Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2901c Rv2901c |
mtbc0_003083 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2469. Function unknown. Foldseek best (non-significant) hit: 4m7d-assembly1_C Crystal structure of Lsm2-8 complex bound to the RNA (prob 0.16, TM 0.31). | DUF2469 |
Still unknown |
| Rv2908c Rv2908c |
mtbc0_003090 |
hypothetical protein | RNA-binding protein. Pfam: KH_KhpA-B (PF13083.14). | KH_KhpA-B |
Family assigned |
| Rv2910c Rv2910c |
- |
hypothetical protein | Contains SnoaL_4 (PF13577.13) domain(s); putative function inferred from the domain architecture. | SnoaL_4 |
Family assigned |
| Rv2915c Rv2915c |
mtbc0_003097 |
hypothetical protein | Amidohydrolase family protein. Pfam: Amidohydro_1 (PF01979.27). | Amidohydro_1 |
Family assigned |
| Rv2917 Rv2917 |
- |
hypothetical protein | Contains ResIII (PF04851.22), DEAD (PF00270.36), SWI2_SNF2 (PF18766.8) domain(s); putative function inferred from the domain architecture. | ResIII DEAD SWI2_SNF2 |
Family assigned |
| Rv2923c Rv2923c |
mtbc0_003106 |
hypothetical protein | OsmC family protein. Pfam: OsmC (PF02566.25). | OsmC |
Family assigned |
| Rv2926c Rv2926c |
- |
hypothetical protein | Contains YceD (PF02620.23) domain(s); putative function inferred from the domain architecture. | YceD |
Family assigned |
| sepIVA Rv2927c |
mtbc0_003110 |
hypothetical protein | Cell division protein SepIVA. | Resolved | |
| Rv2929 Rv2929 |
mtbc0_003112 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2954c Rv2954c |
mtbc0_003136 |
hypothetical protein | [2%2C4-di-O-methyl-alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3)-2-O-methyl-alpha-L-rhamnopyranosyl] dimycocerosyl phenol-phthiocerol 3'''-O-methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_9 (PF08003.18), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | Methyltransf_23 Methyltransf_9 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| Rv2955c Rv2955c |
mtbc0_003137 |
hypothetical protein | [2-O-methyl-alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3)-2-O-methyl-alpha-L-rhamnopyranosyl] dimycocerosyl phenol-phthiocerol 4'''-O-methyltransferase. Pfam: Methyltransf_21 (PF05050.20). | Methyltransf_21 |
Resolved |
| Rv2956 Rv2956 |
mtbc0_003138 |
hypothetical protein | [alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3)-2-O-methyl-alpha-L-rhamnopyranosyl] dimycocerosyl phenol-phthiocerol 2'''-O-methyltransferase. Pfam: Methyltransf_21 (PF05050.20). | Methyltransf_21 |
Resolved |
| Rv2960c Rv2960c |
mtbc0_003143 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2969c Rv2969c |
mtbc0_003153 |
hypothetical protein | Mycothiol-dependent reductase. Pfam: Thioredoxin_4 (PF13462.13). | Thioredoxin_4 |
Resolved |
| Rv2970A Rv2970A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2972c Rv2972c |
mtbc0_003157 |
hypothetical protein | HNH endonuclease family protein. Pfam: GmrSD_C (PF07510.17). | GmrSD_C |
Family assigned |
| Rv2974c Rv2974c |
- |
hypothetical protein | Contains Dak2 (PF02734.23), FakA-like_M (PF21645.4), FakA-like_C (PF13684.12) domain(s); putative function inferred from the domain architecture. | Dak2 FakA-like_M FakA-like_C |
Family assigned |
| Rv2975c Rv2975c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6gj3-assembly1_F The baseplate complex from the type VI secretion syst (prob 0.18, TM 0.62). | Still unknown | |
| Rv2980 Rv2980 |
mtbc0_003165 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3515. Function unknown. Foldseek best (non-significant) hit: 5y39-assembly1_B Crystal structure of Ragulator complex (p18 76-145) (prob 0.38, TM 0.58). | DUF3515 |
Still unknown |
| Rv2990c Rv2990c |
mtbc0_003175 |
hypothetical protein | Class I SAM-dependent methyltransferase. | Resolved | |
| Rv2991 Rv2991 |
mtbc0_003176 |
hypothetical protein | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28), Pyridox_ox_2 (PF12900.14). | PNPOx_N Pyridox_ox_2 |
Resolved |
| Rv2998 Rv2998 |
mtbc0_003186 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3005c Rv3005c |
mtbc0_003194 |
hypothetical protein | DoxX family protein. Pfam: DoxX (PF07681.18), MauE (PF07291.17). | DoxX MauE |
Family assigned |
| Rv3008 Rv3008 |
mtbc0_003197 |
hypothetical protein | MgtC/SapB family protein. | Family assigned | |
| Rv3013 Rv3013 |
mtbc0_003202 |
hypothetical protein | Amino acid-binding protein. | Family assigned | |
| Rv3015c Rv3015c |
mtbc0_003204 |
