Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0195 Rv0195 |
mtbc0_000209 |
two component transcriptional regulator | Response regulator transcription factor. Pfam: GerE (PF00196.26). | GerE |
Resolved |
| Rv0196 Rv0196 |
mtbc0_000210 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_13 (PF16925.11), TetR_C_13_2 (PF21993.2). | TetR_N TetR_C_13 TetR_C_13_2 |
Family assigned |
| Rv0197 Rv0197 |
- |
oxidoreductase | Oxidoreductase. Pfam: Molybdop_Fe4S4 (PF04879.22), Molybdopterin (PF00384.28), Molydop_binding (PF01568.28). | Molybdop_Fe4S4 Molybdopterin Molydop_binding |
Resolved |
| zmp1 Rv0198c |
mtbc0_000212 |
zinc metalloprotease | Zinc metalloprotease Zmp1. Pfam: Peptidase_M13_N (PF05649.19), Peptidase_M13 (PF01431.28). | Peptidase_M13_N Peptidase_M13 |
Resolved |
| omamA Rv0199 |
mtbc0_000213 |
membrane protein | Mce-associated membrane (Mam) protein OmamA (orphaned Mam protein A), an exported virulence factor that stabilises the Mce lipid-transport complexes. RefSeq leaves this locus 'hypothetical protein'; here it is re-annotated from published genetics/cell biology. Rv0199 is required for cholesterol import (a Mce4-dependent process) and stabilises protein components of the Mce1 transporter complex, a role proposed to be analogous to VirB8 in stabilising Type-IV secretion systems (Perkowski 2016). It was independently identified as an exported, intracellular-growth factor (β-lactamase reporter transposon screen; attenuated macrophage growth) (McCann 2011). Experimentally characterised, not a structural prediction. | Resolved | |
| omamB Rv0200 |
mtbc0_000214 |
transmembrane protein | Mce-associated membrane protein OmamB, a component of the Mce1 fatty-acid transporter. RefSeq leaves this locus 'hypothetical protein'. A forward genetic screen for reduced fatty-acid import by M. tuberculosis within macrophages identified Rv0200/OmamB among the putative components of the Mce1 fatty-acid transporter, alongside Rv3723/LucA, Rv0172/Mce1D and Rv0655/MceG (Nazarova 2019). Paralogue of OmamA (Rv0199). Experimentally characterised, not a structural prediction. | Resolved | |
| Rv0201c Rv0201c |
mtbc0_000215 |
hypothetical protein | XRE/Cro-family helix-turn-helix transcriptional regulator (PGAP). No Pfam domain above threshold, but Foldseek strongly matches DNA-binding folds (prob 1.00, TM=0.81). Putative DNA-binding regulator. | Family assigned | |
| mmpL11 Rv0202c |
mtbc0_000216 |
transmembrane transport protein MmpL11 | RND transporter MmpL11. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| Rv0203 Rv0203 |
mtbc0_000217 |
hypothetical protein | Secreted heme-binding hemophore (Pfam MHB PF16525). Captures host-derived heme and delivers it across the cell envelope for iron acquisition, a component of the mycobacterial heme-uptake system important for growth on heme as an iron source. | MHB |
Resolved |
| Rv0204c Rv0204c |
mtbc0_000218 |
transmembrane protein | TIGR00374 family protein. Pfam: LPG_synthase_TM (PF03706.19). | LPG_synthase_TM |
Family assigned |
| Rv0205 Rv0205 |
mtbc0_000219 |
transmembrane protein | AI-2E family transporter. Pfam: AI-2E_transport (PF01594.23). | AI-2E_transport |
Family assigned |
| mmpL3 Rv0206c |
mtbc0_000220 |
transmembrane transport protein MmpL3 | Trehalose monomycolate RND transporter MmpL3. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| Rv0207c Rv0207c |
