Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1352 Rv1352 |
mtbc0_001452 |
hypothetical protein | Contains Rv1352 (PF27111.1) domain(s); putative function inferred from the domain architecture. | Rv1352 |
Family assigned |
| Rv1353c Rv1353c |
mtbc0_001453 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein. Pfam: TetR_N (PF00440.30), TetR_C_1 (PF02909.23). | TetR_N TetR_C_1 |
Family assigned |
| Rv1354c Rv1354c |
mtbc0_001454 |
hypothetical protein | Bifunctional diguanylate cyclase/phosphodiesterase. Pfam: GAF_2 (PF13185.13), GAF (PF01590.33), GGDEF (PF00990.27), EAL (PF00563.26). | GAF_2 GAF GGDEF EAL |
Resolved |
| moeY Rv1355c |
mtbc0_001455 |
molybdopterin biosynthesis protein MoeY | Rv1355c family protein. Pfam: ThiF (PF00899.28). | ThiF |
Family assigned |
| Rv1356c Rv1356c |
- |
hypothetical protein | TrzA: N-acyl amino acid transferase. N-acylates L-tryptophan (highest specificity for C5:0-CoA) in the trzAS cluster for N-acylated tryptazolone biosynthesis. RefSeq still annotates it hypothetical. | Resolved | |
| Rv1357c Rv1357c |
mtbc0_001457 |
hypothetical protein | Cyclic diguanylate phosphodiesterase. Pfam: EAL (PF00563.26). | EAL |
Resolved |
| Rv1358 Rv1358 |
mtbc0_001459 |
transcriptional regulator | LuxR C-terminal-related transcriptional regulator. Pfam: HTH_77 (PF25872.1), GerE (PF00196.26). | HTH_77 GerE |
Family assigned |
| Rv1359 Rv1359 |
- |
transcriptional regulator | Transcriptional regulator. | Family assigned | |
| Rv1360 Rv1360 |
mtbc0_001462 |
oxidoreductase | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| PPE19 Rv1361c |
- |
PPE family protein PPE19 | PPE family protein PPE19. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv1362c Rv1362c |
mtbc0_001464 |
membrane protein | IcmL/VirB8-like membrane-protein fold. RefSeq leaves it 'membrane protein'. The AlphaFold model superposes on an IcmL-like type-IV-secretion protein (PDB 5cnl; Foldseek prob 1.0, E 1e-4, TM 0.75); its neighbour Rv1363c shares a VirB8-periplasmic-domain fold (7q1v) and the two are mutual STRING partners. A membrane-associated secretion-system-like fold; no classical T4SS is annotated in M. tuberculosis. | Family assigned | |
| Rv1363c Rv1363c |
mtbc0_001465 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1364c Rv1364c |
- |
sigma factor regulatory protein | Sigma factor regulatory protein. Pfam: PAS_4 (PF08448.17), SpoIIE (PF07228.18), HATPase_c_2 (PF13581.13), STAS_2 (PF13466.13), STAS (PF01740.27). | PAS_4 SpoIIE HATPase_c_2 STAS_2 STAS |
Family assigned |
| rsfA Rv1365c |
mtbc0_001467 |
anti-sigma-F factor antagonist RsfA | Anti-sigma-F factor antagonist RsfA. Pfam: STAS (PF01740.27), STAS_2 (PF13466.13). | STAS STAS_2 |
Resolved |
| Rv1366 Rv1366 |
mtbc0_001468 |
hypothetical protein | GTP pyrophosphokinase family protein. Pfam: RelA_SpoT (PF04607.24). | RelA_SpoT |
Family assigned |
| Rv1366A Rv1366A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 9erv-assembly1_A Structure of Salmonella CapRel bound to Bas11 Gp54 (prob 0.30, TM 0.40). | Still unknown | |
| Rv1367c Rv1367c |
- |
hypothetical protein | Contains Beta-lactamase (PF00144.30) domain(s); putative function inferred from the domain architecture. | Beta-lactamase |
