Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1703c Rv1703c |
mtbc0_001812 |
methyltransferase | O-methyltransferase. Pfam: Methyltransf_3 (PF01596.24), Methyltransf_24 (PF13578.13). | Methyltransf_3 Methyltransf_24 |
Resolved |
| cycA Rv1704c |
mtbc0_001813 |
D-serine/alanine/glycine transporter protein CycA | Amino acid permease. Pfam: AA_permease (PF00324.28), AA_permease_2 (PF13520.13). | AA_permease AA_permease_2 |
Resolved |
| PPE22 Rv1705c |
- |
PPE family protein PPE22 | PPE family protein PPE22. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv1706A Rv1706A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3q1p-assembly1_B Crystal structure of CDP-Chase (prob 0.41, TM 0.85). | Still unknown | |
| PPE23 Rv1706c |
- |
PPE family protein PPE23 | PPE family protein PPE23. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv1707 Rv1707 |
mtbc0_001817 |
transmembrane protein | SulP family inorganic anion transporter. Pfam: Sulfate_transp (PF00916.27), STAS (PF01740.27). | Sulfate_transp STAS |
Family assigned |
| Rv1708 Rv1708 |
- |
initiation inhibitor protein | Initiation inhibitor protein. Pfam: AAA_31 (PF13614.13), ParA (PF10609.16), CBP_BcsQ (PF06564.19), CbiA (PF01656.30), ArsA_ATPase (PF02374.22), Fer4_NifH (PF00142.25). | AAA_31 ParA CBP_BcsQ CbiA ArsA_ATPase Fer4_NifH |
Resolved |
| scpA Rv1709 |
mtbc0_001819 |
segregation and condensation protein ScpA | Segregation/condensation protein A. Pfam: SMC_ScpA (PF02616.20). | SMC_ScpA |
Resolved |
| scpB Rv1710 |
mtbc0_001820 |
segregation and condensation protein ScpB | SMC-Scp complex subunit ScpB. Pfam: SMC_ScpB (PF04079.23). | SMC_ScpB |
Family assigned |
| Rv1711 Rv1711 |
mtbc0_001821 |
RNA pseudouridine synthase | Pseudouridine synthase. Pfam: S4 (PF01479.31), PseudoU_synth_2 (PF00849.28). | S4 PseudoU_synth_2 |
Resolved |
| cmk Rv1712 |
mtbc0_001822 |
cytidylate kinase | (d)CMP kinase. Pfam: Cytidylate_kin2 (PF13189.13), Cytidylate_kin (PF02224.25), AAA_18 (PF13238.13). | Cytidylate_kin2 Cytidylate_kin AAA_18 |
Resolved |
| engA Rv1713 |
mtbc0_001823 |
GTPase Der | Ribosome biogenesis GTPase Der. Pfam: MMR_HSR1 (PF01926.30), FeoB_N (PF02421.25), GTP_EFTU (PF00009.34), KH_dom-like (PF14714.12). | MMR_HSR1 FeoB_N GTP_EFTU KH_dom-like |
Resolved |
| Rv1714 Rv1714 |
mtbc0_001824 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| fadB3 Rv1715 |
- |
3-hydroxybutyryl-CoA dehydrogenase FadB | 3-hydroxybutyryl-CoA dehydrogenase FadB. Pfam: 3HCDH_N (PF02737.25), NAD_binding_2 (PF03446.22), 3HCDH (PF00725.28). | 3HCDH_N NAD_binding_2 3HCDH |
Resolved |
| Rv1716 Rv1716 |
- |
hypothetical protein | Contains Cyclase (PF04199.20) domain(s); putative function inferred from the domain architecture. | Cyclase |
Family assigned |
| Rv1717 Rv1717 |
mtbc0_001827 |
hypothetical protein | Cupin domain-containing protein. Pfam: Cupin_2 (PF07883.18). | Cupin_2 |
Family assigned |
| Rv1718 Rv1718 |
mtbc0_001828 |
hypothetical protein | 3-keto-5-aminohexanoate cleavage protein. Pfam: BKACE (PF05853.19). | BKACE |
Resolved |
| Rv1719 Rv1719 |
mtbc0_001829 |
transcriptional regulator | IclR family transcriptional regulator. Pfam: HTH_IclR (PF09339.17), HTH_23 (PF13384.13), MarR_2 (PF12802.14), DUF7343 (PF24034.2), HTH_24 (PF13412.13), HTH_Crp_2 (PF13545.13), MarR (PF01047.29), IclR_C (PF01614.25). | HTH_IclR HTH_23 MarR_2 DUF7343 HTH_24 HTH_Crp_2 MarR IclR_C |
Family assigned |
| vapC12 Rv1720c |
mtbc0_001832 |
ribonuclease VapC12 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB12 Rv1721c |
mtbc0_001833 |
antitoxin VapB12 | Antitoxin. Pfam: FitA-like_RHH (PF22513.3). | FitA-like_RHH |
Resolved |
| Rv1722 Rv1722 |
mtbc0_001834 |
carboxylase | Biotin carboxylase. | Resolved | |
| Rv1723 Rv1723 |
mtbc0_001835 |
hydrolase | Serine hydrolase. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Resolved |
| Rv1724c Rv1724c |
mtbc0_001836 |
hypothetical protein | Conserved hypothetical; Foldseek hits non-conclusive (moderate TM). Function unknown. | Still unknown | |
| Rv1725c Rv1725c |
mtbc0_001837 |
hypothetical protein | Winged helix-turn-helix transcriptional regulator. Pfam: HxlR (PF01638.24). | HxlR |
Family assigned |
| Rv1726 Rv1726 |
mtbc0_001838 |
oxidoreductase | FAD-binding oxidoreductase. Pfam: FAD_binding_4 (PF01565.29), BBE (PF08031.18). | FAD_binding_4 BBE |
Resolved |
| Rv1727 Rv1727 |
mtbc0_001839 |
hypothetical protein | TIGR03086 family metal-binding protein. Pfam: MDMPI_N (PF11716.14). | MDMPI_N |
Family assigned |
| Rv1728c Rv1728c |
mtbc0_001840 |
hypothetical protein | Glycoside hydrolase. Pfam: VldE (PF26571.1). | VldE |
Resolved |
| Rv1729c Rv1729c |
mtbc0_001841 |
S-adenosylmethionine-dependent methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| Rv1730c Rv1730c |
mtbc0_001842 |
penicillin-binding protein | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| gabD2 Rv1731 |
mtbc0_001843 |
succinate-semialdehyde dehydrogenase | Succinic semialdehyde dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv1732c Rv1732c |
mtbc0_001844 |
hypothetical protein | Thioredoxin family protein. Pfam: AhpC-TSA (PF00578.28), Redoxin (PF08534.17). | AhpC-TSA Redoxin |
Family assigned |
| Rv1733c Rv1733c |
mtbc0_001845 |
transmembrane protein | Contains Rv1733c (PF27099.1) domain(s); putative function inferred from the domain architecture. | Rv1733c |
Family assigned |
| Rv1734c Rv1734c |
- |
hypothetical protein | Contains 2-oxoacid_dh (PF00198.29) domain(s); putative function inferred from the domain architecture. | 2-oxoacid_dh |
Family assigned |
| Rv1735a Rv1735a |
- |
hypothetical protein | C4-dicarboxylate / malic-acid transporter family membrane protein (eggNOG COG1275, TDT/DASS-like; COG category P). Short ORF (partial); transported solute undetermined. | Family assigned | |
| Rv1735c Rv1735c |
- |
membrane protein | Membrane protein. Pfam: SLAC1 (PF03595.23). | SLAC1 |
Family assigned |
| narX Rv1736c |
mtbc0_001849 |
nitrate reductase-like protein NarX | Respiratory nitrate reductase subunit gamma. Pfam: Molybdopterin (PF00384.28), Nitrate_red_del (PF02613.21), Nitrate_red_gam (PF02665.20). | Molybdopterin Nitrate_red_del Nitrate_red_gam |
Family assigned |
| narK2 Rv1737c |
mtbc0_001850 |
nitrate/nitrite transporter | Nitrate transporter NarK. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| Rv1738 Rv1738 |
mtbc0_001851 |
hypothetical protein | DUF1876 domain-containing protein. Pfam: Rv2632c-like (PF08962.17). | Rv2632c-like |
Family assigned |
| Rv1739c Rv1739c |
mtbc0_001852 |
sulfate ABC transporter permease | SulP family inorganic anion transporter. Pfam: Sulfate_transp (PF00916.27), STAS (PF01740.27). | Sulfate_transp STAS |
Family assigned |
| vapB34 Rv1740 |
mtbc0_001853 |
antitoxin VapB34 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Family assigned |
| vapC34 Rv1741 |
mtbc0_001854 |
ribonuclease VapC34 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv1742 Rv1742 |
mtbc0_001855 |
hypothetical protein | LolA-superfamily fold (lipoprotein / lipid carrier-like beta-barrel). RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on a LolA-superfamily protein (PDB 3buu; Foldseek prob 1.0, E 3e-8, TM 0.57). STRING context: the toxin vapC34 (Rv1741). A carrier/periplasmic-binding fold; the cargo is undemonstrated. | Family assigned | |
| pknE Rv1743 |
mtbc0_001856 |
serine/threonine-protein kinase PknE | Serine/threonine protein kinase PknE. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), Thioredoxin_4 (PF13462.13). | Pkinase PK_Tyr_Ser-Thr Thioredoxin_4 |
Resolved |
| Rv1744c Rv1744c |
mtbc0_001857 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| idi Rv1745c |
mtbc0_001858 |
isopentenyl-diphosphate delta-isomerase | Isopentenyl-diphosphate Delta-isomerase. Pfam: NUDIX (PF00293.35). | NUDIX |
Resolved |
| pknF Rv1746 |
mtbc0_001859 |
serine/threonine-protein kinase PknF | Serine/threonine protein kinase PknF. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24). | Pkinase PK_Tyr_Ser-Thr |
Resolved |
| Rv1747 Rv1747 |
mtbc0_001860 |
ABC transporter ATP-binding protein/permease | ATP-binding cassette domain-containing protein. Pfam: Yop-YscD_cpl (PF16697.11), FHA (PF00498.32), ABC_tran (PF00005.34), AAA_21 (PF13304.13), ABC2_membrane (PF01061.30). | Yop-YscD_cpl FHA ABC_tran AAA_21 ABC2_membrane |
Family assigned |
| Rv1748 Rv1748 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6rf0-assembly1_C Crystal structure of the light-driven sodium pump KR2 (prob 0.20, TM 0.32). | Still unknown | |
| Rv1749c Rv1749c |
mtbc0_001862 |
integral membrane protein | DUF6790 family protein. | DUF6790 |
Family assigned |
| fadD1 Rv1750c |
mtbc0_001863 |
fatty-acid--CoA ligase FadD1 | Fatty-acid--CoA ligase FadD1. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |