Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| rpsG Rv0683 |
- |
30S ribosomal protein S7 | 30S ribosomal protein S7. Pfam: Ribosomal_S7 (PF00177.28). | Ribosomal_S7 |
Resolved |
| fusA1 Rv0684 |
- |
elongation factor G | Elongation factor G. Pfam: GTP_EFTU (PF00009.34), EF-G_D2 (PF22042.3), GTP_EFTU_D2 (PF03144.32), EFG_III (PF14492.13), EFG_IV (PF03764.25), EFG_C (PF00679.31). | GTP_EFTU EF-G_D2 GTP_EFTU_D2 EFG_III EFG_IV EFG_C |
Resolved |
| tuf Rv0685 |
- |
elongation factor Tu | Elongation factor Tu. Pfam: GTP_EFTU (PF00009.34), GTP_EFTU_D2 (PF03144.32), GTP_EFTU_D3 (PF03143.24). | GTP_EFTU GTP_EFTU_D2 GTP_EFTU_D3 |
Resolved |
| Rv0686 Rv0686 |
mtbc0_000725 |
membrane protein | SHOCT domain-containing protein. | Family assigned | |
| Rv0687 Rv0687 |
mtbc0_000726 |
NAD-dependent oxidoreductase | Rv0687 family mycofactocin-dependent SDR oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv0688 Rv0688 |
mtbc0_000727 |
ferredoxin reductase | FAD/NAD(P)-binding oxidoreductase. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox (PF00070.34), Reductase_C (PF14759.13). | Pyr_redox_2 Pyr_redox Reductase_C |
Resolved |
| Rv0689c Rv0689c |
- |
hypothetical protein | eggNOG ortholog of COG3324 (amino-acid-metabolism COG category E), annotated with translation-initiation-factor-related GO activity. RefSeq leaves it 'hypothetical protein'. A weak, GO-level functional transfer; treated as a family hint only. | Family assigned | |
| Rv0690c Rv0690c |
mtbc0_000730 |
hypothetical protein | Class I (Rossmann-fold) S-adenosyl-L-methionine (SAM)-dependent methyltransferase: HHpred returns 25/25 hits to SAM-MTases (convergent, best 73%) and the protein is soluble (DeepTMHMM GLOB, 0 TM). It lies adjacent to the mycofactocin (MFT) biosynthesis operon (mftABC...) and is STRING-linked to all mft genes, BUT it is NOT the mycofactocin methyltransferase: M. tuberculosis does NOT methylate mycofactocin, and the characterised MftM is the distal, non-operonic MSMEG_6237 of M. smegmatis (Pena-Ortiz 2022). The methyl-acceptor substrate of Rv0690c is undetermined. | DUF2332 |
Family assigned |
| Rv0691A Rv0691A |
- |
mycofactocin precursor | Mycofactocin precursor. Pfam: MftA (PF23709.2). | MftA |
Resolved |
| mftR Rv0691c |
mtbc0_000731 |
mycofactocin biosynthesis transcriptional regulator MftR | Mycofactocin system transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_14 (PF17754.7). | TetR_N TetR_C_14 |
Family assigned |
| mftB Rv0692 |
mtbc0_000733 |
mycofactocin system protein MftB | Mycofactocin biosynthesis chaperone MftB. Pfam: MftB_chaperone (PF26520.1). | MftB_chaperone |
Resolved |
| mftC Rv0693 |
mtbc0_000734 |
mycofactocin radical SAM maturase MftC | Mycofactocin radical SAM maturase. Pfam: Radical_SAM (PF04055.28), SPASM (PF13186.12). | Radical_SAM SPASM |
Resolved |
| mftD Rv0694 |
mtbc0_000735 |
mycofactocin system heme/flavin oxidoreductase MftD | Pre-mycofactocin synthase MftD. Pfam: FMN_dh (PF01070.25), IMPDH (PF00478.32), Glu_synthase (PF01645.24). | FMN_dh IMPDH Glu_synthase |
Resolved |
| mftE Rv0695 |
