Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2795c Rv2795c |
mtbc0_002974 |
hypothetical protein | Metallophosphoesterase. Pfam: Metallophos (PF00149.34). | Metallophos |
Resolved |
| Rv2797c Rv2797c |
mtbc0_002976 |
hypothetical protein | Alpha/beta hydrolase family protein. Pfam: Abhydrolase_8 (PF06259.19). | Abhydrolase_8 |
Family assigned |
| Rv2798c Rv2798c |
mtbc0_002977 |
hypothetical protein | ESAT-6-like (WXG100) / ESX-secretion family protein (EsxF-like, four-helical bundle). RefSeq leaves it 'hypothetical protein'. | Family assigned | |
| Rv2803 Rv2803 |
- |
hypothetical protein | Contains TacA1 (PF08681.19) domain(s); putative function inferred from the domain architecture. | TacA1 |
Family assigned |
| Rv2804c Rv2804c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2805 Rv2805 |
mtbc0_002985 |
hypothetical protein | Transposase. | Resolved | |
| Rv2807 Rv2807 |
- |
hypothetical protein | Contains rve (PF00665.33) domain(s); putative function inferred from the domain architecture. | rve |
Family assigned |
| Rv2808 Rv2808 |
mtbc0_002988 |
hypothetical protein | Belongs to the SdhE/Sdh5/YgfY family (Pfam DUF5669 89.6% full-length, plus strongly converging YgfY-like / SdhE / Sdh5 hits at 83-88%): the FAD-assembly / flavinylation-factor fold of succinate dehydrogenase. The same fold is also used by CptB-type toxin-antitoxin antitoxins. Genomic context is ambiguous (singleton, not adjacent to sdh genes nor to a toxin; flanked by an integrase-domain hypothetical Rv2807 and Rv2809), so the family/fold is confidently assigned but the specific role (SDH flavinylation vs CptB-like antitoxin) is undetermined. | Resolved | |
| Rv2809 Rv2809 |
mtbc0_002989 |
hypothetical protein | Tentatively resembles a peptide-chain-release-factor fold: several converging HHpred hits (~56-62%) to the Actinobacteria/Chloroflexi VLRF1 release factor (Pfam PF18859) and to the eRF1 middle domain / eRF1 domain 2. The top hit is an Actinobacteria-specific family, taxonomically apt for M. tuberculosis. LOW confidence: all probabilities are below the confident threshold and E-values are high, so this is a lead (possible translation-termination-related fold) to validate, not an assignment. | Family assigned | |
| Rv2811 Rv2811 |
mtbc0_002991 |
hypothetical protein | Transposase (eggNOG COG3677, IS-family transposase; COG category L) in an RD (RDsurDR) mobile context. A mobile-element function. | Family assigned | |
| Rv2813 Rv2813 |
mtbc0_002993 |
hypothetical protein | ExeA family protein. Pfam: AAA_22 (PF13401.13). | AAA_22 |
Family assigned |
| Rv2825c Rv2825c |
- |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: structural ASCH hit contradicts the DUF1802 Pfam assignment; function unknown. | DUF1802 |
Still unknown |
| Rv2826c Rv2826c |
mtbc0_003004 |
hypothetical protein | MenT4, a DUF1814 nucleotidyltransferase toxin of the MenAT4 module. RefSeq names only the generic 'AbiEii/AbiGii toxin family'; the MenT4 identity is established (Cai 2020). | AbiEii |
Resolved |
| Rv2827c Rv2827c |
mtbc0_003005 |
hypothetical protein | MenA4, the type IV antitoxin of the MenAT4 module (AbiEi family). RefSeq names only 'type IV TA AbiEi family antitoxin'; the MenA4 identity is established (Beck 2020). | AbiEi_1 |
Resolved |
| Rv2828A Rv2828A |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2277. Function unknown. Foldseek best (non-significant) hit: 5wi4-assembly1_C CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH A (prob 0.20, TM 0.63). | DUF2277 |
Still unknown |
