Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2660c Rv2660c |
mtbc0_002834 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8pui-assembly1_A human PHOX2B C-terminal domain including the polyA fr (prob 0.02, TM 0.30). | Still unknown | |
| Rv2661c Rv2661c |
mtbc0_002835 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2662 Rv2662 |
mtbc0_002836 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2663 Rv2663 |
mtbc0_002837 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 7vd7-assembly1_A Toxin - Antitoxin complex from Salmonella enterica serovar Typh (prob 1.00, TM 0.66). Structure-based, putative. | Family assigned | |
| Rv2664 Rv2664 |
mtbc0_002838 |
hypothetical protein | DNA-binding transcriptional regulator (winged-HTH / ECF-sigma-factor-like fold), structural homolog of the mycobacterial transcription factor Rv2667/CymA (ClpC2/CymA system) RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv2665 Rv2665 |
mtbc0_002839 |
hypothetical protein | Arginine RICH protein. | Resolved | |
| clpC2 Rv2667 |
- |
ATP-dependent protease ATP-binding subunit ClpC | ATP-dependent protease ATP-binding subunit ClpC. Pfam: Clp_N (PF02861.26). | Clp_N |
Family assigned |
| Rv2668 Rv2668 |
mtbc0_002842 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 3cfu-assembly1_A Crystal structure of the yjhA protein from Bacillus subtilis. N (prob 1.00, TM 0.61). Structure-based, putative. | Family assigned | |
| Rv2669 Rv2669 |
mtbc0_002843 |
GCN5-like N-acetyltransferase | N-acetyltransferase. Pfam: Acetyltransf_3 (PF13302.14), Acetyltransf_10 (PF13673.14), Acetyltransf_1 (PF00583.32), Acetyltransf_7 (PF13508.14). | Acetyltransf_3 Acetyltransf_10 Acetyltransf_1 Acetyltransf_7 |
Resolved |
| zapE Rv2670c |
mtbc0_002844 |
hypothetical protein | Cell division protein ZapE. Pfam: AFG1_ATPase (PF03969.23). | AFG1_ATPase |
Resolved |
| ribD Rv2671 |
mtbc0_002845 |
bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | Bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. Pfam: RibD_C (PF01872.23). | RibD_C |
Resolved |
| Rv2672 Rv2672 |
mtbc0_002846 |
protease | Alpha/beta fold hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Abhydrolase_4 |
Resolved |
| aftC Rv2673 |
mtbc0_002847 |
alpha-(1->3)-arabinofuranosyltransferase | Arabinofuranan 3-O-arabinosyltransferase. Pfam: GT87 (PF09594.17). | GT87 |
Resolved |
| msrB Rv2674 |
mtbc0_002848 |
peptide methionine sulfoxide reductase MsrB | Peptide-methionine (R)-S-oxide reductase MsrB. Pfam: SelR (PF01641.27). | SelR |
Resolved |
| Rv2675c Rv2675c |
mtbc0_002849 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| hemQ Rv2676c |
mtbc0_002850 |
hypothetical protein | Hydrogen peroxide-dependent heme synthase. Pfam: Chlor_dismutase (PF06778.19). | Chlor_dismutase |
Resolved |
| hemY Rv2677c |
- |
protoporphyrinogen oxidase | Protoporphyrinogen oxidase. Pfam: NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | NAD_binding_8 Amino_oxidase |
Resolved |
| hemE Rv2678c |
mtbc0_002852 |
uroporphyrinogen decarboxylase | Uroporphyrinogen decarboxylase. Pfam: URO-D (PF01208.24). | URO-D |
Resolved |
| echA15 Rv2679 |
mtbc0_002853 |
enoyl-CoA hydratase EchA15 | Enoyl-CoA hydratase/isomerase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv2680 Rv2680 |
mtbc0_002854 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3000. Function unknown. Foldseek best (non-significant) hit: 8any-assembly1_f Human mitochondrial ribosome in complex with LRPPRC, (prob 0.44, TM 0.39). | DUF3000 |
Still unknown |
| Rv2681 Rv2681 |
mtbc0_002855 |
hypothetical protein | Ribonuclease D. Pfam: DNA_pol_A_exo1 (PF01612.27), HRDC (PF00570.29), DNA_pol_A_exoN (PF18305.7). | DNA_pol_A_exo1 HRDC DNA_pol_A_exoN |
Resolved |
| dxs1 Rv2682c |
- |
1-deoxy-D-xylulose 5-phosphate synthase | 1-deoxy-D-xylulose 5-phosphate synthase. Pfam: DXP_synthase_N (PF13292.12), TPP_enzyme_C (PF02775.27), Transket_pyr (PF02779.30), Transketolase_C (PF02780.26). | DXP_synthase_N TPP_enzyme_C Transket_pyr Transketolase_C |
Resolved |
| Rv2683 Rv2683 |
- |
hypothetical protein | Contains CBS (PF00571.34) domain(s); putative function inferred from the domain architecture. | CBS |
Family assigned |
| arsA Rv2684 |
mtbc0_002858 |
arsenic-transport integral membrane protein ArsA | ArsB/NhaD family transporter. Pfam: ArsB (PF02040.21), CitMHS (PF03600.23), Na_sulph_symp (PF00939.26). | ArsB CitMHS Na_sulph_symp |
Family assigned |
| arsB1 Rv2685 |
- |
arsenic-transport integral membrane protein ArsB | Arsenic-transport integral membrane protein ArsB. Pfam: CitMHS (PF03600.23), ArsB (PF02040.21), NhaB (PF06450.19). | CitMHS ArsB NhaB |
Resolved |
| Rv2686c Rv2686c |
mtbc0_002860 |
antibiotic ABC transporter permease | Fluoroquinolones efflux ABC transporter permease. | Family assigned | |
| Rv2687c Rv2687c |
mtbc0_002861 |
antibiotic ABC transporter permease | Fluoroquinolone transporter permease. Pfam: FLQE3_permease (PF24686.2). | FLQE3_permease |
Family assigned |
| Rv2688c Rv2688c |
mtbc0_002862 |
antibiotic ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34), AAA_21 (PF13304.13). | ABC_tran AAA_21 |
Family assigned |
| Rv2689c Rv2689c |
mtbc0_002863 |
hypothetical protein | Class I SAM-dependent RNA methyltransferase. Pfam: TRAM (PF01938.27), tRNA_U5-meth_tr (PF05958.18). | TRAM tRNA_U5-meth_tr |
Resolved |
| Rv2690c Rv2690c |
- |
integral membrane protein | Integral membrane protein. Pfam: AA_permease_2 (PF13520.13). | AA_permease_2 |
Family assigned |
| ceoB Rv2691 |
- |
TRK system potassium uptake protein CeoB | TRK system potassium uptake protein CeoB. Pfam: TrkA_N (PF02254.25), TrkA_C (PF02080.27). | TrkA_N TrkA_C |
Resolved |
| ceoC Rv2692 |
- |
TRK system potassium uptake protein CeoC | TRK system potassium uptake protein CeoC. Pfam: NAD_binding_7 (PF13241.13), F420_oxidored (PF03807.24), TrkA_N (PF02254.25), ApbA (PF02558.23), NAD_binding_10 (PF13460.13), TrkA_C (PF02080.27). | NAD_binding_7 F420_oxidored TrkA_N ApbA NAD_binding_10 TrkA_C |
Resolved |
| Rv2693c Rv2693c |
mtbc0_002867 |
integral membrane protein | Conserved hypothetical protein; DUF domain(s) DUF3159. Function unknown. | DUF3159 |
Still unknown |
| Rv2694c Rv2694c |
mtbc0_002868 |
hypothetical protein | OB-fold nucleic acid binding domain-containing protein. | Family assigned | |
