MTBC Gene Atlas

Genes

1086 genes matched.

GeneMTBC0Legacy (H37Rv)MTBC0 PGAP / revisedPfamVerdict
Rv1716
Rv1716		 - hypothetical protein Contains Cyclase (PF04199.20) domain(s); putative function inferred from the domain architecture. Cyclase Family assigned
Rv1717
Rv1717		 mtbc0_001827 hypothetical protein Cupin domain-containing protein. Pfam: Cupin_2 (PF07883.18). Cupin_2 Family assigned
Rv1718
Rv1718		 mtbc0_001828 hypothetical protein 3-keto-5-aminohexanoate cleavage protein. Pfam: BKACE (PF05853.19). BKACE Resolved
Rv1724c
Rv1724c		 mtbc0_001836 hypothetical protein Conserved hypothetical; Foldseek hits non-conclusive (moderate TM). Function unknown. Still unknown
Rv1725c
Rv1725c		 mtbc0_001837 hypothetical protein Winged helix-turn-helix transcriptional regulator. Pfam: HxlR (PF01638.24). HxlR Family assigned
Rv1727
Rv1727		 mtbc0_001839 hypothetical protein TIGR03086 family metal-binding protein. Pfam: MDMPI_N (PF11716.14). MDMPI_N Family assigned
Rv1728c
Rv1728c		 mtbc0_001840 hypothetical protein Glycoside hydrolase. Pfam: VldE (PF26571.1). VldE Resolved
Rv1732c
Rv1732c		 mtbc0_001844 hypothetical protein Thioredoxin family protein. Pfam: AhpC-TSA (PF00578.28), Redoxin (PF08534.17). AhpC-TSA Redoxin Family assigned
Rv1734c
Rv1734c		 - hypothetical protein Contains 2-oxoacid_dh (PF00198.29) domain(s); putative function inferred from the domain architecture. 2-oxoacid_dh Family assigned
Rv1735a
Rv1735a		 - hypothetical protein C4-dicarboxylate / malic-acid transporter family membrane protein (eggNOG COG1275, TDT/DASS-like; COG category P). Short ORF (partial); transported solute undetermined. Family assigned
Rv1738
Rv1738		 mtbc0_001851 hypothetical protein DUF1876 domain-containing protein. Pfam: Rv2632c-like (PF08962.17). Rv2632c-like Family assigned
Rv1742
Rv1742		 mtbc0_001855 hypothetical protein LolA-superfamily fold (lipoprotein / lipid carrier-like beta-barrel). RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on a LolA-superfamily protein (PDB 3buu; Foldseek prob 1.0, E 3e-8, TM 0.57). STRING context: the toxin vapC34 (Rv1741). A carrier/periplasmic-binding fold; the cargo is undemonstrated. Family assigned
Rv1748
Rv1748		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6rf0-assembly1_C Crystal structure of the light-driven sodium pump KR2 (prob 0.20, TM 0.32). Still unknown
Rv1752
Rv1752		 - hypothetical protein Contains GFO_IDH_MocA_C3 (PF22725.2) domain(s); putative function inferred from the domain architecture. GFO_IDH_MocA_C3 Family assigned
Rv1754c
Rv1754c		 mtbc0_001867 hypothetical protein AraH1: endo-D-arabinanase of glycoside hydrolase family GH183 (Pfam DUF4185). With AraH2 (Rv3707c), cleaves the D-arabinan of arabinogalactan/lipoarabinomannan, with a distinct substrate preference; involved in mycobacterial cell-wall modification/degradation. DUF4185 Resolved
Rv1761c
Rv1761c		 mtbc0_001876 hypothetical protein DUF5073 family protein. DUF5073 Family assigned
Rv1762c
Rv1762c		 mtbc0_001877 hypothetical protein Heavy metal-binding domain-containing protein. Pfam: YbjQ_1 (PF01906.24). YbjQ_1 Family assigned
Rv1765c
Rv1765c		 - hypothetical protein Contains DUF222 (PF02720.23), HNH (PF01844.30) domain(s); putative function inferred from the domain architecture. DUF222 HNH Family assigned
Rv1766
Rv1766		 mtbc0_001880 hypothetical protein Metal-sensitive transcriptional regulator. Pfam: Trns_repr_metal (PF02583.23). Trns_repr_metal Family assigned
Rv1767
Rv1767		 mtbc0_001881 hypothetical protein Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). CMD Family assigned
Rv1769
Rv1769		 mtbc0_001883 hypothetical protein Putative PLP-dependent enzyme of the alanine-racemase (fold type III) superfamily: the closest structural matches are D-threonine aldolases (TM 0.81, PDB 4v15/7dib) and eggNOG reports an 'alanine racemase, N-terminal domain'. A deaminase/aldolase activity is a fold-level inference — no catalytic site verified. The locus appears in the TB literature only as a vaccine or diagnostic ANTIGEN candidate (3 papers), never functionally. Resolved
Rv1770
Rv1770		 - hypothetical protein Contains Peptidase_M28 (PF04389.23) domain(s); putative function inferred from the domain architecture. Peptidase_M28 Family assigned
Rv1772
Rv1772		 mtbc0_001886 hypothetical protein ANTAR domain-containing protein. Pfam: ANTAR (PF03861.20). ANTAR Family assigned
Rv1775
Rv1775		 mtbc0_001889 hypothetical protein Contains DAPG_hydrolase (PF18089.8) domain(s); putative function inferred from the domain architecture. DAPG_hydrolase Family assigned
Rv1778c
Rv1778c		 mtbc0_001892 hypothetical protein Conserved hypothetical protein of 149 aa whose single domain, DUF6941 (PF22091, residues 5-130), belongs to Pfam clan CL0159 (E-set, immunoglobulin-like fold). Function unknown. What is established is an architectural oddity rather than an activity: in H37Rv every other cytoplasmic E-set domain is an accessory module inside a large enzyme (366-1215 aa: bglS, alpha-mannosidase, ceramidase, glgE, glgP, malQ, pepN), whereas here the Ig-like domain is the entire protein, and Pfam describes DUF6941 itself as a family of uncharacterised bacterial proteins sharing similarity with the Ig-like modules of xylosyltransferases, alkylpurine DNA glycosylases and cycloisomaltooligosaccharide glucanotransferases. The domain leaves no N-terminal room for a signal peptide, so the predicted cytoplasmic localisation is constrained by the architecture and not only by DeepTMHMM - which makes the nearest structural analogues found by Foldseek (RbmA, the Vibrio cholerae biofilm scaffolding protein; complement C3) informative as folds but misleading as compartments, both being extracellular adhesion/matrix Ig-folds. No paralogue carries DUF6941 elsewhere in H37Rv. Non-essential (NE), not vulnerable (CRISPRi VI +1.56), genus-restricted (deepest homolog within Mycobacterium), and never mentioned in the literature. DUF6941 Still unknown
Rv1780
Rv1780		 mtbc0_001894 hypothetical protein BPI/SPLUNC1-like lipid-binding fold (PDB 5I7L); putative lipid-binding protein. Family assigned
Rv1794
Rv1794		 mtbc0_001907 hypothetical protein ESX secretion-associated protein EspG. Pfam: ESX-1_EspG (PF14011.12). ESX-1_EspG Family assigned
Rv1804c
Rv1804c		 mtbc0_001917 hypothetical protein Secreted protein that activates macrophage pro-inflammatory responses by binding the host IkappaB-alpha PEST domain. RefSeq leaves it 'hypothetical'. Highly conserved secretory Rv1804c directly interacts with the PEST domain of IkappaB-alpha, activating it in an IKKalpha-independent manner; it inhibits mycobacterial survival and is enriched in attenuated rather than virulent strains (Zheng 2024). Also an antibody-eliciting antigen in active TB (Ben Amor 2005). DUF732 Resolved
Rv1805c
Rv1805c		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv1810
Rv1810		 - hypothetical protein Secreted protein of the mycobacterial DUF732 family. All-vs-all structural clustering (Foldseek on ESMFold models, phase36) places it in a tight fold family (median TM-score 0.67) that includes the characterised host-directed effectors Rv1804c (sequesters host IkappaB-alpha) and Rv3354 (targets the host COP9 signalosome), plus the secreted antigen Rv1271c. It shares the family's N-terminal signal peptide (DeepTMHMM) and the ~110-aa secreted fold. A host-interaction / secreted-effector role is therefore plausible, but the specific molecular target of THIS member is not experimentally established (the DUF732 family is functionally heterogeneous). DUF732 Family assigned
Rv1813c
Rv1813c		 mtbc0_001925 hypothetical protein DUF4189; structure solved (PDB 7NHZ, Rv1813c); secreted DUF4189-family protein. DUF4189 Family assigned
Rv1815
Rv1815		 mtbc0_001927 hypothetical protein Protease-like fold (L5 protease, PDB 5MRT); putative peptidase. Family assigned
