Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1674c Rv1674c |
mtbc0_001781 |
transcriptional regulator | Metalloregulator ArsR/SmtB family transcription factor. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27), Rhodanese (PF00581.26). | HTH_20 HTH_5 Rhodanese |
Family assigned |
| cmr Rv1675c |
mtbc0_001783 |
HTH-type transcriptional regulator Cmr | HTH-type transcriptional regulator Cmr. Pfam: cNMP_binding (PF00027.36), HTH_Crp_2 (PF13545.13). | cNMP_binding HTH_Crp_2 |
Family assigned |
| Rv1676 Rv1676 |
mtbc0_001784 |
hypothetical protein | Peroxiredoxin-like family protein. Pfam: AhpC-TSA (PF00578.28), AhpC-TSA_2 (PF13911.13). | AhpC-TSA AhpC-TSA_2 |
Family assigned |
| dsbF Rv1677 |
mtbc0_001785 |
lipoprotein DsbF | Protein disulfide oxidoreductase. Pfam: Redoxin (PF08534.17), AhpC-TSA (PF00578.28), Thioredoxin_2 (PF13098.14), Thioredoxin (PF00085.27). | Redoxin AhpC-TSA Thioredoxin_2 Thioredoxin |
Resolved |
| Rv1678 Rv1678 |
mtbc0_001786 |
integral membrane protein | Polytopic integral membrane protein with a GT-C-like / membrane-enzyme-chaperone fold; weakly linked to M.tb Emb arabinosyltransferases (cell-wall GT-C family); specific function undetermined RefSeq leaves this locus uncharacterised. | Family assigned | |
| fadE16 Rv1679 |
mtbc0_001787 |
acyl-CoA dehydrogenase FadE16 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| Rv1680 Rv1680 |
mtbc0_001788 |
hypothetical protein | Phosphate/phosphite/phosphonate ABC transporter substrate-binding protein. Pfam: Phosphonate-bd (PF12974.13). | Phosphonate-bd |
Family assigned |
| moeX Rv1681 |
mtbc0_001789 |
molybdopterin biosynthesis protein MoeX | Radical SAM protein. Pfam: Fer4_12 (PF13353.12), Radical_SAM (PF04055.28). | Fer4_12 Radical_SAM |
Resolved |
| Rv1682 Rv1682 |
- |
hypothetical protein | SMC-like coiled-coil ATPase of the chromosome-segregation / structural-maintenance family (eggNOG COG1196), in an RD (DS6) context. Coiled-coil ATPase fold; precise role undetermined. | Family assigned | |
| Rv1683 Rv1683 |
mtbc0_001791 |
bifunctional long-chain acyl-CoA synthase/lipase | Acyl-CoA synthetase. Pfam: Abhydrolase_1 (PF00561.27), AMP-binding (PF00501.35). | Abhydrolase_1 AMP-binding |
Resolved |
| Rv1684 Rv1684 |
mtbc0_001792 |
hypothetical protein | Trm112 family protein. Pfam: Trm112p (PF03966.23). | Trm112p |
Family assigned |
| Rv1685c Rv1685c |
mtbc0_001793 |
hypothetical protein | TetR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_16 (PF17920.7). | TetR_N TetR_C_16 |
Family assigned |
| Rv1686c Rv1686c |
- |
ABC transporter permease | ABC transporter permease. Pfam: ABC2_membrane (PF01061.30), ABC2_membrane_3 (PF12698.14), ABC2_membrane_2 (PF12679.14). | ABC2_membrane ABC2_membrane_3 ABC2_membrane_2 |
Family assigned |
| Rv1687c Rv1687c |
mtbc0_001795 |
ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34), AAA_21 (PF13304.13). | ABC_tran AAA_21 |
Family assigned |
| mpg Rv1688 |
mtbc0_001796 |
3-methyladenine DNA glycosylase | DNA-3-methyladenine glycosylase. Pfam: Pur_DNA_glyco (PF02245.22). | Pur_DNA_glyco |
Resolved |
| tyrS Rv1689 |
mtbc0_001797 |
tyrosine--tRNA ligase | Tyrosine--tRNA ligase. Pfam: tRNA-synt_1b (PF00579.32), SYY_C-terminal (PF22421.2). | tRNA-synt_1b SYY_C-terminal |
Resolved |
| lprJ Rv1690 |
mtbc0_001798 |
lipoprotein LprJ | Lipoprotein LprJ. | DUF732 |
Resolved |
| Rv1691 Rv1691 |
mtbc0_001799 |
hypothetical protein | TPR-repeat fold (PDB 2PL2); putative protein-protein-interaction scaffold. | Family assigned | |
| Rv1692 Rv1692 |
mtbc0_001800 |
phosphatase | HAD-IIA family hydrolase. Pfam: Hydrolase (PF00702.33), Hydrolase_6 (PF13344.13), Hydrolase_like (PF13242.13), GNAT_like (PF18407.8). | Hydrolase Hydrolase_6 Hydrolase_like GNAT_like |
Family assigned |
| Rv1693 Rv1693 |
mtbc0_001801 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dxr-assembly1_B Crystal structure of the yeast inter-membrane space c (prob 0.44, TM 0.55). | Still unknown | |
| tlyA Rv1694 |
mtbc0_001802 |
16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA | 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA. Pfam: S4 (PF01479.31), FtsJ (PF01728.26). | S4 FtsJ |
Resolved |
| ppnK Rv1695 |
mtbc0_001803 |
inorganic polyphosphate/ATP-NAD kinase | NAD kinase. Pfam: NAD_kinase (PF01513.27), NAD_kinase_C (PF20143.5). | NAD_kinase NAD_kinase_C |
Resolved |
| recN Rv1696 |
mtbc0_001804 |
DNA repair protein RecN | DNA repair protein RecN. Pfam: SMC_N (PF02463.26). | SMC_N |
Resolved |
| steA Rv1697 |
mtbc0_001805 |
hypothetical protein | Putative cytokinetic ring protein SteA. Pfam: SteA-like_C (PF12555.14). | SteA-like_C |
Family assigned |
| mctB Rv1698 |
mtbc0_001806 |
copper transporter MctB | Copper transporter MctB. Pfam: MctB (PF11382.14). | MctB |
Resolved |
| pyrG Rv1699 |
mtbc0_001807 |
CTP synthase | CTP synthase. Pfam: CTP_synth_N (PF06418.21), GATase (PF00117.35), Peptidase_C26 (PF07722.20). | CTP_synth_N GATase Peptidase_C26 |
Resolved |
| Rv1700 Rv1700 |
mtbc0_001808 |
NUDIX hydrolase | ADP-ribose diphosphatase. Pfam: NDPSase_N (PF28549.1), NUDIX (PF00293.35). | NDPSase_N NUDIX |
Resolved |
| xerD Rv1701 |
mtbc0_001809 |
tyrosine recombinase XerD | Site-specific tyrosine recombinase XerD. Pfam: Phage_int_SAM_1 (PF02899.24), Phage_integrase (PF00589.28). | Phage_int_SAM_1 Phage_integrase |
Resolved |
| Rv1702c Rv1702c |
mtbc0_001810 |
hypothetical protein | HNH endonuclease signature motif containing protein. | DUF222 |
Resolved |
| Rv1703c Rv1703c |
mtbc0_001812 |
methyltransferase | O-methyltransferase. Pfam: Methyltransf_3 (PF01596.24), Methyltransf_24 (PF13578.13). | Methyltransf_3 Methyltransf_24 |
Resolved |
| cycA Rv1704c |
mtbc0_001813 |
D-serine/alanine/glycine transporter protein CycA | Amino acid permease. Pfam: AA_permease (PF00324.28), AA_permease_2 (PF13520.13). | AA_permease AA_permease_2 |
Resolved |
| PPE22 Rv1705c |
- |
PPE family protein PPE22 | PPE family protein PPE22. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv1706A Rv1706A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3q1p-assembly1_B Crystal structure of CDP-Chase (prob 0.41, TM 0.85). | Still unknown | |
| PPE23 Rv1706c |
- |
PPE family protein PPE23 | PPE family protein PPE23. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv1707 Rv1707 |
mtbc0_001817 |
transmembrane protein | SulP family inorganic anion transporter. Pfam: Sulfate_transp (PF00916.27), STAS (PF01740.27). | Sulfate_transp STAS |
Family assigned |
| Rv1708 Rv1708 |
- |
initiation inhibitor protein | Initiation inhibitor protein. Pfam: AAA_31 (PF13614.13), ParA (PF10609.16), CBP_BcsQ (PF06564.19), CbiA (PF01656.30), ArsA_ATPase (PF02374.22), Fer4_NifH (PF00142.25). | AAA_31 ParA CBP_BcsQ CbiA ArsA_ATPase Fer4_NifH |
Resolved |
| scpA Rv1709 |
mtbc0_001819 |
segregation and condensation protein ScpA | Segregation/condensation protein A. Pfam: SMC_ScpA (PF02616.20). | SMC_ScpA |
Resolved |
| scpB Rv1710 |
mtbc0_001820 |
segregation and condensation protein ScpB | SMC-Scp complex subunit ScpB. Pfam: SMC_ScpB (PF04079.23). | SMC_ScpB |
Family assigned |
| Rv1711 Rv1711 |
mtbc0_001821 |
RNA pseudouridine synthase | Pseudouridine synthase. Pfam: S4 (PF01479.31), PseudoU_synth_2 (PF00849.28). | S4 PseudoU_synth_2 |
Resolved |
| cmk Rv1712 |
mtbc0_001822 |
cytidylate kinase | (d)CMP kinase. Pfam: Cytidylate_kin2 (PF13189.13), Cytidylate_kin (PF02224.25), AAA_18 (PF13238.13). | Cytidylate_kin2 Cytidylate_kin AAA_18 |
Resolved |
| engA Rv1713 |
mtbc0_001823 |
GTPase Der | Ribosome biogenesis GTPase Der. Pfam: MMR_HSR1 (PF01926.30), FeoB_N (PF02421.25), GTP_EFTU (PF00009.34), KH_dom-like (PF14714.12). | MMR_HSR1 FeoB_N GTP_EFTU KH_dom-like |
Resolved |
| Rv1714 Rv1714 |
mtbc0_001824 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| fadB3 Rv1715 |
- |
3-hydroxybutyryl-CoA dehydrogenase FadB | 3-hydroxybutyryl-CoA dehydrogenase FadB. Pfam: 3HCDH_N (PF02737.25), NAD_binding_2 (PF03446.22), 3HCDH (PF00725.28). | 3HCDH_N NAD_binding_2 3HCDH |
Resolved |
| Rv1716 Rv1716 |
- |
hypothetical protein | Contains Cyclase (PF04199.20) domain(s); putative function inferred from the domain architecture. | Cyclase |
Family assigned |
| Rv1717 Rv1717 |
mtbc0_001827 |
hypothetical protein | Cupin domain-containing protein. Pfam: Cupin_2 (PF07883.18). | Cupin_2 |
Family assigned |
| Rv1718 Rv1718 |
mtbc0_001828 |
hypothetical protein | 3-keto-5-aminohexanoate cleavage protein. Pfam: BKACE (PF05853.19). | BKACE |
Resolved |
| Rv1719 Rv1719 |
mtbc0_001829 |
transcriptional regulator | IclR family transcriptional regulator. Pfam: HTH_IclR (PF09339.17), HTH_23 (PF13384.13), MarR_2 (PF12802.14), DUF7343 (PF24034.2), HTH_24 (PF13412.13), HTH_Crp_2 (PF13545.13), MarR (PF01047.29), IclR_C (PF01614.25). | HTH_IclR HTH_23 MarR_2 DUF7343 HTH_24 HTH_Crp_2 MarR IclR_C |
Family assigned |
| vapC12 Rv1720c |
mtbc0_001832 |
ribonuclease VapC12 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB12 Rv1721c |
mtbc0_001833 |
antitoxin VapB12 | Antitoxin. Pfam: FitA-like_RHH (PF22513.3). | FitA-like_RHH |
Resolved |
| Rv1722 Rv1722 |
mtbc0_001834 |
carboxylase | ATP-grasp carboxylase-family protein (UniProt: 'possible carboxylase'). The AlphaFold model matches N5-carboxyaminoimidazole ribonucleotide synthetase, PurK (TM 0.64-0.67, PDB 3k5h/3k5i), while eggNOG proposes a biotin-carboxylase (AccC) role. Putative carboxylase — the ATP-grasp fold is shared by biotin carboxylases and PurK-type carboxylases, so the carboxylated substrate is undetermined and no catalytic site is verified. | Resolved |