| Rv2695 Rv2695 |
mtbc0_002869 |
hypothetical protein | Alpha/beta fold hydrolase. | Resolved | |
| Rv2696c Rv2696c |
mtbc0_002870 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3710. Function unknown. | DUF3710 |
Still unknown |
| dut Rv2697c |
- |
deoxyuridine 5'-triphosphate nucleotidohydrolase | Deoxyuridine 5'-triphosphate nucleotidohydrolase. Pfam: dUTPase (PF00692.25), DCD (PF22769.2). | dUTPase DCD |
Resolved |
| Rv2698 Rv2698 |
mtbc0_002872 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3093. Function unknown. | DUF3093 |
Still unknown |
| Rv2699c Rv2699c |
mtbc0_002873 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4193. Function unknown. | DUF4193 |
Still unknown |
| cei Rv2700 |
mtbc0_002874 |
hypothetical protein | Envelope integrity protein Cei. Pfam: LytR_C (PF13399.12). | LytR_C |
Resolved |
| suhB Rv2701c |
mtbc0_002875 |
inositol-1-monophosphatase SuhB | Inositol-1-monophosphatase SuhB. Pfam: Inositol_P (PF00459.31). | Inositol_P |
Resolved |
| ppgK Rv2702 |
mtbc0_002876 |
polyphosphate glucokinase | ROK family protein. Pfam: ROK (PF00480.27). | ROK |
Family assigned |
| sigA Rv2703 |
mtbc0_002877 |
RNA polymerase sigma factor SigA | RNA polymerase sigma factor. Pfam: Sigma70_r1_2 (PF00140.26), Sigma70_r2 (PF04542.21), Sigma70_r3 (PF04539.23), Sigma70_r4 (PF04545.23). | Sigma70_r1_2 Sigma70_r2 Sigma70_r3 Sigma70_r4 |
Resolved |
| Rv2704 Rv2704 |
mtbc0_002878 |
hypothetical protein | RidA family protein. Pfam: Ribonuc_L-PSP (PF01042.27). | Ribonuc_L-PSP |
Family assigned |
| Rv2705c Rv2705c |
mtbc0_002879 |
hypothetical protein | DUF952 domain-containing protein. | DUF952 |
Family assigned |
| Rv2706c Rv2706c |
mtbc0_002880 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2707 Rv2707 |
mtbc0_002881 |
hypothetical protein | YihY/virulence factor BrkB family protein. Pfam: Virul_fac_BrkB (PF03631.21). | Virul_fac_BrkB |
Family assigned |
| Rv2708c Rv2708c |
- |
hypothetical protein | Small zinc-ribbon / zinc-binding protein (structural zinc coordinated by a Cys-rich CxxC motif): three converging lines - HHpred top hit an uncharacterized zinc-binding protein (3RMQ, 96.5% E0.0076) plus a convergent zinc-finger/zinc-ribbon/metallochaperone theme (CPxCG zinc finger 8Q5B, RNA-polymerase Zn-ribbon subunits, hydrogenase-maturation factors HypF/HypA/HypE, LysW, rubredoxin); and the protein sequence itself carries a C-G-E-V-F...C-P-D-C-K-R motif consistent with zinc coordination. The specific molecular function is undetermined (candidate metallochaperone or nucleic-acid-binding zinc-ribbon). RefSeq leaves this locus uncharacterised. | DUF3039 |
Family assigned |
| Rv2709 Rv2709 |
mtbc0_002883 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3099. Function unknown. | DUF3099 |
Still unknown |
| sigB Rv2710 |
mtbc0_002884 |
RNA polymerase sigma factor SigB | Sigma-70 family RNA polymerase sigma factor SigB. Pfam: Sigma70_r1_2 (PF00140.26), Sigma70_r2 (PF04542.21), Sigma70_r3 (PF04539.23), Sigma70_r4 (PF04545.23). | Sigma70_r1_2 Sigma70_r2 Sigma70_r3 Sigma70_r4 |
Family assigned |