Family assigned |
| lprF Rv1368 |
mtbc0_001471 |
lipoprotein LprF | Lipoprotein LprF. Pfam: LppX_LprAFG (PF07161.20). | LppX_LprAFG |
Resolved |
| Rv1371 Rv1371 |
mtbc0_001472 |
membrane protein | Cytochrome b5 domain-containing protein. Pfam: Cyt-b5 (PF00173.34), FA_desaturase (PF00487.31). | Cyt-b5 FA_desaturase |
Family assigned |
| Rv1372 Rv1372 |
- |
alpha-pyrone synthesis polyketide synthase-like protein | Alpha-pyrone synthesis polyketide synthase-like protein. Pfam: Chal_sti_synt_N (PF00195.26), FAE1_CUT1_RppA (PF08392.19), ACP_syn_III (PF08545.17), Chal_sti_synt_C (PF02797.22), ACP_syn_III_C (PF08541.17). | Chal_sti_synt_N FAE1_CUT1_RppA ACP_syn_III Chal_sti_synt_C ACP_syn_III_C |
Family assigned |
| Rv1373 Rv1373 |
mtbc0_001474 |
glycolipid sulfotransferase | Glycolipid sulfotransferase. Pfam: Sulfotransfer_1 (PF00685.34). | Sulfotransfer_1 |
Resolved |
| Rv1374c Rv1374c |
mtbc0_001475 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7x75-assembly1_D Cryo-EM structure of Streptomyces coelicolor RNAP-pro (prob 0.04, TM 0.33). | Still unknown | |
| Rv1375 Rv1375 |
mtbc0_001476 |
hypothetical protein | YcaO-like family protein. Pfam: YcaO (PF02624.22). | YcaO |
Family assigned |
| Rv1376 Rv1376 |
mtbc0_001477 |
hypothetical protein | TfuA-like protein. Pfam: TfuA (PF07812.19). | TfuA |
Family assigned |
| Rv1377c Rv1377c |
mtbc0_001478 |
transferase | Class I SAM-dependent methyltransferase. Pfam: MTS (PF05175.21), Methyltransf_23 (PF13489.13), TehB (PF03848.21), Methyltransf_31 (PF13847.13), Ubie_methyltran (PF01209.25), Methyltransf_25 (PF13649.13), CMAS (PF02353.27), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19), TPMT (PF05724.18). | MTS Methyltransf_23 TehB Methyltransf_31 Ubie_methyltran Methyltransf_25 CMAS Methyltransf_11 Methyltransf_12 TPMT |
Resolved |
| Rv1378c Rv1378c |
- |
hypothetical protein | HNH endonuclease / nuclease of the 13E12-repeat family (eggNOG COG1403, COG category V), in an RD (DS6) context. HNH active-site motif; target undetermined. | DUF222 |
Family assigned |
| pyrR Rv1379 |
mtbc0_001480 |
bifunctional pyrimidine operon regulatory protein/uracil phosphoribosyltransferase | Bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR. Pfam: Pribosyltran (PF00156.34). | Pribosyltran |
Family assigned |
| pyrB Rv1380 |
mtbc0_001481 |
aspartate carbamoyltransferase | Aspartate carbamoyltransferase catalytic subunit. Pfam: OTCace_N (PF02729.27), OTCace (PF00185.31). | OTCace_N OTCace |
Family assigned |
| pyrC Rv1381 |
mtbc0_001482 |
dihydroorotase | Dihydroorotase. Pfam: DHOase (PF12890.14), Amidohydro_1 (PF01979.27). | DHOase Amidohydro_1 |
Resolved |
| Rv1382 Rv1382 |
mtbc0_001483 |
hypothetical protein | Transporter. Pfam: bPH_11 (PF25362.2). | bPH_11 |
Resolved |
| carA Rv1383 |
mtbc0_001484 |
carbamoyl-phosphate synthase small subunit | Glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit. Pfam: CPSase_sm_chain (PF00988.29), GATase (PF00117.35), Peptidase_C26 (PF07722.20). | CPSase_sm_chain GATase Peptidase_C26 |
Family assigned |
| carB Rv1384 |
- |
carbamoyl-phosphate synthase large subunit | Carbamoyl-phosphate synthase large subunit. Pfam: CPSase_L_D2 (PF02786.23), CPSase_L_D3 (PF02787.26), CPSase_L_D1 (PF25596.2), Dala_Dala_lig_C (PF07478.19), ATP-grasp (PF02222.28), MGS (PF02142.28). | CPSase_L_D2 CPSase_L_D3 CPSase_L_D1 Dala_Dala_lig_C ATP-grasp MGS |
Family assigned |
| pyrF Rv1385 |
mtbc0_001486 |
orotidine 5'-phosphate decarboxylase | Orotidine-5'-phosphate decarboxylase. Pfam: OMPdecase (PF00215.31). | OMPdecase |
Resolved |
| PE15 Rv1386 |
- |
PE family protein PE15 | PE family protein PE15. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PPE20 Rv1387 |
- |
PPE family protein PPE20 | PPE family protein PPE20. Pfam: PPE (PF00823.26), PPE-PPW (PF18878.6). | PPE PPE-PPW |
Family assigned |
| mihF Rv1388 |
- |
integration host factor MihF | Integration host factor MihF. Pfam: H2TH_5 (PF22525.2). | H2TH_5 |
Resolved |
| gmk Rv1389 |
mtbc0_001490 |
guanylate kinase | Guanylate kinase. Pfam: Guanylate_kin (PF00625.28). | Guanylate_kin |
Resolved |
| rpoZ Rv1390 |
mtbc0_001491 |
DNA-directed RNA polymerase subunit omega | DNA-directed RNA polymerase subunit omega. Pfam: RNA_pol_Rpb6 (PF01192.28). | RNA_pol_Rpb6 |
Family assigned |
| dfp Rv1391 |
mtbc0_001492 |
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC. Pfam: Flavoprotein (PF02441.25), DFP (PF04127.23). | Flavoprotein DFP |
Resolved |
| metK Rv1392 |
- |
S-adenosylmethionine synthetase | S-adenosylmethionine synthetase. Pfam: S-AdoMet_synt_N (PF00438.26), S-AdoMet_synt_M (PF02772.22), S-AdoMet_synt_C (PF02773.22). | S-AdoMet_synt_N S-AdoMet_synt_M S-AdoMet_synt_C |
Resolved |
| Rv1393c Rv1393c |
mtbc0_001494 |
monoxygenase | NAD(P)/FAD-dependent oxidoreductase. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox_3 (PF13738.13), NAD_binding_8 (PF13450.13), FMO-like (PF00743.26). | Pyr_redox_2 Pyr_redox_3 NAD_binding_8 FMO-like |
Resolved |
| cyp132 Rv1394c |
- |
cytochrome P450 Cyp132 | Cytochrome P450 Cyp132. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv1395 Rv1395 |
- |
HTH-type transcriptional regulator | HTH-type transcriptional regulator. Pfam: Arabinose_bd (PF12625.13), HTH_18 (PF12833.14). | Arabinose_bd HTH_18 |
Family assigned |
| PE_PGRS25 Rv1396c |
- |
PE-PGRS family protein PE_PGRS25 | PE-PGRS family protein PE_PGRS25. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| vapC10 Rv1397c |
mtbc0_001498 |
ribonuclease VapC10 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB10 Rv1398c |
mtbc0_001499 |
antitoxin VapB10 | CopG family transcriptional regulator. Pfam: RHH_5 (PF07878.18), RHH_1 (PF01402.28). | RHH_5 RHH_1 |
Family assigned |
| nlhH Rv1399c |
mtbc0_001500 |
carboxylesterase NlhH | Alpha/beta hydrolase. Pfam: BD-FAE (PF20434.6), COesterase (PF00135.35), Abhydrolase_3 (PF07859.20). | BD-FAE COesterase Abhydrolase_3 |
Family assigned |
| lipI Rv1400c |
mtbc0_001501 |
lipase | Alpha/beta hydrolase. Pfam: BD-FAE (PF20434.6), COesterase (PF00135.35), Abhydrolase_3 (PF07859.20). | BD-FAE COesterase Abhydrolase_3 |
Family assigned |
| Rv1401 Rv1401 |
- |
membrane protein | Membrane protein. Pfam: YhhN (PF07947.20). | YhhN |
Family assigned |
| priA Rv1402 |
- |
primosomal protein N' | Primosomal protein N'. Pfam: PriA_3primeBD (PF17764.7), PriA_C_2 (PF27106.1). | PriA_3primeBD PriA_C_2 |
Family assigned |