Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| papA3 Rv1182 |
mtbc0_001270 |
acyltransferase papA3 | Acyltransferase PapA3. Pfam: Condensation (PF00668.26). | Condensation |
Resolved |
| mmpL10 Rv1183 |
mtbc0_001271 |
transmembrane transport protein MmpL10 | RND transporter MmpL10. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| chp2 Rv1184c |
mtbc0_001272 |
hypothetical protein | Diacyltrehalose acyltransferase Chp2. Pfam: PE-PPE (PF08237.18). | PE-PPE |
Resolved |
| fadD21 Rv1185c |
mtbc0_001273 |
fatty-acid--CoA ligase FadD21 | Fatty-acid--AMP ligase FAAL21/FadD21. Pfam: AMP-binding (PF00501.35), AMP-dom_DIP2-like (PF23024.2). | AMP-binding AMP-dom_DIP2-like |
Resolved |
| Rv1186c Rv1186c |
mtbc0_001274 |
hypothetical protein | PucR family transcriptional regulator. Pfam: HTH_30 (PF13556.13). | HTH_30 |
Family assigned |
| rocA Rv1187 |
mtbc0_001275 |
pyrroline-5-carboxylate dehydrogenase RocA | L-glutamate gamma-semialdehyde dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv1188 Rv1188 |
mtbc0_001276 |
proline dehydrogenase | Proline dehydrogenase. Pfam: Pro_dh (PF01619.25). | Pro_dh |
Resolved |
| sigI Rv1189 |
mtbc0_001277 |
ECF RNA polymerase sigma factor SigI | RNA polymerase sigma factor SigI. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19). | Sigma70_r2 Sigma70_r4_2 |
Resolved |
| Rv1190 Rv1190 |
mtbc0_001278 |
hypothetical protein | Alpha/beta fold hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Resolved |
| Rv1191 Rv1191 |
mtbc0_001279 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Hydrolase_4 |
Family assigned |
| Rv1192 Rv1192 |
mtbc0_001280 |
hypothetical protein | Alpha/beta-hydrolase-FOLD protein: the AlphaFold model matches the Burkholderia glumae lipase (TM 0.77-0.78, PDB 2es4), and eggNOG describes the orthologous group as 'acetyltransferases and hydrolases with the alpha/beta hydrolase fold'. Putative hydrolase — this fold is shared by esterases, lipases, peptidases, dehalogenases and catalytically dead members alike, and no catalytic triad is verified here. | Family assigned | |
| fadD36 Rv1193 |
mtbc0_001281 |
fatty-acid--CoA ligase FadD36 | Acyl-CoA synthetase. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| Rv1194c Rv1194c |
mtbc0_001282 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| PE13 Rv1195 |
- |
PE family protein PE13 | PE family protein PE13. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PPE18 Rv1196 |
- |
PPE family protein PPE18 | PPE family protein PPE18. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| esxK Rv1197 |
mtbc0_001285 |
ESAT-6 like protein EsxK | Type VII secretion system ESX-5 protein EsxJ. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| esxL Rv1198 |
mtbc0_001286 |
ESAT-6 like protein EsxL | Type VII secretion system ESX-5 protein EsxL. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| Rv1199c Rv1199c |
mtbc0_001287 |
insertion sequence element IS1081 transposase | IS256-like element IS1081 family transposase. Pfam: Transposase_mut (PF00872.25). | Transposase_mut |
Family assigned |
| Rv1200 Rv1200 |
mtbc0_001288 |
integral membrane transport protein | MHS family MFS transporter. Pfam: Sugar_tr (PF00083.31), MFS_1 (PF07690.22). | Sugar_tr MFS_1 |
Family assigned |
| dapD Rv1201c |
mtbc0_001289 |
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase. Pfam: THDPS_M (PF14789.12), Hexapep_2 (PF14602.13). | THDPS_M Hexapep_2 |
Resolved |
| dapE Rv1202 |
- |
succinyl-diaminopimelate desuccinylase DapE | Succinyl-diaminopimelate desuccinylase DapE. Pfam: Peptidase_M28 (PF04389.23), Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20). | Peptidase_M28 Peptidase_M20 M20_dimer |
Resolved |
| Rv1203c Rv1203c |
- |
hypothetical protein | LuxR-family transcriptional regulator (eggNOG COG2909, GerE/HTH DNA-binding output domain; COG category K). RefSeq leaves it 'hypothetical protein'. Regulon undetermined. | Family assigned | |
| Rv1204c Rv1204c |
- |
hypothetical protein | LuxR-family transcriptional regulator (eggNOG COG2909, GerE/HTH; COG category K), large multidomain protein. RefSeq leaves it 'hypothetical protein'. Regulon undetermined. | Family assigned | |
| Rv1205 Rv1205 |
mtbc0_001293 |
hypothetical protein | TIGR00730 family Rossman fold protein. Pfam: LDcluster4 (PF18306.7), Lysine_decarbox (PF03641.20). | LDcluster4 Lysine_decarbox |
Family assigned |
| fadD6 Rv1206 |
mtbc0_001294 |
fatty-acid--CoA ligase FadD6 | Long-chain-acyl-CoA synthetase FadD6. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| folP2 Rv1207 |
mtbc0_001295 |
dihydropteroate synthase | Dihydropteroate synthase. Pfam: Pterin_bind (PF00809.29). | Pterin_bind |
Resolved |
| gpgS Rv1208 |
mtbc0_001296 |
glucosyl-3-phosphoglycerate synthase | Glucosyl-3-phosphoglycerate synthase. Pfam: Glycos_transf_2 (PF00535.33). | Glycos_transf_2 |
Resolved |
| Rv1209 Rv1209 |
mtbc0_001297 |
hypothetical protein | DivIVA domain-containing protein. | Family assigned | |
| tagA Rv1210 |
mtbc0_001298 |
DNA-3-methyladenine glycosylase I TagA | DNA-3-methyladenine glycosylase I. Pfam: Adenine_glyco (PF03352.19). | Adenine_glyco |
Resolved |
| Rv1211 Rv1211 |
- |
hypothetical protein | Natively unfolded (intrinsically disordered) protein required for growth and pathogenesis; binds the calmodulin antagonist trifluoperazine (Kd 41 uM) in its C-terminal region while remaining unfolded. An earlier 'calmodulin-like Ca2+-binding protein (CAMLP)' assignment is CONTESTED: the structural study shows it does not bind Ca2+. A drug-interaction target of unfixed molecular function. | DUF3117 |
Family assigned |
| glgA Rv1212c |
mtbc0_001300 |
capsular glucan synthase | Glycogen synthase. Pfam: Glyco_transf_4 (PF13439.13), Glyco_trans_4_4 (PF13579.13), Glyco_transf_5 (PF08323.18), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13), Glyco_trans_1_2 (PF13524.13). | Glyco_transf_4 Glyco_trans_4_4 Glyco_transf_5 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Resolved |
| glgC Rv1213 |
- |
glucose-1-phosphate adenylyltransferase | Glucose-1-phosphate adenylyltransferase. Pfam: NTP_transferase (PF00483.30), Hexapep_GlmU (PF24894.2). | NTP_transferase Hexapep_GlmU |
Resolved |
| PE14 Rv1214c |
- |
PE family protein PE14 | PE family protein PE14. Pfam: PE (PF00934.26). | PE |
Family assigned |
| Rv1215c Rv1215c |
mtbc0_001303 |
hypothetical protein | CocE/NonD family hydrolase. Pfam: Peptidase_S15 (PF02129.25), Peptidase_S9 (PF00326.28), PepX_C (PF08530.17). | Peptidase_S15 Peptidase_S9 PepX_C |
Family assigned |
| Rv1216c Rv1216c |
mtbc0_001304 |
integral membrane protein | Isoprenylcysteine carboxylmethyltransferase family protein. Pfam: DUF1295 (PF06966.18), PEMT (PF04191.19), ICMT (PF04140.20). | DUF1295 PEMT ICMT |
Family assigned |
| Rv1217c Rv1217c |
mtbc0_001305 |
tetronasin ABC transporter integral membrane protein | Multidrug efflux ABC transporter permease. | Family assigned | |
| Rv1218c Rv1218c |
mtbc0_001306 |
tetronasin ABC transporter ATP-binding protein | Multidrug efflux ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34), AAA_21 (PF13304.13), DrrA1-3_C (PF13732.13). | ABC_tran AAA_21 DrrA1-3_C |
Family assigned |
| raaS Rv1219c |
mtbc0_001307 |
transcriptional regulator | Transcriptional regulator RaaS. Pfam: TetR_N (PF00440.30), TetR_C_25 (PF17933.7). | TetR_N TetR_C_25 |
Family assigned |
| Rv1220c Rv1220c |
- |
methyltransferase | Methyltransferase. Pfam: Methyltransf_3 (PF01596.24), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_24 (PF13578.13), Methyltransf_11 (PF08241.19). | Methyltransf_3 Methyltransf_31 Methyltransf_25 Methyltransf_24 Methyltransf_11 |
Resolved |
| sigE Rv1221 |
mtbc0_001309 |
ECF RNA polymerase sigma factor SigE | RNA polymerase sigma factor SigE. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r4_2 Sigma70_r4 |
Resolved |
| rseA Rv1222 |
mtbc0_001310 |
anti-sigma E factor RseA | Anti-sigma E factor RseA. | Resolved | |
| htrA Rv1223 |
- |
serine protease HtrA | Serine protease HtrA. Pfam: Trypsin (PF00089.33), Trypsin_2 (PF13365.13), PDZ_2 (PF13180.13), PDZ (PF00595.30), PDZ_6 (PF17820.8). | Trypsin Trypsin_2 PDZ_2 PDZ PDZ_6 |
Resolved |
| tatB Rv1224 |
mtbc0_001312 |
Sec-independent protein translocase protein TatB | Sec-independent protein translocase protein TatB. Pfam: TatA_B_E (PF02416.22). | TatA_B_E |
Resolved |
| Rv1225c Rv1225c |
mtbc0_001313 |
hypothetical protein | HAD-IIA family hydrolase. Pfam: Hydrolase_6 (PF13344.13), Hydrolase (PF00702.33), HAD_2 (PF13419.13), Hydrolase_like (PF13242.13). | Hydrolase_6 Hydrolase HAD_2 Hydrolase_like |
Family assigned |
| Rv1226c Rv1226c |
mtbc0_001314 |
transmembrane protein | PH domain-containing protein. Pfam: bPH_2 (PF03703.21). | bPH_2 |
Family assigned |
| Rv1227c Rv1227c |
mtbc0_001315 |
transmembrane protein | PH domain-containing protein. Pfam: bPH_2 (PF03703.21). | bPH_2 |
Family assigned |
| lpqX Rv1228 |
mtbc0_001316 |
lipoprotein LpqX | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1228a Rv1228a |
- |
hypothetical protein | Antitoxin of the Phd/YefM family, type II toxin-antitoxin system (eggNOG ortholog of the Phd_YefM antitoxin). RefSeq leaves it 'hypothetical protein'. The cognate toxin is undetermined. | Family assigned | |
| mrp Rv1229c |
mtbc0_001318 |
multiple resistance/pH adaptation protein | Mrp/NBP35 family ATP-binding protein. Pfam: FeS_assembly_P (PF01883.25), ParA (PF10609.16), AAA_31 (PF13614.13), CbiA (PF01656.30), MipZ (PF09140.18). | FeS_assembly_P ParA AAA_31 CbiA MipZ |
Family assigned |
| Rv1230c Rv1230c |
mtbc0_001319 |
membrane protein | Lytic transglycosylase domain-containing protein. Pfam: SLT_2 (PF13406.12). | SLT_2 |
Family assigned |