MTBC Gene Atlas

Genes

1086 genes matched.

GeneMTBC0Legacy (H37Rv)MTBC0 PGAP / revisedPfamVerdict
Rv0566c
Rv0566c		 mtbc0_000595 hypothetical protein YajQ family cyclic di-GMP-binding protein. Pfam: YajQ (PF04461.19). YajQ Family assigned
Rv0569
Rv0569		 mtbc0_000599 hypothetical protein DosR (dormancy survival regulon) protein; conserved hypothetical protein over-expressed under hypoxia. NMR solution structure determined (five antiparallel beta-sheets + one alpha-helix), structurally homologous to Rv2302; proposed to contribute to hypoxic signal transduction by binding DNA to up-regulate the adjacent Rv0570. Immunodominant Th1 latency antigen. Precise molecular function unfixed. DUF1918 Family assigned
Rv0571c
Rv0571c		 mtbc0_000601 hypothetical protein Phosphoribosyltransferase family protein. Pfam: Pribosyltran (PF00156.34), DLH (PF01738.25). Pribosyltran DLH Family assigned
Rv0572c
Rv0572c		 mtbc0_000602 hypothetical protein Contains MT0599 (PF25859.1) domain(s); putative function inferred from the domain architecture. MT0599 Family assigned
Rv0574c
Rv0574c		 mtbc0_000604 hypothetical protein CapA family protein. Pfam: PGA_cap (PF09587.16). PGA_cap Family assigned
TB27.3
Rv0577		 mtbc0_000607 hypothetical protein VOC family protein. Pfam: Glyoxalase (PF00903.32), Glyoxalase_6 (PF18029.8). Glyoxalase Glyoxalase_6 Family assigned
Rv0579
Rv0579		 mtbc0_000609 hypothetical protein Mut7-C RNAse domain-containing protein. Pfam: Ub-Mut7C (PF14451.13), Mut7-C (PF01927.23). Ub-Mut7C Mut7-C Family assigned
Rv0580c
Rv0580c		 mtbc0_000610 hypothetical protein Mycobacterial cell wall protein Rv0580c. Resolved
yrbE2A
Rv0587		 mtbc0_000617 hypothetical protein ABC transporter permease. Pfam: MlaE (PF02405.22). MlaE Family assigned
Rv0588
Rv0588		 mtbc0_000618 hypothetical protein ABC transporter permease. Pfam: MlaE (PF02405.22). MlaE Family assigned
Rv0597c
Rv0597c		 mtbc0_000627 hypothetical protein ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). AAA_14 DUF4143 Family assigned
Rv0603
Rv0603		 mtbc0_000633 hypothetical protein Secreted protein with a solved NMR structure (PDB 2LRA, Rv0603); fold characterised, function not established. Family assigned
Rv0607
Rv0607		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6j9r-assembly1_A Coiled-coil Domain of Drosophila TRIM Protein Brat (prob 0.02, TM 0.20). Still unknown
Rv0609A
Rv0609A		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6teo-assembly2_D Crystal structure of a yeast Snu114-Prp8 complex (prob 0.01, TM 0.28). Still unknown
Rv0610c
Rv0610c		 mtbc0_000642 hypothetical protein N-terminal region matches the SseB N-terminal domain family (Pfam PF07179, HHpred probability ~96%, E=0.09), with converging hits to DUF3234 (PF11572) and the structural-genomics protein TTHA0547 (PDB 2Z0R). A domain/fold is assigned by profile-profile search (HHpred), but both families are poorly characterised, so the precise function in M. tuberculosis remains undefined. (The lower VbhA/Fic-antitoxin hits are high-E-value noise.) Family assigned
Rv0611c
Rv0611c		 mtbc0_000643 hypothetical protein Small SH3-like / beta-barrel domain protein (SH3-like superfamily protein-protein/peptide interaction module): HHpred top hit YorP SH3-like fold 97.68% E0.0013 (borderline significant), with convergence on SH3-like beta-barrels (PetP cytochrome-b6f SH3 subunit, L24 ribosomal-protein SH3-barrel, Tudor domain, ydhK/DUF1541). SH3-like domains mediate protein-protein/peptide interactions; the specific binding partner is undetermined. RefSeq leaves this locus uncharacterised. DUF4926 Family assigned
Rv0612
