Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1291c Rv1291c |
mtbc0_001382 |
hypothetical protein | Secreted protein of the mycobacterial DUF732 family. All-vs-all structural clustering (Foldseek on ESMFold models, phase36) places it in a tight fold family (median TM-score 0.67) that includes the characterised host-directed effectors Rv1804c (sequesters host IkappaB-alpha) and Rv3354 (targets the host COP9 signalosome), plus the secreted antigen Rv1271c. It shares the family's N-terminal signal peptide (DeepTMHMM) and the ~110-aa secreted fold. A host-interaction / secreted-effector role is therefore plausible, but the specific molecular target of THIS member is not experimentally established (the DUF732 family is functionally heterogeneous). | DUF732 |
Family assigned |
| Rv1303 Rv1303 |
mtbc0_001395 |
hypothetical protein | ATP synthase subunit I. Pfam: ATP-synt_I (PF03899.22). | ATP-synt_I |
Family assigned |
| Rv1312 Rv1312 |
mtbc0_001404 |
hypothetical protein | Membrane protein encoded as the terminal gene of the F1F0-ATP synthase operon (Rv1303-atpBEFGHDC-Rv1312; operon structure established in the published M. tuberculosis oxidative-phosphorylation literature), co-transcribed with the atp genes and under strong purifying selection. The convergent context — co-transcription within the ATP-synthase operon, predicted membrane localisation, and an in-vivo fitness requirement (Tn-seq) — makes it a candidate accessory / associated component of the mycobacterial ATP synthase (oxidative phosphorylation). Whether it is a structural subunit, an assembly factor, or a co-regulated membrane protein is not established. RefSeq leaves it 'hypothetical protein'. | DUF2550 |
Family assigned |
| Rv1322 Rv1322 |
mtbc0_001418 |
hypothetical protein | Contains Rv1322 (PF27609.1) domain(s); putative function inferred from the domain architecture. | Rv1322 |
Family assigned |
| Rv1322A Rv1322A |
- |
hypothetical protein | Contains Glyoxalase (PF00903.32), Glyoxalase_3 (PF13468.13), Glyoxalase_4 (PF13669.13) domain(s); putative function inferred from the domain architecture. | Glyoxalase Glyoxalase_3 Glyoxalase_4 |
Family assigned |
| Rv1339 Rv1339 |
- |
hypothetical protein | Contains Anti-Pycsar_Apyc1 (PF23023.2), Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14) domain(s); putative function inferred from the domain architecture. | Anti-Pycsar_Apyc1 Lactamase_B Lactamase_B_2 |
Family assigned |
| Rv1342c Rv1342c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3817 |
Family assigned |
| Rv1351 Rv1351 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1352 Rv1352 |
mtbc0_001452 |
hypothetical protein | Contains Rv1352 (PF27111.1) domain(s); putative function inferred from the domain architecture. | Rv1352 |
Family assigned |
| Rv1354c Rv1354c |
mtbc0_001454 |
hypothetical protein | Bifunctional diguanylate cyclase/phosphodiesterase. Pfam: GAF_2 (PF13185.13), GAF (PF01590.33), GGDEF (PF00990.27), EAL (PF00563.26). | GAF_2 GAF GGDEF EAL |
Resolved |
| Rv1356c Rv1356c |
- |
hypothetical protein | TrzA: N-acyl amino acid transferase. N-acylates L-tryptophan (highest specificity for C5:0-CoA) in the trzAS cluster for N-acylated tryptazolone biosynthesis. RefSeq still annotates it hypothetical. | Resolved | |
| Rv1357c Rv1357c |
mtbc0_001457 |
hypothetical protein | Cyclic diguanylate phosphodiesterase. Pfam: EAL (PF00563.26). | EAL |
Resolved |
| Rv1366 Rv1366 |
mtbc0_001468 |
hypothetical protein | GTP pyrophosphokinase family protein. Pfam: RelA_SpoT (PF04607.24). | RelA_SpoT |
Family assigned |
| Rv1366A Rv1366A |
- |
