Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2061c Rv2061c |
mtbc0_002194 |
hypothetical protein | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| cobN Rv2062c |
mtbc0_002195 |
cobalamin biosynthesis protein CobN | Cobaltochelatase subunit CobN. Pfam: CobN-Mg_chel (PF02514.22). | CobN-Mg_chel |
Family assigned |
| mazE7 Rv2063 |
- |
antitoxin MazE7 | Antitoxin MazE7. | Resolved | |
| mazF7 Rv2063A |
- |
mRNA interferase MazF7 | MRNA interferase MazF7. Pfam: PemK_toxin (PF02452.24). | PemK_toxin |
Resolved |
| cobG Rv2064 |
mtbc0_002198 |
precorrin-3B synthase | Precorrin-3B synthase. Pfam: NIR_SIR_ferr (PF03460.23). | NIR_SIR_ferr |
Resolved |
| cobH Rv2065 |
mtbc0_002199 |
precorrin-8X methylmutase | Precorrin-8X methylmutase. Pfam: CbiC (PF02570.21). | CbiC |
Resolved |
| cobIJ Rv2066 |
mtbc0_002200 |
bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase | Precorrin-2 C(20)-methyltransferase. Pfam: TP_methylase (PF00590.26). | TP_methylase |
Resolved |
| Rv2067c Rv2067c |
mtbc0_002201 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_9 (PF08003.18), Methyltransf_25 (PF13649.13), Methyltransf_31 (PF13847.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19), Methyltransf_23 (PF13489.13). | Methyltransf_9 Methyltransf_25 Methyltransf_31 Methyltransf_12 Methyltransf_11 Methyltransf_23 |
Resolved |
| blaC Rv2068c |
- |
beta-lactamase | Beta-lactamase. Pfam: Beta-lactamase2 (PF13354.13), Beta-lactamase (PF00144.30). | Beta-lactamase2 Beta-lactamase |
Resolved |
| sigC Rv2069 |
mtbc0_002203 |
ECF RNA polymerase sigma factor SigC | RNA polymerase sigma factor SigC. Pfam: Sigma70_r2 (PF04542.21), Sigma70_ECF (PF07638.18), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_ECF Sigma70_r4_2 Sigma70_r4 |
Resolved |
| cobK Rv2070c |
mtbc0_002204 |
precorrin-6A reductase | Cobalt-precorrin-6A reductase. Pfam: CbiJ (PF02571.21). | CbiJ |
Resolved |
| cobM Rv2071c |
mtbc0_002205 |
precorrin-4 C(11)-methyltransferase | Precorrin-4 C(11)-methyltransferase. Pfam: TP_methylase (PF00590.26). | TP_methylase |
Resolved |
| cobL Rv2072c |
mtbc0_002206 |
precorrin-6Y C(5,15)-methyltransferase | Bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase. Pfam: TP_methylase (PF00590.26). | TP_methylase |
Resolved |
| Rv2073c Rv2073c |
mtbc0_002207 |
oxidoreductase | SDR family NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv2074 Rv2074 |
mtbc0_002208 |
pyridoxamine 5'-phosphate oxidase | F420-dependent biliverdin reductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| Rv2075c Rv2075c |
mtbc0_002209 |
hypothetical protein | Contains PI-PLC_cat (PF26178.1) domain(s); putative function inferred from the domain architecture. | PI-PLC_cat |
Family assigned |
| Rv2076c Rv2076c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv2077A Rv2077A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6uuj-assembly2_E Structure of PE5-PPE4-EspG3 complex from the type VII (prob 0.90, TM 0.69). | Still unknown | |
| Rv2077c Rv2077c |
mtbc0_002210 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2078 Rv2078 |
mtbc0_002212 |
hypothetical protein | DUF2563 family protein. | DUF2563 |
Family assigned |
| Rv2079 Rv2079 |
mtbc0_002213 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Hydro_N_hd (PF22905.3), Abhydrolase_8 (PF06259.19). | Hydro_N_hd Abhydrolase_8 |
Family assigned |
| lppJ Rv2080 |
mtbc0_002214 |
lipoprotein LppJ | Contains LppJ (PF27220.1) domain(s); putative function inferred from the domain architecture. | LppJ |
Family assigned |
| Rv2081c Rv2081c |
mtbc0_002216 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2082 Rv2082 |
mtbc0_002215 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5632, DUF5631. Function unknown. | DUF5632 DUF5631 |
Still unknown |
| Rv2083 Rv2083 |
mtbc0_002219 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2084 Rv2084 |
mtbc0_002220 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 1l7c-assembly1_A alpha-catenin fragment, residues 385-651 (prob 0.21, TM 0.26). | Still unknown | |
| Rv2085 Rv2085 |
- |
hypothetical protein | Transposase of insertion sequence IS1556 (eggNOG COG2963, transposase; COG category L). A mobile-element function. | Family assigned | |
| Rv2086 Rv2086 |
- |
hypothetical protein | Transposase of insertion sequence IS1556 (eggNOG COG2801, DDE transposase; COG category L). A mobile-element function. | Family assigned | |
| pknJ Rv2088 |
mtbc0_002222 |
transmembrane serine/threonine-protein kinase PknJ | Serine/threonine protein kinase PknJ. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), PknH_C (PF14032.13). | Pkinase PK_Tyr_Ser-Thr PknH_C |
Resolved |
| pepE Rv2089c |
mtbc0_002223 |
dipeptidase PepE | Xaa-Pro peptidase family protein. Pfam: Creatinase_N (PF01321.25), Peptidase_M24 (PF00557.30). | Creatinase_N Peptidase_M24 |
Family assigned |
| Rv2090 Rv2090 |
- |
5'-3' exonuclease | 5'-3' exonuclease. Pfam: 5_3_exonuc_N (PF02739.23), 5_3_exonuc (PF01367.26). | 5_3_exonuc_N 5_3_exonuc |
Resolved |
| Rv2091c Rv2091c |
mtbc0_002225 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF4333. Function unknown. | DUF4333 |
Still unknown |
| helY Rv2092c |
mtbc0_002226 |
ATP-dependent DNA helicase HelY | RNA helicase. Pfam: ResIII (PF04851.22), DEAD (PF00270.36), Helicase_C (PF00271.38), SH3_HelY (PF26090.1), DSHCT (PF08148.18). | ResIII DEAD Helicase_C SH3_HelY DSHCT |
Resolved |
| tatC Rv2093c |
mtbc0_002227 |
Sec-independent protein translocase transmembrane protein TatC | Twin-arginine translocase subunit TatC. Pfam: TatC (PF00902.24). | TatC |
Family assigned |
| tatA Rv2094c |
mtbc0_002228 |
Sec-independent protein translocase membrane-bound protein TatA | Sec-independent protein translocase subunit TatA. Pfam: TatA_B_E (PF02416.22). | TatA_B_E |
Family assigned |
| pafC Rv2095c |
mtbc0_002229 |
proteasome accessory factor C | YafY family protein. Pfam: HTH_PafC (PF19187.7), WYL (PF13280.13), WCX (PF25583.2). | HTH_PafC WYL WCX |
Family assigned |
| pafB Rv2096c |
mtbc0_002230 |
proteasome accessory factor B | YafY family protein. Pfam: WYL (PF13280.13), WCX (PF25583.2). | WYL WCX |
Family assigned |
| pafA Rv2097c |
mtbc0_002231 |
proteasome accessory factor PafA | Pup--protein ligase. Pfam: Pup_ligase (PF03136.21). | Pup_ligase |
Resolved |
| Rv2100 Rv2100 |
- |
hypothetical protein | HNH endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). Lies in a region-of-difference (RDcap_Asia3) context. HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| helZ Rv2101 |
mtbc0_002234 |
helicase HelZ | DEAD/DEAH box helicase. Pfam: DUF3670 (PF12419.14), SNF2-rel_dom (PF00176.30), Helicase_C (PF00271.38). | DUF3670 SNF2-rel_dom Helicase_C |
Resolved |
| Rv2102 Rv2102 |
- |
hypothetical protein | Contains SWIM (PF04434.23) domain(s); putative function inferred from the domain architecture. | SWIM |
Family assigned |
| vapC37 Rv2103c |
mtbc0_002236 |
ribonuclease VapC37 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv2104a Rv2104a |
- |
hypothetical protein | Proteasome-alpha-subunit-family protein, located in the M. tuberculosis proteasome gene region. HHpred: 25/25 top hits are 20S-proteasome alpha-type subunits (incl. the M.tb proteasome alpha 3MI0, 88.4%); eggNOG COG0638 (20S proteasome alpha/beta) with EC 3.4.25.1. Genomic context: immediately flanked by the proteasome core/Pup genes prcA (Rv2109c), prcB (Rv2110c) and pafA (Rv2097c); under purifying selection. At 85 aa it is a small/partial proteasome-alpha-fold protein - whether a bona fide additional subunit or a proteasome-associated protein is undetermined (the canonical alpha subunit is prcA/Rv2109c). | Family assigned | |
| vapB37 Rv2104c |
mtbc0_002237 |
antitoxin VapB37 | Antitoxin. | Resolved | |
| PE22 Rv2107 |
- |
PE family protein PE22 | PE family protein PE22. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PPE36 Rv2108 |
- |
PPE family protein PPE36 | PPE family protein PPE36. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| prcA Rv2109c |
mtbc0_002241 |
proteasome subunit alpha | Proteasome subunit alpha. Pfam: Proteasome (PF00227.32). | Proteasome |
Family assigned |
| prcB Rv2110c |
mtbc0_002242 |
proteasome subunit beta | Proteasome subunit beta. Pfam: Proteasome (PF00227.32). | Proteasome |
Family assigned |
| pup Rv2111c |
- |
ubiquitin-like protein Pup | Ubiquitin-like protein Pup. Pfam: Pup (PF05639.17). | Pup |
Family assigned |
| dop Rv2112c |
- |
pup deamidase/depupylase | Pup deamidase/depupylase. Pfam: Pup_ligase (PF03136.21). | Pup_ligase |
Resolved |