Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| dinG Rv1329c |
mtbc0_001426 |
ATP-dependent helicase DinG | ATP-dependent helicase DinG. Pfam: DEAD (PF00270.36), Helicase_C_2 (PF13307.13). | DEAD Helicase_C_2 |
Resolved |
| pncB1 Rv1330c |
mtbc0_001427 |
nicotinic acid phosphoribosyltransferase PncB1 | Nicotinate phosphoribosyltransferase. Pfam: NAPRTase_N (PF17767.8), QRPTase_C (PF01729.26), NAPRTase (PF04095.23). | NAPRTase_N QRPTase_C NAPRTase |
Resolved |
| clpS Rv1331 |
mtbc0_001428 |
ATP-dependent Clp protease adapter protein ClpS | ATP-dependent Clp protease adapter ClpS. Pfam: ClpS (PF02617.23). | ClpS |
Resolved |
| Rv1332 Rv1332 |
- |
transcriptional regulator | Transcriptional regulator. | DUF2017 |
Family assigned |
| Rv1333 Rv1333 |
mtbc0_001430 |
hydrolase | P1 family peptidase. Pfam: Peptidase_S58 (PF03576.20). | Peptidase_S58 |
Family assigned |
| mec Rv1334 |
mtbc0_001431 |
[CysO | CysO-cysteine peptidase. Pfam: Prok-JAB (PF14464.12). | Prok-JAB |
Resolved |
| cysO Rv1335 |
mtbc0_001432 |
sulfur carrier protein CysO | Sulfur carrier protein CysO. Pfam: ThiS (PF02597.27). | ThiS |
Resolved |
| cysM Rv1336 |
mtbc0_001433 |
O-phosphoserine sulfhydrylase | O-phosphoserine sulfhydrylase. Pfam: PALP (PF00291.32). | PALP |
Resolved |
| Rv1337 Rv1337 |
mtbc0_001434 |
integral membrane protein | Rhomboid family intramembrane serine protease. Pfam: Rhomboid (PF01694.29). | Rhomboid |
Family assigned |
| murI Rv1338 |
mtbc0_001435 |
glutamate racemase | Glutamate racemase. Pfam: Asp_Glu_race (PF01177.28). | Asp_Glu_race |
Resolved |
| Rv1339 Rv1339 |
- |
hypothetical protein | Contains Anti-Pycsar_Apyc1 (PF23023.2), Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14) domain(s); putative function inferred from the domain architecture. | Anti-Pycsar_Apyc1 Lactamase_B Lactamase_B_2 |
Family assigned |
| rphA Rv1340 |
mtbc0_001437 |
ribonuclease PH | Ribonuclease PH. Pfam: RNase_PH (PF01138.28), RNase_PH_C (PF03725.21). | RNase_PH RNase_PH_C |
Resolved |
| rdgB Rv1341 |
mtbc0_001438 |
non-canonical purine NTP pyrophosphatase | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase. Pfam: Ham1p_like (PF01725.22). | Ham1p_like |
Family assigned |
| Rv1342c Rv1342c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3817 |
Family assigned |
| lprD Rv1343c |
mtbc0_001440 |
lipoprotein LprD | GutM/SrlR-like operon-regulator-family protein (eggNOG COG1566, COG category V). RefSeq leaves it 'hypothetical protein'. Regulatory role suggested by orthology; target operon undetermined. | Family assigned | |
| mbtL Rv1344 |
- |
acyl carrier protein MbtL | Acyl carrier protein MbtL. Pfam: PP-binding (PF00550.32). | PP-binding |
Resolved |
| mbtM Rv1345 |
mtbc0_001442 |
long-chain-fatty-acid--ACP ligase MbtM | Long-chain-fatty acid--ACP ligase MbtM. Pfam: AMP-binding (PF00501.35). | AMP-binding |
Resolved |
| mbtN Rv1346 |
mtbc0_001443 |
acyl-[acyl-carrier-protein | Acyl-ACP dehydrogenase MbtN. Pfam: Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Resolved |
| mbtK Rv1347c |
mtbc0_001444 |
lysine N-acetyltransferase MbtK | Lysine N-acyltransferase MbtK. Pfam: Acetyltransf_8 (PF13523.13). | Acetyltransf_8 |
Resolved |
| irtA Rv1348 |
mtbc0_001446 |
iron ABC transporter ATP-binding protein/permease IrtA | Iron ABC transporter ATP-binding protein/permease IrtA. Pfam: FAD_binding_9 (PF08021.18), SIP (PF04954.19), ABC_membrane (PF00664.29), ABC_tran (PF00005.34). | FAD_binding_9 SIP ABC_membrane ABC_tran |
Family assigned |
| irtB Rv1349 |
mtbc0_001447 |
