Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1575 Rv1575 |
- |
phage protein | Phage protein. | Resolved | |
| Rv1576c Rv1576c |
mtbc0_001683 |
phage capsid protein | Phage major capsid protein. | Resolved | |
| Rv1577c Rv1577c |
- |
phage prohead protease | Phage prohead protease. Pfam: Peptidase_S78 (PF04586.23). | Peptidase_S78 |
Resolved |
| Rv1578c Rv1578c |
mtbc0_001685 |
phage protein | Phage terminase small subunit P27 family. Pfam: Terminase_4 (PF05119.18). | Terminase_4 |
Family assigned |
| est12 Rv1579c |
mtbc0_001686 |
phage protein | EST12 (early secreted target, 12 kDa), a secreted effector encoded in region-of-difference RD3. RefSeq leaves it 'hypothetical'. Secreted EST12 binds the receptor for activated C kinase 1 (RACK1) and recruits the deubiquitinase UCHL5 to deubiquitinate NLRP3, triggering NLRP3-caspase-1-gasdermin-D pyroptosis and IL-1beta release; it also regulates Myc via RACK1-JNK-AP1. A crystal structure identifies Y80 as the RACK1-binding residue; ΔEST12 is more susceptible in vitro and in vivo (Qu 2020). | Resolved | |
| Rv1580c Rv1580c |
mtbc0_001687 |
phage protein | Prophage phiRv1 protein; serologically detectable antigen (M. bovis diagnostic serology). A prophage-encoded protein of unknown molecular function. | Family assigned | |
| Rv1581c Rv1581c |
mtbc0_001688 |
phage protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1582c Rv1582c |
mtbc0_001689 |
phage protein | Phage/plasmid primase%2C P4 family. Pfam: D5_N (PF08706.17), DUF5906 (PF19263.6). | D5_N DUF5906 |
Family assigned |
| Rv1583c Rv1583c |
mtbc0_001690 |
phage protein | Conserved hypothetical protein; DUF domain(s) DUF2742. Function unknown. | DUF2742 |
Still unknown |
| Rv1584c Rv1584c |
mtbc0_001691 |
phage protein | Prophage phiRv1 recombination-directionality factor (RDF/excisionase). RefSeq leaves it of unknown function. In the phiRv1 prophage-like element, the serine integrase Rv1586c catalyses integration/excision and the small basic Rv1584c protein controls the directionality of recombination (Bibb 2002). | Family assigned | |
| Rv1585c Rv1585c |
mtbc0_001692 |
phage protein | Prophage phiRv1 protein (within region-of-difference RD149). RefSeq leaves it of unknown function. Part of the phiRv1 prophage-like element, variably deleted in Beijing-lineage isolates (Stavrum 2008). Molecular function unknown. | Family assigned | |
| Rv1586c Rv1586c |
mtbc0_001693 |
phage integrase | Recombinase family protein. | Family assigned | |
| Rv1587c Rv1587c |
- |
hypothetical protein | HNH-family endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| Rv1588c Rv1588c |
- |
hypothetical protein | HNH-family endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V; description masked as 'DUF222'). HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| bioB Rv1589 |
mtbc0_001695 |
biotin synthetase | Biotin synthase BioB. Pfam: Radical_SAM (PF04055.28), BATS (PF06968.19). | Radical_SAM BATS |
Resolved |
| Rv1590 Rv1590 |
mtbc0_001696 |
hypothetical protein | Contains BsaP (PF26519.1) domain(s); putative function inferred from the domain architecture. | BsaP |
Family assigned |
| Rv1591 Rv1591 |
mtbc0_001697 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF2567. Function unknown. | DUF2567 |
Still unknown |
| Rv1592c Rv1592c |
mtbc0_001698 |
hypothetical protein | Lipase family protein. Pfam: LIP (PF03583.21). | LIP |
Family assigned |
| Rv1593c Rv1593c |
mtbc0_001699 |
hypothetical protein | NUDIX domain-containing protein. Pfam: NUDIX (PF00293.35), WHD_AraR (PF19368.6), WHD_NrtR (PF21906.3). | NUDIX WHD_AraR WHD_NrtR |
Family assigned |
| nadA Rv1594 |
- |
quinolinate synthetase A | Quinolinate synthetase A. Pfam: NadA (PF02445.22). | NadA |
Resolved |
| nadB Rv1595 |
mtbc0_001701 |
L-aspartate oxidase | L-aspartate oxidase. Pfam: FAD_binding_2 (PF00890.31), Succ_DH_flav_C (PF02910.26). | FAD_binding_2 Succ_DH_flav_C |
Resolved |
| nadC Rv1596 |
mtbc0_001702 |
nicotinate-nucleotide pyrophosphatase | Carboxylating nicotinate-nucleotide diphosphorylase. Pfam: QRPTase_N (PF02749.23), QRPTase_C (PF01729.26). | QRPTase_N QRPTase_C |
Resolved |
| Rv1597 Rv1597 |
mtbc0_001703 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_11 (PF08241.19). | Methyltransf_11 |
Family assigned |
| Rv1598c Rv1598c |
mtbc0_001704 |
hypothetical protein | Nitroreductase family deazaflavin-dependent oxidoreductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Family assigned |
| hisD Rv1599 |
mtbc0_001705 |