Rv0612		 mtbc0_000644 hypothetical protein Belongs to the DUF6155 family (Pfam PF19652, HHpred 96.6%, near full-length), with a converging hit to DUF6880 (PF21810, 96%) and to the nuclear proteasome-tether protein Cut8 (Pfam PF08559 / PDB 3Q5W, ~94%, E~4). A domain is assigned; the Cut8 match is a suggestive lead toward a proteasome-associated role (plausible given the Mtb Pup-proteasome), but at moderate E-value it is not asserted, and the DUF families are uncharacterised, so the precise function remains undefined. (The many ribosomal-S20 / TPR hits below ~85% with E>>1 are noise.) Family assigned
Rv0613c
Rv0613c		 mtbc0_000645 hypothetical protein SEC-C domain-containing protein. Pfam: SEC-C (PF02810.22). SEC-C Family assigned
Rv0614
Rv0614		 mtbc0_000646 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3wbn-assembly1_A Crystal structure of MATE in complex with MaL6 (prob 0.03, TM 0.32). Still unknown
Rv0616c
Rv0616c		 Hypothetical protein — Still unknown
Rv0628c
Rv0628c		 mtbc0_000661 hypothetical protein FIST N-terminal domain-containing protein. Pfam: FIST (PF08495.16), FIST_C (PF10442.15). FIST FIST_C Family assigned
Rv0633c
Rv0633c		 mtbc0_000666 hypothetical protein Membrane protein co-transcribed with echA3 (enoyl-CoA hydratase, fatty-acid beta-oxidation), under purifying selection. Contextual candidate: associated with fatty-acid / lipid beta-oxidation metabolism. Its molecular role is not established. Family assigned
Rv0634A
Rv0634A		 - hypothetical protein Contains VapB_antitoxin (PF09957.16) domain(s); putative function inferred from the domain architecture. VapB_antitoxin Family assigned
Rv0647c
Rv0647c		 - hypothetical protein Contains ABC1 (PF03109.23), UbiB_N (PF27536.1) domain(s); putative function inferred from the domain architecture. ABC1 UbiB_N Family assigned
Rv0674
Rv0674		 mtbc0_000713 hypothetical protein PaaX family transcriptional regulator C-terminal domain-containing protein. Pfam: PaaX (PF07848.19), PaaX_M (PF20803.3), PaaX_C (PF08223.17). PaaX PaaX_M PaaX_C Family assigned
mmpR5
Rv0678		 mtbc0_000717 hypothetical protein Siderophore transport transcriptional regulator MmpR5. Pfam: HTH_MmpR5 (PF27059.1). HTH_MmpR5 Family assigned
Rv0679c
Rv0679c		 mtbc0_000718 hypothetical protein Membrane protein (16.6 kDa) of the cell envelope implicated in host-cell invasion; a dimorphic antigen carrying a Beijing-genotype-specific Asn142Lys polymorphism with distinct antibody responses. Rv0679c-derived peptides bind A549/U937 cells and TLR2/TLR4 and inhibit bacillary entry, suggesting a role in invasion (Zhao 2017). Molecular function unfixed. DUF3060 Family assigned
Rv0689c
Rv0689c		 - hypothetical protein eggNOG ortholog of COG3324 (amino-acid-metabolism COG category E), annotated with translation-initiation-factor-related GO activity. RefSeq leaves it 'hypothetical protein'. A weak, GO-level functional transfer; treated as a family hint only. Family assigned
Rv0690c
Rv0690c		 mtbc0_000730 hypothetical protein Class I (Rossmann-fold) S-adenosyl-L-methionine (SAM)-dependent methyltransferase: HHpred returns 25/25 hits to SAM-MTases (convergent, best 73%) and the protein is soluble (DeepTMHMM GLOB, 0 TM). It lies adjacent to the mycofactocin (MFT) biosynthesis operon (mftABC...) and is STRING-linked to all mft genes, BUT it is NOT the mycofactocin methyltransferase: M. tuberculosis does NOT methylate mycofactocin, and the characterised MftM is the distal, non-operonic MSMEG_6237 of M. smegmatis (Pena-Ortiz 2022). The methyl-acceptor substrate of Rv0690c is undetermined. DUF2332 Family assigned
Rv0698
Rv0698		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv0699
Rv0699		 mtbc0_000740 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv0712
Rv0712		 mtbc0_000754 hypothetical protein Formylglycine-generating enzyme family protein. Pfam: FGE-sulfatase (PF03781.23). FGE-sulfatase Family assigned
Rv0724A
