Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| ideR Rv2711 |
mtbc0_002885 |
iron-dependent repressor and activator IdeR | Iron-dependent transcriptional regulator IdeR. Pfam: Fe_dep_repress (PF01325.26), Fe_dep_repr_C (PF02742.22), DtxR (PF18357.8), FeoA (PF04023.21). | Fe_dep_repress Fe_dep_repr_C DtxR FeoA |
Family assigned |
| Rv2712c Rv2712c |
mtbc0_002886 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4192. Function unknown. Foldseek best (non-significant) hit: 7ya9-assembly1_A-2 Fis1 (Mitochondrial fission 1 protein) (prob 0.99, TM 0.57). | DUF4192 |
Still unknown |
| sthA Rv2713 |
mtbc0_002887 |
pyridine nucleotide transhydrogenase | Si-specific NAD(P)(+) transhydrogenase. Pfam: Pyr_redox_2 (PF07992.21), FAD_oxidored (PF12831.14), GIDA (PF01134.29), FAD_binding_2 (PF00890.31), Pyr_redox_3 (PF13738.13), Pyr_redox (PF00070.34), Pyr_redox_dim (PF02852.29). | Pyr_redox_2 FAD_oxidored GIDA FAD_binding_2 Pyr_redox_3 Pyr_redox Pyr_redox_dim |
Resolved |
| Rv2714 Rv2714 |
mtbc0_002888 |
hypothetical protein | PAC2 family protein. Pfam: PAC2 (PF09754.16). | PAC2 |
Family assigned |
| Rv2715 Rv2715 |
mtbc0_002889 |
hydrolase | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 |
Family assigned |
| Rv2716 Rv2716 |
mtbc0_002890 |
hypothetical protein | PhzF family phenazine biosynthesis protein. Pfam: PhzC-PhzF (PF02567.22). | PhzC-PhzF |
Family assigned |
| Rv2717c Rv2717c |
mtbc0_002891 |
hypothetical protein | FABP family protein. Pfam: THAP4_heme-bd (PF08768.18). | THAP4_heme-bd |
Family assigned |
| nrdR Rv2718c |
mtbc0_002892 |
transcriptional regulator NrdR | Transcriptional regulator NrdR. Pfam: Zn_ribbon_NrdR (PF22811.3), ATP-cone (PF03477.22). | Zn_ribbon_NrdR ATP-cone |
Family assigned |
| chiZ Rv2719c |
mtbc0_002893 |
membrane protein | Cell wall hydrolase ChiZ. Pfam: LysM (PF01476.27). | LysM |
Resolved |
| lexA Rv2720 |
mtbc0_002894 |
repressor LexA | Transcriptional repressor LexA. Pfam: LexA_DNA_bind (PF01726.23), Peptidase_S24 (PF00717.29). | LexA_DNA_bind Peptidase_S24 |
Resolved |
| Rv2721c Rv2721c |
mtbc0_002895 |
hypothetical protein | LGFP repeat-containing protein. Pfam: LGFP (PF08310.18), ArfC (PF27542.1). | LGFP ArfC |
Family assigned |
| Rv2722 Rv2722 |
mtbc0_002896 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2723 Rv2723 |
mtbc0_002897 |
integral membrane protein | TerC/Alx family metal homeostasis membrane protein. Pfam: TerC (PF03741.23). | TerC |
Family assigned |
| fadE20 Rv2724c |
mtbc0_002898 |
acyl-CoA dehydrogenase FadE20 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| hflX Rv2725c |
- |
GTP-binding protein HflX | GTP-binding protein HflX. Pfam: GTP-bdg_N (PF13167.12), GTP-bdg_M (PF16360.11), MMR_HSR1 (PF01926.30). | GTP-bdg_N GTP-bdg_M MMR_HSR1 |
Family assigned |
| dapF Rv2726c |
mtbc0_002900 |
diaminopimelate epimerase | Diaminopimelate epimerase. Pfam: DAP_epimerase (PF01678.25). | DAP_epimerase |
Resolved |
| miaA Rv2727c |
mtbc0_002901 |
tRNA delta(2)-isopentenylpyrophosphate transferase | TRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA. Pfam: IPPT (PF01715.24). | IPPT |
