Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0731c Rv0731c |
mtbc0_000773 |
S-adenosylmethionine-dependent methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| secY Rv0732 |
mtbc0_000774 |
preprotein translocase SecY | Preprotein translocase subunit SecY. Pfam: SecY (PF00344.26). | SecY |
Family assigned |
| adk Rv0733 |
mtbc0_000775 |
adenylate kinase | Adenylate kinase. Pfam: AAA_33 (PF13671.13), AAA_18 (PF13238.13), ADK (PF00406.30), AAA_17 (PF13207.13). | AAA_33 AAA_18 ADK AAA_17 |
Resolved |
| mapA Rv0734 |
- |
methionine aminopeptidase | Methionine aminopeptidase. Pfam: Peptidase_M24 (PF00557.30). | Peptidase_M24 |
Resolved |
| sigL Rv0735 |
mtbc0_000777 |
ECF RNA polymerase sigma factor SigL | Sigma-70 family RNA polymerase sigma factor SigL. Pfam: Sigma70_ECF (PF07638.18), Sigma70_r2 (PF04542.21), PhyR_sigma2 (PF22029.3), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_ECF Sigma70_r2 PhyR_sigma2 Sigma70_r4_2 Sigma70_r4 |
Family assigned |
| rslA Rv0736 |
mtbc0_000778 |
anti-sigma-L factor RslA | Anti-sigma-L factor RslA. Pfam: zf-HC2 (PF13490.12). | zf-HC2 |
Resolved |
| Rv0737 Rv0737 |
mtbc0_000780 |
transcriptional regulator | MarR family transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29), HTH_27 (PF13463.13). | MarR_2 MarR HTH_27 |
Family assigned |
| Rv0738 Rv0738 |
mtbc0_000782 |
hypothetical protein | TIGR03086 family metal-binding protein. Pfam: MDMPI_N (PF11716.14). | MDMPI_N |
Family assigned |
| Rv0739 Rv0739 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4226. Function unknown. Foldseek best (non-significant) hit: 8e4g-assembly1_a Remodeling of the bacteriophage T7 during initial inf (prob 0.99, TM 0.69). | DUF4226 |
Still unknown |
| Rv0740 Rv0740 |
mtbc0_000785 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF7956. Function unknown. Foldseek best (non-significant) hit: 7jxh-assembly2_A HER2 in complex with JBJ-08-178-01 (prob 0.08, TM 0.30). | DUF7956 |
Still unknown |
| Rv0742 Rv0742 |
- |
hypothetical protein | Contains PE (PF00934.26) domain(s); putative function inferred from the domain architecture. | PE |
Family assigned |
| Rv0743c Rv0743c |
mtbc0_000788 |
hypothetical protein | DUF6036 family nucleotidyltransferase. | DUF6036 |
Family assigned |
| Rv0744c Rv0744c |
mtbc0_000789 |
transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: HTH_17 (PF12728.14). | HTH_17 |
Family assigned |
| Rv0745 Rv0745 |
- |
hypothetical protein | ATP-dependent DNA helicase of the RecQ family (eggNOG COG0514, EC 3.6.4.12). RefSeq leaves it 'hypothetical protein'. A DEAD/DEAH-box superfamily-II helicase; biological pathway (recombination/repair) undetermined here. | Family assigned | |
| PE_PGRS9 Rv0746 |
- |
PE-PGRS family protein PE_PGRS9 | PE-PGRS family protein PE_PGRS9. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| PE_PGRS10 Rv0747 |
- |
PE-PGRS family protein PE_PGRS10 | PE-PGRS family protein PE_PGRS10. Pfam: PE (PF00934.26). | PE |
Family assigned |
| vapB31 Rv0748 |
mtbc0_000794 |
antitoxin VapB31 | Ribbon-helix-helix protein%2C CopG family. Pfam: RHH_1 (PF01402.28). | RHH_1 |
Family assigned |
| vapC31 Rv0749 |
mtbc0_000795 |
ribonuclease VapC31 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0749A Rv0749A |
- |
hypothetical protein | Transposase of an insertion sequence (eggNOG COG2801, IS3/IS630-type DDE transposase; COG category L), partial ORF in an RD (130) mobile context. A mobile-element function, not a host-metabolic gene. | Family assigned | |
| Rv0750 Rv0750 |
mtbc0_000797 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF7956. Function unknown. | DUF7956 |
Still unknown |
| mmsB Rv0751c |
mtbc0_000798 |
3-hydroxyisobutyrate dehydrogenase | 3-hydroxyisobutyrate dehydrogenase. Pfam: NAD_binding_2 (PF03446.22), F420_oxidored (PF03807.24), 2-Hacid_dh_C (PF02826.26), NAD_binding_11 (PF14833.12). | NAD_binding_2 F420_oxidored 2-Hacid_dh_C NAD_binding_11 |
Resolved |
| fadE9 Rv0752c |
mtbc0_000799 |
acyl-CoA dehydrogenase FadE9 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17), ACOX_C_alpha1 (PF22924.2). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 ACOX_C_alpha1 |
Family assigned |
| mmsA Rv0753c |
mtbc0_000800 |
methylmalonate-semialdehyde dehydrogenase | CoA-acylating methylmalonate-semialdehyde dehydrogenase. Pfam: Aldedh (PF00171.28), LuxC (PF05893.20). | Aldedh LuxC |
Resolved |
| PE_PGRS11 Rv0754 |
- |
PE-PGRS family protein PE_PGRS11 | PE-PGRS family protein PE_PGRS11. Pfam: PE (PF00934.26), PGRS (PF21526.3), His_Phos_1 (PF00300.28). | PE PGRS His_Phos_1 |
