Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1928c Rv1928c |
mtbc0_002042 |
short-chain type dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv1929c Rv1929c |
mtbc0_002043 |
hypothetical protein | TIGR03085 family metal-binding protein. | Family assigned | |
| Rv1930c Rv1930c |
mtbc0_002044 |
hypothetical protein | Glutamine amidotransferase. | Resolved | |
| Rv1931c Rv1931c |
- |
transcriptional regulator | Transcriptional regulator. Pfam: DJ-1_PfpI (PF01965.31), HTH_18 (PF12833.14). | DJ-1_PfpI HTH_18 |
Family assigned |
| tpx Rv1932 |
mtbc0_002046 |
2-Cys peroxiredoxin | Thiol peroxidase. Pfam: Redoxin (PF08534.17), AhpC-TSA (PF00578.28). | Redoxin AhpC-TSA |
Resolved |
| fadE18 Rv1933c |
mtbc0_002047 |
acyl-CoA dehydrogenase FadE18 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| fadE17 Rv1934c |
mtbc0_002048 |
acyl-CoA dehydrogenase FadE17 | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Resolved |
| echA13 Rv1935c |
mtbc0_002049 |
enoyl-CoA hydratase EchA13 | Enoyl-CoA hydratase. Pfam: ECH_2 (PF16113.11), ECH_1 (PF00378.26). | ECH_2 ECH_1 |
Resolved |
| Rv1936 Rv1936 |
mtbc0_002050 |
monooxygenase | LLM class flavin-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv1937 Rv1937 |
mtbc0_002051 |
oxygenase | FAD-binding oxidoreductase. Pfam: Fer2 (PF00111.33), FAD_binding_6 (PF00970.31), NAD_binding_1 (PF00175.27). | Fer2 FAD_binding_6 NAD_binding_1 |
Resolved |
| ephB Rv1938 |
mtbc0_002052 |
epoxide hydrolase EphB | Epoxide hydrolase EphB. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 |
Resolved |
| Rv1939 Rv1939 |
mtbc0_002053 |
oxidoreductase | Flavin reductase family protein. Pfam: Flavin_Reduct (PF01613.25). | Flavin_Reduct |
Family assigned |
| ribA1 Rv1940 |
- |
riboflavin biosynthesis protein RibA | Riboflavin biosynthesis protein RibA. Pfam: DHBP_synthase (PF00926.25), GTP_cyclohydro2 (PF00925.26). | DHBP_synthase GTP_cyclohydro2 |
Resolved |
| Rv1941 Rv1941 |
mtbc0_002055 |
short-chain type dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| mazF5 Rv1942c |
mtbc0_002056 |
toxin MazF5 | Type II toxin-antitoxin system PemK/MazF family toxin. Pfam: PemK_toxin (PF02452.24). | PemK_toxin |
Family assigned |
| mazE5 Rv1943c |
mtbc0_002057 |
antitoxin MazE5 | Type II toxin-antitoxin system antitoxin MazE5. | Resolved | |
| Rv1944c Rv1944c |
mtbc0_002058 |
hypothetical protein | SEC-C domain-containing protein. Pfam: SEC-C (PF02810.22). | SEC-C |
Family assigned |
| Rv1945 Rv1945 |
mtbc0_002059 |
hypothetical protein | HNH endonuclease signature motif containing protein. Pfam: DUF222 (PF02720.23), HNH (PF01844.30). | DUF222 HNH |
Resolved |
| lppG Rv1946c |
mtbc0_002060 |
lipoprotein | Lipoprotein. | Family assigned | |
| Rv1947 Rv1947 |
mtbc0_002061 |
hypothetical protein | Superfamily-II helicase (eggNOG COG1061, DEAD/SNF2-like; COG categories K/L), in an RD (RDcap_Spain4) context. Helicase fold; biological role undetermined. | Family assigned | |
| Rv1948c Rv1948c |
mtbc0_002063 |
hypothetical protein | Suppressor-of-Fused-like fold (PDB 4KMA); fold characterised, function not established. | Family assigned | |
| Rv1949c Rv1949c |
|
Conserved hypothetical protein | — | Still unknown | |
| Rv1950c Rv1950c |
mtbc0_002065 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1951c Rv1951c |
mtbc0_002066 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6z6f-assembly1_C HDAC-PC (prob 0.15, TM 0.64). | Still unknown | |
| vapB14 Rv1952 |
mtbc0_002067 |
antitoxin VapB14 | Antitoxin. Pfam: FitA-like_RHH (PF22513.3). | FitA-like_RHH |
Resolved |
| vapC14 Rv1953 |
- |
ribonuclease VapC14 | Ribonuclease VapC14. | Resolved | |
| Rv1954A Rv1954A |
|
Hypothetical protein | — | Still unknown | |
| Rv1954c Rv1954c |
mtbc0_002069 |
hypothetical protein | Hypoxia-induced protein and empirically validated human T-cell antigen of the anti-TB response (Gideon 2012). Molecular function still undefined. | Resolved | |
