Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| vapB35 Rv1962A |
- |
antitoxin VapB35 | Antitoxin VapB35. | Resolved | |
| vapC35 Rv1962c |
mtbc0_002077 |
ribonuclease VapC35 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| mce3R Rv1963c |
mtbc0_002079 |
transcriptional repressor Mce3R | TetR family transcriptional regulator Mce3R. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| yrbE3A Rv1964 |
mtbc0_002080 |
integral membrane protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| yrbE3B Rv1965 |
mtbc0_002081 |
integral membrane protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| mce3A Rv1966 |
- |
Mce family protein Mce3A | Mce family protein Mce3A. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3B Rv1967 |
mtbc0_002083 |
Mce family protein Mce3B | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3C Rv1968 |
mtbc0_002084 |
Mce family protein Mce3C | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3D Rv1969 |
mtbc0_002085 |
Mce family protein Mce3D | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| lprM Rv1970 |
mtbc0_002086 |
Mce family lipoprotein LprM | Mce family lipoprotein LprM. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce3F Rv1971 |
mtbc0_002087 |
Mce family protein Mce3F | MlaD family protein. Pfam: MlaD (PF02470.26). | MlaD |
Family assigned |
| Rv1972 Rv1972 |
mtbc0_002088 |
Mce associated membrane protein | Mce associated membrane protein. | Resolved | |
| Rv1973 Rv1973 |
mtbc0_002089 |
Mce associated membrane protein | Outer-membrane protein (OMP) of the mycobacterial cell envelope. RefSeq leaves it of unknown function. Predicted as a beta-barrel OMP and experimentally localised to the outer membrane (detected in the membrane fraction and surface-accessible to proteinase K), tripling the count of known Mtb OMPs (Song 2008). Precise function unfixed. | Family assigned | |
| Rv1974 Rv1974 |
mtbc0_002090 |
membrane protein | Candidate accessory component of the Mce lipid-import transporters (Mce1 / Mce3 multi-subunit ABC-like complexes), coupled to the Mce3 lipid-import transporter (yrbE3/mce3A-F complex; Mce3R regulon). Rv1974 is a genomic neighbour within the operon and STRING context partner (synteny corroborates the neighborhood channel) of Rv1972:972;mce3F:956;Rv1973:944;lprM:934;mce3A:856;mce3C:854;mce3B:819;yrbE3A:789;yrbE3B:764;mce3D:756 (context-driven, text-mining excluded). It is under strong purifying selection on 145,209 MTBC genomes (3 segregating sites). No dedicated functional study of Rv1974 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | DUF732 |
Still unknown |
| Rv1975 Rv1975 |
mtbc0_002091 |
hypothetical protein | CAP domain-containing protein. Pfam: CAP (PF00188.33). | CAP |
Family assigned |
| Rv1976c Rv1976c |
mtbc0_002092 |
hypothetical protein | NYN domain-containing protein. Pfam: NYN_YacP (PF05991.18). | NYN_YacP |
Family assigned |
| Rv1977 Rv1977 |
mtbc0_002099 |
hypothetical protein | M48 family metallopeptidase. Pfam: Peptidase_M48 (PF01435.25). | Peptidase_M48 |
Family assigned |
| Rv1978 Rv1978 |
mtbc0_002100 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| Rv1979c Rv1979c |
mtbc0_002101 |
permease | APC family permease. Pfam: AA_permease_2 (PF13520.13), AA_permease (PF00324.28). | AA_permease_2 AA_permease |
Family assigned |
| mpt64 Rv1980c |
mtbc0_002102 |
immunogenic protein Mpt64 | Immunoprotective protein Mpt64. | DUF3298 |
Resolved |
| nrdF1 Rv1981c |
- |
ribonucleoside-diphosphate reductase subunit beta NrdF1 | Ribonucleoside-diphosphate reductase subunit beta NrdF1. Pfam: Ribonuc_red_sm (PF00268.28). | Ribonuc_red_sm |
Family assigned |
| vapB36 Rv1982A |
- |
antitoxin VapB36 | Antitoxin VapB36. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Resolved |
| vapC36 Rv1982c |
mtbc0_002104 |
ribonuclease VapC36 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| PE_PGRS35 Rv1983 |
- |
PE-PGRS family protein PE_PGRS35 | PE-PGRS family protein PE_PGRS35. Pfam: PE (PF00934.26), PGRS (PF21526.3), PE-PGRS_C (PF20729.3). | PE PGRS PE-PGRS_C |
Family assigned |
| Rv1984a Rv1984a |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 1n91-assembly1_A Solution NMR Structure of Protein yggU from Escherichia coli. N (prob 1.00, TM 0.70). Structure-based, putative. | DUF167 |
Family assigned |
| cfp21 Rv1984c |
mtbc0_002107 |
cutinase | Cutinase Cfp21. Pfam: Cutinase (PF01083.29). | Cutinase |
Resolved |
| Rv1985c Rv1985c |
mtbc0_002109 |
HTH-type transcriptional regulator | ArgP/LysG family DNA-binding transcriptional regulator. Pfam: HTH_1 (PF00126.34), LysR_substrate (PF03466.26). | HTH_1 LysR_substrate |
Family assigned |
| lysE Rv1986 |
mtbc0_002110 |
amino acid transporter | L-lysine exporter. Pfam: LysE (PF01810.25). | LysE |
Resolved |
| Rv1987 Rv1987 |
mtbc0_002111 |
chitinase | Cellulose-binding protein. Pfam: CBM_2 (PF00553.26). | CBM_2 |
Family assigned |
| erm(37) Rv1988 |
- |
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37). Pfam: RrnaAD (PF00398.27), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | RrnaAD Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv1989c Rv1989c |
mtbc0_002113 |
hypothetical protein | RES family NAD+ phosphorylase. Pfam: RES (PF08808.18). | RES |
Family assigned |
| Rv1990c Rv1990c |
mtbc0_002114 |
transcriptional regulator | Antitoxin Xre/MbcA/ParS toxin-binding domain-containing protein. Pfam: Xre_MbcA_ParS_C (PF09722.16). | Xre_MbcA_ParS_C |
Family assigned |
| mazE6 Rv1991A |
- |
antitoxin MazE6 | Antitoxin MazE6. | Resolved | |
| mazF6 Rv1991c |
mtbc0_002117 |
mRNA interferase MazF6 | Type II toxin-antitoxin system toxin endoribonuclease MazF6. Pfam: PemK_toxin (PF02452.24). | PemK_toxin |
Resolved |
| ctpG Rv1992c |
mtbc0_002119 |
cation transporter ATPase G | Cation transporter ATPase CptG. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | E1-E2_ATPase Hydrolase |
Resolved |
| Rv1993c Rv1993c |
mtbc0_002120 |
hypothetical protein | DUF1490 family protein. | DUF1490 |
Family assigned |
| cmtR Rv1994c |
mtbc0_002121 |
HTH-type transcriptional regulator CmtR | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27). | HTH_20 HTH_5 |
Family assigned |
| Rv1995 Rv1995 |
mtbc0_002122 |
hypothetical protein | Hemerythrin domain-containing protein. Pfam: Hemerythrin (PF01814.29). | Hemerythrin |
Family assigned |
| Rv1996 Rv1996 |
mtbc0_002123 |
universal stress protein | Universal stress protein. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| ctpF Rv1997 |
mtbc0_002124 |
cation transporter ATPase F | Cation-transporting P-type ATPase. Pfam: Cation_ATPase_N (PF00690.32), E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33), Cation_ATPase (PF13246.13), Hydrolase_3 (PF08282.19), Cation_ATPase_C (PF00689.27). | Cation_ATPase_N E1-E2_ATPase Hydrolase Cation_ATPase Hydrolase_3 Cation_ATPase_C |
Resolved |
| Rv1998c Rv1998c |
mtbc0_002125 |
hypothetical protein | Isocitrate lyase/phosphoenolpyruvate mutase family protein. Pfam: PEP_mutase (PF13714.13). | PEP_mutase |
Family assigned |
| Rv1999c Rv1999c |
mtbc0_002126 |
transporter | APC family permease. Pfam: AA_permease_2 (PF13520.13), AA_permease (PF00324.28). | AA_permease_2 AA_permease |
Family assigned |
| Rv2000 Rv2000 |
mtbc0_002127 |
hypothetical protein | FAD/NAD(P)-binding protein. Pfam: NAD_binding_8 (PF13450.13). | NAD_binding_8 |
Family assigned |
| Rv2001 Rv2001 |
mtbc0_002128 |
hypothetical protein | Acyl-[acyl-carrier-protein] thioesterase. Pfam: Acyl-ACP_TE (PF01643.24), Acyl-ACP_TE_C (PF20791.4). | Acyl-ACP_TE Acyl-ACP_TE_C |
Resolved |
| fabG3 Rv2002 |
mtbc0_002129 |
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv2003c Rv2003c |
- |
hypothetical protein | Contains Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_23 (PF13489.13) domain(s); putative function inferred from the domain architecture. | Methyltransf_11 Methyltransf_25 Methyltransf_23 |
Family assigned |
| Rv2004c Rv2004c |
mtbc0_002132 |
hypothetical protein | AAA family ATPase. Pfam: Zeta_toxin (PF06414.19), AAA_33 (PF13671.13). | Zeta_toxin AAA_33 |
Family assigned |
| Rv2005c Rv2005c |
mtbc0_002133 |
universal stress protein | Universal stress protein. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| otsB1 Rv2006 |
- |
trehalose-6-phosphate phosphatase OtsB | Trehalose-6-phosphate phosphatase OtsB. Pfam: Hydrolase (PF00702.33), Trehalose_PPase (PF02358.23), Glyco_hydro_65N (PF03636.22), Glyco_hydro_65m (PF03632.22), Glyco_hydro_65C (PF03633.21). | Hydrolase Trehalose_PPase Glyco_hydro_65N Glyco_hydro_65m Glyco_hydro_65C |
Resolved |
| fdxA Rv2007c |
mtbc0_002135 |
ferredoxin | Ferredoxin family protein. Pfam: Fer4 (PF00037.33). | Fer4 |
Family assigned |