Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1723 Rv1723 |
mtbc0_001835 |
hydrolase | Serine hydrolase. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Resolved |
| Rv1724c Rv1724c |
mtbc0_001836 |
hypothetical protein | Conserved hypothetical; Foldseek hits non-conclusive (moderate TM). Function unknown. | Still unknown | |
| Rv1725c Rv1725c |
mtbc0_001837 |
hypothetical protein | Winged helix-turn-helix transcriptional regulator. Pfam: HxlR (PF01638.24). | HxlR |
Family assigned |
| Rv1726 Rv1726 |
mtbc0_001838 |
oxidoreductase | FAD-binding oxidoreductase. Pfam: FAD_binding_4 (PF01565.29), BBE (PF08031.18). | FAD_binding_4 BBE |
Resolved |
| Rv1727 Rv1727 |
mtbc0_001839 |
hypothetical protein | TIGR03086 family metal-binding protein. Pfam: MDMPI_N (PF11716.14). | MDMPI_N |
Family assigned |
| Rv1728c Rv1728c |
mtbc0_001840 |
hypothetical protein | Glycoside hydrolase. Pfam: VldE (PF26571.1). | VldE |
Resolved |
| Rv1729c Rv1729c |
mtbc0_001841 |
S-adenosylmethionine-dependent methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| Rv1730c Rv1730c |
mtbc0_001842 |
penicillin-binding protein | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| gabD2 Rv1731 |
mtbc0_001843 |
succinate-semialdehyde dehydrogenase | Succinic semialdehyde dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv1732c Rv1732c |
mtbc0_001844 |
hypothetical protein | Thioredoxin family protein. Pfam: AhpC-TSA (PF00578.28), Redoxin (PF08534.17). | AhpC-TSA Redoxin |
Family assigned |
| Rv1733c Rv1733c |
mtbc0_001845 |
transmembrane protein | Contains Rv1733c (PF27099.1) domain(s); putative function inferred from the domain architecture. | Rv1733c |
Family assigned |
| Rv1734c Rv1734c |
- |
hypothetical protein | Contains 2-oxoacid_dh (PF00198.29) domain(s); putative function inferred from the domain architecture. | 2-oxoacid_dh |
Family assigned |
| Rv1735a Rv1735a |
- |
hypothetical protein | C4-dicarboxylate / malic-acid transporter family membrane protein (eggNOG COG1275, TDT/DASS-like; COG category P). Short ORF (partial); transported solute undetermined. | Family assigned | |
| Rv1735c Rv1735c |
- |
membrane protein | Membrane protein. Pfam: SLAC1 (PF03595.23). | SLAC1 |
Family assigned |
| narX Rv1736c |
mtbc0_001849 |
nitrate reductase-like protein NarX | Respiratory nitrate reductase subunit gamma. Pfam: Molybdopterin (PF00384.28), Nitrate_red_del (PF02613.21), Nitrate_red_gam (PF02665.20). | Molybdopterin Nitrate_red_del Nitrate_red_gam |
Family assigned |
| narK2 Rv1737c |
mtbc0_001850 |
nitrate/nitrite transporter | Nitrate transporter NarK. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| Rv1738 Rv1738 |
mtbc0_001851 |
hypothetical protein | DUF1876 domain-containing protein. Pfam: Rv2632c-like (PF08962.17). | Rv2632c-like |
Family assigned |
| Rv1739c Rv1739c |
mtbc0_001852 |
sulfate ABC transporter permease | SulP family inorganic anion transporter. Pfam: Sulfate_transp (PF00916.27), STAS (PF01740.27). | Sulfate_transp STAS |
Family assigned |
| vapB34 Rv1740 |
mtbc0_001853 |
antitoxin VapB34 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Family assigned |
| vapC34 Rv1741 |
mtbc0_001854 |
ribonuclease VapC34 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv1742 Rv1742 |
mtbc0_001855 |
hypothetical protein | LolA-superfamily fold (lipoprotein / lipid carrier-like beta-barrel). RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on a LolA-superfamily protein (PDB 3buu; Foldseek prob 1.0, E 3e-8, TM 0.57). STRING context: the toxin vapC34 (Rv1741). A carrier/periplasmic-binding fold; the cargo is undemonstrated. | Family assigned | |
| pknE Rv1743 |
mtbc0_001856 |
serine/threonine-protein kinase PknE | Serine/threonine protein kinase PknE. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), Thioredoxin_4 (PF13462.13). | Pkinase PK_Tyr_Ser-Thr Thioredoxin_4 |
Resolved |
| Rv1744c Rv1744c |
mtbc0_001857 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| idi Rv1745c |
mtbc0_001858 |
isopentenyl-diphosphate delta-isomerase | Isopentenyl-diphosphate Delta-isomerase. Pfam: NUDIX (PF00293.35). | NUDIX |
Resolved |
| pknF Rv1746 |
mtbc0_001859 |
serine/threonine-protein kinase PknF | Serine/threonine protein kinase PknF. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24). | Pkinase PK_Tyr_Ser-Thr |
Resolved |
| Rv1747 Rv1747 |
mtbc0_001860 |
