Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0543c Rv0543c |
mtbc0_000572 |
hypothetical protein | Member of the DUF3349 (PF11829) protein superfamily, found predominantly in Mycobacterium and Rhodococcus. The inaugural DUF3349 structure was solved for Rv0543c by NMR: a monomeric five-alpha-helix bundle (Buchko 2011); comparative structures show two structural subfamilies (Buchko 2020). Biological function unknown but family-restricted to these genera. | DUF3349 |
Family assigned |
| Rv0544c Rv0544c |
mtbc0_000573 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| pitA Rv0545c |
mtbc0_000574 |
low-affinity inorganic phosphate transporter | Anion permease. Pfam: PHO4 (PF01384.26). | PHO4 |
Resolved |
| Rv0546c Rv0546c |
mtbc0_000575 |
hypothetical protein | VOC family protein. Pfam: Glyoxalase (PF00903.32). | Glyoxalase |
Family assigned |
| Rv0547c Rv0547c |
mtbc0_000576 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), adh_short_C2 (PF13561.13). | adh_short adh_short_C2 |
Family assigned |
| menB Rv0548c |
- |
1,4-dihydroxy-2-naphthoyl-CoA synthase | 1,4-dihydroxy-2-naphthoyl-CoA synthase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| vapC3 Rv0549c |
mtbc0_000578 |
ribonuclease VapC3 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB3 Rv0550c |
mtbc0_000579 |
antitoxin VapB3 | Type II toxin-antitoxin system CcdA family antitoxin. Pfam: CcdA (PF07362.19). | CcdA |
Family assigned |
| fadD8 Rv0551c |
mtbc0_000580 |
fatty-acid--CoA ligase FadD8 | Fatty-acid--CoA ligase FadD8. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| Rv0552 Rv0552 |
mtbc0_000581 |
hypothetical protein | Amidohydrolase. Pfam: Amidohydro_3 (PF07969.18), Amidohydro_1 (PF01979.27). | Amidohydro_3 Amidohydro_1 |
Resolved |
| menC Rv0553 |
mtbc0_000582 |
muconate cycloisomerase | O-succinylbenzoate synthase. Pfam: Enolase_like_N (PF18374.7), MR_MLE_C (PF13378.13). | Enolase_like_N MR_MLE_C |
Resolved |
| bpoC Rv0554 |
mtbc0_000583 |
non-heme bromoperoxidase BpoC | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14), Hydrolase_4 (PF12146.16), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Abhydrolase_6 Hydrolase_4 Abhydrolase_4 |
Family assigned |
| menD Rv0555 |
mtbc0_000584 |
bifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase. Pfam: TPP_enzyme_N (PF02776.24). | TPP_enzyme_N |
Resolved |
| Rv0556 Rv0556 |
mtbc0_000585 |
transmembrane protein | Polymorphic-toxin / contact-dependent immunity-protein-like fold (Tsi4-like). RefSeq leaves it 'membrane protein'. | Family assigned | |
| mgtA Rv0557 |
- |
GDP-mannose-dependent alpha-mannosyltransferase | GDP-mannose-dependent alpha-mannosyltransferase. Pfam: Glyco_transf_4 (PF13439.13), Glyco_trans_4_4 (PF13579.13), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13). | Glyco_transf_4 Glyco_trans_4_4 Glycos_transf_1 Glyco_trans_1_4 |
Resolved |
| menH Rv0558 |
- |
demethylmenaquinone methyltransferase | Demethylmenaquinone methyltransferase. Pfam: Ubie_methyltran (PF01209.25), Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | Ubie_methyltran Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv0559c Rv0559c |
mtbc0_000588 |
hypothetical protein | Lipoprotein of the LprJ-like family (secreted, salicylate/rifampicin-stress-induced). RefSeq leaves it 'hypothetical protein'. | DUF732 |
Family assigned |
| Rv0560c Rv0560c |
- |
benzoquinone methyltransferase | Benzoquinone methyltransferase. Pfam: TPMT (PF05724.18), MTS (PF05175.21), Methyltransf_23 (PF13489.13), PrmA (PF06325.20), Ubie_methyltran (PF01209.25), Methyltransf_25 (PF13649.13), Methyltransf_31 (PF13847.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | TPMT MTS Methyltransf_23 PrmA Ubie_methyltran Methyltransf_25 Methyltransf_31 Methyltransf_11 Methyltransf_12 |
Resolved |
| menJ Rv0561c |
mtbc0_000590 |
oxidoreductase | Menaquinone reductase. Pfam: FAD_binding_3 (PF01494.26), Pyr_redox_2 (PF07992.21), Lycopene_cycl (PF05834.19), FAD_oxidored (PF12831.14), FAD_binding_2 (PF00890.31), GIDA (PF01134.29), NAD_binding_8 (PF13450.13). | FAD_binding_3 Pyr_redox_2 Lycopene_cycl FAD_oxidored FAD_binding_2 GIDA NAD_binding_8 |
Resolved |
| grcC1 Rv0562 |
mtbc0_000591 |
polyprenyl-diphosphate synthase GrcC | Polyprenyl-diphosphate synthase GrcC. Pfam: polyprenyl_synt (PF00348.23). | polyprenyl_synt |
Resolved |
| htpX Rv0563 |
mtbc0_000592 |
protease HtpX | Zinc metalloprotease HtpX. Pfam: Peptidase_M48 (PF01435.25). | Peptidase_M48 |
Resolved |
| gpdA1 Rv0564c |
mtbc0_000593 |
glycerol-3-phosphate dehydrogenase | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase. Pfam: NAD_Gly3P_dh_N (PF01210.30), F420_oxidored (PF03807.24), NAD_Gly3P_dh_C (PF07479.20), GPD_NAD_C_bact (PF20618.4). | NAD_Gly3P_dh_N F420_oxidored NAD_Gly3P_dh_C GPD_NAD_C_bact |
Resolved |
| Rv0565c Rv0565c |
mtbc0_000594 |
monooxygenase | NAD(P)/FAD-dependent oxidoreductase. Pfam: Thi4 (PF01946.24), Pyr_redox_2 (PF07992.21), FMO-like (PF00743.26), Pyr_redox_3 (PF13738.13), NAD_binding_8 (PF13450.13). | Thi4 Pyr_redox_2 FMO-like Pyr_redox_3 NAD_binding_8 |
Resolved |
| Rv0566c Rv0566c |
mtbc0_000595 |
hypothetical protein | YajQ family cyclic di-GMP-binding protein. Pfam: YajQ (PF04461.19). | YajQ |
Family assigned |
| Rv0567 Rv0567 |
mtbc0_000597 |
methyltransferase/methylase | Methyltransferase. Pfam: Dimerisation (PF08100.19), Methyltransf_2 (PF00891.25), Methyltransf_23 (PF13489.13), MTS (PF05175.21), Methyltransf_12 (PF08242.19), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | Dimerisation Methyltransf_2 Methyltransf_23 MTS Methyltransf_12 Methyltransf_25 Methyltransf_11 |
Resolved |
| cyp135B1 Rv0568 |
mtbc0_000598 |
cytochrome P450 Cyp135B1 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv0569 Rv0569 |
mtbc0_000599 |
hypothetical protein | DosR (dormancy survival regulon) protein; conserved hypothetical protein over-expressed under hypoxia. NMR solution structure determined (five antiparallel beta-sheets + one alpha-helix), structurally homologous to Rv2302; proposed to contribute to hypoxic signal transduction by binding DNA to up-regulate the adjacent Rv0570. Immunodominant Th1 latency antigen. Precise molecular function unfixed. | DUF1918 |
Family assigned |
| nrdZ Rv0570 |
mtbc0_000600 |
vitamin B12-dependent ribonucleoside-diphosphate reductase | Adenosylcobalamin-dependent ribonucleoside-diphosphate reductase. Pfam: ATP-cone (PF03477.22), Ribonuc_red_lgN (PF00317.27), Ribonuc_red_lgC (PF02867.21). | ATP-cone Ribonuc_red_lgN Ribonuc_red_lgC |
Resolved |
| Rv0571c Rv0571c |
mtbc0_000601 |
hypothetical protein | Phosphoribosyltransferase family protein. Pfam: Pribosyltran (PF00156.34), DLH (PF01738.25). | Pribosyltran DLH |
Family assigned |
| Rv0572c Rv0572c |
mtbc0_000602 |
hypothetical protein | Contains MT0599 (PF25859.1) domain(s); putative function inferred from the domain architecture. | MT0599 |
Family assigned |
| pncB2 Rv0573c |
mtbc0_000603 |
nicotinic acid phosphoribosyltransferase PncB2 | Nicotinate phosphoribosyltransferase. Pfam: NAPRTase_N (PF17767.8), NAPRTase (PF04095.23). | NAPRTase_N NAPRTase |
Resolved |
| Rv0574c Rv0574c |
mtbc0_000604 |
hypothetical protein | CapA family protein. Pfam: PGA_cap (PF09587.16). | PGA_cap |
Family assigned |
| Rv0575c Rv0575c |
mtbc0_000605 |
oxidoreductase | FAD-binding domain. Pfam: FAD_binding_3 (PF01494.26). | FAD_binding_3 |
Resolved |
| Rv0576 Rv0576 |
mtbc0_000606 |
transcriptional regulator | TIGR03086 family metal-binding protein. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27), Polyketide_cyc2 (PF10604.16), AHSA1 (PF08327.18). | HTH_20 HTH_5 Polyketide_cyc2 AHSA1 |
Family assigned |
| TB27.3 Rv0577 |
mtbc0_000607 |
hypothetical protein | VOC family protein. Pfam: Glyoxalase (PF00903.32), Glyoxalase_6 (PF18029.8). | Glyoxalase Glyoxalase_6 |
Family assigned |
| PE_PGRS7 Rv0578c |
- |
PE-PGRS family protein PE_PGRS7 | PE-PGRS family protein PE_PGRS7. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv0579 Rv0579 |
mtbc0_000609 |
hypothetical protein | Mut7-C RNAse domain-containing protein. Pfam: Ub-Mut7C (PF14451.13), Mut7-C (PF01927.23). | Ub-Mut7C Mut7-C |
Family assigned |
| Rv0580c Rv0580c |
mtbc0_000610 |
hypothetical protein | Mycobacterial cell wall protein Rv0580c. | Resolved | |
| vapB26 Rv0581 |
mtbc0_000611 |
antitoxin VapB26 | Type II toxin-antitoxin system antitoxin VapB26. Pfam: RHH_1 (PF01402.28). | RHH_1 |
Resolved |
| vapC26 Rv0582 |
mtbc0_000612 |
ribonuclease VapC26 | Type II toxin-antitoxin system toxin ribonuclease C26. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| lpqN Rv0583c |
mtbc0_000613 |
lipoprotein LpqN | LpqN/LpqT family lipoprotein. Pfam: Lpp-LpqN (PF10738.16). | Lpp-LpqN |
Family assigned |
| Rv0584 Rv0584 |
mtbc0_000614 |
glycosidase | GH92 family glycosyl hydrolase. Pfam: Glyco_hydro_92N (PF17678.8), Glyco_hydro_92 (PF07971.19). | Glyco_hydro_92N Glyco_hydro_92 |
Family assigned |
| Rv0585c Rv0585c |
mtbc0_000615 |
integral membrane protein | Lysylphosphatidylglycerol synthase transmembrane domain-containing protein. Pfam: LPG_synthase_TM (PF03706.19). | LPG_synthase_TM |
Family assigned |
| mce2R Rv0586 |
mtbc0_000616 |
HTH-type transcriptional regulator Mce2R | FadR family transcriptional regulator Mce2R. Pfam: GntR (PF00392.28), FCD (PF07729.18). | GntR FCD |
Family assigned |
| yrbE2A Rv0587 |
mtbc0_000617 |
hypothetical protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| Rv0588 Rv0588 |
mtbc0_000618 |
hypothetical protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| mce2A Rv0589 |
- |
Mce family protein Mce2A | Mce family protein Mce2A. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce2C Rv0591 |
mtbc0_000621 |
Mce family protein Mce2C | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce2D Rv0592 |
mtbc0_000622 |
Mce family protein Mce2D | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| lprL Rv0593 |
- |
Mce family lipoprotein LprL | Mce family lipoprotein LprL. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |