in its coding direction and coloured by annotation verdict. Click a gene to open its page.

◀ Pan left Pan right ▶ + Zoom in − Zoom out window 533 992–693 992 bp (160 000 bp)
+ strand − strand Rv0441c (Rv0441c) — family_assigned: pyridoxamine 5'-phosphate oxidase family protein Rv0443 (Rv0443) — requalified: mycothiol transferase rskA (Rv0444c) — requalified: anti-sigma-K factor RskA sigK (Rv0445c) — family_assigned: sigma-70 family RNA polymerase sigma factor SigK Rv0446c (Rv0446c) — family_assigned: DUF1295 domain-containing protein ufaA1 (Rv0447c) — requalified: class I SAM-dependent methyltransferase Rv0449c (Rv0449c) — requalified: NAD(P)/FAD-dependent oxidoreductase mmpS4 (Rv0451c) — requalified: siderophore RND transporter accessory protein MmpS4 Rv0452 (Rv0452) — family_assigned: TetR family transcriptional regulator Rv0455c (Rv0455c) — family_assigned: DUF5078 domain-containing protein echA2 (Rv0456c) — family_assigned: crotonase/enoyl-CoA hydratase family protein Rv0457c (Rv0457c) — family_assigned: prolyl oligopeptidase family protein Rv0458 (Rv0458) — family_assigned: aldehyde dehydrogenase family protein Rv0459 (Rv0459) — family_assigned: DUF779 domain-containing protein lpdC (Rv0462) — requalified: dihydrolipoyl dehydrogenase Rv0463 (Rv0463) — dark: hypothetical protein Rv0464c (Rv0464c) — family_assigned: carboxymuconolactone decarboxylase family protein ramB (Rv0465c) — family_assigned: acetate metabolism transcriptional regulator RamB Rv0466 (Rv0466) — requalified: acyl-[acyl-carrier-protein] thioesterase fadB2 (Rv0468) — requalified: 3-hydroxybutyryl-CoA dehydrogenase FadB2 Rv0471c (Rv0471c) — requalified: 1%2C4-dihydroxy-2-naphthoate prenyltransferase Rv0472c (Rv0472c) — family_assigned: TetR/AcrR family transcriptional regulator Rv0473 (Rv0473) — dark: DUF445 domain-containing protein Rv0474 (Rv0474) — family_assigned: helix-turn-helix transcriptional regulator hbhA (Rv0475) — requalified: heparin-binding hemagglutinin HbhA Rv0477 (Rv0477) — dark: DUF2599 domain-containing protein deoC (Rv0478) — requalified: deoxyribose-phosphate aldolase Rv0479c (Rv0479c) — family_assigned: DUF2993 domain-containing protein Rv0480c (Rv0480c) — family_assigned: carbon-nitrogen hydrolase family protein Rv0481c (Rv0481c) — family_assigned: DUF2505 domain-containing protein murB (Rv0482) — requalified: UDP-N-acetylmuramate dehydrogenase lprQ (Rv0483) — requalified: L%2CD-transpeptidase LdtMt5 Rv0484c (Rv0484c) — family_assigned: SDR family oxidoreductase Rv0485 (Rv0485) — family_assigned: transcriptional regulator mshA (Rv0486) — requalified: D-inositol-3-phosphate glycosyltransferase Rv0487 (Rv0487) — family_assigned: YbjN domain-containing protein senX3 (Rv0490) — requalified: two-component system sensor histidine kinase SenX3 Rv0492c (Rv0492c) — family_assigned: GMC family oxidoreductase Rv0497 (Rv0497) — family_assigned: hypothetical protein Rv0498 (Rv0498) — requalified: sugar phosphate isomerase/epimerase Rv0499 (Rv0499) — family_assigned: thioesterase family protein galE2 (Rv0501) — family_assigned: SDR family oxidoreductase Rv0502 (Rv0502) — family_assigned: lysophospholipid acyltransferase family protein cmaA2 (Rv0503c) — requalified: cyclopropane mycolic acid synthase CmaA2 Rv0504c (Rv0504c) — family_assigned: MaoC family dehydratase N-terminal domain-containing protein mmpS2 (Rv0506) — family_assigned: MmpS family protein mmpL2 (Rv0507) — requalified: RND transporter MmpL2 Rv0508 (Rv0508) — family_assigned: glutaredoxin family protein hemA (Rv0509) — requalified: glutamyl-tRNA reductase hemC (Rv0510) — requalified: hydroxymethylbilane synthase hemB (Rv0512) — requalified: porphobilinogen synthase Rv0513 (Rv0513) — family_assigned: DUF3093 domain-containing protein Rv0514 (Rv0514) — dark: hypothetical protein oprA (Rv0516c) — requalified: osmosensory protein OprA Rv0518 (Rv0518) — family_assigned: SGNH/GDSL hydrolase family protein Rv0523c (Rv0523c) — family_assigned: nitroreductase family deazaflavin-dependent oxidoreductase hemL (Rv0524) — requalified: glutamate-1-semialdehyde 2%2C1-aminomutase Rv0525 (Rv0525) — family_assigned: histidine phosphatase family protein Rv0528 (Rv0528) — requalified: cytochrome c biogenesis protein ResB ccsA (Rv0529) — requalified: c-type cytochrome biogenesis protein CcsB Rv0530 (Rv0530) — family_assigned: MinD/ParA family protein Rv0531 (Rv0531) — family_assigned: DUF4229 domain-containing protein fabH (Rv0533c) — requalified: beta-ketoacyl-ACP synthase III menA (Rv0534c) — requalified: 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase Rv0537c (Rv0537c) — dark: hypothetical protein ptrp (Rv0538) — family_assigned: hypothetical protein Rv0540 (Rv0540) — family_assigned: DUF2064 domain-containing protein Rv0541c (Rv0541c) — family_assigned: integral membrane protein menE (Rv0542c) — requalified: o-succinylbenzoate--CoA ligase Rv0543c (Rv0543c) — family_assigned: DUF3349 domain-containing protein Rv0544c (Rv0544c) — family_assigned: hypothetical protein pitA (Rv0545c) — requalified: anion permease Rv0546c (Rv0546c) — family_assigned: VOC family protein Rv0547c (Rv0547c) — family_assigned: SDR family oxidoreductase vapC3 (Rv0549c) — family_assigned: type II toxin-antitoxin system VapC family toxin vapB3 (Rv0550c) — family_assigned: type II toxin-antitoxin system CcdA family antitoxin fadD8 (Rv0551c) — requalified: fatty-acid--CoA ligase FadD8 Rv0552 (Rv0552) — requalified: amidohydrolase menC (Rv0553) — requalified: o-succinylbenzoate synthase bpoC (Rv0554) — family_assigned: alpha/beta hydrolase menD (Rv0555) — requalified: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxyli Rv0556 (Rv0556) — family_assigned: DUF3592 domain-containing protein Rv0559c (Rv0559c) — family_assigned: DUF732 domain-containing protein menJ (Rv0561c) — requalified: menaquinone reductase grcC1 (Rv0562) — requalified: polyprenyl-diphosphate synthase GrcC htpX (Rv0563) — requalified: zinc metalloprotease HtpX gpdA1 (Rv0564c) — requalified: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Rv0565c (Rv0565c) — requalified: NAD(P)/FAD-dependent oxidoreductase Rv0566c (Rv0566c) — family_assigned: YajQ family cyclic di-GMP-binding protein Rv0567 (Rv0567) — requalified: methyltransferase cyp135B1 (Rv0568) — requalified: cytochrome P450 Rv0569 (Rv0569) — family_assigned: DUF1918 domain-containing protein nrdZ (Rv0570) — requalified: adenosylcobalamin-dependent ribonucleoside-diphosphate reduc Rv0571c (Rv0571c) — family_assigned: phosphoribosyltransferase family protein Rv0572c (Rv0572c) — family_assigned: hypothetical protein pncB2 (Rv0573c) — requalified: nicotinate phosphoribosyltransferase Rv0574c (Rv0574c) — family_assigned: CapA family protein Rv0575c (Rv0575c) — requalified: FAD-binding domain Rv0576 (Rv0576) — family_assigned: TIGR03086 family metal-binding protein TB27.3 (Rv0577) — family_assigned: VOC family protein Rv0579 (Rv0579) — family_assigned: Mut7-C RNAse domain-containing protein Rv0580c (Rv0580c) — requalified: mycobacterial cell wall protein Rv0580c vapB26 (Rv0581) — requalified: type II toxin-antitoxin system antitoxin VapB26 vapC26 (Rv0582) — requalified: type II toxin-antitoxin system toxin ribonuclease C26 lpqN (Rv0583c) — family_assigned: LpqN/LpqT family lipoprotein Rv0584 (Rv0584) — family_assigned: GH92 family glycosyl hydrolase Rv0585c (Rv0585c) — family_assigned: lysylphosphatidylglycerol synthase transmembrane domain-cont mce2R (Rv0586) — family_assigned: FadR family transcriptional regulator Mce2R yrbE2A (Rv0587) — family_assigned: ABC transporter permease Rv0588 (Rv0588) — family_assigned: ABC transporter permease mce2C (Rv0591) — family_assigned: virulence factor Mce family protein 556 kb 583 kb 610 kb 636 kb 662 kb 689 kb

■ resolved (requalified)   ■ family assigned   ■ still unknown (dark)  ·  the centred gene is outlined in black.