ABC transporter ATP-binding protein/permease | ATP-binding cassette domain-containing protein. Pfam: Yop-YscD_cpl (PF16697.11), FHA (PF00498.32), ABC_tran (PF00005.34), AAA_21 (PF13304.13), ABC2_membrane (PF01061.30). | Yop-YscD_cpl FHA ABC_tran AAA_21 ABC2_membrane |
Family assigned |
| Rv1748 Rv1748 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6rf0-assembly1_C Crystal structure of the light-driven sodium pump KR2 (prob 0.20, TM 0.32). | Still unknown | |
| Rv1749c Rv1749c |
mtbc0_001862 |
integral membrane protein | DUF6790 family protein. | DUF6790 |
Family assigned |
| fadD1 Rv1750c |
mtbc0_001863 |
fatty-acid--CoA ligase FadD1 | Fatty-acid--CoA ligase FadD1. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| Rv1751 Rv1751 |
- |
oxidoreductase | Oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), NAD_binding_8 (PF13450.13). | FAD_binding_3 NAD_binding_8 |
Resolved |
| Rv1752 Rv1752 |
- |
hypothetical protein | Contains GFO_IDH_MocA_C3 (PF22725.2) domain(s); putative function inferred from the domain architecture. | GFO_IDH_MocA_C3 |
Family assigned |
| PPE24 Rv1753c |
- |
PPE family protein PPE24 | PPE family protein PPE24. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv1754c Rv1754c |
mtbc0_001867 |
hypothetical protein | AraH1: endo-D-arabinanase of glycoside hydrolase family GH183 (Pfam DUF4185). With AraH2 (Rv3707c), cleaves the D-arabinan of arabinogalactan/lipoarabinomannan, with a distinct substrate preference; involved in mycobacterial cell-wall modification/degradation. | DUF4185 |
Resolved |
| cut1 Rv1758 |
- |
cutinase | Cutinase. Pfam: Cutinase (PF01083.29). | Cutinase |
Resolved |
| wag22 Rv1759c |
- |
PE-PGRS family protein Wag22 | PE-PGRS family protein Wag22. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1760 Rv1760 |
- |
diacylglycerol acyltransferase | Diacylglycerol acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Resolved |
| Rv1761c Rv1761c |
mtbc0_001876 |
hypothetical protein | DUF5073 family protein. | DUF5073 |
Family assigned |
| Rv1762c Rv1762c |
mtbc0_001877 |
hypothetical protein | Heavy metal-binding domain-containing protein. Pfam: YbjQ_1 (PF01906.24). | YbjQ_1 |
Family assigned |
| Rv1765c Rv1765c |
- |
hypothetical protein | Contains DUF222 (PF02720.23), HNH (PF01844.30) domain(s); putative function inferred from the domain architecture. | DUF222 HNH |
Family assigned |
| Rv1766 Rv1766 |
mtbc0_001880 |
hypothetical protein | Metal-sensitive transcriptional regulator. Pfam: Trns_repr_metal (PF02583.23). | Trns_repr_metal |
Family assigned |
| Rv1767 Rv1767 |
mtbc0_001881 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| PE_PGRS31 Rv1768 |
- |
PE-PGRS family protein PE_PGRS31 | PE-PGRS family protein PE_PGRS31. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1769 Rv1769 |
mtbc0_001883 |
hypothetical protein | Putative PLP-dependent enzyme of the alanine-racemase (fold type III) superfamily: the closest structural matches are D-threonine aldolases (TM 0.81, PDB 4v15/7dib) and eggNOG reports an 'alanine racemase, N-terminal domain'. A deaminase/aldolase activity is a fold-level inference — no catalytic site verified. The locus appears in the TB literature only as a vaccine or diagnostic ANTIGEN candidate (3 papers), never functionally. | Resolved | |
| Rv1770 Rv1770 |
- |
hypothetical protein | Contains Peptidase_M28 (PF04389.23) domain(s); putative function inferred from the domain architecture. | Peptidase_M28 |
Family assigned |
| Rv1771 Rv1771 |
mtbc0_001885 |
L-gulono-1,4-lactone dehydrogenase | L-gulono-1%2C4-lactone dehydrogenase. Pfam: FAD_binding_4 (PF01565.29), ALO (PF04030.20). | FAD_binding_4 ALO |
Resolved |
| Rv1772 Rv1772 |
mtbc0_001886 |
hypothetical protein | ANTAR domain-containing protein. Pfam: ANTAR (PF03861.20). | ANTAR |
Family assigned |
| Rv1773c Rv1773c |
mtbc0_001887 |
transcriptional regulator | IclR family transcriptional regulator. Pfam: HTH_IclR (PF09339.17), MarR_2 (PF12802.14), IclR_C (PF01614.25). | HTH_IclR MarR_2 IclR_C |
Family assigned |
| Rv1774 Rv1774 |
mtbc0_001888 |
oxidoreductase | FAD-binding oxidoreductase. Pfam: FAD_binding_4 (PF01565.29). | FAD_binding_4 |
Resolved |
| Rv1775 Rv1775 |
mtbc0_001889 |
hypothetical protein | Contains DAPG_hydrolase (PF18089.8) domain(s); putative function inferred from the domain architecture. | DAPG_hydrolase |
Family assigned |
| Rv1776c Rv1776c |
mtbc0_001890 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |