Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1751 Rv1751 |
- |
oxidoreductase | Oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), NAD_binding_8 (PF13450.13). | FAD_binding_3 NAD_binding_8 |
Resolved |
| Rv1752 Rv1752 |
- |
hypothetical protein | Contains GFO_IDH_MocA_C3 (PF22725.2) domain(s); putative function inferred from the domain architecture. | GFO_IDH_MocA_C3 |
Family assigned |
| PPE24 Rv1753c |
- |
PPE family protein PPE24 | PPE family protein PPE24. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv1754c Rv1754c |
mtbc0_001867 |
hypothetical protein | AraH1: endo-D-arabinanase of glycoside hydrolase family GH183 (Pfam DUF4185). With AraH2 (Rv3707c), cleaves the D-arabinan of arabinogalactan/lipoarabinomannan, with a distinct substrate preference; involved in mycobacterial cell-wall modification/degradation. | DUF4185 |
Resolved |
| cut1 Rv1758 |
- |
cutinase | Cutinase. Pfam: Cutinase (PF01083.29). | Cutinase |
Resolved |
| wag22 Rv1759c |
- |
PE-PGRS family protein Wag22 | PE-PGRS family protein Wag22. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1760 Rv1760 |
- |
diacylglycerol acyltransferase | Diacylglycerol acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Resolved |
| Rv1761c Rv1761c |
mtbc0_001876 |
hypothetical protein | DUF5073 family protein. | DUF5073 |
Family assigned |
| Rv1762c Rv1762c |
mtbc0_001877 |
hypothetical protein | Heavy metal-binding domain-containing protein. Pfam: YbjQ_1 (PF01906.24). | YbjQ_1 |
Family assigned |
| Rv1765c Rv1765c |
- |
hypothetical protein | Contains DUF222 (PF02720.23), HNH (PF01844.30) domain(s); putative function inferred from the domain architecture. | DUF222 HNH |
Family assigned |
| Rv1766 Rv1766 |
mtbc0_001880 |
hypothetical protein | Metal-sensitive transcriptional regulator. Pfam: Trns_repr_metal (PF02583.23). | Trns_repr_metal |
Family assigned |
| Rv1767 Rv1767 |
mtbc0_001881 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| PE_PGRS31 Rv1768 |
- |
PE-PGRS family protein PE_PGRS31 | PE-PGRS family protein PE_PGRS31. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1769 Rv1769 |
mtbc0_001883 |
hypothetical protein | Amino acid deaminase/aldolase. | Resolved | |
| Rv1770 Rv1770 |
- |
hypothetical protein | Contains Peptidase_M28 (PF04389.23) domain(s); putative function inferred from the domain architecture. | Peptidase_M28 |
Family assigned |
| Rv1771 Rv1771 |
mtbc0_001885 |
L-gulono-1,4-lactone dehydrogenase | L-gulono-1%2C4-lactone dehydrogenase. Pfam: FAD_binding_4 (PF01565.29), ALO (PF04030.20). | FAD_binding_4 ALO |
Resolved |
| Rv1772 Rv1772 |
mtbc0_001886 |
hypothetical protein | ANTAR domain-containing protein. Pfam: ANTAR (PF03861.20). | ANTAR |
Family assigned |
| Rv1773c Rv1773c |
mtbc0_001887 |
transcriptional regulator | IclR family transcriptional regulator. Pfam: HTH_IclR (PF09339.17), MarR_2 (PF12802.14), IclR_C (PF01614.25). | HTH_IclR MarR_2 IclR_C |
Family assigned |
| Rv1774 Rv1774 |
mtbc0_001888 |
oxidoreductase | FAD-binding oxidoreductase. Pfam: FAD_binding_4 (PF01565.29). | FAD_binding_4 |
Resolved |
| Rv1775 Rv1775 |
mtbc0_001889 |
hypothetical protein | Contains DAPG_hydrolase (PF18089.8) domain(s); putative function inferred from the domain architecture. | DAPG_hydrolase |
Family assigned |
| Rv1776c Rv1776c |
mtbc0_001890 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| cyp144 Rv1777 |
- |
cytochrome P450 Cyp144 | Cytochrome P450 Cyp144. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv1778c Rv1778c |
mtbc0_001892 |
hypothetical protein | Conserved hypothetical; Foldseek best hit (RbmA, TM 0.38) not conclusive. Function unknown. | DUF6941 |
Still unknown |
| Rv1779c Rv1779c |
mtbc0_001893 |
integral membrane protein | Conserved hypothetical protein; DUF domain(s) DUF4407. Function unknown. | DUF4407 |
Still unknown |
| Rv1780 Rv1780 |
mtbc0_001894 |
hypothetical protein | BPI/SPLUNC1-like lipid-binding fold (PDB 5I7L); putative lipid-binding protein. | Family assigned | |
| malQ Rv1781c |
mtbc0_001895 |