Family assigned |
| PPE12 Rv0755c |
- |
PPE family protein PPE12 | PPE family protein PPE12. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv0756c Rv0756c |
mtbc0_000805 |
hypothetical protein | Candidate accessory component of the PhoP-PhoR two-component virulence regulatory system, coupled to the PhoP-PhoR two-component signalling locus (phoP Rv0757 / phoR Rv0758). Rv0756c is genomically and contextually associated (STRING context-driven, text-mining excluded) with phoP:774;phoR:736;lprB:714;lprC:698;Rv2876:671;pirG:670;Rv0513:663;lpqB:663. It is under purifying selection on 145,209 MTBC genomes (26 segregating sites). No dedicated functional study of Rv0756c exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | Family assigned | |
| phoP Rv0757 |
mtbc0_000806 |
two component system response transcriptional positive regulator PhoP | Two-component system response regulator PhoP. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Resolved |
| phoR Rv0758 |
mtbc0_000807 |
two component system response sensor kinase PhoR | Sensory box histidine kinase PhoR. Pfam: HAMP (PF00672.31), HisKA (PF00512.32), HATPase_c (PF02518.32). | HAMP HisKA HATPase_c |
Resolved |
| Rv0759c Rv0759c |
- |
hypothetical protein | Contains HIT (PF01230.30) domain(s); putative function inferred from the domain architecture. | HIT |
Family assigned |
| Rv0760c Rv0760c |
mtbc0_000809 |
hypothetical protein | Ketosteroid isomerase family protein. Pfam: NTF2 (PF02136.27), SnoaL_2 (PF12680.14). | NTF2 SnoaL_2 |
Family assigned |
| adhB Rv0761c |
- |
alcohol dehydrogenase B | Alcohol dehydrogenase B. Pfam: ADH_N (PF08240.18), ADH_zinc_N (PF00107.33). | ADH_N ADH_zinc_N |
Resolved |
| Rv0762c Rv0762c |
mtbc0_000811 |
hypothetical protein | Nuclear transport factor 2 family protein. | Family assigned | |
| Rv0763c Rv0763c |
mtbc0_000812 |
ferredoxin | Ferredoxin. Pfam: Fer4_19 (PF06902.17), Fer4_15 (PF13459.12), Fer4_13 (PF13370.12). | Fer4_19 Fer4_15 Fer4_13 |
Resolved |
| cyp51 Rv0764c |
mtbc0_000813 |
lanosterol 14-alpha demethylase | Lanosterol 14-alpha demethylase. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv0765c Rv0765c |
mtbc0_000814 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| cyp123 Rv0766c |
mtbc0_000815 |
cytochrome P450 Cyp123 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv0767c Rv0767c |
mtbc0_000816 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| aldA Rv0768 |
mtbc0_000817 |
aldehyde dehydrogenase AldA | Aldehyde dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv0769 Rv0769 |
mtbc0_000818 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv0770 Rv0770 |
mtbc0_000819 |
oxidoreductase | NAD(P)-dependent oxidoreductase. Pfam: NAD_binding_2 (PF03446.22), NAD_binding_11 (PF14833.12). | NAD_binding_2 NAD_binding_11 |
Resolved |
| Rv0771 Rv0771 |
mtbc0_000820 |
4-carboxymuconolactone decarboxylase | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| purD Rv0772 |
mtbc0_000821 |
phosphoribosylamine--glycine ligase | Phosphoribosylamine--glycine ligase. Pfam: GARS_N (PF02844.22), GARS_A (PF01071.25), GARS_C (PF02843.23). | GARS_N GARS_A GARS_C |
Resolved |
| ggtA Rv0773c |
- |
bifunctional cephalosporin acylase/gamma-glutamyltranspeptidase | Bifunctional cephalosporin acylase/gamma-glutamyltranspeptidase. Pfam: G_glu_transpept (PF01019.28). | G_glu_transpept |
Resolved |
| Rv0774c Rv0774c |
mtbc0_000823 |
hypothetical protein | Iron-stress inducible esterase. Pfam: Esterase (PF00756.27). | Esterase |
Resolved |
| Rv0775 Rv0775 |
mtbc0_000824 |
hypothetical protein | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_31 (PF17940.7). | TetR_N TetR_C_31 |
Family assigned |
| Rv0776c Rv0776c |
mtbc0_000825 |
hypothetical protein | Predicted nuclease with an RNase-H-like fold (eggNOG COG4328). Nuclease fold at orthology level; substrate/role undetermined. | DUF429 |
Family assigned |
| purB Rv0777 |
mtbc0_000826 |
adenylosuccinate lyase PurB | Adenylosuccinate lyase. Pfam: Lyase_1 (PF00206.26), ADSL_C (PF10397.15). | Lyase_1 ADSL_C |
Resolved |
| cyp126 Rv0778 |
mtbc0_000827 |
cytochrome P450 Cyp126 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv0779c Rv0779c |
mtbc0_000828 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| purC Rv0780 |
mtbc0_000829 |
phosphoribosylaminoimidazole-succinocarboxamide synthase | Phosphoribosylaminoimidazolesuccinocarboxamide synthase. Pfam: SAICAR_synt (PF01259.25). | SAICAR_synt |
Resolved |