Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| mmaA2 Rv0644c |
mtbc0_000682 |
cyclopropane mycolic acid synthase CmaA | Cyclopropane mycolic acid synthase MmaA2. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| mmaA1 Rv0645c |
mtbc0_000683 |
mycolic acid methyltransferase MmaA1 | Mycolic acid methyltransferase MmaA1. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_11 |
Resolved |
| lipG Rv0646c |
mtbc0_000684 |
lipase/esterase LipG | Lipase/esterase LipG. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 |
Resolved |
| Rv0647c Rv0647c |
- |
hypothetical protein | Contains ABC1 (PF03109.23), UbiB_N (PF27536.1) domain(s); putative function inferred from the domain architecture. | ABC1 UbiB_N |
Family assigned |
| Rv0648 Rv0648 |
- |
alpha-mannosidase | Alpha-mannosidase. Pfam: Glyco_hydro_38N (PF01074.29), Alpha-mann_mid (PF09261.17), NPCBM_assoc (PF10633.16). | Glyco_hydro_38N Alpha-mann_mid NPCBM_assoc |
Resolved |
| fabD2 Rv0649 |
- |
malonyl CoA-acyl carrier protein transacylase | Malonyl CoA-acyl carrier protein transacylase. | DUF7158 |
Resolved |
| Rv0650 Rv0650 |
mtbc0_000688 |
sugar kinase | ROK family protein. Pfam: ROK (PF00480.27). | ROK |
Family assigned |
| rplJ Rv0651 |
mtbc0_000689 |
50S ribosomal protein L10 | 50S ribosomal protein L10. Pfam: Ribosomal_L10 (PF00466.26), RL10_C (PF27436.1). | Ribosomal_L10 RL10_C |
Resolved |
| rplL Rv0652 |
mtbc0_000690 |
50S ribosomal protein L7/L12 | 50S ribosomal protein L7/L12. Pfam: Ribosomal_L12_N (PF16320.11), Ribosomal_L12 (PF00542.25). | Ribosomal_L12_N Ribosomal_L12 |
Resolved |
| Rv0653c Rv0653c |
mtbc0_000691 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_33 (PF13305.12). | TetR_N TetR_C_33 |
Family assigned |
| Rv0654 Rv0654 |
mtbc0_000692 |
carotenoid cleavage oxygenase | Carotenoid cleavage oxygenase. Pfam: RPE65 (PF03055.22). | RPE65 |
Resolved |
| mkl Rv0655 |
- |
ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34). | ABC_tran |
Family assigned |
| vapC6 Rv0656c |
mtbc0_000694 |
ribonuclease VapC6 | Ribonuclease VapC6. | Resolved | |
| vapB6 Rv0657c |
mtbc0_000695 |
antitoxin VapB6 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: VapB_antitoxin (PF09957.16). | VapB_antitoxin |
Family assigned |
| Rv0658c Rv0658c |
mtbc0_000696 |
integral membrane protein | CPBP family intramembrane glutamic endopeptidase. Pfam: Rce1-like (PF02517.22). | Rce1-like |
Family assigned |
| mazF2 Rv0659c |
mtbc0_000697 |
toxin MazF2 | Type II toxin-antitoxin system PemK/MazF family toxin. Pfam: PemK_toxin (PF02452.24). | PemK_toxin |
Family assigned |
| mazE2 Rv0660c |
mtbc0_000698 |
antitoxin MazE2 | Ribbon-helix-helix protein%2C CopG family. Pfam: RHH_1 (PF01402.28). | RHH_1 |
Family assigned |
| vapC7 Rv0661c |
mtbc0_000699 |
ribonuclease VapC7 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB7 Rv0662c |
mtbc0_000700 |
antitoxin VapB7 | Antitoxin. | Resolved | |
| atsD Rv0663 |
mtbc0_000701 |
arylsulfatase AtsD | Arylsulfatase AtsD. Pfam: Sulfatase (PF00884.29). | Sulfatase |
Resolved |
| vapB8 Rv0664 |
- |
antitoxin VapB8 | Antitoxin VapB8. | Resolved | |
| vapC8 Rv0665 |
mtbc0_000703 |
ribonuclease VapC8 | PIN domain-containing protein. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0666 Rv0666 |
mtbc0_000704 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| rpoB Rv0667 |
mtbc0_000705 |
DNA-directed RNA polymerase subunit beta | DNA-directed RNA polymerase subunit beta. Pfam: RNA_pol_Rpb2_1 (PF04563.21), RNA_pol_Rpb2_2 (PF04561.20), RNA_pol_Rpb2_3 (PF04565.22), RNA_pol_Rpb2_45 (PF10385.15), RNA_pol_Rpb2_6 (PF00562.34), RNA_pol_Rpb2_7 (PF04560.26). | RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_3 RNA_pol_Rpb2_45 RNA_pol_Rpb2_6 RNA_pol_Rpb2_7 |
Family assigned |
| rpoC Rv0668 |
- |
DNA-directed RNA polymerase subunit beta' | DNA-directed RNA polymerase subunit beta'. Pfam: RNA_pol_Rpb1_1 (PF04997.18), RNA_pol_Rpb1_2 (PF00623.26), RNA_pol_Rpb1_3 (PF04983.24), RNA_pol_Rpb1_4 (PF05000.23), RNA_pol_Rpb1_5 (PF04998.23). | RNA_pol_Rpb1_1 RNA_pol_Rpb1_2 RNA_pol_Rpb1_3 RNA_pol_Rpb1_4 RNA_pol_Rpb1_5 |
Family assigned |
| Rv0669c Rv0669c |
mtbc0_000708 |
neutral ceramidase | Neutral ceramidase. Pfam: Ceramidase_alk (PF04734.19), Ceramidse_alk_C (PF17048.12). | Ceramidase_alk Ceramidse_alk_C |
Resolved |
| end Rv0670 |
mtbc0_000709 |
endonuclease IV | Deoxyribonuclease IV. Pfam: AP_endonuc_2 (PF01261.31). | AP_endonuc_2 |
Resolved |
| lpqP Rv0671 |
mtbc0_000710 |
lipoprotein LpqP | PHB depolymerase family esterase. Pfam: Esterase_PHB (PF10503.15). | Esterase_PHB |
Family assigned |
| fadE8 Rv0672 |
mtbc0_000711 |
acyl-CoA dehydrogenase FadE8 | Acyl-CoA dehydrogenase family protein. Pfam: AidB_N (PF18158.7), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | AidB_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| echA4 Rv0673 |
mtbc0_000712 |
enoyl-CoA hydratase EchA4 | Crotonase/enoyl-CoA hydratase family protein. Pfam: ECH_2 (PF16113.11), ECH_1 (PF00378.26). | ECH_2 ECH_1 |
Family assigned |
| Rv0674 Rv0674 |
mtbc0_000713 |
hypothetical protein | PaaX family transcriptional regulator C-terminal domain-containing protein. Pfam: PaaX (PF07848.19), PaaX_M (PF20803.3), PaaX_C (PF08223.17). | PaaX PaaX_M PaaX_C |
Family assigned |
| echA5 Rv0675 |
- |
enoyl-CoA hydratase EchA5 | Enoyl-CoA hydratase EchA5. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| mmpL5 Rv0676c |
mtbc0_000715 |
transmembrane transport protein MmpL5 | Siderophore RND transporter MmpL5. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| mmpS5 Rv0677c |
mtbc0_000716 |
membrane protein MmpS5 | Siderophore transporter accessory protein MmpS5. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Resolved |
| mmpR5 Rv0678 |
mtbc0_000717 |
hypothetical protein | Siderophore transport transcriptional regulator MmpR5. Pfam: HTH_MmpR5 (PF27059.1). | HTH_MmpR5 |
Family assigned |
| Rv0679c Rv0679c |
mtbc0_000718 |
hypothetical protein | Membrane protein (16.6 kDa) of the cell envelope implicated in host-cell invasion; a dimorphic antigen carrying a Beijing-genotype-specific Asn142Lys polymorphism with distinct antibody responses. Rv0679c-derived peptides bind A549/U937 cells and TLR2/TLR4 and inhibit bacillary entry, suggesting a role in invasion (Zhao 2017). Molecular function unfixed. | DUF3060 |
Family assigned |
| Rv0680c Rv0680c |
mtbc0_000719 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3060. Function unknown. | DUF3060 |
Still unknown |
| Rv0681 Rv0681 |
mtbc0_000720 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_C_33 (PF13305.12). | TetR_C_33 |
Family assigned |
| rpsL Rv0682 |
mtbc0_000721 |
30S ribosomal protein S12 | 30S ribosomal protein S12. Pfam: Ribosom_S12_S23 (PF00164.32). | Ribosom_S12_S23 |
Resolved |
| rpsG Rv0683 |
- |
30S ribosomal protein S7 | 30S ribosomal protein S7. Pfam: Ribosomal_S7 (PF00177.28). | Ribosomal_S7 |
Resolved |
| fusA1 Rv0684 |
- |
elongation factor G | Elongation factor G. Pfam: GTP_EFTU (PF00009.34), EF-G_D2 (PF22042.3), GTP_EFTU_D2 (PF03144.32), EFG_III (PF14492.13), EFG_IV (PF03764.25), EFG_C (PF00679.31). | GTP_EFTU EF-G_D2 GTP_EFTU_D2 EFG_III EFG_IV EFG_C |
Resolved |
| tuf Rv0685 |
- |
elongation factor Tu | Elongation factor Tu. Pfam: GTP_EFTU (PF00009.34), GTP_EFTU_D2 (PF03144.32), GTP_EFTU_D3 (PF03143.24). | GTP_EFTU GTP_EFTU_D2 GTP_EFTU_D3 |
Resolved |
| Rv0686 Rv0686 |
mtbc0_000725 |
membrane protein | SHOCT domain-containing protein. | Family assigned | |
| Rv0687 Rv0687 |
mtbc0_000726 |
NAD-dependent oxidoreductase | Rv0687 family mycofactocin-dependent SDR oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv0688 Rv0688 |
mtbc0_000727 |
ferredoxin reductase | FAD/NAD(P)-binding oxidoreductase. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox (PF00070.34), Reductase_C (PF14759.13). | Pyr_redox_2 Pyr_redox Reductase_C |
Resolved |
| Rv0689c Rv0689c |
- |
hypothetical protein | eggNOG ortholog of COG3324 (amino-acid-metabolism COG category E), annotated with translation-initiation-factor-related GO activity. RefSeq leaves it 'hypothetical protein'. A weak, GO-level functional transfer; treated as a family hint only. | Family assigned | |
| Rv0690c Rv0690c |
mtbc0_000730 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2332. Function unknown. Foldseek best (non-significant) hit: 8rpr-assembly1_A Crystal Structure of SgvM methyltransferase in comple (prob 0.47, TM 0.27). | DUF2332 |
Still unknown |
| Rv0691A Rv0691A |
- |
mycofactocin precursor | Mycofactocin precursor. Pfam: MftA (PF23709.2). | MftA |
Resolved |
| mftR Rv0691c |
mtbc0_000731 |
mycofactocin biosynthesis transcriptional regulator MftR | Mycofactocin system transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_14 (PF17754.7). | TetR_N TetR_C_14 |
Family assigned |
| mftB Rv0692 |
mtbc0_000733 |
mycofactocin system protein MftB | Mycofactocin biosynthesis chaperone MftB. Pfam: MftB_chaperone (PF26520.1). | MftB_chaperone |
Resolved |