Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| egtC Rv3702c |
mtbc0_003924 |
amidohydrolase EgtC | Ergothioneine biosynthesis protein EgtC. Pfam: GATase_4 (PF13230.12). | GATase_4 |
Resolved |
| etgB Rv3703c |
mtbc0_003925 |
iron(II)-dependent oxidoreductase EgtB | Ergothioneine biosynthesis protein EgtB. Pfam: DinB_2 (PF12867.13), FGE-sulfatase (PF03781.23). | DinB_2 FGE-sulfatase |
Resolved |
| gshA Rv3704c |
mtbc0_003926 |
glutamate--cysteine ligase | Ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Pfam: GCS2 (PF04107.19). | GCS2 |
Resolved |
| Rv3705A Rv3705A |
- |
hypothetical protein | Acid-stress / persistence-associated protein; member of the TcrXY (acid-sensing two-component) regulon required for persistent infection (Stupar 2024). Precise molecular role undefined. | Family assigned | |
| Rv3705c Rv3705c |
mtbc0_003927 |
hypothetical protein | Sensor domain-containing protein. Pfam: PknH_C (PF14032.13). | PknH_C |
Family assigned |
| Rv3706c Rv3706c |
mtbc0_003929 |
hypothetical protein | Effector of the TcrXY acid-sensing two-component system regulon, required for persistent infection. RefSeq leaves it of unknown function. Rv3706c, with Rv3705A, is a characterised member of the TcrXY regulon implicated in Mtb survival in vivo by mitigating redox stress at acidic pH (Stupar 2024). Molecular function unfixed. | Family assigned | |
| Rv3707c Rv3707c |
- |
hypothetical protein | AraH2: endo-D-arabinofuranase, founding member (with AraH1/Rv1754c) of glycoside hydrolase family GH183 (Pfam DUF4185). Cleaves the D-arabinan core of arabinogalactan / lipoarabinomannan, i.e. mycobacterial cell-wall remodelling/degradation. NOTE: RefSeq/PGAP still annotate this gene as a hypothetical protein; it was characterised experimentally by Behrens et al. 2023. | DUF4185 |
Resolved |
| asd Rv3708c |
mtbc0_003931 |
aspartate-semialdehyde dehydrogenase | Aspartate-semialdehyde dehydrogenase. Pfam: Semialdhyde_dh (PF01118.31), Semialdhyde_dhC (PF02774.24). | Semialdhyde_dh Semialdhyde_dhC |
Resolved |
| ask Rv3709c |
mtbc0_003932 |
aspartokinase | Aspartate kinase. Pfam: AA_kinase (PF00696.34), ACT (PF01842.32), ACT_7 (PF13840.13), ACT_9 (PF22468.3). | AA_kinase ACT ACT_7 ACT_9 |
Resolved |
| leuA Rv3710 |
mtbc0_003933 |
2-isopropylmalate synthase | 2-isopropylmalate synthase. Pfam: HMGL-like (PF00682.26), IPMS_D2 (PF22615.2), LeuA_dimer (PF08502.16). | HMGL-like IPMS_D2 LeuA_dimer |
Resolved |
| dnaQ Rv3711c |
mtbc0_003934 |
DNA polymerase III subunit epsilon | DEDDh family exonuclease. Pfam: RNase_T (PF00929.32). | RNase_T |
Family assigned |
| Rv3712 Rv3712 |
mtbc0_003935 |
ligase | Mur ligase family protein. Pfam: Mur_ligase_M (PF08245.19), MurT_C (PF08353.16). | Mur_ligase_M MurT_C |
Family assigned |
| cobQ2 Rv3713 |
mtbc0_003936 |
cobyric acid synthase CobQ | Type 1 glutamine amidotransferase. Pfam: GATase_3 (PF07685.21). | GATase_3 |
Resolved |
| Rv3714c Rv3714c |
mtbc0_003937 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| recR Rv3715c |
mtbc0_003938 |
recombination protein RecR | Recombination mediator RecR. Pfam: RecR_HhH (PF21176.4), RecR_ZnF (PF02132.22), Toprim_4 (PF13662.13), Toprim (PF01751.29), RecR_C (PF21175.3). | RecR_HhH RecR_ZnF Toprim_4 Toprim RecR_C |
Resolved |
| Rv3716c Rv3716c |
mtbc0_003939 |