Rv1823
Rv1823		 mtbc0_001937 hypothetical protein Small coiled-coil membrane protein, candidate divisome / cell-division-associated component (FtsB/FtsL-like); paralog of the uncharacterized Rv1825; coiled-coil fold limits confidence RefSeq leaves this locus uncharacterised. DUF881 Family assigned
Rv1824
Rv1824		 mtbc0_001938 hypothetical protein Small basic family protein. DUF1290 Family assigned
Rv1825
Rv1825		 mtbc0_001939 hypothetical protein Divisome / cell-division-associated coiled-coil membrane protein (DUF881 family, FtsB/FtsL-like): a single-pass (1-TM) membrane protein with a coiled-coil, structurally solved (PDB 3GMG, annotated unknown-function). HHpred converges on divisome components above the coiled-coil de-novo noise: Cg1604 (cell-division peptidoglycan-hydrolysis regulator) 96.5% E0.18, FtsB/FtsL 96% E0.1-0.2, ZapB, MreC, MctB. Paralog of Rv1823 (also a divisome candidate) and STRING-linked to it (921) plus Rv0012/pgsA2 (cell-division/membrane context). Candidate component of the M. tuberculosis septal/cell-division machinery, possibly coordinating peptidoglycan hydrolysis; precise role undetermined. RefSeq leaves this locus uncharacterised. DUF881 Family assigned
Rv1829
Rv1829		 - hypothetical protein Contains BFN_dom (PF02577.20) domain(s); putative function inferred from the domain architecture. BFN_dom Family assigned
Rv1831
Rv1831		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv1836c
Rv1836c		 mtbc0_001949 hypothetical protein Substrate-binding domain-containing protein. Pfam: SBP_bac_11 (PF13531.12). SBP_bac_11 Family assigned
Rv1841c
Rv1841c		 mtbc0_001954 hypothetical protein Hemolysin family protein. Pfam: CNNM (PF01595.26), CBS (PF00571.34). CNNM CBS Family assigned
Rv1842c
Rv1842c		 mtbc0_001955 hypothetical protein Hemolysin family protein. Pfam: CNNM (PF01595.26), CBS (PF00571.34), CorC_HlyC (PF03471.23). CNNM CBS CorC_HlyC Family assigned
apa
Rv1860		 - hypothetical protein Contains FAP (PF07174.18) domain(s); putative function inferred from the domain architecture. FAP Family assigned
Rv1864c
Rv1864c		 - hypothetical protein Contains MOSC (PF03473.24) domain(s); putative function inferred from the domain architecture. MOSC Family assigned
Rv1866
Rv1866		 - hypothetical protein Contains CoA_transf_3 (PF02515.23) domain(s); putative function inferred from the domain architecture. CoA_transf_3 Family assigned
Rv1867
Rv1867		 mtbc0_001980 hypothetical protein Acetyl-CoA acetyltransferase. Pfam: TLP1_add_C (PF18313.8). TLP1_add_C Resolved
Rv1868
Rv1868		 mtbc0_001981 hypothetical protein NAD(P)H-binding protein. Pfam: Rph_4th (PF27448.1). Rph_4th Family assigned
Rv1870c
Rv1870c		 - hypothetical protein No Pfam domain above threshold; Foldseek indicates a fold similar to 4uob-assembly1_A Crystal structure of Deinococcus radiodurans Endonuclease III-3 (prob 1.00, TM 0.56). Structure-based, putative. Family assigned
Rv1871c
Rv1871c		 mtbc0_001984 hypothetical protein Nitroreductase family deazaflavin-dependent oxidoreductase. Pfam: F420H2_quin_red (PF04075.21). F420H2_quin_red Family assigned
Rv1873
Rv1873		 mtbc0_001986 hypothetical protein Conserved hypothetical protein with an X-ray crystal structure at 1.38 A: a 16.2 kDa monomer adopting a primarily alpha-helical fold with limited similarity to known structures (COG5579). Not a novel fold but a model for sequence-related orthologues. Function unknown. (The UniProt auto-name 'Calpastatin' is a database artefact and is not adopted.) DUF1810 Family assigned
Rv1874
Rv1874		 - hypothetical protein No Pfam domain above threshold; Foldseek indicates a fold similar to 2ftr-assembly1_B Crystal structure of an ethyl tert-butyl ether d (ethd) family (prob 1.00, TM 0.62). Structure-based, putative. Family assigned
Rv1875
Rv1875		 mtbc0_001988 hypothetical protein PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28). PNPOx_N Resolved