Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2644c Rv2644c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3azo-assembly2_B Crystal structure of puromycin hydrolase (prob 0.14, TM 0.69). | Still unknown | |
| Rv2645 Rv2645 |
mtbc0_002820 |
hypothetical protein | Immunodominant T-cell antigen encoded in region-of-difference RD13 (present in M. tuberculosis, absent from BCG and M. bovis); a cell-mediated-immunity-based diagnostic/vaccine antigen. Despite this immunological characterisation, its molecular/biochemical function remains unknown (verdict kept 'dark'). | Family assigned | |
| Rv2647 Rv2647 |
- |
hypothetical protein | Secreted virulence factor that inhibits macrophage pyroptosis by promoting NLRP3 ubiquitination/degradation. RefSeq leaves it 'hypothetical'. Rv2647 binds ISG15 and competitively inhibits ISGylation of NLRP3, enhancing its ubiquitination and degradation; this inactivates NLRP3-caspase-1-GSDMD, reduces IL-1beta and promotes Mtb survival (Jin 2025). | Resolved | |
| Rv2660c Rv2660c |
mtbc0_002834 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8pui-assembly1_A human PHOX2B C-terminal domain including the polyA fr (prob 0.02, TM 0.30). | Still unknown | |
| Rv2661c Rv2661c |
mtbc0_002835 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2662 Rv2662 |
mtbc0_002836 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2663 Rv2663 |
mtbc0_002837 |
hypothetical protein | BrnT/RelE-superfamily ribonuclease toxin and the toxin half of a HigBA-like module Rv2663-Rv2664 (toxin-first operon). Left 'hypothetical protein' by RefSeq, it is re-annotated here on three concordant lines of evidence: an ESMFold model matching a type II TA-complex toxin fold (Foldseek 7vd7, prob 1.00), MTBC-restricted operon synteny (Rv2664 11 bp downstream, 100% identity in M. bovis; no detectable M. canettii orthologue, i.e. a young MTBC-specific module), and an AlphaFold3 heterodimer with the antitoxin Rv2664 predicting a credible interface (inter-chain ipTM ~0.62). The complex is an in-silico prediction, not a biochemical assay. | Resolved | |
| Rv2664 Rv2664 |
mtbc0_002838 |
hypothetical protein | HTH/HigA-like antitoxin and the antitoxin half of the HigBA-like module Rv2663-Rv2664. RefSeq leaves it 'hypothetical protein' and single-structure search (Foldseek/ESMFold) failed to assign it (best hits non-significant). Profile-profile search (HHpred) confidently matches HigA-family ribbon-helix-helix/HTH antitoxins (probability ~99%), resolving a fold that structure search missed. Supported by operon synteny (immediately downstream of the toxin Rv2663, 100% identity in M. bovis) and by the AlphaFold3 heterodimer with Rv2663 (inter-chain ipTM ~0.62). | Resolved | |
| Rv2665 Rv2665 |
mtbc0_002839 |
hypothetical protein | Arginine RICH protein. | Resolved | |
| Rv2668 Rv2668 |
mtbc0_002842 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 3cfu-assembly1_A Crystal structure of the yjhA protein from Bacillus subtilis. N (prob 1.00, TM 0.61). Structure-based, putative. | Family assigned | |
| zapE Rv2670c |
mtbc0_002844 |
hypothetical protein | Cell division protein ZapE. Pfam: AFG1_ATPase (PF03969.23). | AFG1_ATPase |
Resolved |
| Rv2675c Rv2675c |
mtbc0_002849 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| hemQ Rv2676c |
mtbc0_002850 |
hypothetical protein | Hydrogen peroxide-dependent heme synthase. Pfam: Chlor_dismutase (PF06778.19). | Chlor_dismutase |
Resolved |
| Rv2680 Rv2680 |
mtbc0_002854 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3000. Function unknown. Foldseek best (non-significant) hit: 8any-assembly1_f Human mitochondrial ribosome in complex with LRPPRC, (prob 0.44, TM 0.39). | DUF3000 |
Still unknown |
| Rv2681 Rv2681 |
mtbc0_002855 |
hypothetical protein | Ribonuclease D. Pfam: DNA_pol_A_exo1 (PF01612.27), HRDC (PF00570.29), DNA_pol_A_exoN (PF18305.7). | DNA_pol_A_exo1 HRDC DNA_pol_A_exoN |
Resolved |
| Rv2683 Rv2683 |
- |
hypothetical protein | Contains CBS (PF00571.34) domain(s); putative function inferred from the domain architecture. | CBS |
Family assigned |
| Rv2689c Rv2689c |
mtbc0_002863 |
hypothetical protein | Class I SAM-dependent RNA methyltransferase. Pfam: TRAM (PF01938.27), tRNA_U5-meth_tr (PF05958.18). | TRAM tRNA_U5-meth_tr |
Resolved |
| Rv2694c Rv2694c |
mtbc0_002868 |
hypothetical protein | OB-fold nucleic acid binding domain-containing protein. | Family assigned | |
| Rv2695 Rv2695 |
mtbc0_002869 |
hypothetical protein | Alpha/beta fold hydrolase. | Resolved | |
| Rv2696c Rv2696c |
mtbc0_002870 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3710. Function unknown. | DUF3710 |
Still unknown |
| Rv2699c Rv2699c |
mtbc0_002873 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4193. Function unknown. | DUF4193 |
Still unknown |
| cei Rv2700 |
mtbc0_002874 |
hypothetical protein | Envelope integrity protein Cei. Pfam: LytR_C (PF13399.12). | LytR_C |
Resolved |
| Rv2704 Rv2704 |
mtbc0_002878 |
hypothetical protein | RidA family protein. Pfam: Ribonuc_L-PSP (PF01042.27). | Ribonuc_L-PSP |
Family assigned |
| Rv2705c Rv2705c |
mtbc0_002879 |
hypothetical protein | DUF952 domain-containing protein. | DUF952 |
Family assigned |
| Rv2706c Rv2706c |
mtbc0_002880 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2707 Rv2707 |
mtbc0_002881 |
hypothetical protein | YihY/virulence factor BrkB family protein. Pfam: Virul_fac_BrkB (PF03631.21). | Virul_fac_BrkB |
Family assigned |
| Rv2708c Rv2708c |
- |
hypothetical protein | Small zinc-ribbon / zinc-binding protein (structural zinc coordinated by a Cys-rich CxxC motif): three converging lines - HHpred top hit an uncharacterized zinc-binding protein (3RMQ, 96.5% E0.0076) plus a convergent zinc-finger/zinc-ribbon/metallochaperone theme (CPxCG zinc finger 8Q5B, RNA-polymerase Zn-ribbon subunits, hydrogenase-maturation factors HypF/HypA/HypE, LysW, rubredoxin); and the protein sequence itself carries a C-G-E-V-F...C-P-D-C-K-R motif consistent with zinc coordination. The specific molecular function is undetermined (candidate metallochaperone or nucleic-acid-binding zinc-ribbon). RefSeq leaves this locus uncharacterised. | DUF3039 |
Family assigned |
| Rv2712c Rv2712c |
mtbc0_002886 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4192. Function unknown. Foldseek best (non-significant) hit: 7ya9-assembly1_A-2 Fis1 (Mitochondrial fission 1 protein) (prob 0.99, TM 0.57). | DUF4192 |
Still unknown |
| Rv2714 Rv2714 |
mtbc0_002888 |
hypothetical protein | PAC2 family protein. Pfam: PAC2 (PF09754.16). | PAC2 |
Family assigned |
| Rv2716 Rv2716 |
mtbc0_002890 |
hypothetical protein | PhzF family phenazine biosynthesis protein. Pfam: PhzC-PhzF (PF02567.22). | PhzC-PhzF |
Family assigned |
| Rv2717c Rv2717c |
mtbc0_002891 |
hypothetical protein | FABP family protein. Pfam: THAP4_heme-bd (PF08768.18). | THAP4_heme-bd |
Family assigned |
| Rv2721c Rv2721c |
mtbc0_002895 |
hypothetical protein | LGFP repeat-containing protein. Pfam: LGFP (PF08310.18), ArfC (PF27542.1). | LGFP ArfC |
Family assigned |
| Rv2722 Rv2722 |
mtbc0_002896 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2728c Rv2728c |
mtbc0_002902 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5hee-assembly1_B Crystal structure of the TK2203 protein (prob 1.00, TM 0.73). Structure-based, putative. | Family assigned | |
| Rv2730 Rv2730 |
mtbc0_002904 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5ejw-assembly1_A Crystal structure of chromobox homolog 7 (CBX7) chrom (prob 0.01, TM 0.29). | Still unknown | |
| Rv2731 Rv2731 |
mtbc0_002905 |
hypothetical protein | Conserved protein with a strong STRING experimental association (score 788) to scpA (a segregation-and-condensation protein of the SMC/condensin chromosome-segregation complex), and itself part of a transcriptional regulon (second concordant channel). Contextual candidate: associated with chromosome segregation / condensation. Guilt-by-association, not an established function. | DUF349 |
Family assigned |
| Rv2734 Rv2734 |
mtbc0_002908 |
hypothetical protein | DUF5131 family protein. | DUF5131 |
Family assigned |
| Rv2735c Rv2735c |
mtbc0_002909 |
hypothetical protein | Three-Cys-motif partner protein TcmP. | Resolved | |
| Rv2738c Rv2738c |
mtbc0_002913 |
hypothetical protein | Psp-like envelope-stress system protein (paralogue of the Rv2742c Psp module). RefSeq leaves it 'hypothetical protein'. | DUF3046 |
Family assigned |
| Rv2742c Rv2742c |
- |
hypothetical protein | Component of the mycobacterial Psp-like (phage-shock-protein) envelope-stress system. RefSeq leaves it 'hypothetical'. Rv2742c belongs to a four-gene module (clgR-pspA[Rv2744c]-rv2743c-rv2742c) regulated by ClgR and required for envelope integrity, surface-stress tolerance, MprAB-sigmaE stress signalling and intramacrophage growth; the module is restricted to tuberculous mycobacteria (Datta 2015). | DUF3046 |
Resolved |
| Rv2743c Rv2743c |
mtbc0_002920 |
hypothetical protein | Contains Rv2743c (PF25587.2) domain(s); putative function inferred from the domain architecture. | Rv2743c |
Family assigned |
| 35kd_ag Rv2744c |
- |
hypothetical protein | Contains PspA_IM30 (PF04012.18) domain(s); putative function inferred from the domain architecture. | PspA_IM30 |
Family assigned |
| Rv2749 Rv2749 |
mtbc0_002926 |
hypothetical protein | Putative quinol monooxygenase. Pfam: ABM (PF03992.23). | ABM |
Family assigned |
| Rv2751 Rv2751 |
mtbc0_002928 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| Rv2762c Rv2762c |
mtbc0_002939 |
hypothetical protein | Winged helix-turn-helix domain-containing protein. | Family assigned | |
| Rv2771c Rv2771c |
mtbc0_002950 |
hypothetical protein | Flavodoxin family protein. | Family assigned | |
| Rv2774c Rv2774c |
mtbc0_002953 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8rrr-assembly1_E Alpha-synuclein amyloid fibril (prob 0.00, TM 0.13). | Still unknown | |
| Rv2777c Rv2777c |
mtbc0_002956 |
hypothetical protein | Metal-dependent hydrolase. Pfam: Metal_hydrol (PF10118.15). | Metal_hydrol |
Resolved |
| Rv2778c Rv2778c |
mtbc0_002957 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16). | Polyketide_cyc2 |
Family assigned |
| Rv2787 Rv2787 |
mtbc0_002966 |
hypothetical protein | AAA family ATPase. Pfam: T7SS_EccA1_N (PF21545.4), CbiA (PF01656.30). | T7SS_EccA1_N CbiA |
Family assigned |