Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2862c Rv2862c |
mtbc0_003043 |
hypothetical protein | LiaF-like integral membrane protein (eggNOG COG4758), accessory inhibitor of a LiaRS-type two-component cell-envelope-stress response. Family-level; the cognate two-component partner in M. tuberculosis is undetermined. | DUF1707 |
Family assigned |
| vapC23 Rv2863 |
mtbc0_003045 |
ribonuclease VapC23 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv2864c Rv2864c |
mtbc0_003046 |
penicillin-binding lipoprotein | Penicillin-binding protein. Pfam: MecA_N (PF05223.18), Transpeptidase (PF00905.28). | MecA_N Transpeptidase |
Family assigned |
| relF Rv2865 |
mtbc0_003047 |
antitoxin RelF | Type II toxin-antitoxin system antitoxin RelF. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| relG Rv2866 |
mtbc0_003048 |
toxin RelG | Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: ParE_toxin (PF05016.22). | ParE_toxin |
Family assigned |
| Rv2867c Rv2867c |
mtbc0_003049 |
GCN5-like N-acetyltransferase | GNAT family N-acetyltransferase. Pfam: DUF4081 (PF13312.12), Acetyltransf_1 (PF00583.32), FR47 (PF08445.17). | DUF4081 Acetyltransf_1 FR47 |
Family assigned |
| gcpE Rv2868c |
mtbc0_003050 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) | Flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase. Pfam: GcpE (PF04551.20), GcpE_C (PF26540.1). | GcpE GcpE_C |
Resolved |
| rip Rv2869c |
mtbc0_003051 |
zinc metalloprotease | Zinc metalloprotease Rip. Pfam: Peptidase_M50 (PF02163.29), PDZ_6 (PF17820.8). | Peptidase_M50 PDZ_6 |
Resolved |
| dxr Rv2870c |
mtbc0_003052 |
1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Pfam: DXP_reductoisom (PF02670.23), DXP_redisom_C (PF08436.18), DXPR_C (PF13288.13). | DXP_reductoisom DXP_redisom_C DXPR_C |
Resolved |
| vapB43 Rv2871 |
mtbc0_003053 |
antitoxin VapB43 | Ribbon-helix-helix domain-containing protein. Pfam: RHH_1 (PF01402.28). | RHH_1 |
Family assigned |
| vapC43 Rv2872 |
mtbc0_003054 |
ribonuclease VapC43 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| mpt83 Rv2873 |
mtbc0_003055 |
cell surface lipoprotein | Cell surface glycolipoprotein Mpt83. Pfam: Fasciclin (PF02469.28). | Fasciclin |
Resolved |
| dipZ Rv2874 |
- |
integral membrane C-type cytochrome biogenesis protein DipZ | Integral membrane C-type cytochrome biogenesis protein DipZ. Pfam: DsbD_TM (PF02683.23), Redoxin (PF08534.17), AhpC-TSA (PF00578.28), Thioredoxin_10 (PF17991.8). | DsbD_TM Redoxin AhpC-TSA Thioredoxin_10 |
Resolved |
| mpt70 Rv2875 |
mtbc0_003058 |
major secreted immunogenic protein Mpt70 | Fasciclin domain-containing protein. Pfam: Fasciclin (PF02469.28). | Fasciclin |
Family assigned |
| Rv2876 Rv2876 |
- |
transmembrane protein | Transmembrane protein. | DUF2631 |
Resolved |
| Rv2877c Rv2877c |
- |
integral membrane protein | Integral membrane protein. | Family assigned | |
| mpt53 Rv2878c |
mtbc0_003061 |
soluble secreted antigen Mpt53 | Protein disulfide oxidoreductase. Pfam: AhpC-TSA (PF00578.28), Redoxin (PF08534.17), Thioredoxin_2 (PF13098.14). | AhpC-TSA Redoxin Thioredoxin_2 |
Resolved |
| cdsA Rv2881c |
mtbc0_003063 |
phosphatidate cytidylyltransferase | Phosphatidate cytidylyltransferase. Pfam: CTP_transf_1 (PF01148.26). | CTP_transf_1 |
Resolved |
| frr Rv2882c |
mtbc0_003064 |
ribosome recycling factor | Ribosome recycling factor. Pfam: RRF (PF01765.25). | RRF |
Resolved |
| pyrH Rv2883c |
mtbc0_003065 |
uridylate kinase | UMP kinase. Pfam: AA_kinase (PF00696.34). | AA_kinase |
Resolved |
| Rv2884 Rv2884 |
- |
transcriptional regulator | Transcriptional regulator. Pfam: GlnR_1st (PF21695.4), Trans_reg_C (PF00486.35). | GlnR_1st Trans_reg_C |
Family assigned |
| Rv2885c Rv2885c |
- |
transposase | Transposase. Pfam: HTH_OrfB_IS605 (PF12323.15), OrfB_IS605 (PF01385.26), Cas12f1-like_TNB (PF07282.19). | HTH_OrfB_IS605 OrfB_IS605 Cas12f1-like_TNB |
Resolved |
| Rv2886c Rv2886c |
- |
resolvase | Resolvase. Pfam: Resolvase (PF00239.27). | Resolvase |
Resolved |
| Rv2887 Rv2887 |
mtbc0_003069 |
HTH-type transcriptional regulator | MarR family transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29), HTH_24 (PF13412.13). | MarR_2 MarR HTH_24 |
Family assigned |
| amiC Rv2888c |
mtbc0_003070 |
amidase AmiC | Amidase. Pfam: Amidase (PF01425.27). | Amidase |
Resolved |
| tsf Rv2889c |
mtbc0_003071 |
elongation factor EF-Ts | Translation elongation factor Ts. Pfam: EF_TS (PF00889.26). | EF_TS |
Resolved |
| rpsB Rv2890c |
mtbc0_003072 |
30S ribosomal protein S2 | 30S ribosomal protein S2. Pfam: Ribosomal_S2 (PF00318.26). | Ribosomal_S2 |
Resolved |
| Rv2891 Rv2891 |
- |
hypothetical protein | Contains Peptidase_M23 (PF01551.30) domain(s); putative function inferred from the domain architecture. | Peptidase_M23 |
Family assigned |
| PPE45 Rv2892c |
- |
PPE family protein PPE45 | PPE family protein PPE45. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| Rv2893 Rv2893 |
mtbc0_003075 |
oxidoreductase | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| xerC Rv2894c |
mtbc0_003076 |
tyrosine recombinase XerC | Tyrosine recombinase XerC. Pfam: Phage_int_SAM_1 (PF02899.24), Phage_integrase (PF00589.28). | Phage_int_SAM_1 Phage_integrase |
Resolved |
| viuB Rv2895c |
mtbc0_003077 |
mycobactin utilization protein ViuB | Siderophore-interacting protein. Pfam: FAD_binding_9 (PF08021.18), SIP (PF04954.19). | FAD_binding_9 SIP |
Resolved |
| dprA Rv2896c |
mtbc0_003078 |
hypothetical protein | DNA-processing protein DprA. Pfam: DNA_processg_A (PF02481.22), WHD_DprA (PF17782.8). | DNA_processg_A WHD_DprA |
Resolved |
| Rv2897c Rv2897c |
mtbc0_003079 |
hypothetical protein | YifB family Mg chelatase-like AAA ATPase. Pfam: Lon_C (PF05362.20), ChlI (PF13541.13), Mg_chelatase (PF01078.28), Mg_chelatase_C (PF13335.13). | Lon_C ChlI Mg_chelatase Mg_chelatase_C |
Family assigned |
| Rv2898c Rv2898c |
mtbc0_003080 |
hypothetical protein | YraN family protein. | UPF0102 |
Family assigned |
| fdhD Rv2899c |
mtbc0_003081 |
formate dehydrogenase accessory protein FdhD | Formate dehydrogenase accessory sulfurtransferase FdhD. Pfam: FdhD-NarQ (PF02634.22). | FdhD-NarQ |
Resolved |
| fdhF Rv2900c |
mtbc0_003082 |
formate dehydrogenase subunit alpha FdhF | FdhF/YdeP family oxidoreductase. Pfam: Molybdopterin (PF00384.28), Molydop_binding (PF01568.28). | Molybdopterin Molydop_binding |
Family assigned |
| Rv2901c Rv2901c |
mtbc0_003083 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2469. Function unknown. Foldseek best (non-significant) hit: 4m7d-assembly1_C Crystal structure of Lsm2-8 complex bound to the RNA (prob 0.16, TM 0.31). | DUF2469 |
Still unknown |
| rnhB Rv2902c |
mtbc0_003084 |
ribonuclease HII | Ribonuclease HII. Pfam: RNase_HII (PF01351.26). | RNase_HII |
Resolved |
| lepB Rv2903c |
mtbc0_003085 |
signal peptidase | Signal peptidase I. Pfam: Peptidase_S26 (PF10502.15). | Peptidase_S26 |
Resolved |
| rplS Rv2904c |
mtbc0_003086 |
50S ribosomal protein L19 | 50S ribosomal protein L19. Pfam: Ribosomal_L19 (PF01245.27). | Ribosomal_L19 |
Resolved |
| lppW Rv2905 |
mtbc0_003087 |
lipoprotein LppW | Serine-hydrolase of the class A beta-lactamase / penicillin-binding fold. RefSeq leaves it 'lipoprotein LppW'. Two independent signals converge: eggNOG annotates a 'Beta-lactamase' orthologous group (COG V, defense), and the AlphaFold model superposes on the class A beta-lactamase PenL (PDB 5gld; Foldseek prob 1.0, E 8e-10, TM 0.71). A locus distinct from the canonical M. tuberculosis beta-lactamase BlaC (Rv2068c); the Ser-x-x-Lys catalytic motif and the substrate are not demonstrated here. | Family assigned | |
| trmD Rv2906c |
mtbc0_003088 |
tRNA (guanine-N1)-methyltransferase | TRNA (guanosine(37)-N1)-methyltransferase TrmD. Pfam: tRNA_m1G_MT (PF01746.27). | tRNA_m1G_MT |
Resolved |
| rimM Rv2907c |
mtbc0_003089 |
16S rRNA processing protein RimM | Ribosome maturation factor RimM. Pfam: RimM (PF01782.25), PRC (PF05239.22), PRC_RimM (PF24986.2). | RimM PRC PRC_RimM |
Resolved |
| Rv2908c Rv2908c |
mtbc0_003090 |
hypothetical protein | RNA-binding protein. Pfam: KH_KhpA-B (PF13083.14). | KH_KhpA-B |
Family assigned |
| rpsP Rv2909c |
mtbc0_003091 |
30S ribosomal protein S16 | 30S ribosomal protein S16. Pfam: Ribosomal_S16 (PF00886.25). | Ribosomal_S16 |
Resolved |
| Rv2910c Rv2910c |
- |
hypothetical protein | Contains SnoaL_4 (PF13577.13) domain(s); putative function inferred from the domain architecture. | SnoaL_4 |
Family assigned |
| dacB2 Rv2911 |
- |
penicillin-binding protein DacB2 | Penicillin-binding protein DacB2. Pfam: Peptidase_S11 (PF00768.26), Beta-lactamase2 (PF13354.13). | Peptidase_S11 Beta-lactamase2 |
Family assigned |
| Rv2912c Rv2912c |
mtbc0_003094 |
TetR family HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv2913c Rv2913c |
mtbc0_003095 |
D-amino acid aminohydrolase | Amidohydrolase family protein. Pfam: Amidohydro_3 (PF07969.18). | Amidohydro_3 |
Family assigned |