| Rv2828c Rv2828c |
mtbc0_003006 |
hypothetical protein | DUF1802 family protein. | DUF1802 |
Family assigned |
| Rv2840c Rv2840c |
- |
hypothetical protein | Contains YlxR (PF04296.19) domain(s); putative function inferred from the domain architecture. | YlxR |
Family assigned |
| Rv2843 Rv2843 |
mtbc0_003022 |
hypothetical protein | Small membrane protein, invariant across 145,209 genomes (3 segregating sites only — a constraint read from invariance itself, the pN/pS being unpowered here). Its fold weakly resembles actinobacterial respiratory-supercomplex accessory subunits (HHpred 7Q21_l, E~1.8, near the TM-helix promiscuity floor). Function undetermined; the supercomplex association is a weak, uncorroborated structural hint. | Family assigned | |
| Rv2844 Rv2844 |
mtbc0_003023 |
hypothetical protein | Ferritin-like domain-containing protein. | DUF4439 |
Family assigned |
| Rv2854 Rv2854 |
mtbc0_003033 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Hydrolase_4 Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| Rv2862c Rv2862c |
mtbc0_003043 |
hypothetical protein | LiaF-like integral membrane protein (eggNOG COG4758), accessory inhibitor of a LiaRS-type two-component cell-envelope-stress response. Family-level; the cognate two-component partner in M. tuberculosis is undetermined. | DUF1707 |
Family assigned |
| Rv2879c Rv2879c |
|
Conserved hypothetical protein | Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs | Family assigned | |
| Rv2880c Rv2880c |
|
Conserved hypothetical protein | Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs | Family assigned | |
| Rv2891 Rv2891 |
- |
hypothetical protein | Contains Peptidase_M23 (PF01551.30) domain(s); putative function inferred from the domain architecture. | Peptidase_M23 |
Family assigned |
| dprA Rv2896c |
mtbc0_003078 |
hypothetical protein | DNA-processing protein DprA. Pfam: DNA_processg_A (PF02481.22), WHD_DprA (PF17782.8). | DNA_processg_A WHD_DprA |
Resolved |
| Rv2897c Rv2897c |
mtbc0_003079 |
hypothetical protein | YifB family Mg chelatase-like AAA ATPase. Pfam: Lon_C (PF05362.20), ChlI (PF13541.13), Mg_chelatase (PF01078.28), Mg_chelatase_C (PF13335.13). | Lon_C ChlI Mg_chelatase Mg_chelatase_C |
Family assigned |
| Rv2898c Rv2898c |
mtbc0_003080 |
hypothetical protein | YraN family protein. | UPF0102 |
Family assigned |
| Rv2901c Rv2901c |
mtbc0_003083 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2469. Function unknown. Foldseek best (non-significant) hit: 4m7d-assembly1_C Crystal structure of Lsm2-8 complex bound to the RNA (prob 0.16, TM 0.31). | DUF2469 |
Still unknown |
| Rv2908c Rv2908c |
mtbc0_003090 |
hypothetical protein | RNA-binding protein. Pfam: KH_KhpA-B (PF13083.14). | KH_KhpA-B |
Family assigned |
| Rv2910c Rv2910c |
- |
hypothetical protein | Contains SnoaL_4 (PF13577.13) domain(s); putative function inferred from the domain architecture. | SnoaL_4 |
Family assigned |
| Rv2915c Rv2915c |
mtbc0_003097 |
hypothetical protein | Amidohydrolase family protein. Pfam: Amidohydro_1 (PF01979.27). | Amidohydro_1 |
Family assigned |
| Rv2917 Rv2917 |
- |
hypothetical protein | Contains ResIII (PF04851.22), DEAD (PF00270.36), SWI2_SNF2 (PF18766.8) domain(s); putative function inferred from the domain architecture. | ResIII DEAD SWI2_SNF2 |
Family assigned |
| Rv2923c Rv2923c |
mtbc0_003106 |
hypothetical protein | OsmC family protein. Pfam: OsmC (PF02566.25). | OsmC |
Family assigned |
| Rv2926c Rv2926c |
- |
hypothetical protein | Contains YceD (PF02620.23) domain(s); putative function inferred from the domain architecture. | YceD |
Family assigned |
| sepIVA Rv2927c |
mtbc0_003110 |
hypothetical protein | Cell division protein SepIVA. | Resolved | |
| Rv2929 Rv2929 |
mtbc0_003112 |
hypothetical protein | Secreted protein co-transcribed with tesA (a thioesterase involved in lipid / PDIM-related metabolism) under purifying selection. Contextual candidate: associated with lipid / thioesterase-linked metabolism. Its molecular role is not established. | Family assigned | |
| Rv2954c Rv2954c |
mtbc0_003136 |
hypothetical protein | [2%2C4-di-O-methyl-alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3)-2-O-methyl-alpha-L-rhamnopyranosyl] dimycocerosyl phenol-phthiocerol 3'''-O-methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_9 (PF08003.18), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | Methyltransf_23 Methyltransf_9 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| Rv2955c Rv2955c |
mtbc0_003137 |
hypothetical protein | [2-O-methyl-alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3)-2-O-methyl-alpha-L-rhamnopyranosyl] dimycocerosyl phenol-phthiocerol 4'''-O-methyltransferase. Pfam: Methyltransf_21 (PF05050.20). | Methyltransf_21 |
Resolved |
| Rv2956 Rv2956 |
mtbc0_003138 |
hypothetical protein | [alpha-L-fucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->3)-2-O-methyl-alpha-L-rhamnopyranosyl] dimycocerosyl phenol-phthiocerol 2'''-O-methyltransferase. Pfam: Methyltransf_21 (PF05050.20). | Methyltransf_21 |
Resolved |
| Rv2960c Rv2960c |
mtbc0_003143 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2969c Rv2969c |
mtbc0_003153 |
hypothetical protein | Mycothiol-dependent reductase. Pfam: Thioredoxin_4 (PF13462.13). | Thioredoxin_4 |
Resolved |
| Rv2970A Rv2970A |
- |
hypothetical protein | Aldo-keto reductase (NADP) family ORF (eggNOG COG0656, EC 1.1.1.346; COG category S). Short ORF matching the AKR family at strong orthology (partial); substrate undetermined. | Family assigned | |
| Rv2972c Rv2972c |
mtbc0_003157 |
hypothetical protein | HNH endonuclease family protein. Pfam: GmrSD_C (PF07510.17). | GmrSD_C |
Family assigned |
| Rv2974c Rv2974c |
- |
hypothetical protein | Contains Dak2 (PF02734.23), FakA-like_M (PF21645.4), FakA-like_C (PF13684.12) domain(s); putative function inferred from the domain architecture. | Dak2 FakA-like_M FakA-like_C |
Family assigned |
| Rv2975c Rv2975c |
- |
hypothetical protein | Putative dihydroxyacetone (glycerone) kinase, DhaK/DhaL-family subunit (eggNOG COG1461, EC 2.7.1.28/2.7.1.29/4.6.1.15; UniProt 'DhaL domain-containing protein'). RefSeq leaves it 'hypothetical protein'. Small ORF (84 aa) matching the kinase subunit at strong orthology and structurally (TM 0.71); partner subunit and operon undetermined, no catalytic site verified. | Family assigned | |
| Rv2980 Rv2980 |
mtbc0_003165 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3515. Function unknown. Foldseek best (non-significant) hit: 5y39-assembly1_B Crystal structure of Ragulator complex (p18 76-145) (prob 0.38, TM 0.58). | DUF3515 |
Still unknown |
| Rv2990c Rv2990c |
mtbc0_003175 |
hypothetical protein | Class I SAM-dependent methyltransferase. | Resolved | |
| Rv2991 Rv2991 |
mtbc0_003176 |
hypothetical protein | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28), Pyridox_ox_2 (PF12900.14). | PNPOx_N Pyridox_ox_2 |
Resolved |
| Rv2998 Rv2998 |
mtbc0_003186 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2998A Rv2998A |
|
Conserved hypothetical protein | — | Family assigned |