Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2609c Rv2609c |
mtbc0_002777 |
membrane protein | NUDIX domain-containing protein. Pfam: NUDIX (PF00293.35). | NUDIX |
Family assigned |
| pimA Rv2610c |
mtbc0_002778 |
alpha-(1-2)-phosphatidylinositol mannosyltransferase | Phosphatidyl-myo-inositol alpha-mannosyltransferase. Pfam: Glyco_transf_4 (PF13439.13), Glyco_trans_4_4 (PF13579.13), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13), Glyco_trans_1_2 (PF13524.13). | Glyco_transf_4 Glyco_trans_4_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Resolved |
| Rv2611c Rv2611c |
mtbc0_002779 |
phosphatidylinositol mannoside acyltransferase | Phosphatidylinositol mannoside acyltransferase. Pfam: Lip_A_acyltrans (PF03279.19). | Lip_A_acyltrans |
Resolved |
| pgsA1 Rv2612c |
- |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. Pfam: CDP-OH_P_transf (PF01066.27). | CDP-OH_P_transf |
Resolved |
| Rv2613c Rv2613c |
mtbc0_002781 |
AP-4-A phosphorylase | ATP adenylyltransferase. Pfam: DcpS_C (PF11969.14), HIT (PF01230.30). | DcpS_C HIT |
Resolved |
| Rv2614A Rv2614A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| thrS Rv2614c |
mtbc0_002782 |
threonine--tRNA ligase | Threonine--tRNA ligase. Pfam: tRNA_SAD (PF07973.20), tRNA-synt_2b (PF00587.31), HGTP_anticodon (PF03129.26). | tRNA_SAD tRNA-synt_2b HGTP_anticodon |
Resolved |
| PE_PGRS45 Rv2615c |
- |
PE-PGRS family protein PE_PGRS45 | PE-PGRS family protein PE_PGRS45. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv2616 Rv2616 |
mtbc0_002785 |
hypothetical protein | DUF1990 family protein. | DUF1990 |
Family assigned |
| Rv2617c Rv2617c |
mtbc0_002786 |
transmembrane protein | DoxX family membrane protein. Pfam: DoxX (PF07681.18). | DoxX |
Family assigned |
| Rv2618 Rv2618 |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 6cmv-assembly3_F Crystal structure of Archaeal Biofilm Regulator (AbfR2) from Su (prob 1.00, TM 0.57). Structure-based, putative. | Family assigned | |
| Rv2619c Rv2619c |
mtbc0_002788 |
hypothetical protein | Cupin domain-containing protein. | Family assigned | |
| Rv2620c Rv2620c |
mtbc0_002789 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2621c Rv2621c |
mtbc0_002790 |
transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: HTH_20 (PF12840.14). | HTH_20 |
Family assigned |
| Rv2622 Rv2622 |
mtbc0_002791 |
methyltransferase | Methyltransferase domain-containing protein. Pfam: Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | Methyltransf_25 Methyltransf_11 |
Family assigned |
| TB31.7 Rv2623 |
mtbc0_002792 |
universal stress protein | Universal stress protein TB31.7. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| Rv2624c Rv2624c |
- |
universal stress protein | Universal stress protein. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| Rv2625c Rv2625c |
mtbc0_002794 |
zinc metalloprotease Rip3 | Site-2 protease family protein. Pfam: Peptidase_M50 (PF02163.29), CBS (PF00571.34). | Peptidase_M50 CBS |
Family assigned |
| hrp1 Rv2626c |
mtbc0_002795 |
hypoxic response protein | Hypoxic response protein Hrp1. Pfam: CBS (PF00571.34). | CBS |
Resolved |
| Rv2627c Rv2627c |
mtbc0_002796 |
hypothetical protein | Alpha/beta hydrolase. | Family assigned | |
| Rv2628 Rv2628 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7xzi-assembly1_F Cryo-EM structure of TOC-TIC supercomplex from Chlamy (prob 0.10, TM 0.32). | Still unknown | |
| Rv2629 Rv2629 |
mtbc0_002798 |
hypothetical protein | Contains baeRF_family10 (PF18854.7), baeRF_family2 (PF18844.7) domain(s); putative function inferred from the domain architecture. | baeRF_family10 baeRF_family2 |
Family assigned |
| Rv2630 Rv2630 |
mtbc0_002799 |
hypothetical protein | Archease. Pfam: Archease (PF01951.22). | Archease |
Resolved |
| Rv2631 Rv2631 |
- |
RNA-splicing ligase RtcB | RNA-splicing ligase RtcB. Pfam: RtcB (PF01139.23). | RtcB |
Resolved |
| Rv2632c Rv2632c |
mtbc0_002801 |
hypothetical protein | DUF1876 domain-containing protein. Pfam: Rv2632c-like (PF08962.17). | Rv2632c-like |
Family assigned |
| Rv2633c Rv2633c |
mtbc0_002802 |
hypothetical protein | Non-heme di-iron catalase. Pfam: Hemerythrin (PF01814.29). | Hemerythrin |
Resolved |
| PE_PGRS46 Rv2634c |
- |
PE-PGRS family protein PE_PGRS46 | PE-PGRS family protein PE_PGRS46. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv2635 Rv2635 |
mtbc0_002805 |
hypothetical protein | Nucleoid-associated protein (NAP); a small intrinsically disordered protein (IDP) that undergoes liquid-liquid phase separation. RefSeq leaves this locus 'hypothetical protein'. By in-silico analysis and circular dichroism Rv2635 is established as an IDP; GFP-tagged Rv2635 phase-separates into reversible condensates (FRAP); it binds DNA sequence-independently (EMSA) and, when over-expressed in E. coli, causes nucleoid compaction and co-localises with the condensed nucleoid. Its unstructured regions are required for phase separation and its C-terminus for DNA binding, indicating a phase-separating NAP role in mycobacteria (Chandra 2025). Experimentally characterised. | Resolved | |
| Rv2636 Rv2636 |
mtbc0_002806 |
O-phosphotransferase | Chloramphenicol phosphotransferase CPT family protein. Pfam: CPT (PF07931.19). | CPT |
Family assigned |
| dedA Rv2637 |
mtbc0_002807 |
transmembrane protein DedA | DedA family protein. Pfam: VTT_dom (PF09335.17). | VTT_dom |
Family assigned |
| Rv2638 Rv2638 |
mtbc0_002808 |
hypothetical protein | Anti-sigma factor antagonist. Pfam: STAS_2 (PF13466.13), STAS (PF01740.27). | STAS_2 STAS |
Resolved |
| Rv2639c Rv2639c |
mtbc0_002809 |
integral membrane protein | YnfA family protein. | UPF0060 |
Family assigned |
| Rv2640c Rv2640c |
mtbc0_002810 |
ArsR family transcriptional regulator | Rv2640c family ArsR-like transcriptional regulator. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27). | HTH_20 HTH_5 |
Family assigned |
| cadI Rv2641 |
mtbc0_002811 |
cadmium inducible protein CadI | Cadmium-induced metalloenzyme CadI. Pfam: Glyoxalase (PF00903.32). | Glyoxalase |
Resolved |
| Rv2642 Rv2642 |
mtbc0_002812 |
ArsR family transcriptional regulator | Metalloregulator ArsR/SmtB family transcription factor. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27). | HTH_20 HTH_5 |
Family assigned |
| arsC Rv2643 |
mtbc0_002813 |
arsenic-transport integral membrane protein ArsC | ACR3 family arsenite efflux transporter. Pfam: SBF (PF01758.22), LMWPc (PF01451.28). | SBF LMWPc |
Family assigned |
| Rv2644c Rv2644c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3azo-assembly2_B Crystal structure of puromycin hydrolase (prob 0.14, TM 0.69). | Still unknown | |
| Rv2645 Rv2645 |
mtbc0_002820 |
hypothetical protein | Immunodominant T-cell antigen encoded in region-of-difference RD13 (present in M. tuberculosis, absent from BCG and M. bovis); a cell-mediated-immunity-based diagnostic/vaccine antigen. Despite this immunological characterisation, its molecular/biochemical function remains unknown (verdict kept 'dark'). | Still unknown | |
| Rv2646 Rv2646 |
mtbc0_002821 |
integrase | Tyrosine-type recombinase/integrase. Pfam: Phage_integrase (PF00589.28). | Phage_integrase |
Resolved |
| Rv2647 Rv2647 |
- |
hypothetical protein | Secreted virulence factor that inhibits macrophage pyroptosis by promoting NLRP3 ubiquitination/degradation. RefSeq leaves it 'hypothetical'. Rv2647 binds ISG15 and competitively inhibits ISGylation of NLRP3, enhancing its ubiquitination and degradation; this inactivates NLRP3-caspase-1-GSDMD, reduces IL-1beta and promotes Mtb survival (Jin 2025). | Resolved | |
| Rv2650c Rv2650c |
mtbc0_002824 |
prophage protein | Phage major capsid protein. Pfam: Phage_capsid (PF05065.20). | Phage_capsid |
Resolved |
| Rv2651c Rv2651c |
mtbc0_001684 |
prophage protease | HK97 family phage prohead protease. Pfam: Peptidase_S78 (PF04586.23). | Peptidase_S78 |
Family assigned |
| Rv2652c Rv2652c |
- |
prophage protein | Prophage protein. Pfam: Terminase_4 (PF05119.18). | Terminase_4 |
Resolved |
| Rv2653c Rv2653c |
mtbc0_002827 |
toxin | Type II toxin-antitoxin system toxin. | Resolved | |
| Rv2654c Rv2654c |
mtbc0_002828 |
antitoxin | Type II toxin-antitoxin system antitoxin. | Resolved | |
| Rv2655c Rv2655c |
mtbc0_002829 |
prophage protein | AAA+-type ATPase of the SpoVK/Ycf46/Vps4 family (eggNOG COG0464, post-translational COG category O). A AAA+ ATPase (chaperone/unfoldase-type); specific substrate/pathway undetermined. | DUF3631 |
Family assigned |
| Rv2656c Rv2656c |
mtbc0_002830 |
prophage protein | Conserved hypothetical protein; DUF domain(s) DUF2742. Function unknown. | DUF2742 |
Still unknown |
| Rv2657c Rv2657c |
mtbc0_002831 |
prophage protein | Helix-turn-helix domain-containing protein. Pfam: HTH_17 (PF12728.14). | HTH_17 |
Family assigned |
| Rv2658c Rv2658c |
mtbc0_002832 |
prophage protein | Protein of prophage phiRv2, within region-of-difference RD11; hypoxia-induced and recognised as an antigen. A prophage-encoded protein whose enzymatic/molecular function is unknown. | Family assigned | |
| Rv2659c Rv2659c |
mtbc0_002833 |
prophage integrase | Tyrosine-type recombinase/integrase. Pfam: Integrase_N_phage (PF26003.1), Phage_int_SAM_3 (PF14659.13), Phage_integrase (PF00589.28). | Integrase_N_phage Phage_int_SAM_3 Phage_integrase |
Resolved |