Rv1684 Family assigned · medium auto-curated
H37Rv Rv1684 · MTBC0 mtbc0_001792 ·
74 aa · 1922601–1922825 (+) ·
RefSeq NP_216200.1
Annotation: from legacy to revised
| Legacy (H37Rv / Mycobrowser) | hypothetical protein |
|---|---|
| MTBC0 PGAP re-annotation | Trm112 family protein |
| Revised (this work) | Trm112 family protein. Pfam: Trm112p (PF03966.23). |
Auto-curated: this verdict and function were generated by rules from PGAP + Pfam + Foldseek and have not been hand-reviewed.
Curated reference (UniProt)
| UniProt |
O33186
TrEMBL · unreviewed
· Evidence at protein level
|
|---|---|
| UniProt name | UPF0434 protein Rv1684 |
UniProt still lists this protein as UPF0434 protein Rv1684; the revised annotation above is ahead of the current UniProt record.
Functional vocabulary (eggNOG-mapper, orthology transfer)
| COG category |
S Function unknown
|
|---|---|
| eggNOG description | Trm112p-like protein |
| Orthologous group | COG2835 |
Orthology-based transfer (eggNOG 5.0.2, diamond). EC/KO/GO/CAZy are computed annotations, not manual curation; cross-check against the primary literature before treating a specific reaction as established.
Domains (Pfam, hmmscan --cut_ga)
| Pfam | Accession | i-Evalue | Residues | Description |
|---|---|---|---|---|
Trm112p | PF03966.23 | 2.0e-11 | 3–44 | Trm112p-like protein |
Functional interaction network (STRING v12, guilt-by-association)
Closest characterised functional partner: Rv1683 (bifunctional long-chain acyl-CoA synthase/lipase), high confidence from genomic context alone (score 918 excluding text-mining). This association is the citable seed of a function hypothesis for this hypothetical protein.
| Partner | Product | Score | No text-mining | Channels (≥400) |
|---|---|---|---|---|
Rv1683 |
bifunctional long-chain acyl-CoA synthase/lipase | 918 | 918 ctx | neighborhood:881 |
Rv0759c hyp |
hypothetical protein | 783 | 783 | coexpression:775 |
Rv2673 aftC |
alpha-(1->3)-arabinofuranosyltransferase | 673 | 673 ctx | cooccurence:670 |
Rv2001 hyp |
hypothetical protein | 664 | 664 ctx | cooccurence:663 |
Rv3802c |
membrane protein | 617 | 617 ctx | cooccurence:613 |
Rv0466 hyp |
hypothetical protein | 605 | 605 ctx | cooccurence:604 |
Rv2342 hyp |
hypothetical protein | 601 | 602 ctx | cooccurence:405 |
Rv1650 pheT |
phenylalanine--tRNA ligase subunit beta | 549 | 549 ctx | neighborhood:544 |
Rv3805c aftB |
terminal beta-(1->2)-arabinofuranosyltransferase | 539 | 540 ctx | cooccurence:512 |
Rv1476 |
membrane protein | 483 | 483 ctx | cooccurence:483 |
Rv0224c |
methyltransferase | 465 | 465 | |
Rv3795 embB |
arabinosyltransferase B | 462 | 462 ctx | cooccurence:445 |
Rv3794 embA |
arabinosyltransferase A | 458 | 459 ctx | cooccurence:443 |
Rv2525c hyp |
hypothetical protein | 454 | 455 ctx | cooccurence:453 |
Rv1682 hyp |
hypothetical protein | 440 | 441 ctx | neighborhood:441 |
STRING combines evidence channels (neighborhood, fusion, cooccurrence, coexpression, experimental, database, text-mining) into a 0–1000 score. The ctx badge marks edges carried by the genomic-context channels (conserved neighborhood, fusion, phylogenetic co-occurrence), which are independent of orthology and structure and the strongest signal for an unknown gene. The no text-mining column recomputes the score from data alone, so a link that does not depend on the literature is visible. Association is a function hypothesis, not proof: corroborate with the operon context and the primary literature before assigning a function.
Evidence
- Legacy H37Rv annotation: hypothetical protein
- MTBC0 PGAP product: Trm112 family protein
- Pfam (hmmscan --cut_ga): Trm112p PF03966.23 (E=2e-11)
- (auto-curated by rules from PGAP + Pfam + Foldseek; not hand-reviewed)
Sources
- Ancestral sequence & coordinates: Harrison LB et al. (2024), An imputed ancestral reference genome for the MTBC, doi:10.1101/2023.09.07.556366
- Product annotation: NCBI PGAP on MTBC0; legacy from H37Rv NC_000962.3 (RefSeq NP_216200.1)
- Domains: Pfam-A via hmmscan --cut_ga — Trm112p (PF03966.23)
- Sequence-level signal: ESM Atlas (EvolutionaryScale × BioHub) — exploratory
- Controlled vocabulary: eggNOG-mapper 2.1.12 (Cantalapiedra et al. 2021,
doi:10.1093/molbev/msab293), eggNOG 5.0 DB
(Huerta-Cepas et al. 2019) — OG
COG2835 - Curated reference: UniProt O33186 (TrEMBL, unreviewed; Evidence at protein level)
- Interaction network: STRING v12.0 (Szklarczyk et al. 2023,
doi:10.1093/nar/gkac1000), taxon 83332, CC-BY 4.0 —
19 functional partner(s); context anchor
Rv1683 - Primary literature: none located yet; annotation rests on the domain/homology sources above.
Ancestral MTBC0 protein sequence
>mtbc0_001792|Rv1684| MLDEALLAILVCPADRGPLVLVEDGDIQVLYNPRLRRAYRIEDGIPVLLVDEAREVDEDEHARLMARGRPAAPQ