hypothetical protein | RelA/SpoT-homolog (RSH) / small-alarmone-synthetase (SAS) family protein: a (p)ppGpp-synthetase-domain protein of the stringent-response/alarmone superfamily (HHpred 99.69%, E 1.7e-16 to a RelA/SpoT-family protein over 74 cols). At 86 aa it is a minimal single-domain SAS, DISTINCT from the main bifunctional Rel(Mtb)/Rv2583c (738 aa). The FaRel2/ATfaRel2 (toxSAS) hits raise the possibility of a toxic small-alarmone-synthetase (toxSAS; TA / phage-defence) rather than a canonical (p)ppGpp synthetase; the neighbouring hypothetical Rv1366 (STRING 834) is a candidate cognate partner. Subtype (synthetase vs toxSAS) undetermined. CONTEXT (twin-synthetase landscape, Sinha 2023): M. tuberculosis has two characterised bifunctional synthetases - Rel(Rv2583c) and the RNase-HII-fused short SAS RelZ (~500 aa); at 86 aa Rv1366A matches NEITHER (too short for RelZ), so it is a candidate ADDITIONAL monofunctional small/toxic alarmone synthetase, not yet experimentally characterised. | Family assigned | |
| Rv1367c Rv1367c |
- |
hypothetical protein | Contains Beta-lactamase (PF00144.30) domain(s); putative function inferred from the domain architecture. | Beta-lactamase |
Family assigned |
| Rv1374c Rv1374c |
mtbc0_001475 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7x75-assembly1_D Cryo-EM structure of Streptomyces coelicolor RNAP-pro (prob 0.04, TM 0.33). | Still unknown | |
| Rv1375 Rv1375 |
mtbc0_001476 |
hypothetical protein | YcaO-like family protein. Pfam: YcaO (PF02624.22). | YcaO |
Family assigned |
| Rv1376 Rv1376 |
mtbc0_001477 |
hypothetical protein | TfuA-like protein. Pfam: TfuA (PF07812.19). | TfuA |
Family assigned |
| Rv1378c Rv1378c |
- |
hypothetical protein | HNH endonuclease / nuclease of the 13E12-repeat family (eggNOG COG1403, COG category V), in an RD (DS6) context. HNH active-site motif; target undetermined. | DUF222 |
Family assigned |
| Rv1382 Rv1382 |
mtbc0_001483 |
hypothetical protein | Transporter. Pfam: bPH_11 (PF25362.2). | bPH_11 |
Resolved |
| Rv1413 Rv1413 |
- |
hypothetical protein | Contains Ala_racemase_N (PF01168.27) domain(s); putative function inferred from the domain architecture. | Ala_racemase_N |
Family assigned |
| Rv1414 Rv1414 |
- |
hypothetical protein | Contains D-ser_dehydrat (PF14031.14) domain(s); putative function inferred from the domain architecture. | D-ser_dehydrat |
Family assigned |
| Rv1419 Rv1419 |
mtbc0_001519 |
hypothetical protein | Lectin. Pfam: Ricin_B_lectin (PF00652.29). | Ricin_B_lectin |
Resolved |
| rapZ Rv1421 |
mtbc0_001521 |
hypothetical protein | RNase adapter RapZ. Pfam: RapZ-like_N (PF03668.22), PapZ_C (PF22740.2). | RapZ-like_N PapZ_C |
Resolved |
| cuvA Rv1422 |
mtbc0_001522 |
hypothetical protein | Carbon utilization/virulence protein CuvA. Pfam: CofD (PF01933.24). | CofD |
Resolved |
| Rv1428c Rv1428c |
mtbc0_001528 |
hypothetical protein | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27), DAGAT (PF03982.19). | Acyltransferase DAGAT |
Family assigned |
| Rv1429 Rv1429 |
mtbc0_001529 |
hypothetical protein | PucR family transcriptional regulator. Pfam: RsbRD_N (PF14361.13), GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | RsbRD_N GGDEF_2 HTH_30 |
Family assigned |
| Rv1431 Rv1431 |
mtbc0_001531 |
hypothetical protein | Polytopic integral membrane protein with 11 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3556 |
Family assigned |
| ldtMt3 Rv1433 |
mtbc0_001533 |
hypothetical protein | L%2CD-transpeptidase LdtMt3. Pfam: Big_10 (PF17964.8), YkuD (PF03734.20). | Big_10 YkuD |
Resolved |
| Rv1434 Rv1434 |
mtbc0_001534 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| hsr1 Rv1435c |
mtbc0_001535 |
hypothetical protein | Hsr1 (host splicing regulator 1), a secreted virulence factor that disrupts host snRNP biogenesis. RefSeq leaves it 'hypothetical'. Secreted Rv1435c/hsr1 targets specific exon-skipping events and facilitates a direct interaction between Mtb phagosomes and U5 snRNA and SNRPF; genetic deletion reverses the splicing changes and attenuates growth ex vivo and in vivo (Chauhan 2025). | Resolved | |
| Rv1439c Rv1439c |
mtbc0_001540 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_2 (PF12680.14). | SnoaL_2 |
Family assigned |
| Rv1443c Rv1443c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 1z94-assembly1_A X-Ray Crystal Structure of Protein CV1439 from Chromobacterium (prob 1.00, TM 0.76). Structure-based, putative. | DUF8410 |
Family assigned |
| Rv1444c Rv1444c |
- |
hypothetical protein | Conserved protein co-transcribed with devB (6-phosphogluconolactonase) and opcA (the OpcA glucose-6-phosphate-dehydrogenase assembly/activator) in the oxidative pentose-phosphate operon, under purifying selection. Contextual candidate: associated with the oxidative pentose-phosphate pathway. Its molecular role is not established. | Family assigned | |
| Rv1455 Rv1455 |
mtbc0_001557 |
hypothetical protein | Contains DcsG_N (PF27100.1) domain(s); putative function inferred from the domain architecture. | DcsG_N |
Family assigned |
| sufB Rv1461 |
mtbc0_001563 |
hypothetical protein | Intein-containing Fe-S cluster assembly protein SufB. Pfam: SufBD_N (PF19295.6), SUFBD_core (PF01458.24). | SufBD_N SUFBD_core |
Resolved |
| sufD Rv1462 |
mtbc0_001564 |
hypothetical protein | Fe-S cluster assembly protein SufD. Pfam: SUFBD_core (PF01458.24). | SUFBD_core |
Resolved |
| Rv1466 Rv1466 |
mtbc0_001568 |
hypothetical protein | Metal-sulfur cluster assembly factor. Pfam: FeS_assembly_P (PF01883.25). | FeS_assembly_P |
Resolved |
| Rv1480 Rv1480 |
mtbc0_001583 |
hypothetical protein | DUF58; fold of the BatB/DUF58 family (PDB 3IBS); putative integrity/assembly protein. | DUF58 |
Family assigned |
| Rv1482c Rv1482c |
mtbc0_001585 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| Rv1486c Rv1486c |
mtbc0_001589 |
hypothetical protein | Contains Rv1486c_N (PF27075.1), Rv1486c_C (PF27076.1) domain(s); putative function inferred from the domain architecture. | Rv1486c_N Rv1486c_C |
Family assigned |
| Rv1487 Rv1487 |
mtbc0_001590 |
hypothetical protein | NfeD family protein. Pfam: NfeD (PF01957.26). | NfeD |
Family assigned |
| Rv1488 Rv1488 |
mtbc0_001591 |
hypothetical protein | SPFH domain-containing protein. Pfam: Band_7 (PF01145.32). | Band_7 |
Family assigned |
| Rv1489 Rv1489 |
- |
hypothetical protein | Contains DoxX_2 (PF13564.12) domain(s); putative function inferred from the domain architecture. | DoxX_2 |
Family assigned |
| Rv1489A Rv1489A |
- |
hypothetical protein | Contains MM_CoA_mutase (PF01642.29) domain(s); putative function inferred from the domain architecture. | MM_CoA_mutase |
Family assigned |
| Rv1498A Rv1498A |
- |
hypothetical protein | Contains Dodecin (PF07311.18) domain(s); putative function inferred from the domain architecture. | Dodecin |
Family assigned |
| Rv1499 Rv1499 |
mtbc0_001604 |
hypothetical protein | Glycosyltransferase (part1). | Resolved | |
| Rv1501 Rv1501 |
mtbc0_001606 |
hypothetical protein | Phytanoyl-CoA dioxygenase family protein. Pfam: PhyH (PF05721.20). | PhyH |
Family assigned |
| Rv1502 Rv1502 |
mtbc0_001607 |
hypothetical protein | Glycoside-hydrolase fold (PDB 5MUI); putative glycosidase. | Family assigned | |
| Rv1503c Rv1503c |
|
Conserved hypothetical protein | Belongs to the DegT DnrJ EryC1 family | DegT_DnrJ_EryC1 |
Family assigned |