Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| pbpB Rv2163c |
mtbc0_002299 |
penicillin-binding membrane protein PbpB | D%2CD-transpeptidase PbpB. Pfam: PBP_dimer (PF03717.21), Transpeptidase (PF00905.28). | PBP_dimer Transpeptidase |
Resolved |
| Rv2164c Rv2164c |
mtbc0_002300 |
hypothetical protein | Cell-division / septum-associated membrane protein (eggNOG COG2919, 'essential cell division protein FtsB-like'; COG category D). RefSeq leaves it 'hypothetical protein'. Division-machinery role at orthology level. | Family assigned | |
| rsmH Rv2165c |
mtbc0_002301 |
rRNA small subunit methyltransferase H | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH. Pfam: Methyltransf_5 (PF01795.26). | Methyltransf_5 |
Resolved |
| mraZ Rv2166c |
mtbc0_002302 |
transcriptional regulator MraZ | Division/cell wall cluster transcriptional repressor MraZ. Pfam: MraZ (PF02381.24). | MraZ |
Resolved |
| Rv2169c Rv2169c |
mtbc0_002303 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3040. Function unknown. | DUF3040 |
Still unknown |
| Rv2170 Rv2170 |
mtbc0_002304 |
GCN5-like N-acetyltransferase | N-acetyltransferase. Pfam: FR47 (PF08445.17), Acetyltransf_1 (PF00583.32), Acetyltransf_7 (PF13508.14). | FR47 Acetyltransf_1 Acetyltransf_7 |
Resolved |
| lppM Rv2171 |
mtbc0_002305 |
lipoprotein LppM | Lipoprotein LppM. Pfam: LppM (PF21946.2). | LppM |
Resolved |
| Rv2172c Rv2172c |
mtbc0_002306 |
hypothetical protein | Mycobacterial-type methylenetetrahydrofolate reductase. Pfam: MTHFR_2 (PF19345.6). | MTHFR_2 |
Resolved |
| idsA2 Rv2173 |
mtbc0_002307 |
geranylgeranyl pyrophosphate synthetase IdsA | Bifunctional (2E%2C6E)-farnesyl/geranyl diphosphate synthase. Pfam: polyprenyl_synt (PF00348.23). | polyprenyl_synt |
Resolved |
| mptA Rv2174 |
mtbc0_002308 |
alpha(1->6)-mannopyranosyltransferase A | Alpha-(1->6)-mannopyranosyltransferase A. Pfam: MptA_B_family (PF26314.1), MptA_C (PF27552.1). | MptA_B_family MptA_C |
Resolved |
| Rv2175c Rv2175c |
- |
DNA-binding protein | DNA-binding protein. Pfam: Rv2175c_wHTH (PF21531.4), Rv2175c_C (PF18367.7). | Rv2175c_wHTH Rv2175c_C |
Family assigned |
| pknL Rv2176 |
mtbc0_002310 |
serine/threonine-protein kinase PknL | Protein kinase. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24). | Pkinase PK_Tyr_Ser-Thr |
Resolved |
| Rv2177c Rv2177c |
- |
transposase | Transposase. Pfam: Transposase_20 (PF02371.23). | Transposase_20 |
Resolved |
| aroG Rv2178c |
mtbc0_002313 |
phospho-2-dehydro-3-deoxyheptonate aldolase AroG | 3-deoxy-7-phosphoheptulonate synthase class II. Pfam: DAHP_synth_2 (PF01474.23). | DAHP_synth_2 |
Resolved |
| Rv2179c Rv2179c |
mtbc0_002314 |
3'-5' exoribonuclease | Polyadenylate-specific 3'-exoribonuclease AS. Pfam: Rv2179c-like (PF16473.12). | Rv2179c-like |
Resolved |
| Rv2180c Rv2180c |
mtbc0_002315 |
integral membrane protein | Integral membrane protein. | Family assigned | |
| Rv2181 Rv2181 |
mtbc0_002316 |
alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase | Alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase. Pfam: GT87 (PF09594.17). | GT87 |
Resolved |
| Rv2182c Rv2182c |
mtbc0_002317 |
1-acylglycerol-3-phosphate O-acyltransferase | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). | Acyltransferase |
Family assigned |
| Rv2183c Rv2183c |
mtbc0_002318 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2184c Rv2184c |
- |
hypothetical protein | Contains ArsA_ATPase (PF02374.22), ArsA_HSP20 (PF17886.8) domain(s); putative function inferred from the domain architecture. | ArsA_ATPase ArsA_HSP20 |
Family assigned |
| TB16.3 Rv2185c |
mtbc0_002320 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| Rv2186c Rv2186c |
mtbc0_002321 |
hypothetical protein | Polyketide cyclase / dehydrase and lipid transport. | Resolved | |
| fadD15 Rv2187 |
mtbc0_002322 |
long-chain-fatty-acid--CoA ligase FadD15 | Long-chain fatty acid--CoA ligase. Pfam: AMP-binding (PF00501.35), AMP-binding_C_3 (PF23562.3). | AMP-binding AMP-binding_C_3 |
Resolved |
| pimB Rv2188c |
mtbc0_002323 |
alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase | GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase. Pfam: Glyco_transf_4 (PF13439.13), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13), Glyco_trans_1_2 (PF13524.13). | Glyco_transf_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Resolved |
| Rv2189c Rv2189c |
mtbc0_002324 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: the real M1 alanyl-aminopeptidase PepN is Rv2467 (paralogue-of-fold). | Still unknown | |
| ripC Rv2190c |
mtbc0_002325 |
endopeptidase | Peptidoglycan hydrolase RipC. Pfam: NLPC_P60 (PF00877.26). | NLPC_P60 |
Resolved |
| Rv2191 Rv2191 |
- |
hypothetical protein | Contains RNase_T (PF00929.32), UvrC_M (PF27096.1) domain(s); putative function inferred from the domain architecture. | RNase_T UvrC_M |
Family assigned |
| trpD Rv2192c |
mtbc0_002328 |
anthranilate phosphoribosyltransferase | Anthranilate phosphoribosyltransferase. Pfam: Glycos_trans_3N (PF02885.23), Glycos_transf_3 (PF00591.28). | Glycos_trans_3N Glycos_transf_3 |
Resolved |
| ctaE Rv2193 |
mtbc0_002329 |
cytochrome C oxidase subunit III | Heme-copper oxidase subunit III. Pfam: COX3 (PF00510.24). | COX3 |
Family assigned |
| qcrC Rv2194 |
mtbc0_002330 |
ubiquinol-cytochrome C reductase cytochrome subunit C | Cytochrome c. Pfam: Cytochrom_C (PF00034.27), Cytochrome_CBB3 (PF13442.12). | Cytochrom_C Cytochrome_CBB3 |
Resolved |
| qcrA Rv2195 |
mtbc0_002331 |
ubiquinol-cytochrome C reductase rieske iron-sulfur subunit | QcrA, the Rieske iron-sulfur protein of the cytochrome bcc (bc1) complex of the respiratory chain. RefSeq leaves this locus uncharacterised, but Rv2195 is qcrA, part of the qcrCAB operon (with qcrB/Rv2196, the target of telacebec/Q203). Resistance to QcrB inhibitors can arise via QcrA mutations in the stigmatellin pocket (Lupien 2020), and qcrA is an essential, human-homolog-free drug target (Cloete 2016). | Resolved | |
| qcrB Rv2196 |
mtbc0_002332 |
ubiquinol-cytochrome C reductase cytochrome subunit B | Cytochrome bc complex cytochrome b subunit. Pfam: Cytochrome_B (PF00033.25), Cytochrom_B_N_2 (PF13631.12). | Cytochrome_B Cytochrom_B_N_2 |
Family assigned |
| Rv2197c Rv2197c |
- |
transmembrane protein | Transmembrane protein. | DUF2561 |
Resolved |
| mmpS3 Rv2198c |
mtbc0_002334 |
membrane protein MmpS3 | MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| Rv2199c Rv2199c |
mtbc0_002335 |
cytochrome c oxidase polypeptide 4 | Cytochrome c oxidase subunit 4. Pfam: Cyt_c_ox_IV (PF12270.14). | Cyt_c_ox_IV |
Family assigned |
| ctaC Rv2200c |
mtbc0_002336 |
cytochrome C oxidase subunit II | Cytochrome c oxidase subunit II. Pfam: COX2 (PF00116.27). | COX2 |
Family assigned |
| asnB Rv2201 |
mtbc0_002337 |
asparagine synthetase | Asparagine synthase (glutamine-hydrolyzing). Pfam: GATase_6 (PF13522.12), GATase_7 (PF13537.12), Asn_synthase (PF00733.28). | GATase_6 GATase_7 Asn_synthase |
Resolved |
| adoK Rv2202c |
mtbc0_002338 |
adenosine kinase | Carbohydrate kinase family protein. Pfam: PfkB (PF00294.30). | PfkB |
Family assigned |
| Rv2203 Rv2203 |
mtbc0_002339 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF8174. Function unknown. | DUF8174 |
Still unknown |
| Rv2204c Rv2204c |
mtbc0_002340 |
hypothetical protein | Iron-sulfur cluster assembly accessory protein. Pfam: Fe-S_biosyn (PF01521.27). | Fe-S_biosyn |
Resolved |
| Rv2205c Rv2205c |
mtbc0_002341 |
hypothetical protein | Glycerate kinase. Pfam: Gly_kinase (PF02595.21). | Gly_kinase |
Resolved |
| Rv2206 Rv2206 |
mtbc0_002342 |
transmembrane protein | Candidate accessory component of the de novo cobalamin (vitamin B12) biosynthesis (nucleotide-loop assembly operon), coupled to the cobalamin nucleotide-loop assembly operon (cobT Rv2207 / cobS Rv2208). Rv2206 is a genomic neighbour within the operon and STRING context partner (synteny corroborates the neighborhood channel) of cobT:789;cobS:787 (context-driven, text-mining excluded). It is under strong purifying selection on 145,209 MTBC genomes (4 segregating sites). No dedicated functional study of Rv2206 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | DUF3043 |
Still unknown |
| cobT Rv2207 |
mtbc0_002343 |
nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. Pfam: DBI_PRT (PF02277.23). | DBI_PRT |
Resolved |
| cobS Rv2208 |
mtbc0_002344 |
adenosylcobinamide-GDP ribazoletransferase | Adenosylcobinamide-GDP ribazoletransferase. Pfam: CobS (PF02654.21). | CobS |
Resolved |
| Rv2209 Rv2209 |
mtbc0_002345 |
integral membrane protein | MFS transporter. | Resolved | |
| ilvE Rv2210c |
mtbc0_002346 |
branched-chain amino acid aminotransferase | Branched-chain amino acid aminotransferase. Pfam: Aminotran_4 (PF01063.25). | Aminotran_4 |
Resolved |
| gcvT Rv2211c |
- |
aminomethyltransferase | Aminomethyltransferase. Pfam: GCV_T (PF01571.27), GCV_T_C (PF08669.18). | GCV_T GCV_T_C |
Resolved |
| Rv2212 Rv2212 |
mtbc0_002348 |
adenylyl cyclase | Adenylyl cyclase. Pfam: Guanylate_cyc (PF00211.26). | Guanylate_cyc |
Resolved |
| pepB Rv2213 |
mtbc0_002349 |
cytosol aminopeptidase | Leucyl aminopeptidase. Pfam: Peptidase_M17_N (PF02789.24), Peptidase_M17 (PF00883.27). | Peptidase_M17_N Peptidase_M17 |
Resolved |
| ephD Rv2214c |
mtbc0_002350 |
oxidoreductase EphD | SDR family oxidoreductase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14), adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 adh_short KR adh_short_C2 |
Family assigned |