hypothetical protein | Methionine synthase. Pfam: Meth_synt_2 (PF01717.25). | Meth_synt_2 |
Resolved |
| Rv3026c Rv3026c |
mtbc0_003217 |
hypothetical protein | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). | Acyltransferase |
Family assigned |
| Rv3032A Rv3032A |
- |
hypothetical protein | Membrane metalloprotease-like fold (YxkI-like). RefSeq leaves it 'hypothetical protein'. | Family assigned | |
| Rv3033 Rv3033 |
mtbc0_003225 |
hypothetical protein | Secreted anti-apoptotic virulence factor. RefSeq leaves it 'hypothetical'. Rv3033 represses the intrinsic (caspase-9-mediated) but not the extrinsic apoptotic pathway in infected macrophages, blocking both mitochondrial cytochrome-c release and ER-stress (PERK) activation, thereby promoting bacillary survival (Zhang 2018). | DUF4333 |
Resolved |
| Rv3035 Rv3035 |
- |
hypothetical protein | Contains PQQ_2 (PF13360.14) domain(s); putative function inferred from the domain architecture. | PQQ_2 |
Family assigned |
| TB22.2 Rv3036c |
mtbc0_003228 |
hypothetical protein | RsiV family protein. | DUF3298 |
Family assigned |
| Rv3038c Rv3038c |
mtbc0_003230 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_23 (PF13489.13), Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19). | Ubie_methyltran Methyltransf_31 Methyltransf_23 Methyltransf_11 Methyltransf_25 Methyltransf_12 |
Family assigned |
| Rv3040c Rv3040c |
mtbc0_003232 |
hypothetical protein | NUDIX hydrolase. | Resolved | |
| Rv3046c Rv3046c |
mtbc0_003238 |
hypothetical protein | Member of the DUF3349 (PF11829) protein superfamily, predominant in Mycobacterium and Rhodococcus. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on the solved DUF3349 structure MSMEG_1053 (PDB 2lky; Foldseek prob 1.0, E 2e-4), a five-alpha-helix bundle; same superfamily as Rv0543c (already curated). Genus-restricted fold of unknown biochemical function. | DUF3349 |
Family assigned |
| Rv3047c Rv3047c |
mtbc0_003239 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5y5z-assembly1_Y V/A-type ATPase/synthase from Thermus thermophilus, r (prob 0.06, TM 0.40). | Still unknown | |
| Rv3054c Rv3054c |
mtbc0_003246 |
hypothetical protein | NADPH-dependent FMN reductase. Pfam: FMN_red (PF03358.21), Flavodoxin_2 (PF02525.23). | FMN_red Flavodoxin_2 |
Resolved |
| Rv3067 Rv3067 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF732. Function unknown. Foldseek best (non-significant) hit: 3j9x-assembly1_A A Virus that Infects a Hyperthermophile Encapsidates (prob 0.16, TM 0.56). | DUF732 |
Still unknown |
| Rv3071 Rv3071 |
mtbc0_003264 |
hypothetical protein | DUF190 domain-containing protein. | DUF190 |
Family assigned |
| Rv3072c Rv3072c |
- |
hypothetical protein | Contains Bac_luciferase (PF00296.27) domain(s); putative function inferred from the domain architecture. | Bac_luciferase |
Family assigned |
| Rv3073c Rv3073c |
mtbc0_003267 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF488-N3i, DUF488-N3a, DUF488. Function unknown. Foldseek best (non-significant) hit: 3ijd-assembly2_B-2 Uncharacterized protein Cthe_2304 from Clostridium (prob 0.04, TM 0.37). | DUF488-N3i DUF488-N3a DUF488 |
Still unknown |
| Rv3074 Rv3074 |
mtbc0_003268 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. | DUF222 |
Still unknown |
| Rv3075c Rv3075c |
mtbc0_003269 |
hypothetical protein | CoA ester lyase. Pfam: HpcH_HpaI (PF03328.21). | HpcH_HpaI |
Resolved |
| Rv3076 Rv3076 |
mtbc0_003270 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| Rv3079c Rv3079c |
mtbc0_003273 |
hypothetical protein | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv3081 Rv3081 |
mtbc0_003275 |
hypothetical protein | Nucleotidyltransferase. | DUF2204 |
Resolved |
| Rv3090 Rv3090 |
mtbc0_003284 |
hypothetical protein | SPFH domain-containing protein. Pfam: Band_7 (PF01145.32). | Band_7 |
Family assigned |
| Rv3091 Rv3091 |
mtbc0_003285 |
hypothetical protein | Patatin-like phospholipase family protein. Pfam: Patatin (PF01734.28). | Patatin |
Family assigned |
| Rv3094c Rv3094c |
mtbc0_003288 |
hypothetical protein | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| Rv3096 Rv3096 |
mtbc0_003290 |
hypothetical protein | 1%2C4-beta-xylanase. | Resolved | |
| Rv3098c Rv3098c |
mtbc0_003292 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6xr2-assembly2_E Computationally designed right-handed alpha/alpha hom (prob 0.66, TM 0.57). | Still unknown |