Rv0724A		 Conserved hypothetical protein Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity Family assigned
Rv0725c
Rv0725c		 - hypothetical protein Contains LCM (PF04072.21) domain(s); putative function inferred from the domain architecture. LCM Family assigned
Rv0738
Rv0738		 mtbc0_000782 hypothetical protein TIGR03086 family metal-binding protein. Pfam: MDMPI_N (PF11716.14). MDMPI_N Family assigned
Rv0739
Rv0739		 - hypothetical protein Conserved hypothetical protein; DUF domain(s) DUF4226. Function unknown. Foldseek best (non-significant) hit: 8e4g-assembly1_a Remodeling of the bacteriophage T7 during initial inf (prob 0.99, TM 0.69). DUF4226 Still unknown
Rv0740
Rv0740		 mtbc0_000785 hypothetical protein Conserved hypothetical protein; DUF domain(s) DUF7956. Function unknown. Foldseek best (non-significant) hit: 7jxh-assembly2_A HER2 in complex with JBJ-08-178-01 (prob 0.08, TM 0.30). DUF7956 Still unknown
Rv0742
Rv0742		 - hypothetical protein Contains PE (PF00934.26) domain(s); putative function inferred from the domain architecture. PE Family assigned
Rv0743c
Rv0743c		 mtbc0_000788 hypothetical protein DUF6036 family nucleotidyltransferase. DUF6036 Family assigned
Rv0745
Rv0745		 - hypothetical protein ATP-dependent DNA helicase of the RecQ family (eggNOG COG0514, EC 3.6.4.12). RefSeq leaves it 'hypothetical protein'. A DEAD/DEAH-box superfamily-II helicase; biological pathway (recombination/repair) undetermined here. Family assigned
Rv0749A
Rv0749A		 - hypothetical protein Transposase of an insertion sequence (eggNOG COG2801, IS3/IS630-type DDE transposase; COG category L), partial ORF in an RD (130) mobile context. A mobile-element function, not a host-metabolic gene. Family assigned
Rv0750
Rv0750		 mtbc0_000797 hypothetical protein Conserved hypothetical protein; DUF domain(s) DUF7956. Function unknown. DUF7956 Still unknown
Rv0756c
Rv0756c		 mtbc0_000805 hypothetical protein Candidate accessory component of the PhoP-PhoR two-component virulence regulatory system, coupled to the PhoP-PhoR two-component signalling locus (phoP Rv0757 / phoR Rv0758). Rv0756c is genomically and contextually associated (STRING context-driven, text-mining excluded) with phoP:774;phoR:736;lprB:714;lprC:698;Rv2876:671;pirG:670;Rv0513:663;lpqB:663. It is under purifying selection on 145,209 MTBC genomes (26 segregating sites). No dedicated functional study of Rv0756c exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). Family assigned
Rv0759c
Rv0759c		 - hypothetical protein Contains HIT (PF01230.30) domain(s); putative function inferred from the domain architecture. HIT Family assigned
Rv0760c
Rv0760c		 mtbc0_000809 hypothetical protein Ketosteroid isomerase family protein. Pfam: NTF2 (PF02136.27), SnoaL_2 (PF12680.14). NTF2 SnoaL_2 Family assigned
Rv0762c
Rv0762c		 mtbc0_000811 hypothetical protein Nuclear transport factor 2 family protein. Family assigned
Rv0774c
Rv0774c		 mtbc0_000823 hypothetical protein Iron-stress inducible esterase. Pfam: Esterase (PF00756.27). Esterase Resolved
Rv0775
Rv0775		 mtbc0_000824 hypothetical protein TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_31 (PF17940.7). TetR_N TetR_C_31 Family assigned
Rv0776c
Rv0776c		 mtbc0_000825 hypothetical protein Predicted nuclease with an RNase-H-like fold (eggNOG COG4328). Nuclease fold at orthology level; substrate/role undetermined. DUF429 Family assigned
Rv0784
Rv0784		 - hypothetical protein Carbohydrate-esterase-family-4 (CE4) / polysaccharide deacetylase (NodB-homology domain): a metal-dependent (beta/alpha)8 TIM-barrel deacetylase. The specific substrate within this functionally diverse family (peptidoglycan GlcNAc deacetylase, chitin deacetylase, or acetylxylan esterase) is undetermined. RefSeq leaves this locus uncharacterised. DUF2334 Family assigned