mtbc0_000736 |
mycofactocin system creatinine amidohydrolase family protein MftE | Mycofactocin biosynthesis peptidyl-dipeptidase MftE. Pfam: Creatininase (PF02633.20). | Creatininase |
Resolved |
| mftF Rv0696 |
mtbc0_000737 |
mycofactocin biosynthesis glycosyltransferase MftF | Mycofactocin biosynthesis glycosyltransferase MftF. Pfam: Glyco_tranf_2_3 (PF13641.13), Glycos_transf_2 (PF00535.33), Glyco_tranf_2_2 (PF10111.15), Glyco_trans_2_3 (PF13632.13). | Glyco_tranf_2_3 Glycos_transf_2 Glyco_tranf_2_2 Glyco_trans_2_3 |
Resolved |
| mftG Rv0697 |
mtbc0_000738 |
dehydrogenase | Mycofactocin system GMC family oxidoreductase MftG. Pfam: GMC_oxred_N (PF00732.26), GMC_oxred_C (PF05199.20). | GMC_oxred_N GMC_oxred_C |
Family assigned |
| Rv0698 Rv0698 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0699 Rv0699 |
mtbc0_000740 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| rpsJ Rv0700 |
- |
30S ribosomal protein S10 | 30S ribosomal protein S10. Pfam: Ribosomal_S10 (PF00338.28). | Ribosomal_S10 |
Resolved |
| rplC Rv0701 |
mtbc0_000743 |
50S ribosomal protein L3 | 50S ribosomal protein L3. Pfam: Ribosomal_L3 (PF00297.29). | Ribosomal_L3 |
Resolved |
| rplD Rv0702 |
mtbc0_000744 |
50S ribosomal protein L4 | 50S ribosomal protein L4. Pfam: Ribosomal_L4 (PF00573.28). | Ribosomal_L4 |
Resolved |
| rplW Rv0703 |
mtbc0_000745 |
50S ribosomal protein L23 | 50S ribosomal protein L23. Pfam: Ribosomal_L23 (PF00276.26). | Ribosomal_L23 |
Resolved |
| rplB Rv0704 |
mtbc0_000746 |
50S ribosomal protein L2 | 50S ribosomal protein L2. Pfam: Ribosomal_L2_N (PF00181.31), Ribosomal_L2_C (PF03947.25). | Ribosomal_L2_N Ribosomal_L2_C |
Resolved |
| rpsS Rv0705 |
mtbc0_000747 |
30S ribosomal protein S19 | 30S ribosomal protein S19. Pfam: Ribosomal_S19 (PF00203.27). | Ribosomal_S19 |
Resolved |
| rplV Rv0706 |
mtbc0_000748 |
50S ribosomal protein L22 | 50S ribosomal protein L22. Pfam: Ribosomal_L22 (PF00237.25). | Ribosomal_L22 |
Resolved |
| rpsC Rv0707 |
mtbc0_000749 |
30S ribosomal protein S3 | 30S ribosomal protein S3. Pfam: KH_2 (PF07650.24), Ribosomal_S3_C (PF00189.26). | KH_2 Ribosomal_S3_C |
Resolved |
| rplP Rv0708 |
mtbc0_000750 |
50S ribosomal protein L16 | 50S ribosomal protein L16. Pfam: Ribosomal_L16 (PF00252.25). | Ribosomal_L16 |
Resolved |
| rpmC Rv0709 |
mtbc0_000751 |
50S ribosomal protein L29 | 50S ribosomal protein L29. Pfam: Ribosomal_L29 (PF00831.29). | Ribosomal_L29 |
Resolved |
| rpsQ Rv0710 |
mtbc0_000752 |
30S ribosomal protein S17 | 30S ribosomal protein S17. Pfam: Ribosomal_S17 (PF00366.27). | Ribosomal_S17 |
Resolved |
| atsA Rv0711 |
mtbc0_000753 |
arylsulfatase AtsA | Arylsulfatase AtsA. Pfam: Sulfatase (PF00884.29). | Sulfatase |
Resolved |
| Rv0712 Rv0712 |
mtbc0_000754 |
hypothetical protein | Formylglycine-generating enzyme family protein. Pfam: FGE-sulfatase (PF03781.23). | FGE-sulfatase |
Family assigned |
| Rv0713 Rv0713 |
mtbc0_000755 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF4436. Function unknown. | DUF4436 |
Still unknown |
| rplN Rv0714 |
- |
50S ribosomal protein L14 | 50S ribosomal protein L14. Pfam: Ribosomal_L14 (PF00238.25). | Ribosomal_L14 |
Resolved |
| rplX Rv0715 |
mtbc0_000757 |
50S ribosomal protein L24 | 50S ribosomal protein L24. Pfam: KOW (PF00467.36), ribosomal_L24 (PF17136.11). | KOW ribosomal_L24 |
Resolved |
| rplE Rv0716 |
mtbc0_000758 |
50S ribosomal protein L5 | 50S ribosomal protein L5. Pfam: Ribosomal_L5 (PF00281.25), Ribosomal_L5_C (PF00673.27). | Ribosomal_L5 Ribosomal_L5_C |
Resolved |
| rpsN1 Rv0717 |
- |
30S ribosomal protein S14 | 30S ribosomal protein S14. Pfam: Ribosomal_S14 (PF00253.28). | Ribosomal_S14 |
Resolved |
| rpsH Rv0718 |
- |
30S ribosomal protein S8 | 30S ribosomal protein S8. Pfam: Ribosomal_S8 (PF00410.25). | Ribosomal_S8 |
Resolved |
| rplF Rv0719 |
- |
50S ribosomal protein L6 | 50S ribosomal protein L6. Pfam: Ribosomal_L6 (PF00347.29). | Ribosomal_L6 |
Resolved |
| rplR Rv0720 |
mtbc0_000762 |
50S ribosomal protein L18 | 50S ribosomal protein L18. Pfam: Ribosomal_L18p (PF00861.28). | Ribosomal_L18p |
Resolved |
| rpsE Rv0721 |
mtbc0_000763 |
30S ribosomal protein S5 | 30S ribosomal protein S5. Pfam: Ribosomal_S5 (PF00333.27), Ribosomal_S5_C (PF03719.22). | Ribosomal_S5 Ribosomal_S5_C |
Resolved |
| rpmD Rv0722 |
mtbc0_000764 |
50S ribosomal protein L30 | 50S ribosomal protein L30. Pfam: Ribosomal_L30 (PF00327.26). | Ribosomal_L30 |
Resolved |
| rplO Rv0723 |
mtbc0_000765 |
50S ribosomal protein L15 | 50S ribosomal protein L15. Pfam: Ribosomal_L27A (PF00828.26). | Ribosomal_L27A |
Resolved |
| sppA Rv0724 |
- |
protease IV SppA | Protease IV SppA. Pfam: Peptidase_S49 (PF01343.24). | Peptidase_S49 |
Resolved |
| Rv0724A Rv0724A |
|
Conserved hypothetical protein | Candidate S-adenosyl-L-methionine-dependent methyltransferase: the AlphaFold model matches the solved Mtb methyltransferase Rv0731c (TM 0.90) and M. leprae ML2640 (TM 0.74), concordant with the unreviewed UniProt name and the eggNOG description. Putative — fold-level and orthology-level only, no Pfam domain above threshold, no verified catalytic site, no publication. | Family assigned | |
| Rv0725c Rv0725c |
- |
hypothetical protein | Contains LCM (PF04072.21) domain(s); putative function inferred from the domain architecture. | LCM |
Family assigned |
| Rv0726c Rv0726c |
mtbc0_000768 |
S-adenosylmethionine-dependent methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| fucA Rv0727c |
mtbc0_000769 |
L-fuculose phosphate aldolase FucA | L-fuculose-phosphate aldolase. Pfam: Aldolase_II (PF00596.28). | Aldolase_II |
Resolved |
| serA2 Rv0728c |
mtbc0_000770 |
D-3-phosphoglycerate dehydrogenase SerA | D-3-phosphoglycerate dehydrogenase SerA. Pfam: 2-Hacid_dh (PF00389.37), 2-Hacid_dh_C (PF02826.26). | 2-Hacid_dh 2-Hacid_dh_C |
Resolved |
| xylB Rv0729 |
mtbc0_000771 |
D-xylulose kinase XylB | FGGY-family carbohydrate kinase. Pfam: FGGY_N (PF00370.28), FGGY_C (PF02782.23). | FGGY_N FGGY_C |
Resolved |
| Rv0730 Rv0730 |
- |
GCN5-like N-acetyltransferase | GCN5-like N-acetyltransferase. Pfam: Acetyltransf_3 (PF13302.14), Acetyltransf_1 (PF00583.32). | Acetyltransf_3 Acetyltransf_1 |
Resolved |