Resolved |
| Rv2728c Rv2728c |
mtbc0_002902 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5hee-assembly1_B Crystal structure of the TK2203 protein (prob 1.00, TM 0.73). Structure-based, putative. | Family assigned | |
| Rv2729c Rv2729c |
mtbc0_002903 |
integral membrane protein | DMT family transporter. | Family assigned | |
| Rv2730 Rv2730 |
mtbc0_002904 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5ejw-assembly1_A Crystal structure of chromobox homolog 7 (CBX7) chrom (prob 0.01, TM 0.29). | Still unknown | |
| Rv2731 Rv2731 |
mtbc0_002905 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF349. Function unknown. | DUF349 |
Still unknown |
| Rv2732c Rv2732c |
mtbc0_002906 |
transmembrane protein | Radical-SAM tRNA-modifying enzyme of the MiaB family (tRNA-2-methylthio-N6-dimethylallyladenosine synthase-like). RefSeq leaves it 'hypothetical protein'. | Family assigned | |
| miaB Rv2733c |
mtbc0_002907 |
(dimethylallyl)adenosine tRNA methylthiotransferase | TRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB. Pfam: UPF0004 (PF00919.27), Radical_SAM (PF04055.28). | UPF0004 Radical_SAM |
Resolved |
| Rv2734 Rv2734 |
mtbc0_002908 |
hypothetical protein | DUF5131 family protein. | DUF5131 |
Family assigned |
| Rv2735c Rv2735c |
mtbc0_002909 |
hypothetical protein | Three-Cys-motif partner protein TcmP. | Resolved | |
| recX Rv2736c |
mtbc0_002910 |
regulatory protein RecX | Recombination regulator RecX. Pfam: RecX_HTH1 (PF21982.3), RecX_HTH2 (PF02631.23). | RecX_HTH1 RecX_HTH2 |
Resolved |
| recA Rv2737c |
mtbc0_002911 |
recombinase A | Intein-containing recombinase RecA. Pfam: RecA_N (PF00154.28), Rad51 (PF08423.18), Intein_splicing (PF14890.12), LAGLIDADG_3 (PF14528.12), RecA_C (PF21096.3). | RecA_N Rad51 Intein_splicing LAGLIDADG_3 RecA_C |
Resolved |
| Rv2738c Rv2738c |
mtbc0_002913 |
hypothetical protein | Psp-like envelope-stress system protein (paralogue of the Rv2742c Psp module). RefSeq leaves it 'hypothetical protein'. | DUF3046 |
Family assigned |
| Rv2739c Rv2739c |
mtbc0_002914 |
transferase | Glycosyltransferase. Pfam: Glyco_tran_28_C (PF04101.23), EryCIII-like_C (PF06722.19), UDPGT (PF00201.25). | Glyco_tran_28_C EryCIII-like_C UDPGT |
Resolved |
| ephG Rv2740 |
mtbc0_002915 |
epoxide hydrolase | Epoxide hydrolase. Pfam: LEH (PF07858.19), SnoaL_2 (PF12680.14). | LEH SnoaL_2 |
Resolved |
| PE_PGRS47 Rv2741 |
- |
PE-PGRS family protein PE_PGRS47 | PE-PGRS family protein PE_PGRS47. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv2742c Rv2742c |
- |
hypothetical protein | Component of the mycobacterial Psp-like (phage-shock-protein) envelope-stress system. RefSeq leaves it 'hypothetical'. Rv2742c belongs to a four-gene module (clgR-pspA[Rv2744c]-rv2743c-rv2742c) regulated by ClgR and required for envelope integrity, surface-stress tolerance, MprAB-sigmaE stress signalling and intramacrophage growth; the module is restricted to tuberculous mycobacteria (Datta 2015). | DUF3046 |
Resolved |
| Rv2743c Rv2743c |
mtbc0_002920 |