hypothetical protein | YbaB/EbfC family nucleoid-associated protein. Pfam: YbaB_DNA_bd (PF02575.22). M. tuberculosis carries a second YbaB/EbfC paralog, Rv0030 (this re-annotation campaign), so the two form a YbaB/EbfC nucleoid-associated-protein pair. | YbaB_DNA_bd |
Family assigned |
| Rv3717 Rv3717 |
- |
hypothetical protein | Contains Amidase_3 (PF01520.24) domain(s); putative function inferred from the domain architecture. | Amidase_3 |
Family assigned |
| Rv3718c Rv3718c |
mtbc0_003941 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16). | Polyketide_cyc2 |
Family assigned |
| Rv3719 Rv3719 |
- |
hypothetical protein | Contains FAD_binding_4 (PF01565.29) domain(s); putative function inferred from the domain architecture. | FAD_binding_4 |
Family assigned |
| Rv3720 Rv3720 |
- |
fatty acid synthase | Fatty acid synthase. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_11 |
Resolved |
| dnaZX Rv3721c |
mtbc0_003944 |
DNA polymerase III subunit gamma/tau | DNA polymerase III subunits gamma/tau. Pfam: DNA_pol3_delta2 (PF13177.13), AAA (PF00004.36), AAA_22 (PF13401.13), DNAX_ATPase_lid (PF22608.3), DNA_pol3_gamma3 (PF12169.14). | DNA_pol3_delta2 AAA AAA_22 DNAX_ATPase_lid DNA_pol3_gamma3 |
Family assigned |
| Rv3722c Rv3722c |
mtbc0_003945 |
hypothetical protein | Aminotransferase. Pfam: Asp_aminotransf (PF12897.14). | Asp_aminotransf |
Resolved |
| lucA Rv3723 |
mtbc0_003948 |
transmembrane protein | Lipid uptake coordinator LucA. Pfam: LUCA (PF26307.1). | LUCA |
Resolved |
| cut5a Rv3724A |
|
Probable cutinase precursor [first part] Cut5a | Hydrolysis of cutin (a polyester that forms the structure of plant cuticle). | Cutinase |
Family assigned |
| cut5b Rv3724B |
|
Probable cutinase [second part] Cut5b | Hydrolysis of cutin (a polyester that forms the structure of plant cuticle). | Cutinase |
Family assigned |
| Rv3725 Rv3725 |
- |
oxidoreductase | Oxidoreductase. Pfam: NmrA (PF05368.20), RmlD_sub_bind (PF04321.24), Epimerase (PF01370.28), Polysacc_synt_2 (PF02719.22), adh_short (PF00106.32), KR (PF08659.17), 3Beta_HSD (PF01073.26), GDP_Man_Dehyd (PF16363.12), NAD_binding_4 (PF07993.19), NAD_binding_10 (PF13460.13). | NmrA RmlD_sub_bind Epimerase Polysacc_synt_2 adh_short KR 3Beta_HSD GDP_Man_Dehyd NAD_binding_4 NAD_binding_10 |
Resolved |
| Rv3726 Rv3726 |
mtbc0_003951 |
dehydrogenase | Zinc-binding dehydrogenase. Pfam: ADH_N (PF08240.18). | ADH_N |
Resolved |
| Rv3727 Rv3727 |
mtbc0_003952 |
oxidoreductase | FAD-dependent oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), DAO (PF01266.31), FAD_binding_2 (PF00890.31), NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | FAD_binding_3 DAO FAD_binding_2 NAD_binding_8 Amino_oxidase |
Resolved |
| Rv3728 Rv3728 |
mtbc0_003953 |
membrane protein | MFS transporter. Pfam: Sugar_tr (PF00083.31), MFS_1 (PF07690.22), cNMP_binding (PF00027.36), Patatin (PF01734.28). | Sugar_tr MFS_1 cNMP_binding Patatin |
Resolved |
| Rv3729 Rv3729 |
- |
transferase | Transferase. Pfam: Zn_ribbon_HMPTM (PF23545.2), Radical_SAM (PF04055.28), Fer4_12 (PF13353.12), Methyltransf_23 (PF13489.13), Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Zn_ribbon_HMPTM Radical_SAM Fer4_12 Methyltransf_23 Ubie_methyltran Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| ligD Rv3730c |
mtbc0_003955 |
hypothetical protein | Non-homologous end-joining DNA ligase. Pfam: LigD_Prim-Pol (PF21686.4), DNA_primase_S (PF01896.26). | LigD_Prim-Pol DNA_primase_S |
Resolved |
| ligC Rv3731 |
mtbc0_003956 |
DNA ligase C | ATP-dependent DNA ligase. Pfam: DNA_ligase_A_M (PF01068.27), DNA_ligase_A_C (PF04679.22). | DNA_ligase_A_M DNA_ligase_A_C |
Resolved |
| Rv3732 Rv3732 |
mtbc0_003957 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2330. Function unknown. Foldseek best (non-significant) hit: 6oiu-assembly3_C X-ray crystal structure of the ectodomain of the Toxo (prob 0.14, TM 0.24). | DUF2330 |
Still unknown |
| Rv3733c Rv3733c |
mtbc0_003958 |
hypothetical protein | NUDIX domain-containing protein. Pfam: NUDIX (PF00293.35). | NUDIX |
Family assigned |
| tgs2 Rv3734c |
mtbc0_003959 |
diacyglycerol O-acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| Rv3735 Rv3735 |
mtbc0_003960 |
hypothetical protein | Adenosine-specific kinase. Pfam: Adenosine_kin (PF04008.20). | Adenosine_kin |
Resolved |
| Rv3736 Rv3736 |
mtbc0_003961 |
AraC/XylS family transcriptional regulator | AraC family transcriptional regulator. Pfam: Arabinose_bd (PF12625.13), HTH_18 (PF12833.14). | Arabinose_bd HTH_18 |
Family assigned |
| Rv3737 Rv3737 |
mtbc0_003962 |
transmembrane protein | Threonine/serine exporter family protein. Pfam: ThrE (PF06738.19), ThrE_2 (PF12821.14). | ThrE ThrE_2 |
Family assigned |
| PPE66 Rv3738c |
- |
PPE family protein PPE66 | PPE family protein PPE66. Pfam: PPE (PF00823.26), PPE-PPW (PF18878.6). | PPE PPE-PPW |
Family assigned |
| PPE67 Rv3739c |
- |
PPE family protein PPE67 | PPE family protein PPE67. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| Rv3740c Rv3740c |
mtbc0_003964 |
diacyglycerol O-acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| Rv3741c Rv3741c |
- |
oxidoreductase | Oxidoreductase. | Resolved | |
| Rv3742c Rv3742c |
- |
oxidoreductase | Oxidoreductase. | Resolved | |
| ctpJ Rv3743c |
mtbc0_003966 |
cation transporter ATPase J | Heavy metal translocating P-type ATPase. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | E1-E2_ATPase Hydrolase |
Resolved |
| nmtR Rv3744 |
mtbc0_003967 |
HTH-type transcriptional regulator NmtR | Ni(II)/Co(II)-sensing metalloregulatory transcriptional repressor NmtR. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27), HTH_IclR (PF09339.17), HTH_24 (PF13412.13). | HTH_20 HTH_5 HTH_IclR HTH_24 |
Resolved |
| Rv3745c Rv3745c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2237. Function unknown. | DUF2237 |
Still unknown |
| PE34 Rv3746c |
- |
PE family protein PE34 | PE family protein PE34. Pfam: PE (PF00934.26). | PE |
Family assigned |
| Rv3747 Rv3747 |
mtbc0_003970 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: the real Wzm/Wzt galactan-export ABC transporter is Rv3781/Rv3783 (paralogue-of-fold). | Still unknown | |
| Rv3748 Rv3748 |
mtbc0_003971 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 1qvy-assembly3_C Crystal structure of RhoGDI K(199,200)R double mutant (prob 1.00, TM 0.60). Structure-based, putative. | Family assigned | |
| Rv3749c Rv3749c |
- |
hypothetical protein | VapC50, a PIN-domain ribonuclease toxin of a VapBC type II module (Pfam VapC50_C PF26343). RefSeq leaves it 'hypothetical protein'; toxin activity was characterised by Kim 2016. | VapC50_C |
Resolved |