iron ABC transporter ATP-binding protein/permease IrtB | Iron ABC transporter ATP-binding protein/permease IrtB. Pfam: ABC_tran (PF00005.34). | ABC_tran |
Family assigned |
| fabG2 Rv1350 |
mtbc0_001449 |
3-oxoacyl-ACP reductase FabG | 3-oxoacyl-ACP reductase FabG. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Resolved |
| Rv1351 Rv1351 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1352 Rv1352 |
mtbc0_001452 |
hypothetical protein | Contains Rv1352 (PF27111.1) domain(s); putative function inferred from the domain architecture. | Rv1352 |
Family assigned |
| Rv1353c Rv1353c |
mtbc0_001453 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein. Pfam: TetR_N (PF00440.30), TetR_C_1 (PF02909.23). | TetR_N TetR_C_1 |
Family assigned |
| Rv1354c Rv1354c |
mtbc0_001454 |
hypothetical protein | Bifunctional diguanylate cyclase/phosphodiesterase. Pfam: GAF_2 (PF13185.13), GAF (PF01590.33), GGDEF (PF00990.27), EAL (PF00563.26). | GAF_2 GAF GGDEF EAL |
Resolved |
| moeY Rv1355c |
mtbc0_001455 |
molybdopterin biosynthesis protein MoeY | Rv1355c family protein. Pfam: ThiF (PF00899.28). | ThiF |
Family assigned |
| Rv1356c Rv1356c |
- |
hypothetical protein | TrzA: N-acyl amino acid transferase. N-acylates L-tryptophan (highest specificity for C5:0-CoA) in the trzAS cluster for N-acylated tryptazolone biosynthesis. RefSeq still annotates it hypothetical. | Resolved | |
| Rv1357c Rv1357c |
mtbc0_001457 |
hypothetical protein | Cyclic diguanylate phosphodiesterase. Pfam: EAL (PF00563.26). | EAL |
Resolved |
| Rv1358 Rv1358 |
mtbc0_001459 |
transcriptional regulator | LuxR C-terminal-related transcriptional regulator. Pfam: HTH_77 (PF25872.1), GerE (PF00196.26). | HTH_77 GerE |
Family assigned |
| Rv1359 Rv1359 |
- |
transcriptional regulator | Transcriptional regulator. | Family assigned | |
| Rv1360 Rv1360 |
mtbc0_001462 |
oxidoreductase | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| PPE19 Rv1361c |
- |
PPE family protein PPE19 | PPE family protein PPE19. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv1362c Rv1362c |
mtbc0_001464 |
membrane protein | IcmL/VirB8-like membrane-protein fold. RefSeq leaves it 'membrane protein'. The AlphaFold model superposes on an IcmL-like type-IV-secretion protein (PDB 5cnl; Foldseek prob 1.0, E 1e-4, TM 0.75); its neighbour Rv1363c shares a VirB8-periplasmic-domain fold (7q1v) and the two are mutual STRING partners. A membrane-associated secretion-system-like fold; no classical T4SS is annotated in M. tuberculosis. | Family assigned | |
| Rv1363c Rv1363c |
mtbc0_001465 |
membrane protein | OmamC -- orphaned Mce-associated membrane (Mam) protein. Accessory component of the Mce lipid-transport machinery: omamC is upregulated during carbon starvation and its deletion significantly reduces survival; OmamC raises fatty-acid and mycolic-acid stores during growth in rich medium and speeds their utilisation during starvation, and its level modulates expression of the anti-anti-sigma factor rv0516c and rifampicin tolerance. Molecular activity still undefined: the published evidence is genetic and physiological, not enzymatic. | Family assigned | |
| Rv1364c Rv1364c |
- |
sigma factor regulatory protein | Sigma factor regulatory protein. Pfam: PAS_4 (PF08448.17), SpoIIE (PF07228.18), HATPase_c_2 (PF13581.13), STAS_2 (PF13466.13), STAS (PF01740.27). | PAS_4 SpoIIE HATPase_c_2 STAS_2 STAS |
Family assigned |
| rsfA Rv1365c |
mtbc0_001467 |
anti-sigma-F factor antagonist RsfA | Anti-sigma-F factor antagonist RsfA. Pfam: STAS (PF01740.27), STAS_2 (PF13466.13). | STAS STAS_2 |
Resolved |
| Rv1366 Rv1366 |
mtbc0_001468 |
hypothetical protein | GTP pyrophosphokinase family protein. Pfam: RelA_SpoT (PF04607.24). | RelA_SpoT |
Family assigned |
| Rv1366A Rv1366A |
- |
hypothetical protein | RelA/SpoT-homolog (RSH) / small-alarmone-synthetase (SAS) family protein: a (p)ppGpp-synthetase-domain protein of the stringent-response/alarmone superfamily (HHpred 99.69%, E 1.7e-16 to a RelA/SpoT-family protein over 74 cols). At 86 aa it is a minimal single-domain SAS, DISTINCT from the main bifunctional Rel(Mtb)/Rv2583c (738 aa). The FaRel2/ATfaRel2 (toxSAS) hits raise the possibility of a toxic small-alarmone-synthetase (toxSAS; TA / phage-defence) rather than a canonical (p)ppGpp synthetase; the neighbouring hypothetical Rv1366 (STRING 834) is a candidate cognate partner. Subtype (synthetase vs toxSAS) undetermined. CONTEXT (twin-synthetase landscape, Sinha 2023): M. tuberculosis has two characterised bifunctional synthetases - Rel(Rv2583c) and the RNase-HII-fused short SAS RelZ (~500 aa); at 86 aa Rv1366A matches NEITHER (too short for RelZ), so it is a candidate ADDITIONAL monofunctional small/toxic alarmone synthetase, not yet experimentally characterised. | Family assigned | |
| Rv1367c Rv1367c |
- |
hypothetical protein | Contains Beta-lactamase (PF00144.30) domain(s); putative function inferred from the domain architecture. | Beta-lactamase |
Family assigned |
| lprF Rv1368 |
mtbc0_001471 |
lipoprotein LprF | Lipoprotein LprF. Pfam: LppX_LprAFG (PF07161.20). | LppX_LprAFG |
Resolved |
| Rv1371 Rv1371 |
mtbc0_001472 |
membrane protein | Cytochrome b5 domain-containing protein. Pfam: Cyt-b5 (PF00173.34), FA_desaturase (PF00487.31). | Cyt-b5 FA_desaturase |
Family assigned |
| Rv1372 Rv1372 |
- |
alpha-pyrone synthesis polyketide synthase-like protein | Alpha-pyrone synthesis polyketide synthase-like protein. Pfam: Chal_sti_synt_N (PF00195.26), FAE1_CUT1_RppA (PF08392.19), ACP_syn_III (PF08545.17), Chal_sti_synt_C (PF02797.22), ACP_syn_III_C (PF08541.17). | Chal_sti_synt_N FAE1_CUT1_RppA ACP_syn_III Chal_sti_synt_C ACP_syn_III_C |
Family assigned |
| Rv1373 Rv1373 |
mtbc0_001474 |
glycolipid sulfotransferase | Glycolipid sulfotransferase. Pfam: Sulfotransfer_1 (PF00685.34). | Sulfotransfer_1 |
Resolved |
| Rv1374c Rv1374c |
mtbc0_001475 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7x75-assembly1_D Cryo-EM structure of Streptomyces coelicolor RNAP-pro (prob 0.04, TM 0.33). | Still unknown | |
| Rv1375 Rv1375 |
mtbc0_001476 |
hypothetical protein | YcaO-like family protein. Pfam: YcaO (PF02624.22). | YcaO |
Family assigned |
| Rv1376 Rv1376 |
mtbc0_001477 |
hypothetical protein | TfuA-like protein. Pfam: TfuA (PF07812.19). | TfuA |
Family assigned |
| Rv1377c Rv1377c |
mtbc0_001478 |
transferase | Class I SAM-dependent methyltransferase. Pfam: MTS (PF05175.21), Methyltransf_23 (PF13489.13), TehB (PF03848.21), Methyltransf_31 (PF13847.13), Ubie_methyltran (PF01209.25), Methyltransf_25 (PF13649.13), CMAS (PF02353.27), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19), TPMT (PF05724.18). | MTS Methyltransf_23 TehB Methyltransf_31 Ubie_methyltran Methyltransf_25 CMAS Methyltransf_11 Methyltransf_12 TPMT |
Resolved |
| Rv1378c Rv1378c |
- |
hypothetical protein | HNH endonuclease / nuclease of the 13E12-repeat family (eggNOG COG1403, COG category V), in an RD (DS6) context. HNH active-site motif; target undetermined. | DUF222 |
Family assigned |
| pyrR Rv1379 |
mtbc0_001480 |
bifunctional pyrimidine operon regulatory protein/uracil phosphoribosyltransferase | Bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR. Pfam: Pribosyltran (PF00156.34). | Pribosyltran |
Family assigned |