Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| lppN Rv2270 |
mtbc0_002412 |
lipoprotein LppN | Lipoprotein LppN of the mycobacterial cell envelope; peptides derived from it bind alveolar epithelial (A549) and monocyte-derived (U937) cells and inhibit mycobacterial entry in vitro, implicating it in host-cell adhesion/invasion. Precise molecular function unfixed. | Family assigned | |
| Rv2271 Rv2271 |
mtbc0_002413 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2695. Function unknown. Foldseek best (non-significant) hit: 7kuw-assembly1_A High-throughput design and refinement of stable prote (prob 0.04, TM 0.37). | DUF2695 |
Still unknown |
| Rv2272 Rv2272 |
mtbc0_002414 |
transmembrane protein | YidH family protein. | DUF202 |
Family assigned |
| Rv2273 Rv2273 |
mtbc0_002415 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF202. Function unknown. | DUF202 |
Still unknown |
| mazE8 Rv2274A |
- |
antitoxin MazE8 | Antitoxin MazE8. | Resolved | |
| mazF8 Rv2274c |
mtbc0_002416 |
toxin MazF8 | Toxin. | Resolved | |
| Rv2275 Rv2275 |
- |
cyclo(L-tyrosyl-L-tyrosyl) synthase | Cyclo(L-tyrosyl-L-tyrosyl) synthase. Pfam: CDPS (PF16715.12). | CDPS |
Resolved |
| cyp121 Rv2276 |
mtbc0_002419 |
cytochrome P450 Cyp121 | Mycocyclosin synthase Cyp121. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv2277c Rv2277c |
- |
glycerolphosphodiesterase | Glycerolphosphodiesterase. Pfam: GDPD (PF03009.24). | GDPD |
Resolved |
| Rv2280 Rv2280 |
|
Probable dehydrogenase | Oxidoreduction | FAD-oxidase_C FAD_binding_4 |
Family assigned |
| pitB Rv2281 |
mtbc0_002422 |
phosphate permease | Anion permease. Pfam: PHO4 (PF01384.26). | PHO4 |
Resolved |
| Rv2282c Rv2282c |
mtbc0_002423 |
LysR family HTH-type transcriptional regulator | LysR family transcriptional regulator. Pfam: HTH_1 (PF00126.34), LysR_substrate (PF03466.26). | HTH_1 LysR_substrate |
Family assigned |
| Rv2283 Rv2283 |
mtbc0_002424 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| lipM Rv2284 |
mtbc0_002425 |
esterase LipM | Alpha/beta hydrolase. Pfam: COesterase (PF00135.35), BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20), Peptidase_S9 (PF00326.28). | COesterase BD-FAE Abhydrolase_3 Peptidase_S9 |
Family assigned |
| Rv2285 Rv2285 |
mtbc0_002426 |
diacylglycerol acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| Rv2286c Rv2286c |
mtbc0_002427 |
hypothetical protein | DsbA family protein. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| yjcE Rv2287 |
- |
Na(+)/H(+) transporter | Na(+)/H(+) transporter. Pfam: Na_H_Exchanger (PF00999.27). | Na_H_Exchanger |
Resolved |
| Rv2288 Rv2288 |
mtbc0_002429 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| cdh Rv2289 |
mtbc0_002430 |
CDP-diacylglycerol pyrophosphatase | CDP-diacylglycerol diphosphatase. Pfam: CDH (PF02611.21). | CDH |
Resolved |
| lppO Rv2290 |
mtbc0_002431 |
lipoprotein LppO | Lipoprotein LpqH. Pfam: Myco_19_kDa (PF05481.18). | Myco_19_kDa |
Resolved |
| sseB Rv2291 |
mtbc0_002432 |
thiosulfate sulfurtransferase SseB | Sulfurtransferase. Pfam: Rhodanese (PF00581.26). | Rhodanese |
Resolved |
| Rv2292c Rv2292c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2293c Rv2293c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2294 Rv2294 |
mtbc0_002434 |
cystathionine beta-lyase | MalY/PatB family protein. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Family assigned |
| Rv2295 Rv2295 |
mtbc0_002435 |
hypothetical protein | CbrC family protein. | UPF0167 |
Family assigned |
| Rv2296 Rv2296 |
mtbc0_002436 |
haloalkane dehalogenase | Haloalkane dehalogenase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Resolved |
| Rv2297 Rv2297 |
mtbc0_002437 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2298 Rv2298 |
mtbc0_002438 |
oxidoreductase | Aldo/keto reductase. Pfam: Aldo_ket_red (PF00248.28). | Aldo_ket_red |
Resolved |
| htpG Rv2299c |
mtbc0_002439 |
chaperone protein HtpG | Molecular chaperone HtpG. Pfam: HATPase_c_3 (PF13589.13), HATPase_c (PF02518.32), HSP90 (PF00183.24). | HATPase_c_3 HATPase_c HSP90 |
Resolved |
| Rv2300c Rv2300c |
- |
metallo-hydrolase | Metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |
| cut2 Rv2301 |
mtbc0_002441 |
cutinase | Cutinase family protein. Pfam: Cutinase (PF01083.29). | Cutinase |
Family assigned |
| Rv2302 Rv2302 |
