Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1205 Rv1205 |
mtbc0_001293 |
hypothetical protein | TIGR00730 family Rossman fold protein. Pfam: LDcluster4 (PF18306.7), Lysine_decarbox (PF03641.20). | LDcluster4 Lysine_decarbox |
Family assigned |
| fadD6 Rv1206 |
mtbc0_001294 |
fatty-acid--CoA ligase FadD6 | Long-chain-acyl-CoA synthetase FadD6. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| folP2 Rv1207 |
mtbc0_001295 |
dihydropteroate synthase | Dihydropteroate synthase. Pfam: Pterin_bind (PF00809.29). | Pterin_bind |
Resolved |
| gpgS Rv1208 |
mtbc0_001296 |
glucosyl-3-phosphoglycerate synthase | Glucosyl-3-phosphoglycerate synthase. Pfam: Glycos_transf_2 (PF00535.33). | Glycos_transf_2 |
Resolved |
| Rv1209 Rv1209 |
mtbc0_001297 |
hypothetical protein | DivIVA domain-containing protein. | Family assigned | |
| tagA Rv1210 |
mtbc0_001298 |
DNA-3-methyladenine glycosylase I TagA | DNA-3-methyladenine glycosylase I. Pfam: Adenine_glyco (PF03352.19). | Adenine_glyco |
Resolved |
| Rv1211 Rv1211 |
- |
hypothetical protein | Natively unfolded (intrinsically disordered) protein required for growth and pathogenesis; binds the calmodulin antagonist trifluoperazine (Kd 41 uM) in its C-terminal region while remaining unfolded. An earlier 'calmodulin-like Ca2+-binding protein (CAMLP)' assignment is CONTESTED: the structural study shows it does not bind Ca2+. A drug-interaction target of unfixed molecular function. | DUF3117 |
Family assigned |
| glgA Rv1212c |
mtbc0_001300 |
capsular glucan synthase | Glycogen synthase. Pfam: Glyco_transf_4 (PF13439.13), Glyco_trans_4_4 (PF13579.13), Glyco_transf_5 (PF08323.18), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13), Glyco_trans_1_2 (PF13524.13). | Glyco_transf_4 Glyco_trans_4_4 Glyco_transf_5 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Resolved |
| glgC Rv1213 |
- |
glucose-1-phosphate adenylyltransferase | Glucose-1-phosphate adenylyltransferase. Pfam: NTP_transferase (PF00483.30), Hexapep_GlmU (PF24894.2). | NTP_transferase Hexapep_GlmU |
Resolved |
| PE14 Rv1214c |
- |
PE family protein PE14 | PE family protein PE14. Pfam: PE (PF00934.26). | PE |
Family assigned |
| Rv1215c Rv1215c |
mtbc0_001303 |
hypothetical protein | CocE/NonD family hydrolase. Pfam: Peptidase_S15 (PF02129.25), Peptidase_S9 (PF00326.28), PepX_C (PF08530.17). | Peptidase_S15 Peptidase_S9 PepX_C |
Family assigned |
| Rv1216c Rv1216c |
mtbc0_001304 |
integral membrane protein | Isoprenylcysteine carboxylmethyltransferase family protein. Pfam: DUF1295 (PF06966.18), PEMT (PF04191.19), ICMT (PF04140.20). | DUF1295 PEMT ICMT |
Family assigned |
| Rv1217c Rv1217c |
mtbc0_001305 |
tetronasin ABC transporter integral membrane protein | Multidrug efflux ABC transporter permease. | Family assigned | |
| Rv1218c Rv1218c |
mtbc0_001306 |
tetronasin ABC transporter ATP-binding protein | Multidrug efflux ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34), AAA_21 (PF13304.13), DrrA1-3_C (PF13732.13). | ABC_tran AAA_21 DrrA1-3_C |
Family assigned |
| raaS Rv1219c |
mtbc0_001307 |
transcriptional regulator | Transcriptional regulator RaaS. Pfam: TetR_N (PF00440.30), TetR_C_25 (PF17933.7). | TetR_N TetR_C_25 |
Family assigned |
| Rv1220c Rv1220c |
- |
methyltransferase | Methyltransferase. Pfam: Methyltransf_3 (PF01596.24), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_24 (PF13578.13), Methyltransf_11 (PF08241.19). | Methyltransf_3 Methyltransf_31 Methyltransf_25 Methyltransf_24 Methyltransf_11 |
Resolved |
| sigE Rv1221 |
mtbc0_001309 |
ECF RNA polymerase sigma factor SigE | RNA polymerase sigma factor SigE. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r4_2 Sigma70_r4 |
Resolved |
| rseA Rv1222 |
mtbc0_001310 |
anti-sigma E factor RseA | Anti-sigma E factor RseA. | Resolved | |
| htrA Rv1223 |
- |
serine protease HtrA | Serine protease HtrA. Pfam: Trypsin (PF00089.33), Trypsin_2 (PF13365.13), PDZ_2 (PF13180.13), PDZ (PF00595.30), PDZ_6 (PF17820.8). | Trypsin Trypsin_2 PDZ_2 PDZ PDZ_6 |
Resolved |
| tatB Rv1224 |
mtbc0_001312 |
Sec-independent protein translocase protein TatB | Sec-independent protein translocase protein TatB. Pfam: TatA_B_E (PF02416.22). | TatA_B_E |
Resolved |
| Rv1225c Rv1225c |
mtbc0_001313 |
hypothetical protein | HAD-IIA family hydrolase. Pfam: Hydrolase_6 (PF13344.13), Hydrolase (PF00702.33), HAD_2 (PF13419.13), Hydrolase_like (PF13242.13). | Hydrolase_6 Hydrolase HAD_2 Hydrolase_like |
Family assigned |
| Rv1226c Rv1226c |
mtbc0_001314 |
transmembrane protein | PH domain-containing protein. Pfam: bPH_2 (PF03703.21). | bPH_2 |
Family assigned |
| Rv1227c Rv1227c |
mtbc0_001315 |
transmembrane protein | PH domain-containing protein. Pfam: bPH_2 (PF03703.21). | bPH_2 |
Family assigned |
| lpqX Rv1228 |
mtbc0_001316 |
lipoprotein LpqX | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1228a Rv1228a |
- |
hypothetical protein | Antitoxin of the Phd/YefM family, type II toxin-antitoxin system (eggNOG ortholog of the Phd_YefM antitoxin). RefSeq leaves it 'hypothetical protein'. The cognate toxin is undetermined. | Family assigned | |
| mrp Rv1229c |
mtbc0_001318 |
multiple resistance/pH adaptation protein | Mrp/NBP35 family ATP-binding protein. Pfam: FeS_assembly_P (PF01883.25), ParA (PF10609.16), AAA_31 (PF13614.13), CbiA (PF01656.30), MipZ (PF09140.18). | FeS_assembly_P ParA AAA_31 CbiA MipZ |
Family assigned |
| Rv1230c Rv1230c |
mtbc0_001319 |
membrane protein | Lytic transglycosylase domain-containing protein. Pfam: SLT_2 (PF13406.12). | SLT_2 |
Family assigned |
| Rv1231c Rv1231c |
mtbc0_001320 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF1003. Function unknown. | DUF1003 |
Still unknown |
| Rv1232c Rv1232c |
mtbc0_001321 |
hypothetical protein | Magnesium transporter. Pfam: SH3_actinomycetes (PF26205.1), MgtE_N (PF03448.23), CBS (PF00571.34). | SH3_actinomycetes MgtE_N CBS |
Resolved |
| Rv1233c Rv1233c |
mtbc0_001322 |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF4190 |
Family assigned |
| Rv1234 Rv1234 |
mtbc0_001323 |
transmembrane protein | General stress protein. Pfam: YflT (PF11181.14). | YflT |
Resolved |
| lpqY Rv1235 |
mtbc0_001324 |
trehalose ABC transporter substrate-binding lipoprotein LpqY | Trehalose ABC transporter substrate-binding protein LpqY. Pfam: SBP_bac_1 (PF01547.31), SBP_bac_8 (PF13416.12). | SBP_bac_1 SBP_bac_8 |
Family assigned |
| sugA Rv1236 |
mtbc0_001325 |
sugar ABC transporter permease SugA | Trehalose ABC transporter permease SugA. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| sugB Rv1237 |
mtbc0_001326 |
sugar ABC transporter permease SugB | Trehalose ABC transporter permease SugB. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| sugC Rv1238 |
mtbc0_001327 |
sugar ABC transporter ATP-binding protein SugC | Trehalose ABC transporter ATP-binding protein SugC. Pfam: ABC_tran (PF00005.34), OB_MalK (PF17912.8). | ABC_tran OB_MalK |
Family assigned |
| corA Rv1239c |
mtbc0_001328 |
magnesium and cobalt transport transmembrane protein CorA | Magnesium/cobalt transporter CorA. Pfam: CorA (PF01544.24). | CorA |
Resolved |
| mdh Rv1240 |
mtbc0_001329 |
malate dehydrogenase | Malate dehydrogenase. Pfam: Ldh_1_N (PF00056.30), Ldh_1_C (PF02866.24). | Ldh_1_N Ldh_1_C |
Resolved |
| vapB33 Rv1241 |
mtbc0_001330 |
antitoxin VapB33 | Type II toxin-antitoxin system antitoxin VapB33. | Resolved | |
| vapC33 Rv1242 |
mtbc0_001331 |
ribonuclease VapC33 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| PE_PGRS23 Rv1243c |
- |
PE-PGRS family protein PE_PGRS23 | PE-PGRS family protein PE_PGRS23. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| lpqZ Rv1244 |
mtbc0_001333 |
lipoprotein LpqZ | Glycine betaine ABC transporter substrate-binding protein. Pfam: OpuAC (PF04069.18). | OpuAC |
Family assigned |
| Rv1245c Rv1245c |
mtbc0_001334 |
short-chain type dehydrogenase/reductase | SDR family NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| relE Rv1246c |
mtbc0_001335 |
toxin RelE | Type II toxin-antitoxin system mRNA interferase RelE. Pfam: ParE_toxin (PF05016.22). | ParE_toxin |
Resolved |
| relB Rv1247c |
mtbc0_001336 |
antitoxin RelB | Type II toxin-antitoxin system Phd/YefM family antitoxin. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Family assigned |
| Rv1248c Rv1248c |
mtbc0_001337 |
multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase | Multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit. Pfam: 2-oxogl_dehyd_N (PF16078.11), 2-oxoacid_dh (PF00198.29), E1_dh (PF00676.26), Transket_pyr (PF02779.30), OxoGdeHyase_C (PF16870.11). | 2-oxogl_dehyd_N 2-oxoacid_dh E1_dh Transket_pyr OxoGdeHyase_C |
Family assigned |
| Rv1249c Rv1249c |
mtbc0_001338 |
membrane protein | Hydantoinase / 5-oxoprolinase (ATP-hydrolysing) family enzyme (eggNOG COG1540, COG category R). RefSeq leaves it 'hypothetical protein'. ATP-dependent amidohydrolase activity; exact substrate undetermined. | Family assigned | |
| Rv1250 Rv1250 |
mtbc0_001339 |
MFS-type drug transporter | MFS transporter. Pfam: MFS_1 (PF07690.22), TRI12 (PF06609.19), Sugar_tr (PF00083.31), PUCC (PF03209.22). | MFS_1 TRI12 Sugar_tr PUCC |
Resolved |
| Rv1251c Rv1251c |
mtbc0_001340 |
hypothetical protein | TM0106 family RecB-like putative nuclease. Pfam: PDDEXK_1 (PF12705.14), RNase_H_2 (PF13482.13), AAA_19 (PF13245.13), AAA_30 (PF13604.13), NAT10_TcmA_helicase (PF05127.22), AAA_12 (PF13087.13). | PDDEXK_1 RNase_H_2 AAA_19 AAA_30 NAT10_TcmA_helicase AAA_12 |
Family assigned |
| lprE Rv1252c |
mtbc0_001341 |
lipoprotein LprE | LppP/LprE family lipoprotein. Pfam: Lipoprotein_21 (PF14041.12). | Lipoprotein_21 |
Family assigned |
| deaD Rv1253 |
mtbc0_001342 |
ATP-dependent RNA helicase DeaD | DEAD/DEAH box helicase. Pfam: DEAD (PF00270.36), Helicase_C (PF00271.38), DeaD_dimer (PF25399.2), DbpA (PF03880.22). | DEAD Helicase_C DeaD_dimer DbpA |
Resolved |