Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0572c Rv0572c |
mtbc0_000602 |
hypothetical protein | Contains MT0599 (PF25859.1) domain(s); putative function inferred from the domain architecture. | MT0599 |
Family assigned |
| Rv0574c Rv0574c |
mtbc0_000604 |
hypothetical protein | CapA family protein. Pfam: PGA_cap (PF09587.16). | PGA_cap |
Family assigned |
| TB27.3 Rv0577 |
mtbc0_000607 |
hypothetical protein | VOC family protein. Pfam: Glyoxalase (PF00903.32), Glyoxalase_6 (PF18029.8). | Glyoxalase Glyoxalase_6 |
Family assigned |
| Rv0579 Rv0579 |
mtbc0_000609 |
hypothetical protein | Mut7-C RNAse domain-containing protein. Pfam: Ub-Mut7C (PF14451.13), Mut7-C (PF01927.23). | Ub-Mut7C Mut7-C |
Family assigned |
| Rv0580c Rv0580c |
mtbc0_000610 |
hypothetical protein | Mycobacterial cell wall protein Rv0580c. | Resolved | |
| yrbE2A Rv0587 |
mtbc0_000617 |
hypothetical protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| Rv0588 Rv0588 |
mtbc0_000618 |
hypothetical protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| Rv0597c Rv0597c |
mtbc0_000627 |
hypothetical protein | ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). | AAA_14 DUF4143 |
Family assigned |
| Rv0603 Rv0603 |
mtbc0_000633 |
hypothetical protein | Secreted protein with a solved NMR structure (PDB 2LRA, Rv0603); fold characterised, function not established. | Family assigned | |
| Rv0607 Rv0607 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6j9r-assembly1_A Coiled-coil Domain of Drosophila TRIM Protein Brat (prob 0.02, TM 0.20). | Still unknown | |
| Rv0609A Rv0609A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6teo-assembly2_D Crystal structure of a yeast Snu114-Prp8 complex (prob 0.01, TM 0.28). | Still unknown | |
| Rv0610c Rv0610c |
mtbc0_000642 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2z0r-assembly7_B Crystal structure of hypothetical protein TTHA0547 (prob 1.00, TM 0.70). | Still unknown | |
| Rv0611c Rv0611c |
mtbc0_000643 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: weak fold echo (SH3 beta-barrel, eukaryotic); function unknown. | DUF4926 |
Still unknown |
| Rv0612 Rv0612 |
mtbc0_000644 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6lja-assembly1_A Crystal Structure of exoHep from Bacteroides intestin (prob 0.23, TM 0.31). | Still unknown | |
| Rv0613c Rv0613c |
mtbc0_000645 |
hypothetical protein | SEC-C domain-containing protein. Pfam: SEC-C (PF02810.22). | SEC-C |
Family assigned |
| Rv0614 Rv0614 |
mtbc0_000646 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3wbn-assembly1_A Crystal structure of MATE in complex with MaL6 (prob 0.03, TM 0.32). | Still unknown | |
| Rv0628c Rv0628c |
mtbc0_000661 |
hypothetical protein | FIST N-terminal domain-containing protein. Pfam: FIST (PF08495.16), FIST_C (PF10442.15). | FIST FIST_C |
Family assigned |
| Rv0633c Rv0633c |
mtbc0_000666 |
hypothetical protein | Conserved hypothetical; Foldseek best hit (KirBac channel, TM 0.43, 4.1A) not conclusive. Function unknown. | Still unknown | |
| Rv0634A Rv0634A |
- |
hypothetical protein | Contains VapB_antitoxin (PF09957.16) domain(s); putative function inferred from the domain architecture. | VapB_antitoxin |
Family assigned |
| Rv0647c Rv0647c |
- |
hypothetical protein | Contains ABC1 (PF03109.23), UbiB_N (PF27536.1) domain(s); putative function inferred from the domain architecture. | ABC1 UbiB_N |
Family assigned |
| Rv0674 Rv0674 |
mtbc0_000713 |
hypothetical protein | PaaX family transcriptional regulator C-terminal domain-containing protein. Pfam: PaaX (PF07848.19), PaaX_M (PF20803.3), PaaX_C (PF08223.17). | PaaX PaaX_M PaaX_C |
Family assigned |
| mmpR5 Rv0678 |
mtbc0_000717 |
hypothetical protein | Siderophore transport transcriptional regulator MmpR5. Pfam: HTH_MmpR5 (PF27059.1). | HTH_MmpR5 |
Family assigned |
| Rv0679c Rv0679c |
mtbc0_000718 |
hypothetical protein | Membrane protein (16.6 kDa) of the cell envelope implicated in host-cell invasion; a dimorphic antigen carrying a Beijing-genotype-specific Asn142Lys polymorphism with distinct antibody responses. Rv0679c-derived peptides bind A549/U937 cells and TLR2/TLR4 and inhibit bacillary entry, suggesting a role in invasion (Zhao 2017). Molecular function unfixed. | DUF3060 |
Family assigned |
| Rv0689c Rv0689c |
- |
hypothetical protein | eggNOG ortholog of COG3324 (amino-acid-metabolism COG category E), annotated with translation-initiation-factor-related GO activity. RefSeq leaves it 'hypothetical protein'. A weak, GO-level functional transfer; treated as a family hint only. | Family assigned | |
| Rv0690c Rv0690c |
mtbc0_000730 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2332. Function unknown. Foldseek best (non-significant) hit: 8rpr-assembly1_A Crystal Structure of SgvM methyltransferase in comple (prob 0.47, TM 0.27). | DUF2332 |
Still unknown |
| Rv0698 Rv0698 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0699 Rv0699 |
mtbc0_000740 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0712 Rv0712 |
mtbc0_000754 |
hypothetical protein | Formylglycine-generating enzyme family protein. Pfam: FGE-sulfatase (PF03781.23). | FGE-sulfatase |
Family assigned |
| Rv0725c Rv0725c |
- |
hypothetical protein | Contains LCM (PF04072.21) domain(s); putative function inferred from the domain architecture. | LCM |
Family assigned |
| Rv0738 Rv0738 |
mtbc0_000782 |
hypothetical protein | TIGR03086 family metal-binding protein. Pfam: MDMPI_N (PF11716.14). | MDMPI_N |
Family assigned |
| Rv0739 Rv0739 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4226. Function unknown. Foldseek best (non-significant) hit: 8e4g-assembly1_a Remodeling of the bacteriophage T7 during initial inf (prob 0.99, TM 0.69). | DUF4226 |
Still unknown |
| Rv0740 Rv0740 |
mtbc0_000785 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF7956. Function unknown. Foldseek best (non-significant) hit: 7jxh-assembly2_A HER2 in complex with JBJ-08-178-01 (prob 0.08, TM 0.30). | DUF7956 |
Still unknown |
| Rv0742 Rv0742 |
- |
hypothetical protein | Contains PE (PF00934.26) domain(s); putative function inferred from the domain architecture. | PE |
Family assigned |
| Rv0743c Rv0743c |
mtbc0_000788 |
hypothetical protein | DUF6036 family nucleotidyltransferase. | DUF6036 |
Family assigned |
| Rv0745 Rv0745 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0749A Rv0749A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0750 Rv0750 |
mtbc0_000797 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF7956. Function unknown. | DUF7956 |
Still unknown |
| Rv0756c Rv0756c |
mtbc0_000805 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0759c Rv0759c |
- |
hypothetical protein | Contains HIT (PF01230.30) domain(s); putative function inferred from the domain architecture. | HIT |
Family assigned |
| Rv0760c Rv0760c |
mtbc0_000809 |
hypothetical protein | Ketosteroid isomerase family protein. Pfam: NTF2 (PF02136.27), SnoaL_2 (PF12680.14). | NTF2 SnoaL_2 |
Family assigned |
| Rv0762c Rv0762c |
mtbc0_000811 |
hypothetical protein | Nuclear transport factor 2 family protein. | Family assigned | |
| Rv0774c Rv0774c |
mtbc0_000823 |
hypothetical protein | Iron-stress inducible esterase. Pfam: Esterase (PF00756.27). | Esterase |
Resolved |
| Rv0775 Rv0775 |
mtbc0_000824 |
hypothetical protein | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_31 (PF17940.7). | TetR_N TetR_C_31 |
Family assigned |
| Rv0776c Rv0776c |
mtbc0_000825 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF429. Function unknown. Foldseek best (non-significant) hit: 4pht-assembly1_X ATPase GspE in complex with the cytoplasmic domain of (prob 0.60, TM 0.40). | DUF429 |
Still unknown |
| Rv0784 Rv0784 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2334. Function unknown. Foldseek best (non-significant) hit: 3cqh-assembly1_A Crystal Structure of L-xylulose-5-phosphate 3-epimera (prob 0.21, TM 0.37). | DUF2334 |
Still unknown |
| Rv0786c Rv0786c |
mtbc0_000836 |
hypothetical protein | MBL fold metallo-hydrolase. Pfam: Lactamase_B_3 (PF13483.13), Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14). | Lactamase_B_3 Lactamase_B Lactamase_B_2 |
Resolved |
| Rv0787 Rv0787 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4tmd-assembly1_A X-ray structure of Putative uncharacterized protein ( (prob 0.66, TM 0.36). | Still unknown | |
| Rv0787A Rv0787A |
- |
hypothetical protein | Contains PurS (PF02700.20) domain(s); putative function inferred from the domain architecture. | PurS |
Family assigned |
| Rv0789c Rv0789c |
- |
hypothetical protein | YbjN-like fold (putative sensor / regulatory protein). RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on YbjN, a putative transcription regulator (PDB 6vu7; Foldseek prob 1.0, E 1e-5, TM 0.80). Fold-level assignment; the regulatory role and partners are not established. | Family assigned | |
| Rv0790c Rv0790c |
mtbc0_000841 |
hypothetical protein | Transglutaminase-like domain-containing protein. Pfam: Transglut_core (PF01841.26). | Transglut_core |
Family assigned |