hypothetical protein | Contains Rv2743c (PF25587.2) domain(s); putative function inferred from the domain architecture. | Rv2743c |
Family assigned |
| 35kd_ag Rv2744c |
- |
hypothetical protein | Contains PspA_IM30 (PF04012.18) domain(s); putative function inferred from the domain architecture. | PspA_IM30 |
Family assigned |
| clgR Rv2745c |
mtbc0_002922 |
transcriptional regulator ClgR | Transcriptional regulator ClgR. Pfam: HTH_31 (PF13560.13), HTH_3 (PF01381.29), HTH_25 (PF13413.13). | HTH_31 HTH_3 HTH_25 |
Family assigned |
| pgsA3 Rv2746c |
- |
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Pfam: CDP-OH_P_transf (PF01066.27). | CDP-OH_P_transf |
Resolved |
| argA Rv2747 |
mtbc0_002924 |
L-glutamate alpha-N-acetyltranferase | Amino-acid N-acetyltransferase. Pfam: Acetyltransf_1 (PF00583.32), Acetyltransf_7 (PF13508.14). | Acetyltransf_1 Acetyltransf_7 |
Resolved |
| ftsK Rv2748c |
mtbc0_002925 |
DNA translocase FtsK | DNA translocase FtsK. Pfam: FtsK_4TM (PF13491.12), FtsK_alpha (PF17854.7), FtsK_SpoIIIE (PF01580.25), FtsK_gamma (PF09397.17). | FtsK_4TM FtsK_alpha FtsK_SpoIIIE FtsK_gamma |
Resolved |
| Rv2749 Rv2749 |
mtbc0_002926 |
hypothetical protein | Putative quinol monooxygenase. Pfam: ABM (PF03992.23). | ABM |
Family assigned |
| Rv2750 Rv2750 |
mtbc0_002927 |
dehydrogenase | Rv2750 family mycofactocin-dependent SDR oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv2751 Rv2751 |
mtbc0_002928 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| rnj Rv2752c |
mtbc0_002929 |
ribonuclease J | Ribonuclease J. Pfam: Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14), RNase_J_b_CASP (PF22505.2), RMMBL (PF07521.18), RNase_J_C (PF17770.8). | Lactamase_B Lactamase_B_2 RNase_J_b_CASP RMMBL RNase_J_C |
Resolved |
| dapA Rv2753c |
mtbc0_002930 |
4-hydroxy-tetrahydrodipicolinate synthase | 4-hydroxy-tetrahydrodipicolinate synthase. Pfam: DHDPS (PF00701.29). | DHDPS |
Resolved |
| thyX Rv2754c |
mtbc0_002931 |
thymidylate synthase ThyX | FAD-dependent thymidylate synthase. Pfam: Thy1 (PF02511.21). | Thy1 |
Resolved |
| hsdM Rv2756c |
mtbc0_002933 |
type I restriction/modification system DNA methylase HsdM | Class I SAM-dependent DNA methyltransferase. Pfam: HsdM_N (PF12161.15), N6_Mtase (PF02384.23). | HsdM_N N6_Mtase |
Resolved |
| vapC21 Rv2757c |
mtbc0_002934 |
ribonuclease VapC21 | Type II toxin-antitoxin system toxin ribonuclease C21. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| vapB21 Rv2758c |
mtbc0_002935 |
antitoxin VapB21 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: VapB_antitoxin (PF09957.16). | VapB_antitoxin |
Family assigned |
| vapC42 Rv2759c |
mtbc0_002936 |
ribonuclease VapC42 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB42 Rv2760c |
mtbc0_002937 |
antitoxin VapB42 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Family assigned |
| hsdS Rv2761c |
mtbc0_002938 |
type I restriction/modification system specificity determinant HsdS | Restriction endonuclease subunit S. Pfam: Methylase_S (PF01420.26). | Methylase_S |
Family assigned |