mtbc0_000221 |
hypothetical protein | NYN-domain ribonuclease (Pfam NYN PF01936), of the PIN/NYN metal-dependent RNase superfamily. Putative ribonuclease. | NYN |
Family assigned |
| trmB Rv0208c |
mtbc0_000222 |
tRNA (guanine-N(7)-)-methyltransferase | TRNA (guanosine(46)-N7)-methyltransferase TrmB. Pfam: Methyltransf_4 (PF02390.24). | Methyltransf_4 |
Resolved |
| Rv0209 Rv0209 |
mtbc0_000223 |
hypothetical protein | IniC/dynamin-like protein (isoniazid-induced, iniBAC-family large GTPase-like). RefSeq leaves it 'hypothetical protein'. Distinct locus from iniC/Rv0342. | Family assigned | |
| Rv0210 Rv0210 |
mtbc0_000224 |
hypothetical protein | Conserved hypothetical protein; no Pfam domain above threshold. Foldseek gives only a low-TM (0.21) partial match to Mtb IniA, not conclusive. Uncharacterised. | Still unknown | |
| pckA Rv0211 |
mtbc0_000225 |
phosphoenolpyruvate carboxykinase | Phosphoenolpyruvate carboxykinase (GTP). Pfam: PEPCK_N (PF17297.8), PEPCK_GTP (PF00821.24). | PEPCK_N PEPCK_GTP |
Resolved |
| nadR Rv0212c |
mtbc0_000226 |
transcriptional regulator NadR | Nicotinamide-nucleotide adenylyltransferase. Pfam: CTP_transf_like (PF01467.33), AAA_28 (PF13521.13). | CTP_transf_like AAA_28 |
Resolved |
| Rv0213c Rv0213c |
- |
methyltransferase | Methyltransferase. Pfam: B12-binding (PF02310.25), Radical_SAM (PF04055.28). | B12-binding Radical_SAM |
Resolved |
| fadD4 Rv0214 |
- |
fatty-acid--CoA ligase FadD4 | Fatty-acid--CoA ligase FadD4. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| Rv0216 Rv0216 |
mtbc0_000230 |
hydratase | MaoC family dehydratase. | Family assigned | |
| lipW Rv0217c |
mtbc0_000231 |
esterase LipW | Alpha/beta hydrolase. Pfam: BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20), AXE1 (PF05448.19). | BD-FAE Abhydrolase_3 AXE1 |
Family assigned |
| Rv0218 Rv0218 |
mtbc0_000232 |
transmembrane protein | Molybdopterin-dependent oxidoreductase. Pfam: Oxidored_molyb (PF00174.26). | Oxidored_molyb |
Resolved |
| Rv0219 Rv0219 |
mtbc0_000233 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| lipC Rv0220 |
mtbc0_000234 |
esterase LipC | Esterase LipC. Pfam: COesterase (PF00135.35), BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20), Peptidase_S9 (PF00326.28). | COesterase BD-FAE Abhydrolase_3 Peptidase_S9 |
Resolved |
| Rv0221 Rv0221 |
mtbc0_000235 |
diacyglycerol O-acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| echA1 Rv0222 |
mtbc0_000236 |
enoyl-CoA hydratase EchA1 | Crotonase/enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv0223c Rv0223c |
mtbc0_000237 |
aldehyde dehydrogenase | Aldehyde dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv0224c Rv0224c |
mtbc0_000238 |
methyltransferase | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_11 Methyltransf_25 Methyltransf_12 |
Resolved |
| Rv0225 Rv0225 |
mtbc0_000239 |
hypothetical protein | Glycosyltransferase family 4 (GT-B fold) protein (Pfam Glycos_transf_1 PF00534 with GT4 domains). Transfers a sugar moiety to an acceptor; the specific donor/acceptor is not established. | Glyco_transf_4 Glyco_trans_4_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Family assigned |
| mmpA Rv0226c |
mtbc0_000240 |
