Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| plsB1 Rv1551 |
mtbc0_001657 |
acyltransferase PlsB | Lysophospholipid acyltransferase. Pfam: Acyltransferase (PF01553.27), GPAT_C (PF19277.5). | Acyltransferase GPAT_C |
Resolved |
| frdA Rv1552 |
mtbc0_001659 |
fumarate reductase flavoprotein subunit | Fumarate reductase (quinol) flavoprotein subunit. Pfam: FAD_binding_2 (PF00890.31), Succ_DH_flav_C (PF02910.26). | FAD_binding_2 Succ_DH_flav_C |
Family assigned |
| frdB Rv1553 |
mtbc0_001660 |
fumarate reductase iron-sulfur subunit | Succinate dehydrogenase iron-sulfur subunit. Pfam: Fer2_3 (PF13085.12), Fer4_8 (PF13183.12), Fer4_10 (PF13237.12), Fer4 (PF00037.33), Fer4_7 (PF12838.13), Fer4_17 (PF13534.12). | Fer2_3 Fer4_8 Fer4_10 Fer4 Fer4_7 Fer4_17 |
Family assigned |
| frdC Rv1554 |
mtbc0_001661 |
fumarate reductase membrane anchor subunit | Fumarate reductase subunit C. Pfam: Fumarate_red_C (PF02300.23). | Fumarate_red_C |
Family assigned |
| frdD Rv1555 |
mtbc0_001662 |
fumarate reductase membrane anchor subunit | Fumarate reductase subunit FrdD. Pfam: Fumarate_red_D (PF02313.23). | Fumarate_red_D |
Family assigned |
| Rv1556 Rv1556 |
mtbc0_001663 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_11 (PF16859.11). | TetR_N TetR_C_11 |
Family assigned |
| mmpL6 Rv1557 |
- |
transmembrane transport protein MmpL6 | Transmembrane transport protein MmpL6. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| Rv1558 Rv1558 |
mtbc0_001666 |
hypothetical protein | F420H(2)-dependent quinone reductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Resolved |
| ilvA Rv1559 |
mtbc0_001667 |
threonine dehydratase IlvA | Threonine ammonia-lyase. Pfam: PALP (PF00291.32), Thr_dehydrat_C (PF00585.25). | PALP Thr_dehydrat_C |
Resolved |
| vapB11 Rv1560 |
- |
antitoxin VapB11 | Antitoxin VapB11. Pfam: VapB_antitoxin (PF09957.16). | VapB_antitoxin |
Resolved |
| vapC11 Rv1561 |
mtbc0_001669 |
ribonuclease VapC11 | Type II toxin-antitoxin system toxin ribonuclease VapC11. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| treZ Rv1562c |
- |
malto-oligosyltrehalose trehalohydrolase | Malto-oligosyltrehalose trehalohydrolase. Pfam: Alpha-amylase (PF00128.32), DUF3459 (PF11941.15). | Alpha-amylase DUF3459 |
Resolved |
| treY Rv1563c |
- |
maltooligosyl trehalose synthase | Maltooligosyl trehalose synthase. Pfam: Alpha-amylase (PF00128.32). | Alpha-amylase |
Resolved |
| treX Rv1564c |
- |
maltooligosyl trehalose synthase | Maltooligosyl trehalose synthase. Pfam: CBM_48 (PF02922.25), Alpha-amylase (PF00128.32), Isoamylase_C (PF21331.5). | CBM_48 Alpha-amylase Isoamylase_C |
Resolved |
| Rv1565c Rv1565c |
mtbc0_001673 |
acyltransferase | Acyltransferase family protein. Pfam: Acyl_transf_3 (PF01757.29), SGNH (PF19040.7). | Acyl_transf_3 SGNH |
Family assigned |
| ripD Rv1566c |
mtbc0_001674 |
hypothetical protein | NlpC/P60 family peptidoglycan-binding protein RipD. Pfam: NLPC_P60 (PF00877.26). | NLPC_P60 |
Family assigned |
| Rv1567c Rv1567c |
- |
membrane protein | Membrane protein. | Family assigned | |
| bioA Rv1568 |
mtbc0_001676 |
adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA | Adenosylmethionine--8-amino-7-oxononanoate transaminase. Pfam: Aminotran_3 (PF00202.28). | Aminotran_3 |
Resolved |
| bioF1 Rv1569 |
- |
8-amino-7-oxononanoate synthase | 8-amino-7-oxononanoate synthase. Pfam: Aminotran_1_2 (PF00155.28), Aminotran_5 (PF00266.26), DegT_DnrJ_EryC1 (PF01041.24). | Aminotran_1_2 Aminotran_5 DegT_DnrJ_EryC1 |
Resolved |
| bioD Rv1570 |
mtbc0_001678 |
ATP-dependent dethiobiotin synthetase BioD | Dethiobiotin synthase. Pfam: AAA_26 (PF13500.13), CbiA (PF01656.30). | AAA_26 CbiA |
Resolved |
| Rv1571 Rv1571 |
mtbc0_001679 |
hypothetical protein | 2'-5' RNA ligase family protein. Pfam: 2_5_RNA_ligase2 (PF13563.13). | 2_5_RNA_ligase2 |
Family assigned |
| Rv1573 Rv1573 |
mtbc0_001680 |
phage protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1574 Rv1574 |
- |
phage protein | Phage protein. | Resolved | |
| Rv1575 Rv1575 |
- |
phage protein | Phage protein. | Resolved | |
| Rv1576c Rv1576c |
mtbc0_001683 |
phage capsid protein | Phage major capsid protein. | Resolved | |
| Rv1577c Rv1577c |
- |
phage prohead protease | Phage prohead protease. Pfam: Peptidase_S78 (PF04586.23). | Peptidase_S78 |
Resolved |
| Rv1578c Rv1578c |
mtbc0_001685 |
phage protein | Phage terminase small subunit P27 family. Pfam: Terminase_4 (PF05119.18). | Terminase_4 |
Family assigned |
| est12 Rv1579c |
mtbc0_001686 |
phage protein | EST12 (early secreted target, 12 kDa), a secreted effector encoded in region-of-difference RD3. RefSeq leaves it 'hypothetical'. Secreted EST12 binds the receptor for activated C kinase 1 (RACK1) and recruits the deubiquitinase UCHL5 to deubiquitinate NLRP3, triggering NLRP3-caspase-1-gasdermin-D pyroptosis and IL-1beta release; it also regulates Myc via RACK1-JNK-AP1. A crystal structure identifies Y80 as the RACK1-binding residue; ΔEST12 is more susceptible in vitro and in vivo (Qu 2020). | Resolved | |
| Rv1580c Rv1580c |
mtbc0_001687 |
phage protein | Prophage phiRv1 protein; serologically detectable antigen (M. bovis diagnostic serology). A prophage-encoded protein of unknown molecular function. | Family assigned | |
| Rv1581c Rv1581c |
mtbc0_001688 |
phage protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1582c Rv1582c |
mtbc0_001689 |
phage protein | Phage/plasmid primase%2C P4 family. Pfam: D5_N (PF08706.17), DUF5906 (PF19263.6). | D5_N DUF5906 |
Family assigned |
| Rv1583c Rv1583c |
mtbc0_001690 |
phage protein | Conserved hypothetical protein; DUF domain(s) DUF2742. Function unknown. | DUF2742 |
Still unknown |
| Rv1584c Rv1584c |
mtbc0_001691 |
phage protein | Prophage phiRv1 recombination-directionality factor (RDF/excisionase). RefSeq leaves it of unknown function. In the phiRv1 prophage-like element, the serine integrase Rv1586c catalyses integration/excision and the small basic Rv1584c protein controls the directionality of recombination (Bibb 2002). | Family assigned | |
| Rv1585c Rv1585c |
mtbc0_001692 |
phage protein | Prophage phiRv1 protein (within region-of-difference RD149). RefSeq leaves it of unknown function. Part of the phiRv1 prophage-like element, variably deleted in Beijing-lineage isolates (Stavrum 2008). Molecular function unknown. | Family assigned | |
| Rv1586c Rv1586c |
mtbc0_001693 |
phage integrase | Recombinase family protein. | Family assigned | |
| Rv1587c Rv1587c |
- |
hypothetical protein | HNH-family endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| Rv1588c Rv1588c |
- |
hypothetical protein | HNH-family endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V; description masked as 'DUF222'). HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| bioB Rv1589 |
mtbc0_001695 |
biotin synthetase | Biotin synthase BioB. Pfam: Radical_SAM (PF04055.28), BATS (PF06968.19). | Radical_SAM BATS |
Resolved |
| Rv1590 Rv1590 |
mtbc0_001696 |
hypothetical protein | Contains BsaP (PF26519.1) domain(s); putative function inferred from the domain architecture. | BsaP |
Family assigned |
| Rv1591 Rv1591 |
mtbc0_001697 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF2567. Function unknown. | DUF2567 |
Still unknown |
| Rv1592c Rv1592c |
mtbc0_001698 |
hypothetical protein | Lipase family protein. Pfam: LIP (PF03583.21). | LIP |
Family assigned |
| Rv1593c Rv1593c |
mtbc0_001699 |
hypothetical protein | NUDIX domain-containing protein. Pfam: NUDIX (PF00293.35), WHD_AraR (PF19368.6), WHD_NrtR (PF21906.3). | NUDIX WHD_AraR WHD_NrtR |
Family assigned |
| nadA Rv1594 |
- |
quinolinate synthetase A | Quinolinate synthetase A. Pfam: NadA (PF02445.22). | NadA |
Resolved |
| nadB Rv1595 |
mtbc0_001701 |
L-aspartate oxidase | L-aspartate oxidase. Pfam: FAD_binding_2 (PF00890.31), Succ_DH_flav_C (PF02910.26). | FAD_binding_2 Succ_DH_flav_C |
Resolved |
| nadC Rv1596 |
mtbc0_001702 |
nicotinate-nucleotide pyrophosphatase | Carboxylating nicotinate-nucleotide diphosphorylase. Pfam: QRPTase_N (PF02749.23), QRPTase_C (PF01729.26). | QRPTase_N QRPTase_C |
Resolved |
| Rv1597 Rv1597 |
mtbc0_001703 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_11 (PF08241.19). | Methyltransf_11 |
Family assigned |
| Rv1598c Rv1598c |
mtbc0_001704 |
hypothetical protein | Nitroreductase family deazaflavin-dependent oxidoreductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Family assigned |
| hisD Rv1599 |
mtbc0_001705 |
histidinol dehydrogenase | Histidinol dehydrogenase. Pfam: Histidinol_dh (PF00815.26). | Histidinol_dh |
Resolved |
| hisC1 Rv1600 |
- |
histidinol-phosphate aminotransferase | Histidinol-phosphate aminotransferase. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Resolved |
| hisB Rv1601 |
mtbc0_001707 |
imidazole glycerol-phosphate dehydratase | Imidazoleglycerol-phosphate dehydratase HisB. Pfam: IGPD (PF00475.25). | IGPD |
Resolved |