| higB Rv1955 |
mtbc0_002070 |
toxin HigB | Type II toxin-antitoxin system toxin HigB. Pfam: Gp49 (PF05973.21). | Gp49 |
Resolved |
| higA Rv1956 |
mtbc0_002071 |
antitoxin HigA | Type II toxin-antitoxin system antitoxin HigA. Pfam: HTH_3 (PF01381.29). | HTH_3 |
Resolved |
| Rv1957 Rv1957 |
mtbc0_002072 |
SecB-like chaperone | SecB-like chaperone. | Resolved | |
| Rv1958c Rv1958c |
mtbc0_002073 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8zow-assembly1_c Cryo-EM structure of Metyltetraprole-bound porcine bc (prob 0.02, TM 0.23). | Still unknown | |
| parE1 Rv1959c |
mtbc0_002074 |
toxin ParE1 | Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: ParE_toxin (PF05016.22). | ParE_toxin |
Family assigned |
| parD1 Rv1960c |
mtbc0_002075 |
antitoxin ParD1 | Type II toxin-antitoxin system ParD family antitoxin. Pfam: ParD_antitoxin (PF03693.21). | ParD_antitoxin |
Family assigned |
| Rv1961 Rv1961 |
mtbc0_002076 |
hypothetical protein | Superfamily-II helicase (eggNOG COG1061, DEAD/SNF2-like; COG category L). RefSeq leaves it 'hypothetical protein'. Helicase fold; biological role undetermined. | Family assigned | |
| vapB35 Rv1962A |
- |
antitoxin VapB35 | Antitoxin VapB35. | Resolved | |
| vapC35 Rv1962c |
mtbc0_002077 |
ribonuclease VapC35 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| mce3R Rv1963c |
mtbc0_002079 |
transcriptional repressor Mce3R | TetR family transcriptional regulator Mce3R. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| yrbE3A Rv1964 |
mtbc0_002080 |
integral membrane protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| yrbE3B Rv1965 |
mtbc0_002081 |
integral membrane protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| mce3A Rv1966 |
- |
Mce family protein Mce3A | Mce family protein Mce3A. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3B Rv1967 |
mtbc0_002083 |
Mce family protein Mce3B | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3C Rv1968 |
mtbc0_002084 |
Mce family protein Mce3C | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3D Rv1969 |
mtbc0_002085 |
Mce family protein Mce3D | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| lprM Rv1970 |
mtbc0_002086 |
Mce family lipoprotein LprM | Mce family lipoprotein LprM. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3F Rv1971 |
mtbc0_002087 |
Mce family protein Mce3F | MlaD family protein. Pfam: MlaD (PF02470.26). | MlaD |
Family assigned |
| Rv1972 Rv1972 |
mtbc0_002088 |
Mce associated membrane protein | Mce associated membrane protein. | Resolved | |
| Rv1973 Rv1973 |
mtbc0_002089 |
Mce associated membrane protein | Outer-membrane protein (OMP) of the mycobacterial cell envelope. RefSeq leaves it of unknown function. Predicted as a beta-barrel OMP and experimentally localised to the outer membrane (detected in the membrane fraction and surface-accessible to proteinase K), tripling the count of known Mtb OMPs (Song 2008). Precise function unfixed. | Family assigned | |
| Rv1974 Rv1974 |
mtbc0_002090 |
membrane protein | Candidate accessory component of the Mce lipid-import transporters (Mce1 / Mce3 multi-subunit ABC-like complexes), coupled to the Mce3 lipid-import transporter (yrbE3/mce3A-F complex; Mce3R regulon). Rv1974 is a genomic neighbour within the operon and STRING context partner (synteny corroborates the neighborhood channel) of Rv1972:972;mce3F:956;Rv1973:944;lprM:934;mce3A:856;mce3C:854;mce3B:819;yrbE3A:789;yrbE3B:764;mce3D:756 (context-driven, text-mining excluded). It is under strong purifying selection on 145,209 MTBC genomes (3 segregating sites). No dedicated functional study of Rv1974 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | DUF732 |
Family assigned |
| Rv1975 Rv1975 |
mtbc0_002091 |
hypothetical protein | CAP domain-containing protein. Pfam: CAP (PF00188.33). | CAP |
Family assigned |