mtbc0_002442 |
hypothetical protein | Conserved hypothetical protein with an NMR-determined solution structure: a five-strand antiparallel beta-sheet core with one C-terminal alpha-helix, with no high structural similarity to known proteins (a possible novel fold). Up-regulated under starvation and heat-shock; structural homolog of Rv0569. Biochemical function unknown. | DUF1918 |
Family assigned |
| Rv2303c Rv2303c |
mtbc0_002443 |
antibiotic-resistance protein | Amidohydrolase family protein. Pfam: Amidohydro_2 (PF04909.21). | Amidohydro_2 |
Family assigned |
| Rv2304c Rv2304c |
mtbc0_002444 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2305 Rv2305 |
mtbc0_002445 |
hypothetical protein | Condensation/epimerization-domain-like fold of the non-ribosomal peptide synthetase (NRPS) superfamily. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes strongly on an NRPS epimerization domain (PDB 6ta8; Foldseek prob 1.0, E 3e-21, TM 0.67), and eggNOG places it near D-alanyl carrier / D-Ala-D-Ala chemistry (COG Q, secondary metabolism). Fold/family assignment; the catalysed step and substrate are undemonstrated. | Family assigned | |
| Rv2306A Rv2306A |
|
Possible conserved membrane protein | Possible conserved membrane protein | Family assigned | |
| Rv2306B Rv2306B |
|
Possible conserved membrane protein | Possible conserved membrane protein | VTT_dom |
Family assigned |
| Rv2307A Rv2307A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7nhl-assembly1_2 VgaA-LC, an antibiotic resistance ABCF, in complex wi (prob 0.03, TM 0.37). | Still unknown | |
| Rv2307B Rv2307B |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2mf6-assembly1_C Solution NMR structure of Chimeric Avidin, ChiAVD(I11 (prob 0.28, TM 0.63). | Still unknown | |
| Rv2307D Rv2307D |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2307c Rv2307c |
mtbc0_002447 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Hydrolase_4 |
Family assigned |
| Rv2308 Rv2308 |
mtbc0_002452 |
hypothetical protein | Putative antitoxin (DUF433 + HTH) and a certain paralogue of the validated antitoxin Rv2018; proposed antitoxin half of an ancient Rv2308-Rv2308a operon. The operon is conserved beyond the MTBC to the M. canettii outgroup, with the antitoxin (96% identity) more conserved than its faster-evolving putative toxin partner Rv2308a (45%), the canonical asymmetry of a genuine TA pair. The toxin-antitoxin pairing nonetheless remains a hypothesis: AlphaFold3 predicts no Rv2308-Rv2308a complex (inter-chain ipTM ~0.11). | DUF433 |
Family assigned |
| Rv2308a Rv2308a |
- |
hypothetical protein | Putative VapC/PIN-like ribonuclease toxin, proposed partner of the antitoxin Rv2308 in an ancient operon. Dark to Foldseek/ESMFold; HHpred matches ribonuclease/PIN-like toxin profiles (probability ~99%), i.e. distant family-level homology. Conserved to the M. canettii outgroup (45% identity, full length, 44 bp downstream of Rv2308) and present at 100% identity in M. bovis although unannotated there, so not an H37Rv annotation artefact. The pairing is tentative: AlphaFold3 yields neither a confident monomer fold (pTM ~0.20) nor a Rv2308-Rv2308a complex (ipTM ~0.11); presented as an unconfirmed hypothesis. | Family assigned | |
| Rv2309A Rv2309A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8by2-assembly1_B Structure of the K+/H+ exchanger KefC with GSH. (prob 0.06, TM 0.58). | Still unknown | |
| Rv2310 Rv2310 |
- |
excisionase | Excisionase. Pfam: HTH_17 (PF12728.14). | HTH_17 |
Resolved |
| Rv2311 Rv2311 |
- |
hypothetical protein | Contains SH3_Rv2311 (PF27170.1) domain(s); putative function inferred from the domain architecture. | SH3_Rv2311 |
Family assigned |
| Rv2312 Rv2312 |
mtbc0_002460 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dz1-assembly1_A Crystal structure of Dihydrodipicolinate Synthase fro (prob 0.01, TM 0.27). | Still unknown | |
| Rv2313c Rv2313c |
mtbc0_002461 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. | Family assigned | |
| Rv2314c Rv2314c |
mtbc0_002462 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_3rd |
Family assigned |
| Rv2315c Rv2315c |
mtbc0_002463 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_1st (PF01523.22), PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_1st PmbA_TldD_3rd |
Family assigned |