Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| pmmB Rv3308 |
mtbc0_003516 |
phosphomannomutase PmmB | Phospho-sugar mutase. Pfam: PGM_PMM_I (PF02878.23), PGM_PMM_II (PF02879.23), PGM_PMM_III (PF02880.23). | PGM_PMM_I PGM_PMM_II PGM_PMM_III |
Resolved |
| upp Rv3309c |
mtbc0_003517 |
uracil phosphoribosyltransferase | Uracil phosphoribosyltransferase. Pfam: UPRTase (PF14681.13), Pribosyltran (PF00156.34). | UPRTase Pribosyltran |
Resolved |
| sapM Rv3310 |
mtbc0_003518 |
acid phosphatase | Phosphatidylinositol-3-phosphatase. Pfam: Phosphoesterase (PF04185.20). | Phosphoesterase |
Resolved |
| Rv3311 Rv3311 |
mtbc0_003519 |
hypothetical protein | Primosomal protein. | Family assigned | |
| Rv3312A Rv3312A |
- |
pilin | Pilin. Pfam: Pilin_Mycobact (PF26380.2). | Pilin_Mycobact |
Resolved |
| Rv3312b Rv3312b |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3312c Rv3312c |
mtbc0_003520 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| add Rv3313c |
mtbc0_003523 |
adenosine deaminase | Adenosine deaminase. Pfam: A_deaminase (PF00962.29). | A_deaminase |
Resolved |
| deoA Rv3314c |
mtbc0_003524 |
thymidine phosphorylase | Thymidine phosphorylase. Pfam: Glycos_trans_3N (PF02885.23), Glycos_transf_3 (PF00591.28), PYNP_C (PF07831.20). | Glycos_trans_3N Glycos_transf_3 PYNP_C |
Resolved |
| cdd Rv3315c |
mtbc0_003525 |
cytidine deaminase | Cytidine deaminase. Pfam: dCMP_cyt_deam_2 (PF08211.19), dCMP_cyt_deam_1 (PF00383.30). | dCMP_cyt_deam_2 dCMP_cyt_deam_1 |
Resolved |
| sdhC Rv3316 |
mtbc0_003526 |
succinate dehydrogenase cytochrome B-556 subunit | Succinate dehydrogenase%2C cytochrome b556 subunit. Pfam: Sdh_cyt (PF01127.28). | Sdh_cyt |
Family assigned |
| sdhD Rv3317 |
mtbc0_003527 |
succinate dehydrogenase hydrophobic membrane anchor subunit | Succinate dehydrogenase hydrophobic membrane anchor subunit. Pfam: Sdh_cyt (PF01127.28). | Sdh_cyt |
Family assigned |
| sdhA Rv3318 |
mtbc0_003528 |
succinate dehydrogenase flavoprotein subunit | Succinate dehydrogenase flavoprotein subunit. Pfam: FAD_binding_2 (PF00890.31), Succ_DH_flav_C (PF02910.26). | FAD_binding_2 Succ_DH_flav_C |
Family assigned |
| sdhB Rv3319 |
mtbc0_003529 |
succinate dehydrogenase iron-sulphur protein subunit | Succinate dehydrogenase iron-sulfur subunit. Pfam: Fer2_3 (PF13085.12), Fer4_10 (PF13237.12), Fer4_8 (PF13183.12), Fer4_17 (PF13534.12). | Fer2_3 Fer4_10 Fer4_8 Fer4_17 |
Family assigned |
| vapC44 Rv3320c |
mtbc0_003530 |
ribonuclease VapC44 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB44 Rv3321c |
mtbc0_003531 |
antitoxin VapB44 | CopG family transcriptional regulator. | Family assigned | |
| Rv3322c Rv3322c |
- |
methyltransferase | Methyltransferase. Pfam: Methyltransf_25 (PF13649.13). | Methyltransf_25 |
Resolved |
| moaX Rv3323c |
- |
MoaD-MoaE fusion protein MoaX | MoaD-MoaE fusion protein MoaX. Pfam: ThiS (PF02597.27), MoaE (PF02391.23). | ThiS MoaE |
Resolved |
| moaC3 Rv3324c |
mtbc0_003534 |
cyclic pyranopterin monophosphate synthase accessory protein | Cyclic pyranopterin monophosphate synthase MoaC. Pfam: MoaC (PF01967.28). | MoaC |
Resolved |
| Rv3327 Rv3327 |
mtbc0_000846 |
transposase fusion protein | IS110 family transposase. Pfam: DEDD_Tnp_IS110 (PF01548.24), Transposase_20 (PF02371.23). | DEDD_Tnp_IS110 Transposase_20 |
Family assigned |
| sigJ Rv3328c |
mtbc0_003541 |
ECF RNA polymerase sigma factor SigJ | Sigma-70 family RNA polymerase sigma factor SigJ. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), SnoaL_2 (PF12680.14). | Sigma70_r2 Sigma70_r4_2 SnoaL_2 |
Family assigned |
| Rv3329 Rv3329 |
- |
aminotransferase | Aminotransferase. Pfam: Aminotran_3 (PF00202.28). | Aminotran_3 |
Resolved |
| dacB1 Rv3330 |
mtbc0_003543 |
penicillin-binding protein DacB | D-alanyl-D-alanine carboxypeptidase DacB1. Pfam: Peptidase_S11 (PF00768.26), Beta-lactamase2 (PF13354.13). | Peptidase_S11 Beta-lactamase2 |
Resolved |
| sugI Rv3331 |
- |
sugar-transport integral membrane protein SugI | Sugar-transport integral membrane protein SugI. Pfam: Sugar_tr (PF00083.31), MFS_1 (PF07690.22). | Sugar_tr MFS_1 |
Resolved |
| nagA Rv3332 |
mtbc0_003545 |
N-acetylglucosamine-6-phosphate deacetylase NagA | N-acetylglucosamine-6-phosphate deacetylase. Pfam: Amidohydro_1 (PF01979.27). | Amidohydro_1 |
Resolved |
| prp1 Rv3333c |
mtbc0_003546 |
hypothetical protein | PDZ-interacting protease regulator Ppr1. | DUF732 |
Resolved |
| Rv3334 Rv3334 |
mtbc0_003547 |
MerR family transcriptional regulator | Hypoxia response transcriptional regulator. Pfam: MerR_1 (PF13411.13), MerR (PF00376.30), MerR-DNA-bind (PF09278.18). | MerR_1 MerR MerR-DNA-bind |
Family assigned |
| yhjD Rv3335c |
mtbc0_003548 |
integral membrane protein | Inner membrane protein YhjD. Pfam: Virul_fac_BrkB (PF03631.21). | Virul_fac_BrkB |
Resolved |
| trpS Rv3336c |
mtbc0_003549 |
tryptophan--tRNA ligase | Tryptophan--tRNA ligase. Pfam: tRNA-synt_1b (PF00579.32). | tRNA-synt_1b |
Resolved |
| icd1 Rv3339c |
mtbc0_003551 |
isocitrate dehydrogenase | NADP-dependent isocitrate dehydrogenase. Pfam: Iso_dh (PF00180.26). | Iso_dh |
Resolved |
| metC Rv3340 |
mtbc0_003552 |
O-acetylhomoserine sulfhydrylase | Bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase. Pfam: Cys_Met_Meta_PP (PF01053.27). | Cys_Met_Meta_PP |
Resolved |
| metA Rv3341 |
mtbc0_003553 |
homoserine O-acetyltransferase | Homoserine O-acetyltransferase. Pfam: Abhydrolase_1 (PF00561.27). | Abhydrolase_1 |
Resolved |
| Rv3342 Rv3342 |
mtbc0_003554 |
methyltransferase | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Ubie_methyltran Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| PPE54 Rv3343c |
- |
PPE family protein PPE54 | PPE family protein PPE54. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| PE_PGRS49 Rv3344c |
- |
PE-PGRS family protein PE_PGRS49 | PE-PGRS family protein PE_PGRS49. | Family assigned | |
| PE_PGRS50 Rv3345c |
- |
PE-PGRS family protein PE_PGRS50 | PE-PGRS family protein PE_PGRS50. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv3346c Rv3346c |
mtbc0_003558 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3017. Function unknown. | DUF3017 |
Still unknown |
| PPE55 Rv3347c |
- |
PPE family protein PPE55 | PPE family protein PPE55. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv3348 Rv3348 |
- |
transposase | Transposase. Pfam: DEDD_Tnp_IS110 (PF01548.24). | DEDD_Tnp_IS110 |
Resolved |
| Rv3349c Rv3349c |
- |
transposase | Transposase. Pfam: DDE_Tnp_ISL3 (PF01610.24). | DDE_Tnp_ISL3 |
Resolved |
| PPE56 Rv3350c |
- |
PPE family protein PPE56 | PPE family protein PPE56. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv3351c Rv3351c |
- |
hypothetical protein | Contains BBE (PF08031.18) domain(s); putative function inferred from the domain architecture. | BBE |
Family assigned |
| Rv3352c Rv3352c |
- |
oxidoreductase | Oxidoreductase. Pfam: FAD_binding_4 (PF01565.29). | FAD_binding_4 |
Resolved |
| Rv3353c Rv3353c |
mtbc0_003568 |
hypothetical protein | Oxidoreductase. | Resolved | |
| Rv3354 Rv3354 |
mtbc0_003569 |
hypothetical protein | Secreted protein kinase effector that targets the host COP9 signalosome to suppress apoptosis. RefSeq leaves it 'hypothetical'. Rv3354 is secreted into mononuclear phagocytes and is required for virulence; it targets the JAMM metalloprotease domain of COP9-signalosome subunit 5 (CSN5), destabilising cullin-RING ubiquitin-ligase activity and suppressing apoptosis (Danelishvili 2014). A secreted protein with a signal sequence conserved in M. leprae. | DUF732 |
Resolved |
| Rv3355c Rv3355c |
mtbc0_003570 |
integral membrane protein | Conserved hypothetical protein; DUF domain(s) DUF3017. Function unknown. | DUF3017 |
Still unknown |
| folD Rv3356c |
- |
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase. Pfam: THF_DHG_CYH (PF00763.29), THF_DHG_CYH_C (PF02882.26). | THF_DHG_CYH THF_DHG_CYH_C |
Resolved |
| relJ Rv3357 |
mtbc0_003572 |
antitoxin RelJ | Type II toxin-antitoxin system antitoxin RelJ. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| relK Rv3358 |
mtbc0_003573 |
toxin RelK | Txe/YoeB family addiction module toxin. Pfam: YoeB_toxin (PF06769.21). | YoeB_toxin |
Family assigned |
| Rv3359 Rv3359 |
mtbc0_003574 |
oxidoreductase | NADH:flavin oxidoreductase. Pfam: Oxidored_FMN (PF00724.27). | Oxidored_FMN |
Resolved |