histidinol dehydrogenase | Histidinol dehydrogenase. Pfam: Histidinol_dh (PF00815.26). | Histidinol_dh |
Resolved |
| hisC1 Rv1600 |
- |
histidinol-phosphate aminotransferase | Histidinol-phosphate aminotransferase. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Resolved |
| hisB Rv1601 |
mtbc0_001707 |
imidazole glycerol-phosphate dehydratase | Imidazoleglycerol-phosphate dehydratase HisB. Pfam: IGPD (PF00475.25). | IGPD |
Resolved |
| hisH Rv1602 |
mtbc0_001708 |
imidazole glycerol phosphate synthase subunit HisH | Imidazole glycerol phosphate synthase subunit HisH. Pfam: GATase (PF00117.35). | GATase |
Family assigned |
| hisA Rv1603 |
mtbc0_001709 |
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase | Bifunctional 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase/phosphoribosylanthranilate isomerase PriA. Pfam: His_biosynth (PF00977.28). | His_biosynth |
Resolved |
| impA Rv1604 |
mtbc0_001710 |
inositol-monophosphatase ImpA | Inositol monophosphatase family protein. Pfam: Inositol_P (PF00459.31). | Inositol_P |
Family assigned |
| hisF Rv1605 |
mtbc0_001711 |
imidazole glycerol phosphate synthase subunit HisF | Imidazole glycerol phosphate synthase subunit HisF. Pfam: His_biosynth (PF00977.28). | His_biosynth |
Family assigned |
| hisI Rv1606 |
mtbc0_001712 |
phosphoribosyl-AMP cyclohydrolase | Phosphoribosyl-AMP cyclohydrolase. Pfam: PRA-CH (PF01502.24). | PRA-CH |
Resolved |
| chaA Rv1607 |
mtbc0_001713 |
ionic transporter integral membrane protein ChaA | Calcium:proton antiporter. Pfam: Na_Ca_ex (PF01699.30). | Na_Ca_ex |
Resolved |
| bcpB Rv1608c |
mtbc0_001714 |
peroxiredoxin | Peroxiredoxin BcpB. Pfam: Redoxin (PF08534.17), AhpC-TSA (PF00578.28). | Redoxin AhpC-TSA |
Resolved |
| trpE Rv1609 |
mtbc0_001715 |
anthranilate synthase component I | Anthranilate synthase component I. Pfam: Anth_synt_I_N (PF04715.20), Chorismate_bind (PF00425.25). | Anth_synt_I_N Chorismate_bind |
Resolved |
| Rv1610 Rv1610 |
mtbc0_001716 |
membrane protein | TIGR02234 family membrane protein. Pfam: Trp_oprn_chp (PF09534.16). | Trp_oprn_chp |
Family assigned |
| trpC Rv1611 |
mtbc0_001717 |
indole-3-glycerol phosphate synthase | Indole-3-glycerol phosphate synthase TrpC. Pfam: IGPS (PF00218.28). | IGPS |
Resolved |
| trpB Rv1612 |
- |
tryptophan synthase subunit beta | Tryptophan synthase subunit beta. Pfam: PALP (PF00291.32). | PALP |
Family assigned |
| trpA Rv1613 |
mtbc0_001719 |
tryptophan synthase subunit alpha | Tryptophan synthase subunit alpha. Pfam: Trp_syntA (PF00290.27). | Trp_syntA |
Family assigned |
| lgt Rv1614 |
mtbc0_001720 |
prolipoprotein diacylglyceryl transferase | Prolipoprotein diacylglyceryl transferase. Pfam: LGT (PF01790.24). | LGT |
Resolved |
| Rv1615 Rv1615 |
mtbc0_001722 |
membrane protein | TM2 domain-containing protein. Pfam: TM2 (PF05154.22). | TM2 |
Family assigned |
| Rv1616 Rv1616 |
mtbc0_001723 |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2752 |
Family assigned |
| pykA Rv1617 |
mtbc0_001724 |
pyruvate kinase | Pyruvate kinase. Pfam: PK (PF00224.28), PK_C (PF02887.22). | PK PK_C |
Resolved |
| tesB1 Rv1618 |
mtbc0_001725 |
acyl-CoA thioesterase II | Acyl-CoA thioesterase II. Pfam: 4HBT_3 (PF13622.13), Acyl_CoA_thio (PF02551.22), 4HBT_3C (PF20789.4). | 4HBT_3 Acyl_CoA_thio 4HBT_3C |
Resolved |
| Rv1619 Rv1619 |
mtbc0_001726 |
hypothetical protein | Bifunctional lysylphosphatidylglycerol flippase/synthetase MprF. Pfam: LPG_synthase_C (PF09924.16). | LPG_synthase_C |
Resolved |
| cydC Rv1620c |
mtbc0_001727 |
cytochrome biosyntheisis ABC transporter ATP-binding protein/permease CydC | Thiol reductant ABC exporter subunit CydC. Pfam: ABC_tran (PF00005.34). | ABC_tran |
Family assigned |
| cydD Rv1621c |
- |
cytochrome biosyntheisis ABC transporter ATP-binding protein/permease CydD | Cytochrome biosyntheisis ABC transporter ATP-binding protein/permease CydD. Pfam: ABC_membrane (PF00664.29), ABC_tran (PF00005.34). | ABC_membrane ABC_tran |
Family assigned |
| cydB Rv1622c |
mtbc0_001729 |
cytochrome D ubiquinol oxidase subunit II CydB | Cytochrome d ubiquinol oxidase subunit II. Pfam: Cyt_bd_oxida_II (PF02322.21). | Cyt_bd_oxida_II |
Family assigned |
| cydA Rv1623c |
- |
cytochrome D ubiquinol oxidase subunit I CydA | Cytochrome D ubiquinol oxidase subunit I CydA. Pfam: Cyt_bd_oxida_I (PF01654.23). | Cyt_bd_oxida_I |
Family assigned |
| Rv1624c Rv1624c |
mtbc0_001731 |
membrane protein | HdeD family acid-resistance protein. | DUF308 |
Family assigned |