Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1748 Rv1748 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6rf0-assembly1_C Crystal structure of the light-driven sodium pump KR2 (prob 0.20, TM 0.32). | Still unknown | |
| Rv1752 Rv1752 |
- |
hypothetical protein | Contains GFO_IDH_MocA_C3 (PF22725.2) domain(s); putative function inferred from the domain architecture. | GFO_IDH_MocA_C3 |
Family assigned |
| Rv1754c Rv1754c |
mtbc0_001867 |
hypothetical protein | AraH1: endo-D-arabinanase of glycoside hydrolase family GH183 (Pfam DUF4185). With AraH2 (Rv3707c), cleaves the D-arabinan of arabinogalactan/lipoarabinomannan, with a distinct substrate preference; involved in mycobacterial cell-wall modification/degradation. | DUF4185 |
Resolved |
| Rv1761c Rv1761c |
mtbc0_001876 |
hypothetical protein | DUF5073 family protein. | DUF5073 |
Family assigned |
| Rv1762c Rv1762c |
mtbc0_001877 |
hypothetical protein | Heavy metal-binding domain-containing protein. Pfam: YbjQ_1 (PF01906.24). | YbjQ_1 |
Family assigned |
| Rv1765c Rv1765c |
- |
hypothetical protein | Contains DUF222 (PF02720.23), HNH (PF01844.30) domain(s); putative function inferred from the domain architecture. | DUF222 HNH |
Family assigned |
| Rv1766 Rv1766 |
mtbc0_001880 |
hypothetical protein | Metal-sensitive transcriptional regulator. Pfam: Trns_repr_metal (PF02583.23). | Trns_repr_metal |
Family assigned |
| Rv1767 Rv1767 |
mtbc0_001881 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| Rv1769 Rv1769 |
mtbc0_001883 |
hypothetical protein | Amino acid deaminase/aldolase. | Resolved | |
| Rv1770 Rv1770 |
- |
hypothetical protein | Contains Peptidase_M28 (PF04389.23) domain(s); putative function inferred from the domain architecture. | Peptidase_M28 |
Family assigned |
| Rv1772 Rv1772 |
mtbc0_001886 |
hypothetical protein | ANTAR domain-containing protein. Pfam: ANTAR (PF03861.20). | ANTAR |
Family assigned |
| Rv1775 Rv1775 |
mtbc0_001889 |
hypothetical protein | Contains DAPG_hydrolase (PF18089.8) domain(s); putative function inferred from the domain architecture. | DAPG_hydrolase |
Family assigned |
| Rv1778c Rv1778c |
mtbc0_001892 |
hypothetical protein | Conserved hypothetical; Foldseek best hit (RbmA, TM 0.38) not conclusive. Function unknown. | DUF6941 |
Still unknown |
| Rv1780 Rv1780 |
mtbc0_001894 |
hypothetical protein | BPI/SPLUNC1-like lipid-binding fold (PDB 5I7L); putative lipid-binding protein. | Family assigned | |
| Rv1794 Rv1794 |
mtbc0_001907 |
hypothetical protein | ESX secretion-associated protein EspG. Pfam: ESX-1_EspG (PF14011.12). | ESX-1_EspG |
Family assigned |
| Rv1804c Rv1804c |
mtbc0_001917 |
hypothetical protein | Secreted protein that activates macrophage pro-inflammatory responses by binding the host IkappaB-alpha PEST domain. RefSeq leaves it 'hypothetical'. Highly conserved secretory Rv1804c directly interacts with the PEST domain of IkappaB-alpha, activating it in an IKKalpha-independent manner; it inhibits mycobacterial survival and is enriched in attenuated rather than virulent strains (Zheng 2024). Also an antibody-eliciting antigen in active TB (Ben Amor 2005). | DUF732 |
Resolved |
| Rv1805c Rv1805c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1810 Rv1810 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF732. Function unknown. Foldseek best (non-significant) hit: 2jps-assembly1_A NAB2 N-terminal domain (prob 0.20, TM 0.52). | DUF732 |
Still unknown |
| Rv1813c Rv1813c |
mtbc0_001925 |
hypothetical protein | DUF4189; structure solved (PDB 7NHZ, Rv1813c); secreted DUF4189-family protein. | DUF4189 |
Family assigned |
| Rv1815 Rv1815 |
mtbc0_001927 |
hypothetical protein | Protease-like fold (L5 protease, PDB 5MRT); putative peptidase. | Family assigned | |
| Rv1823 Rv1823 |
mtbc0_001937 |
hypothetical protein | Small coiled-coil membrane protein, candidate divisome / cell-division-associated component (FtsB/FtsL-like); paralog of the uncharacterized Rv1825; coiled-coil fold limits confidence RefSeq leaves this locus uncharacterised. | DUF881 |
Family assigned |
| Rv1824 Rv1824 |
mtbc0_001938 |
hypothetical protein | Small basic family protein. | DUF1290 |
Family assigned |
| Rv1825 Rv1825 |
mtbc0_001939 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF881. Function unknown. Foldseek best (non-significant) hit: 3gmg-assembly1_B Crystal structure of an uncharacterized conserved pro (prob 1.00, TM 0.93). | DUF881 |
Still unknown |
| Rv1829 Rv1829 |
- |
hypothetical protein | Contains BFN_dom (PF02577.20) domain(s); putative function inferred from the domain architecture. | BFN_dom |
Family assigned |
| Rv1831 Rv1831 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1836c Rv1836c |
mtbc0_001949 |
hypothetical protein | Substrate-binding domain-containing protein. Pfam: SBP_bac_11 (PF13531.12). | SBP_bac_11 |
Family assigned |
| Rv1841c Rv1841c |
mtbc0_001954 |
hypothetical protein | Hemolysin family protein. Pfam: CNNM (PF01595.26), CBS (PF00571.34). | CNNM CBS |
Family assigned |
| Rv1842c Rv1842c |
mtbc0_001955 |
hypothetical protein | Hemolysin family protein. Pfam: CNNM (PF01595.26), CBS (PF00571.34), CorC_HlyC (PF03471.23). | CNNM CBS CorC_HlyC |
Family assigned |
| apa Rv1860 |
- |
hypothetical protein | Contains FAP (PF07174.18) domain(s); putative function inferred from the domain architecture. | FAP |
Family assigned |
| Rv1864c Rv1864c |
- |
hypothetical protein | Contains MOSC (PF03473.24) domain(s); putative function inferred from the domain architecture. | MOSC |
Family assigned |
| Rv1866 Rv1866 |
- |
hypothetical protein | Contains CoA_transf_3 (PF02515.23) domain(s); putative function inferred from the domain architecture. | CoA_transf_3 |
Family assigned |
| Rv1867 Rv1867 |
mtbc0_001980 |
hypothetical protein | Acetyl-CoA acetyltransferase. Pfam: TLP1_add_C (PF18313.8). | TLP1_add_C |
Resolved |
| Rv1868 Rv1868 |
mtbc0_001981 |
hypothetical protein | NAD(P)H-binding protein. Pfam: Rph_4th (PF27448.1). | Rph_4th |
Family assigned |
| Rv1870c Rv1870c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 4uob-assembly1_A Crystal structure of Deinococcus radiodurans Endonuclease III-3 (prob 1.00, TM 0.56). Structure-based, putative. | Family assigned | |
| Rv1871c Rv1871c |
mtbc0_001984 |
hypothetical protein | Nitroreductase family deazaflavin-dependent oxidoreductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Family assigned |
| Rv1873 Rv1873 |
mtbc0_001986 |
hypothetical protein | Conserved hypothetical protein with an X-ray crystal structure at 1.38 A: a 16.2 kDa monomer adopting a primarily alpha-helical fold with limited similarity to known structures (COG5579). Not a novel fold but a model for sequence-related orthologues. Function unknown. (The UniProt auto-name 'Calpastatin' is a database artefact and is not adopted.) | DUF1810 |
Family assigned |
| Rv1874 Rv1874 |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 2ftr-assembly1_B Crystal structure of an ethyl tert-butyl ether d (ethd) family (prob 1.00, TM 0.62). Structure-based, putative. | Family assigned | |
| Rv1875 Rv1875 |
mtbc0_001988 |
hypothetical protein | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| Rv1879 Rv1879 |
mtbc0_001993 |
hypothetical protein | Amidohydrolase family protein. Pfam: Amidohydro_2 (PF04909.21). | Amidohydro_2 |
Family assigned |
| Rv1883c Rv1883c |
mtbc0_001997 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| Rv1887 Rv1887 |
mtbc0_002001 |
hypothetical protein | Exopolyphosphatase-like fold (PDB 3HI0); putative phosphatase/hydrolase. | DUF7159 |
Family assigned |
| Rv1890c Rv1890c |
- |
hypothetical protein | Contains YceI (PF04264.19) domain(s); putative function inferred from the domain architecture. | YceI |
Family assigned |
| Rv1891 Rv1891 |
mtbc0_002005 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6xl5-assembly1_D Cryo-EM structure of EcmrR-RNAP-promoter open complex (prob 0.04, TM 0.37). | Still unknown | |
| Rv1893 Rv1893 |
mtbc0_002007 |
hypothetical protein | Contains Rv1893 (PF23706.3) domain(s); putative function inferred from the domain architecture. | Rv1893 |
Family assigned |
| Rv1894c Rv1894c |
mtbc0_002008 |
hypothetical protein | Nitronate monooxygenase family protein. Pfam: NMO (PF03060.22). | NMO |
Family assigned |
| Rv1898 Rv1898 |
mtbc0_002012 |
hypothetical protein | MTH1187 family thiamine-binding protein. Pfam: Thiamine_BP (PF01910.23). | Thiamine_BP |
Family assigned |
| Rv1904 Rv1904 |
mtbc0_002019 |
hypothetical protein | Anti-sigma factor antagonist. Pfam: STAS (PF01740.27), STAS_2 (PF13466.13). | STAS STAS_2 |
Resolved |
| Rv1906c Rv1906c |
mtbc0_002021 |
hypothetical protein | Contains Rv1352 (PF27111.1) domain(s); putative function inferred from the domain architecture. | Rv1352 |
Family assigned |
| Rv1907c Rv1907c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4262. Function unknown. Foldseek best (non-significant) hit: 4q3o-assembly4_H Crystal structure of MGS-MT1, an alpha/beta hydrolase (prob 0.04, TM 0.35). | DUF4262 |
Still unknown |
| Rv1910c Rv1910c |
mtbc0_002025 |
hypothetical protein | YbhB/YbcL family Raf kinase inhibitor-like protein. Pfam: PBP (PF01161.26). | PBP |
Family assigned |