transmembrane protein | MmpA, a conserved inner-membrane protein required for efficient surface transport of trehalose mycolates in Corynebacterineae. RefSeq leaves it 'membrane protein'. Deletion of the ortholog (C. glutamicum NCgl2761 / Rv0226c) abolishes acetylation of trehalose monohydroxycorynomycolate (hTMCM), causing hTMCM accumulation in the inner membrane and reduced outer-membrane h2TDCM; MmpA acts with MtrP and TmaT to drive acetylation-dependent mycolate transport (Cashmore 2021). Named mmpA. | Resolved | |
| Rv0227c Rv0227c |
- |
membrane protein | Membrane protein. Pfam: PorA (PF11271.14). | PorA |
Family assigned |
| Rv0228 Rv0228 |
mtbc0_000242 |
acyltransferase | Acyltransferase. Pfam: Acyl_transf_3 (PF01757.29). | Acyl_transf_3 |
Resolved |
| Rv0229c Rv0229c |
mtbc0_000243 |
hypothetical protein | PIN-domain ribonuclease, VapC-family toxin (Pfam PIN PF01850): the toxin of a VapBC-type toxin-antitoxin module, a metal-dependent mRNA interferase that cleaves RNA. | PIN |
Family assigned |
| php Rv0230c |
mtbc0_000245 |
phosphotriesterase | Phosphotriesterase-related protein. Pfam: PTE (PF02126.26). | PTE |
Resolved |
| fadE4 Rv0231 |
mtbc0_000246 |
acyl-CoA dehydrogenase FadE4 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_1 |
Family assigned |
| Rv0232 Rv0232 |
mtbc0_000247 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| nrdB Rv0233 |
mtbc0_000248 |
ribonucleoside-diphosphate reductase subunit beta NrdB | R2-like ligand-binding oxidase. Pfam: Ribonuc_red_sm (PF00268.28). | Ribonuc_red_sm |
Resolved |
| gabD1 Rv0234c |
- |
succinate-semialdehyde dehydrogenase | Succinate-semialdehyde dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv0235c Rv0235c |
mtbc0_000250 |
transmembrane protein | Lipase maturation factor family protein. Pfam: LMF1 (PF06762.20), LMF1_C (PF25179.2). | LMF1 LMF1_C |
Family assigned |
| Rv0236A Rv0236A |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2613. Function unknown. | DUF2613 |
Still unknown |
| aftD Rv0236c |
mtbc0_000251 |
alpha-(1->3)-arabinofuranosyltransferase | DUF3367 domain-containing protein. Pfam: GT-C_AftD (PF11847.14), CBM_AftD (PF24607.2). | GT-C_AftD CBM_AftD |
Family assigned |
| lpqI Rv0237 |
- |
lipoprotein LpqI | Lipoprotein LpqI. Pfam: Glyco_hydro_3 (PF00933.28). | Glyco_hydro_3 |
Resolved |
| Rv0238 Rv0238 |
mtbc0_000254 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_46 (PF21943.2). | TetR_N TetR_C_46 |
Family assigned |
| vapB24 Rv0239 |
mtbc0_000255 |
antitoxin VapB24 | Antitoxin. | Resolved | |
| vapC24 Rv0240 |
mtbc0_000256 |
ribonuclease VapC24 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| htdX Rv0241c |
mtbc0_000257 |
3-hydroxyacyl-thioester dehydratase HtdX | 3-hydroxyacyl-thioester dehydratase HtdX. Pfam: MaoC_dehydratas (PF01575.26). | MaoC_dehydratas |
Resolved |
| fabG4 Rv0242c |
mtbc0_000258 |
3-oxoacyl-ACP reductase FabG | 3-oxoacyl-ACP reductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Resolved |
| fadA2 Rv0243 |
mtbc0_000259 |
acetyl-CoA acetyltransferase FadA | Acetyl-CoA C-acetyltransferase. Pfam: Thiolase_N (PF00108.30), Thiolase_C (PF02803.25). | Thiolase_N Thiolase_C |
Resolved |
| fadE5 Rv0244c |
mtbc0_000260 |
acyl-CoA dehydrogenase FadE5 | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_C (PF12806.13). | Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_C |
Resolved |