4-alpha-glucanotransferase | 4-alpha-glucanotransferase. Pfam: MalQ_N (PF21226.5), Glyco_hydro_77 (PF02446.24). | MalQ_N Glyco_hydro_77 |
Resolved |
| eccB5 Rv1782 |
mtbc0_001896 |
ESX-5 type VII secretion system protein EccB5 | Type VII secretion system ESX-5 subunit EccB5. Pfam: T7SS_ESX1_EccB (PF05108.19). | T7SS_ESX1_EccB |
Family assigned |
| eccC5 Rv1783 |
- |
ESX-5 type VII secretion system protein EccC5 | ESX-5 type VII secretion system protein EccC5. Pfam: FtsK_SpoIIIE (PF01580.25). | FtsK_SpoIIIE |
Resolved |
| cyp143 Rv1785c |
mtbc0_001898 |
cytochrome P450 Cyp143 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv1786 Rv1786 |
mtbc0_001899 |
ferredoxin | Ferredoxin. Pfam: Fer4_15 (PF13459.12), Fer4_13 (PF13370.12). | Fer4_15 Fer4_13 |
Resolved |
| PPE25 Rv1787 |
- |
PPE family protein PPE25 | PPE family protein PPE25. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PE18 Rv1788 |
- |
PE family protein PE18 | PE family protein PE18. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PPE26 Rv1789 |
- |
PPE family protein PPE26 | PPE family protein PPE26. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PPE27 Rv1790 |
- |
PPE family protein PPE27 | PPE family protein PPE27. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PE19 Rv1791 |
- |
PE family protein PE19 | PE family protein PE19. Pfam: PE (PF00934.26). | PE |
Family assigned |
| esxN Rv1793 |
- |
ESAT-6 like protein EsxN | ESAT-6 like protein EsxN. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| Rv1794 Rv1794 |
mtbc0_001907 |
hypothetical protein | ESX secretion-associated protein EspG. Pfam: ESX-1_EspG (PF14011.12). | ESX-1_EspG |
Family assigned |
| eccD5 Rv1795 |
mtbc0_001908 |
ESX-5 type VII secretion system protein EccD | Type VII secretion system ESX-5 subunit EccD5. Pfam: YukD (PF08817.17), EccD (PF19053.7). | YukD EccD |
Family assigned |
| mycP5 Rv1796 |
mtbc0_001909 |
membrane-anchored mycosin MycP | Type VII secretion system ESX-5 serine protease mycosin MycP5. Pfam: Peptidase_S8 (PF00082.28). | Peptidase_S8 |
Resolved |
| eccE5 Rv1797 |
mtbc0_001910 |
ESX-5 type VII secretion system protein EccE | Type VII secretion system ESX-5 subunit EccE5. Pfam: EccE (PF11203.14). | EccE |
Family assigned |
| eccA5 Rv1798 |
mtbc0_001911 |
ESX-5 type VII secretion system protein EccA | Type VII secretion system ESX-5 AAA family ATPase EccA5. Pfam: T7SS_EccA1_N (PF21545.4), AAA_5 (PF07728.21), AAA (PF00004.36), AAA_lid_6 (PF17866.9). | T7SS_EccA1_N AAA_5 AAA AAA_lid_6 |
Family assigned |
| lppT Rv1799 |
mtbc0_001912 |
lipoprotein LppT | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| PPE28 Rv1800 |
- |
PPE family protein PPE28 | PPE family protein PPE28. Pfam: PPE (PF00823.26), PE-PPE (PF08237.18). | PPE PE-PPE |
Family assigned |
| PPE29 Rv1801 |
- |
PPE family protein PPE29 | PPE family protein PPE29. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PPE30 Rv1802 |
- |
PPE family protein PPE30 | PPE family protein PPE30. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PE_PGRS32 Rv1803c |
- |
PE-PGRS family protein PE_PGRS32 | PE-PGRS family protein PE_PGRS32. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1804c Rv1804c |
mtbc0_001917 |
hypothetical protein | Secreted protein that activates macrophage pro-inflammatory responses by binding the host IkappaB-alpha PEST domain. RefSeq leaves it 'hypothetical'. Highly conserved secretory Rv1804c directly interacts with the PEST domain of IkappaB-alpha, activating it in an IKKalpha-independent manner; it inhibits mycobacterial survival and is enriched in attenuated rather than virulent strains (Zheng 2024). Also an antibody-eliciting antigen in active TB (Ben Amor 2005). | DUF732 |
Resolved |
| Rv1805c Rv1805c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| PE20 Rv1806 |
- |
PE family protein PE20 | PE family protein PE20. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PPE32 Rv1808 |
- |
PPE family protein PPE32 | PPE family protein PPE32. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |